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Q9JKK8

- ATR_MOUSE

UniProt

Q9JKK8 - ATR_MOUSE

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Protein
Serine/threonine-protein kinase ATR
Gene
Atr, Kiaa4069
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates Ser-139 of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication By similarity. Essential for preventing the occurrence of DNA damage during early embryogenesis.4 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Manganese By similarity.

Enzyme regulationi

Activated by DNA, and slightly by ATRIP. Inhibited by caffeine, wortmannin and LY294002 By similarity.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW
  3. protein binding Source: UniProtKB
  4. protein kinase activity Source: MGI
  5. protein serine/threonine kinase activity Source: Reactome
Complete GO annotation...

GO - Biological processi

  1. DNA damage checkpoint Source: MGI
  2. DNA repair Source: MGI
  3. cellular response to DNA damage stimulus Source: MGI
  4. protein phosphorylation Source: MGI
  5. regulation of protein binding Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, DNA-binding, Manganese, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_198626. Meiotic synapsis.
REACT_75800. Meiotic Synapsis.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase ATR (EC:2.7.11.1)
Alternative name(s):
Ataxia telangiectasia and Rad3-related protein
Gene namesi
Name:Atr
Synonyms:Kiaa4069
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:108028. Atr.

Subcellular locationi

Nucleus By similarity. Chromosome
Note: Recruited to chromatin during S-phase. Redistributes to discrete nuclear foci upon DNA damage, hypoxia or replication fork stalling By similarity.3 Publications

GO - Cellular componenti

  1. PML body Source: UniProtKB
  2. XY body Source: MGI
  3. chromosome Source: UniProtKB
  4. nucleoplasm Source: Reactome
  5. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 26352635Serine/threonine-protein kinase ATR
PRO_0000088845Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei431 – 4311Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9JKK8.
PaxDbiQ9JKK8.
PRIDEiQ9JKK8.

PTM databases

PhosphoSiteiQ9JKK8.

Expressioni

Tissue specificityi

Ubiquitous. Expression is highest in testis, where it is restricted to primary spermatocytes. Expression decreases as spermiogenesis proceeds (at protein level).1 Publication

Gene expression databases

CleanExiMM_ATR.
GenevestigatoriQ9JKK8.

Interactioni

Subunit structurei

Forms a heterodimer with ATRIP. Binds to DNA, and to UV-damaged DNA with higher affinity. Interacts with RAD17, MSH2 and HDAC2. Present in a complex containing ATRIP and RPA-coated single-stranded DNA. Present in a complex containing CHD4 and HDAC2. Interacts with EEF1E1. This interaction is enhanced by UV irradiation. Interacts with CLSPN and CEP164 By similarity. Interacts with TELO2 AND TTI1 By similarity. Interacts with ATRIP.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
AtripQ8BMG12EBI-1202426,EBI-5235246

Protein-protein interaction databases

IntActiQ9JKK8. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9JKK8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati799 – 83537HEAT 1
Add
BLAST
Repeati1329 – 136537HEAT 2
Add
BLAST
Domaini1634 – 2179546FAT
Add
BLAST
Domaini2313 – 2558246PI3K/PI4K
Add
BLAST
Domaini2603 – 263533FATC
Add
BLAST

Sequence similaritiesi

Contains 1 FAT domain.
Contains 1 FATC domain.
Contains 2 HEAT repeats.
Contains 1 PI3K/PI4K domain.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5032.
HOVERGENiHBG050619.
InParanoidiQ3TBS8.
PhylomeDBiQ9JKK8.

Family and domain databases

Gene3Di1.10.1070.11. 2 hits.
1.25.10.10. 4 hits.
1.25.40.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR003152. FATC.
IPR021133. HEAT_type_2.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR011990. TPR-like_helical.
IPR012993. UME.
[Graphical view]
PfamiPF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF08064. UME. 1 hit.
[Graphical view]
SMARTiSM00146. PI3Kc. 1 hit.
SM00802. UME. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 5 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS50077. HEAT_REPEAT. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JKK8-1 [UniParc]FASTAAdd to Basket

« Hide

MGDHGLELAS MIPALRELGS ATPEEYNTVV QKPRQILCQF IDRILTDVNV     50
VALELVKKTD AQPTSVMLLD FIQHIMKSSP LMFVNVNGSQ GQNEAKDSCI 100
EFSHWIITRL LRIAATPSCH MLHKKICEVI CSLLFLFKSK NPAIFGVLTR 150
ELLYLFEDLI YLHKRNAVGE VMEWPVVVSR FLSRLDEHMG CLQPAPLQFM 200
NVQNVEFIEV TLLMVLIHIV PTVFFRRQEL LLWQIGCALL EHGSPKIRSL 250
AISLLTELFE LGGLPAQPAS TFFSLFLELL QHLVGMDADQ LKLYEEPLSK 300
LLKTLFPFEA EAYRNIEPVY LNVLLEKLSV MFEDRVLMRL KSDLLKAALC 350
HLLQYFLTFV PAGYESALQV RKVYVTNICR ALVDALGVQK HVGYLLGPFY 400
AALKMESKEI IERIQCQAQQ ENLSGNNDEV SPKRRKLSSS LSSYKKPSRQ 450
PEEIIHVDMD KKSILWNVLK QKAESLQISL ECGTLKNSVA EALEGITVVL 500
QLTALCTVHC SHQDMDGHNV KDHQHKYKKK PPVVVTWMSL DFYTKVLKSC 550
RSLLESVQKL ELELVIDSMV RICDALMYMQ VKSSFKDHVL EELCGMLSLP 600
WIYSYSDDNS LKMTTFATNL LPLSQRVWDS YSPQAQSKCV FLLTLFPRRI 650
FLEWRTAVYN WALKSSHEVI RASCVKGFFI LLHQQNSCNQ IPKMLVDRVK 700
DDSDMVKKEF ASVLGQLVCT LHGMFYLSSS VEPCFEHMDL FSKNLKATSQ 750
HECSSSQVKA STCKPFLFLL TKNTPSPVKL AFIDNLHHLC KHLDFQEDER 800
EVKAVLGTLL NLMEDPDKDV RIAFSGNIKY ILESLNSEDG FVKELFVLRM 850
KEAYTHAQIA RNNELKDTLI LTTGDIGRAA KGDLIPFALL HLLHCLLSKS 900
ASVSGAAYTE IRALVAAKSV KLQNFFSQYK KPICQFLVES LHSSQMTALP 950
SAPCQSSEIR KQDVAHHREM ALNTLSEIAN VFDFPDLNRF LTRTLQVLLP 1000
DLAAKASPAA SALIRTLGKQ LNVSRREILI NNFKYIFSHL VCSCSKDELE 1050
RALHYLKNET EIELGSLLRQ DFQGLHNELL LRIGEHYQQV FNGLSILASF 1100
ASSDDPYQGP RDITSPELMA DYLQPKLLGI LAFFNMQLLS SSVGIEDKKM 1150
ALTSLMSLMK LMGPKHVSSV RVKMMTTLRT GLRFKDDFPE LCCRAWDCFV 1200
RCLDHAYLGP LLSHVIVALL PLIHMQPKET AAIFHYLIIE NRDAVQDFLH 1250
EIYFLPDHPE LEKIKAVLQE YRKETSETTD LQTTLQLSMK AIQHENVDVR 1300
IHALTSLKET LYKNQEKLIK YATDSETVEP VISQLVTVIL KGCQDANSQA 1350
RLLCGECLGE LGAIDPGRLD FSTTETQGKD FTFVTGVEDL SFAYGLLMEL 1400
TRAYLAYADN SRAQDSAAYA IQELLSIYDC REMQSNGPGY QLWKRFPEHV 1450
REILEPHLNT RYKSSQKSTD WSGVTKPIYL SKLGNNFAEW SSSWAGYLIT 1500
KVRDNLASKI FTCCSIMMKH DFKVTIYLLP HILVYVLLGC NQEDQQEVYA 1550
EIMAVLKHDE QHAISTQDSA SDLCQLSTQT VFSVLDHLTQ WARHKFQALN 1600
AEKLAQNKPK GVSNVNFEDY QSVTRFLDLI PQDTLAVASF RSKAYTRAVM 1650
HFESFITEKK QNIQKHLGFL QKLYAAMHEP DGVAGVSAIR KAEPSLKEQI 1700
LEHESIGLLR DATACYDRAI QLEPDQIIHY HGVVKSMLGL GQLSTVITQV 1750
NGVHANRSEW TDELNTYRVE AAWKLSQWDL VENYLAADGK STTWSVRLGQ 1800
LLLSAKKRDT TTFYDTLKLV RAEQIVPLSA ASFERGSYQR GYEFIVRLHM 1850
LCELEHSLKP LFRKSPGDSC NEDSLNWGAR LEMTQNSYRA KEPILALRRA 1900
LLSLNKRPDY NEMVGECWLQ SARVARKAGH HQTAYNALLN AGESRLAELY 1950
VERAKWLWSK GDVHQALIVL QKGVELCFPE NKSPSESKHM LIHGRATLLV 2000
GRFMEETANF ESNAVMKKYK DVTLFLPEWE DGHFYLAKYY DKLMPMVTDN 2050
KMEKQGDLIR YIVLHFGRSL QYGNQFIYQS MPRMLSLWLD FGAKAYEWEK 2100
GGRSDRLQMR NDLAKINSVL TEHTNRLAPY QFLTAFSQLI SRICHSHDEV 2150
FVVLMEIIAK VFLAYPQQAM WMMTAVSKSS YPMRVNRCKE ILTKAIHMKK 2200
SLEKFVGDAT RLTDKLLELC NKSVDGSNST LSMSTHFKML KRLVEDPTFS 2250
EILIPLQSVM IPTLPSVLGA HANHDPFPGH WAYLAGFDDV VEILSSLQKP 2300
KKISLKGSDG KFYIMMCKPK DDLRKDCRLM EFNSLINKSL RKDAESRRRE 2350
LHIRTYAVIP LNDECGIIEW VNNTAGLRPI LTKIYKEKGV YMTGKELRQC 2400
MLPKSAALSE KLKVFQELLL PRHPPVFHEW FLRTFPDPTS WYSSRSAYCR 2450
STAVMSMVGY ILGLGDRHGE NILFDSFTGE CVHVDFNCLF NKGETFEVPE 2500
IVPFRLTHNM VNGMGPMGTE GLFRRACEVT LRLMRDQREP LMSVLKTFLH 2550
DPLVEGSKPV KGHSKAPLNE TGEVVNEKAK THVLDIEQRL QGVIKTRNRV 2600
TGLPLSIEGH VHYLIQEATD ENLLCQMYLG WTPYM 2635
Length:2,635
Mass (Da):300,224
Last modified:March 29, 2005 - v2
Checksum:iC126413D15ACB8DC
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191G → A in BAE24154. 1 Publication
Sequence conflicti19 – 191G → A in BAE34182. 1 Publication
Sequence conflicti19 – 191G → A in BAE42229. 1 Publication
Sequence conflicti2208 – 22081D → E in BAE37964. 1 Publication
Sequence conflicti2347 – 23471R → C in BAE37964. 1 Publication
Sequence conflicti2556 – 25561G → W in BAE21043. 1 Publication
Sequence conflicti2556 – 25561G → W in BAD90361. 1 Publication
Sequence conflicti2563 – 25631H → R in BAE21043. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC091531 Genomic DNA. No translation available.
AC121499 Genomic DNA. No translation available.
AK132223 mRNA. Translation: BAE21043.1.
AK139834 mRNA. Translation: BAE24154.1.
AK157754 mRNA. Translation: BAE34182.1.
AK164916 mRNA. Translation: BAE37964.1.
AK171072 mRNA. Translation: BAE42229.1.
AK220176 mRNA. Translation: BAD90361.1.
AF236887 mRNA. Translation: AAF61728.1.
UniGeneiMm.212462.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC091531 Genomic DNA. No translation available.
AC121499 Genomic DNA. No translation available.
AK132223 mRNA. Translation: BAE21043.1 .
AK139834 mRNA. Translation: BAE24154.1 .
AK157754 mRNA. Translation: BAE34182.1 .
AK164916 mRNA. Translation: BAE37964.1 .
AK171072 mRNA. Translation: BAE42229.1 .
AK220176 mRNA. Translation: BAD90361.1 .
AF236887 mRNA. Translation: AAF61728.1 .
UniGenei Mm.212462.

3D structure databases

ProteinModelPortali Q9JKK8.
ModBasei Search...

Protein-protein interaction databases

IntActi Q9JKK8. 2 interactions.

PTM databases

PhosphoSitei Q9JKK8.

Proteomic databases

MaxQBi Q9JKK8.
PaxDbi Q9JKK8.
PRIDEi Q9JKK8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:108028. Atr.
Rougei Search...

Phylogenomic databases

eggNOGi COG5032.
HOVERGENi HBG050619.
InParanoidi Q3TBS8.
PhylomeDBi Q9JKK8.

Enzyme and pathway databases

Reactomei REACT_198626. Meiotic synapsis.
REACT_75800. Meiotic Synapsis.

Miscellaneous databases

ChiTaRSi ATR. mouse.
PROi Q9JKK8.
SOURCEi Search...

Gene expression databases

CleanExi MM_ATR.
Genevestigatori Q9JKK8.

Family and domain databases

Gene3Di 1.10.1070.11. 2 hits.
1.25.10.10. 4 hits.
1.25.40.10. 2 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR003152. FATC.
IPR021133. HEAT_type_2.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR011990. TPR-like_helical.
IPR012993. UME.
[Graphical view ]
Pfami PF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF08064. UME. 1 hit.
[Graphical view ]
SMARTi SM00146. PI3Kc. 1 hit.
SM00802. UME. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 5 hits.
SSF56112. SSF56112. 2 hits.
PROSITEi PS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS50077. HEAT_REPEAT. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1134 AND 1578-2635.
    Strain: C57BL/6J and NOD.
    Tissue: Brain, Dendritic cell, Egg, Embryo and Lung.
  3. "Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Kitamura H., Nakagawa T., Nagase T., Ohara O., Koga H.
    DNA Res. 11:127-135(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1684-2635.
    Tissue: Embryonic intestine.
  4. "Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice."
    de Klein A., Muijtjens M., van Os R., Verhoeven Y., Smit B., Carr A.M., Lehmann A.R., Hoeijmakers J.H.J.
    Curr. Biol. 10:479-482(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2362-2635, FUNCTION.
  5. "The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes."
    Keegan K.S., Holtzman D.A., Plug A.W., Christenson E.R., Brainerd E.E., Flaggs G., Bentley N.J., Taylor E.M., Meyn M.S., Moss S.B., Carr A.M., Ashley T., Hoekstra M.F.
    Genes Dev. 10:2423-2437(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  6. "ATR disruption leads to chromosomal fragmentation and early embryonic lethality."
    Brown E.J., Baltimore D.
    Genes Dev. 14:397-402(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance."
    Brown E.J., Baltimore D.
    Genes Dev. 17:615-628(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes."
    Takai H., Xie Y., de Lange T., Pavletich N.P.
    Genes Dev. 24:2019-2030(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ATRIP.
  9. "HORMAD2 is essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity."
    Kogo H., Tsutsumi M., Inagaki H., Ohye T., Kiyonari H., Kurahashi H.
    Genes Cells 17:897-912(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  10. "Meiotic DNA double-strand breaks and chromosome asynapsis in mice are monitored by distinct HORMAD2-independent and -dependent mechanisms."
    Wojtasz L., Cloutier J.M., Baumann M., Daniel K., Varga J., Fu J., Anastassiadis K., Stewart A.F., Remenyi A., Turner J.M., Toth A.
    Genes Dev. 26:958-973(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiATR_MOUSE
AccessioniPrimary (citable) accession number: Q9JKK8
Secondary accession number(s): Q3TBS8
, Q3TNX3, Q3TZM6, Q3UT26, Q3V1V6, Q571L3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: September 3, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi