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Q9JKL1 (PKR1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Prokineticin receptor 1

Short name=PK-R1
Alternative name(s):
G-protein coupled receptor 73
Gene names
Name:Prokr1
Synonyms:Gpr73, Pkr1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length393 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed at high levels in the heart, skeletal muscle and pancreas. Expressed at lower levels in the brain, lung, liver and kidney.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 393393Prokineticin receptor 1
PRO_0000070080

Regions

Topological domain1 – 6262Extracellular Potential
Transmembrane63 – 8321Helical; Name=1; Potential
Topological domain84 – 9815Cytoplasmic Potential
Transmembrane99 – 11921Helical; Name=2; Potential
Topological domain120 – 14627Extracellular Potential
Transmembrane147 – 16721Helical; Name=3; Potential
Topological domain168 – 17912Cytoplasmic Potential
Transmembrane180 – 20021Helical; Name=4; Potential
Topological domain201 – 23232Extracellular Potential
Transmembrane233 – 25321Helical; Name=5; Potential
Topological domain254 – 28229Cytoplasmic Potential
Transmembrane283 – 30321Helical; Name=6; Potential
Topological domain304 – 32219Extracellular Potential
Transmembrane323 – 34321Helical; Name=7; Potential
Topological domain344 – 39350Cytoplasmic Potential

Amino acid modifications

Glycosylation111N-linked (GlcNAc...) Potential
Disulfide bond137 ↔ 217 By similarity

Experimental info

Sequence conflict275 – 2762RL → TV in AAF43706. Ref.1
Sequence conflict275 – 2762RL → TV in AAM49570. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9JKL1 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: D0F5E79606D74283

FASTA39344,597
        10         20         30         40         50         60 
METTVGALGE NTTDTFTDFF SALDGHEAQT GSLPFTFSYG DYDMPLDEEE DVTNSRTFFA 

        70         80         90        100        110        120 
AKIVIGMALV GIMLVCGIGN FIFITALARY KKLRNLTNLL IANLAISDFL VAIVCCPFEM 

       130        140        150        160        170        180 
DYYVVRQLSW EHGHVLCASV NYLRTVSLYV STNALLAIAI DRYLAIVHPL RPRMKCQTAA 

       190        200        210        220        230        240 
GLIFLVWSVS ILIAIPAAYF TTETVLVIVE RQEKIFCGQI WPVDQQFYYR SYFLLVFGLE 

       250        260        270        280        290        300 
FVGPVVAMTL CYARVSRELW FKAVPGFQTE QIRRRLRCRR RTVLGLVCVL SAYVLCWAPF 

       310        320        330        340        350        360 
YGFTIVRDFF PSVFVKEKHY LTAFYVVECI AMSNSMINTL CFVTVRNNTS KYLKRILRLQ 

       370        380        390 
WRASPSGSKA SADLDLRTTG IPATEEVDCI RLK 

« Hide

References

« Hide 'large scale' references
[1]"Y-receptor-like genes GPR72 and GPR73: molecular cloning, genomic organisation and assignment to human chromosome 11q21.1 and 2p14 and mouse chromosome 9 and 6."
Parker R., Liu M., Eyre H.J., Copeland N.G., Gilbert D.J., Crawford J., Sutherland G.R., Jenkins N.A., Herzog H.
Biochim. Biophys. Acta 1491:369-375(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus."
Cheng M.Y., Bullock C.M., Li C., Lee A.G., Bermak J.C., Belluzzi J., Weaver D.R., Leslie F.M., Zhou Q.-Y.
Nature 417:405-410(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Forelimb and Spleen.
[4]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF236082 mRNA. Translation: AAF43706.1.
AF487278 mRNA. Translation: AAM49570.1.
AK134279 mRNA. Translation: BAE22080.1.
AK156734 mRNA. Translation: BAE33828.1.
CH466523 Genomic DNA. Translation: EDK99210.1.
BC059003 mRNA. Translation: AAH59003.1.
CCDSCCDS20323.1.
RefSeqNP_067356.2. NM_021381.3.
XP_006506494.1. XM_006506431.1.
XP_006506495.1. XM_006506432.1.
UniGeneMm.333226.

3D structure databases

ProteinModelPortalQ9JKL1.
SMRQ9JKL1. Positions 8-358.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000059034.

Chemistry

ChEMBLCHEMBL1949486.
GuidetoPHARMACOLOGY335.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9JKL1.

Proteomic databases

PRIDEQ9JKL1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000050887; ENSMUSP00000059034; ENSMUSG00000049409.
GeneID58182.
KEGGmmu:58182.
UCSCuc009cto.1. mouse.

Organism-specific databases

CTD10887.
MGIMGI:1929676. Prokr1.

Phylogenomic databases

eggNOGNOG319668.
GeneTreeENSGT00740000115565.
HOGENOMHOG000231664.
HOVERGENHBG039631.
InParanoidQ3U0M4.
KOK08379.
OMANFIFITA.
OrthoDBEOG73NG3D.
TreeFamTF315303.

Gene expression databases

BgeeQ9JKL1.
CleanExMM_PROKR1.
GenevestigatorQ9JKL1.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000611. NPY_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01012. NRPEPTIDEYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio314139.
PROQ9JKL1.
SOURCESearch...

Entry information

Entry namePKR1_MOUSE
AccessionPrimary (citable) accession number: Q9JKL1
Secondary accession number(s): Q3U0M4, Q6PD11
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries