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Q9JKL1

- PKR1_MOUSE

UniProt

Q9JKL1 - PKR1_MOUSE

Protein

Prokineticin receptor 1

Gene

Prokr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy By similarity.By similarity

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: MGI
    2. neuropeptide Y receptor activity Source: InterPro

    GO - Biological processi

    1. circadian rhythm Source: MGI
    2. coronary vasculature development Source: DFLAT
    3. G-protein coupled receptor signaling pathway Source: MGI
    4. negative regulation of apoptotic process Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prokineticin receptor 1
    Short name:
    PK-R1
    Alternative name(s):
    G-protein coupled receptor 73
    Gene namesi
    Name:Prokr1
    Synonyms:Gpr73, Pkr1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1929676. Prokr1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 393393Prokineticin receptor 1PRO_0000070080Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi11 – 111N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi137 ↔ 217PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ9JKL1.

    PTM databases

    PhosphoSiteiQ9JKL1.

    Expressioni

    Tissue specificityi

    Expressed at high levels in the heart, skeletal muscle and pancreas. Expressed at lower levels in the brain, lung, liver and kidney.

    Gene expression databases

    BgeeiQ9JKL1.
    CleanExiMM_PROKR1.
    GenevestigatoriQ9JKL1.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000059034.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JKL1.
    SMRiQ9JKL1. Positions 8-358.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6262ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini84 – 9815CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini120 – 14627ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini168 – 17912CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini201 – 23232ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini254 – 28229CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini304 – 32219ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini344 – 39350CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei63 – 8321Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei99 – 11921Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei147 – 16721Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei180 – 20021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei233 – 25321Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei283 – 30321Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei323 – 34321Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG319668.
    GeneTreeiENSGT00740000115565.
    HOGENOMiHOG000231664.
    HOVERGENiHBG039631.
    InParanoidiQ3U0M4.
    KOiK08379.
    OMAiNFIFITA.
    OrthoDBiEOG73NG3D.
    TreeFamiTF315303.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000611. NPY_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01012. NRPEPTIDEYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JKL1-1 [UniParc]FASTAAdd to Basket

    « Hide

    METTVGALGE NTTDTFTDFF SALDGHEAQT GSLPFTFSYG DYDMPLDEEE    50
    DVTNSRTFFA AKIVIGMALV GIMLVCGIGN FIFITALARY KKLRNLTNLL 100
    IANLAISDFL VAIVCCPFEM DYYVVRQLSW EHGHVLCASV NYLRTVSLYV 150
    STNALLAIAI DRYLAIVHPL RPRMKCQTAA GLIFLVWSVS ILIAIPAAYF 200
    TTETVLVIVE RQEKIFCGQI WPVDQQFYYR SYFLLVFGLE FVGPVVAMTL 250
    CYARVSRELW FKAVPGFQTE QIRRRLRCRR RTVLGLVCVL SAYVLCWAPF 300
    YGFTIVRDFF PSVFVKEKHY LTAFYVVECI AMSNSMINTL CFVTVRNNTS 350
    KYLKRILRLQ WRASPSGSKA SADLDLRTTG IPATEEVDCI RLK 393
    Length:393
    Mass (Da):44,597
    Last modified:July 27, 2011 - v2
    Checksum:iD0F5E79606D74283
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti275 – 2762RL → TV in AAF43706. (PubMed:10760605)Curated
    Sequence conflicti275 – 2762RL → TV in AAM49570. (PubMed:12024206)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF236082 mRNA. Translation: AAF43706.1.
    AF487278 mRNA. Translation: AAM49570.1.
    AK134279 mRNA. Translation: BAE22080.1.
    AK156734 mRNA. Translation: BAE33828.1.
    CH466523 Genomic DNA. Translation: EDK99210.1.
    BC059003 mRNA. Translation: AAH59003.1.
    CCDSiCCDS20323.1.
    RefSeqiNP_067356.2. NM_021381.3.
    XP_006506494.1. XM_006506431.1.
    XP_006506495.1. XM_006506432.1.
    UniGeneiMm.333226.

    Genome annotation databases

    EnsembliENSMUST00000050887; ENSMUSP00000059034; ENSMUSG00000049409.
    GeneIDi58182.
    KEGGimmu:58182.
    UCSCiuc009cto.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF236082 mRNA. Translation: AAF43706.1 .
    AF487278 mRNA. Translation: AAM49570.1 .
    AK134279 mRNA. Translation: BAE22080.1 .
    AK156734 mRNA. Translation: BAE33828.1 .
    CH466523 Genomic DNA. Translation: EDK99210.1 .
    BC059003 mRNA. Translation: AAH59003.1 .
    CCDSi CCDS20323.1.
    RefSeqi NP_067356.2. NM_021381.3.
    XP_006506494.1. XM_006506431.1.
    XP_006506495.1. XM_006506432.1.
    UniGenei Mm.333226.

    3D structure databases

    ProteinModelPortali Q9JKL1.
    SMRi Q9JKL1. Positions 8-358.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000059034.

    Chemistry

    ChEMBLi CHEMBL1949486.
    GuidetoPHARMACOLOGYi 335.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9JKL1.

    Proteomic databases

    PRIDEi Q9JKL1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000050887 ; ENSMUSP00000059034 ; ENSMUSG00000049409 .
    GeneIDi 58182.
    KEGGi mmu:58182.
    UCSCi uc009cto.1. mouse.

    Organism-specific databases

    CTDi 10887.
    MGIi MGI:1929676. Prokr1.

    Phylogenomic databases

    eggNOGi NOG319668.
    GeneTreei ENSGT00740000115565.
    HOGENOMi HOG000231664.
    HOVERGENi HBG039631.
    InParanoidi Q3U0M4.
    KOi K08379.
    OMAi NFIFITA.
    OrthoDBi EOG73NG3D.
    TreeFami TF315303.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 314139.
    PROi Q9JKL1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9JKL1.
    CleanExi MM_PROKR1.
    Genevestigatori Q9JKL1.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000611. NPY_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01012. NRPEPTIDEYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Y-receptor-like genes GPR72 and GPR73: molecular cloning, genomic organisation and assignment to human chromosome 11q21.1 and 2p14 and mouse chromosome 9 and 6."
      Parker R., Liu M., Eyre H.J., Copeland N.G., Gilbert D.J., Crawford J., Sutherland G.R., Jenkins N.A., Herzog H.
      Biochim. Biophys. Acta 1491:369-375(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus."
      Cheng M.Y., Bullock C.M., Li C., Lee A.G., Bermak J.C., Belluzzi J., Weaver D.R., Leslie F.M., Zhou Q.-Y.
      Nature 417:405-410(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Forelimb and Spleen.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiPKR1_MOUSE
    AccessioniPrimary (citable) accession number: Q9JKL1
    Secondary accession number(s): Q3U0M4, Q6PD11
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2003
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3