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Q9JKL1

- PKR1_MOUSE

UniProt

Q9JKL1 - PKR1_MOUSE

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Protein

Prokineticin receptor 1

Gene

Prokr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy (By similarity).By similarity

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: MGI
  2. neuropeptide Y receptor activity Source: InterPro

GO - Biological processi

  1. circadian rhythm Source: MGI
  2. coronary vasculature development Source: DFLAT
  3. G-protein coupled receptor signaling pathway Source: MGI
  4. negative regulation of apoptotic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.
REACT_235286. Peptide ligand-binding receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Prokineticin receptor 1
Short name:
PK-R1
Alternative name(s):
G-protein coupled receptor 73
Gene namesi
Name:Prokr1
Synonyms:Gpr73, Pkr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1929676. Prokr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6262ExtracellularSequence AnalysisAdd
BLAST
Transmembranei63 – 8321Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini84 – 9815CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei99 – 11921Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini120 – 14627ExtracellularSequence AnalysisAdd
BLAST
Transmembranei147 – 16721Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini168 – 17912CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei180 – 20021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini201 – 23232ExtracellularSequence AnalysisAdd
BLAST
Transmembranei233 – 25321Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini254 – 28229CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei283 – 30321Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini304 – 32219ExtracellularSequence AnalysisAdd
BLAST
Transmembranei323 – 34321Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini344 – 39350CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 393393Prokineticin receptor 1PRO_0000070080Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi11 – 111N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi137 ↔ 217PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9JKL1.

PTM databases

PhosphoSiteiQ9JKL1.

Expressioni

Tissue specificityi

Expressed at high levels in the heart, skeletal muscle and pancreas. Expressed at lower levels in the brain, lung, liver and kidney.

Gene expression databases

BgeeiQ9JKL1.
CleanExiMM_PROKR1.
GenevestigatoriQ9JKL1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059034.

Structurei

3D structure databases

ProteinModelPortaliQ9JKL1.
SMRiQ9JKL1. Positions 8-358.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG319668.
GeneTreeiENSGT00770000120614.
HOGENOMiHOG000231664.
HOVERGENiHBG039631.
InParanoidiQ9JKL1.
KOiK08379.
OMAiNFIFITA.
OrthoDBiEOG73NG3D.
TreeFamiTF315303.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01012. NRPEPTIDEYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JKL1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
METTVGALGE NTTDTFTDFF SALDGHEAQT GSLPFTFSYG DYDMPLDEEE
60 70 80 90 100
DVTNSRTFFA AKIVIGMALV GIMLVCGIGN FIFITALARY KKLRNLTNLL
110 120 130 140 150
IANLAISDFL VAIVCCPFEM DYYVVRQLSW EHGHVLCASV NYLRTVSLYV
160 170 180 190 200
STNALLAIAI DRYLAIVHPL RPRMKCQTAA GLIFLVWSVS ILIAIPAAYF
210 220 230 240 250
TTETVLVIVE RQEKIFCGQI WPVDQQFYYR SYFLLVFGLE FVGPVVAMTL
260 270 280 290 300
CYARVSRELW FKAVPGFQTE QIRRRLRCRR RTVLGLVCVL SAYVLCWAPF
310 320 330 340 350
YGFTIVRDFF PSVFVKEKHY LTAFYVVECI AMSNSMINTL CFVTVRNNTS
360 370 380 390
KYLKRILRLQ WRASPSGSKA SADLDLRTTG IPATEEVDCI RLK
Length:393
Mass (Da):44,597
Last modified:July 27, 2011 - v2
Checksum:iD0F5E79606D74283
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti275 – 2762RL → TV in AAF43706. (PubMed:10760605)Curated
Sequence conflicti275 – 2762RL → TV in AAM49570. (PubMed:12024206)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF236082 mRNA. Translation: AAF43706.1.
AF487278 mRNA. Translation: AAM49570.1.
AK134279 mRNA. Translation: BAE22080.1.
AK156734 mRNA. Translation: BAE33828.1.
CH466523 Genomic DNA. Translation: EDK99210.1.
BC059003 mRNA. Translation: AAH59003.1.
CCDSiCCDS20323.1.
RefSeqiNP_067356.2. NM_021381.3.
XP_006506494.1. XM_006506431.1.
XP_006506495.1. XM_006506432.1.
UniGeneiMm.333226.

Genome annotation databases

EnsembliENSMUST00000050887; ENSMUSP00000059034; ENSMUSG00000049409.
GeneIDi58182.
KEGGimmu:58182.
UCSCiuc009cto.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF236082 mRNA. Translation: AAF43706.1 .
AF487278 mRNA. Translation: AAM49570.1 .
AK134279 mRNA. Translation: BAE22080.1 .
AK156734 mRNA. Translation: BAE33828.1 .
CH466523 Genomic DNA. Translation: EDK99210.1 .
BC059003 mRNA. Translation: AAH59003.1 .
CCDSi CCDS20323.1.
RefSeqi NP_067356.2. NM_021381.3.
XP_006506494.1. XM_006506431.1.
XP_006506495.1. XM_006506432.1.
UniGenei Mm.333226.

3D structure databases

ProteinModelPortali Q9JKL1.
SMRi Q9JKL1. Positions 8-358.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000059034.

Chemistry

ChEMBLi CHEMBL1949486.
GuidetoPHARMACOLOGYi 335.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9JKL1.

Proteomic databases

PRIDEi Q9JKL1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000050887 ; ENSMUSP00000059034 ; ENSMUSG00000049409 .
GeneIDi 58182.
KEGGi mmu:58182.
UCSCi uc009cto.1. mouse.

Organism-specific databases

CTDi 10887.
MGIi MGI:1929676. Prokr1.

Phylogenomic databases

eggNOGi NOG319668.
GeneTreei ENSGT00770000120614.
HOGENOMi HOG000231664.
HOVERGENi HBG039631.
InParanoidi Q9JKL1.
KOi K08379.
OMAi NFIFITA.
OrthoDBi EOG73NG3D.
TreeFami TF315303.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.
REACT_235286. Peptide ligand-binding receptors.

Miscellaneous databases

NextBioi 314139.
PROi Q9JKL1.
SOURCEi Search...

Gene expression databases

Bgeei Q9JKL1.
CleanExi MM_PROKR1.
Genevestigatori Q9JKL1.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000611. NPY_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01012. NRPEPTIDEYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Y-receptor-like genes GPR72 and GPR73: molecular cloning, genomic organisation and assignment to human chromosome 11q21.1 and 2p14 and mouse chromosome 9 and 6."
    Parker R., Liu M., Eyre H.J., Copeland N.G., Gilbert D.J., Crawford J., Sutherland G.R., Jenkins N.A., Herzog H.
    Biochim. Biophys. Acta 1491:369-375(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus."
    Cheng M.Y., Bullock C.M., Li C., Lee A.G., Bermak J.C., Belluzzi J., Weaver D.R., Leslie F.M., Zhou Q.-Y.
    Nature 417:405-410(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Forelimb and Spleen.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiPKR1_MOUSE
AccessioniPrimary (citable) accession number: Q9JKL1
Secondary accession number(s): Q3U0M4, Q6PD11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3