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Protein

Tropomodulin-2

Gene

Tmod2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • actin filament organization Source: GO_Central
  • learning or memory Source: MGI
  • muscle contraction Source: GO_Central
  • myofibril assembly Source: GO_Central
  • neuron-neuron synaptic transmission Source: MGI
  • pointed-end actin filament capping Source: InterPro
  • positive regulation of G-protein coupled receptor protein signaling pathway Source: MGI
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomodulin-2
Alternative name(s):
Neuronal tropomodulin
Short name:
N-Tmod
Gene namesi
Name:Tmod2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1355335. Tmod2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001861321 – 351Tropomodulin-2Add BLAST351

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9JKK7.
PeptideAtlasiQ9JKK7.
PRIDEiQ9JKK7.

PTM databases

iPTMnetiQ9JKK7.
PhosphoSitePlusiQ9JKK7.

Expressioni

Tissue specificityi

Neuronal-tissue specific.

Gene expression databases

BgeeiENSMUSG00000032186.
CleanExiMM_TMOD2.
GenevisibleiQ9JKK7. MM.

Interactioni

Subunit structurei

Binds to the N-terminus of tropomyosin and to actin.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi206139. 1 interactor.
IntActiQ9JKK7. 4 interactors.
MINTiMINT-5200854.
STRINGi10090.ENSMUSP00000069956.

Structurei

3D structure databases

ProteinModelPortaliQ9JKK7.
SMRiQ9JKK7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tropomodulin family.Curated

Phylogenomic databases

eggNOGiKOG3735. Eukaryota.
ENOG410YAHM. LUCA.
GeneTreeiENSGT00760000119226.
HOGENOMiHOG000261624.
HOVERGENiHBG056172.
InParanoidiQ9JKK7.
KOiK10370.
OMAiTHVKTFS.
OrthoDBiEOG091G0C3H.
PhylomeDBiQ9JKK7.
TreeFamiTF315841.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR004934. TMOD.
IPR030130. TMOD2.
[Graphical view]
PANTHERiPTHR10901. PTHR10901. 1 hit.
PTHR10901:SF15. PTHR10901:SF15. 1 hit.
PfamiPF03250. Tropomodulin. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9JKK7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALPFQKGLE KYKNIDEDEL LGKLSEEELK QLENVLDDLD PESATLPAGF
60 70 80 90 100
RQKDQTQKAA TGPFDREHLL MYLEKEALEQ KDREDFVPFT GEKKGRVFIP
110 120 130 140 150
KEKPVETRKE EKVTLDPELE EALASASDTE LYDLAAVLGV HNLLNNPKFD
160 170 180 190 200
EETTNGEGRK GPVRNVVKGE KAKPVFEEPP NPTNVEASLQ QMKANDPSLQ
210 220 230 240 250
EVNLNNIKNI PIPTLKEFAK SLETNTHVKK FSLAATRSND PVALAFAEML
260 270 280 290 300
KVNKTLKSLN VESNFITGTG ILALVEALRE NDTLTEIKID NQRQQLGTAV
310 320 330 340 350
EMEIAQMLEE NSRILKFGYQ FTKQGPRTRV AAAITKNNDL VRKKRVEGDR

R
Length:351
Mass (Da):39,511
Last modified:May 1, 2007 - v2
Checksum:i640E9577D4C9CA16
GO
Isoform 2 (identifier: Q9JKK7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     165-240: NVVKGEKAKP...FSLAATRSND → SKLTRALGAW...NANKVFCSKG
     241-351: Missing.

Note: No experimental confirmation available.
Show »
Length:240
Mass (Da):26,811
Checksum:i1616E8D5FFB0F411
GO
Isoform 3 (identifier: Q9JKK7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-191: Missing.

Note: No experimental confirmation available.
Show »
Length:160
Mass (Da):17,982
Checksum:i319E55946D8E694E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26 – 27EE → KR in BAB29946 (PubMed:16141072).Curated2
Sequence conflicti42E → K in BAB29946 (PubMed:16141072).Curated1
Sequence conflicti157E → Q in AAF45297 (Ref. 1) Curated1
Sequence conflicti263S → F in AAF31669 (PubMed:10662549).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0248951 – 191Missing in isoform 3. 1 PublicationAdd BLAST191
Alternative sequenceiVSP_024896165 – 240NVVKG…TRSND → SKLTRALGAWEVPEPAWCMF HQAQCLVSASPSVVTQGTQS YRTHIRGTSSSGEKKSIPDK FAQSAQNANKVFCSKG in isoform 2. 1 PublicationAdd BLAST76
Alternative sequenceiVSP_024897241 – 351Missing in isoform 2. 1 PublicationAdd BLAST111

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237629 mRNA. Translation: AAF45297.1.
AF177170 mRNA. Translation: AAF31669.1.
AK015719 mRNA. Translation: BAB29946.3.
AK076562 mRNA. Translation: BAC36394.1.
AK079077 mRNA. Translation: BAC37527.1.
AK147581 mRNA. Translation: BAE28007.1.
AK164178 mRNA. Translation: BAE37665.1.
BC061124 mRNA. Translation: AAH61124.1.
CCDSiCCDS23345.1. [Q9JKK7-1]
RefSeqiNP_001033799.1. NM_001038710.1. [Q9JKK7-1]
NP_057920.2. NM_016711.3. [Q9JKK7-1]
XP_006511330.1. XM_006511267.3. [Q9JKK7-1]
XP_006511331.1. XM_006511268.2. [Q9JKK7-1]
XP_017168948.1. XM_017313459.1. [Q9JKK7-1]
XP_017168949.1. XM_017313460.1. [Q9JKK7-1]
UniGeneiMm.291880.

Genome annotation databases

EnsembliENSMUST00000064433; ENSMUSP00000069956; ENSMUSG00000032186. [Q9JKK7-1]
ENSMUST00000098552; ENSMUSP00000096152; ENSMUSG00000032186. [Q9JKK7-1]
ENSMUST00000164100; ENSMUSP00000126739; ENSMUSG00000032186. [Q9JKK7-1]
GeneIDi50876.
KEGGimmu:50876.
UCSCiuc009qsj.1. mouse. [Q9JKK7-1]
uc009qsp.1. mouse. [Q9JKK7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237629 mRNA. Translation: AAF45297.1.
AF177170 mRNA. Translation: AAF31669.1.
AK015719 mRNA. Translation: BAB29946.3.
AK076562 mRNA. Translation: BAC36394.1.
AK079077 mRNA. Translation: BAC37527.1.
AK147581 mRNA. Translation: BAE28007.1.
AK164178 mRNA. Translation: BAE37665.1.
BC061124 mRNA. Translation: AAH61124.1.
CCDSiCCDS23345.1. [Q9JKK7-1]
RefSeqiNP_001033799.1. NM_001038710.1. [Q9JKK7-1]
NP_057920.2. NM_016711.3. [Q9JKK7-1]
XP_006511330.1. XM_006511267.3. [Q9JKK7-1]
XP_006511331.1. XM_006511268.2. [Q9JKK7-1]
XP_017168948.1. XM_017313459.1. [Q9JKK7-1]
XP_017168949.1. XM_017313460.1. [Q9JKK7-1]
UniGeneiMm.291880.

3D structure databases

ProteinModelPortaliQ9JKK7.
SMRiQ9JKK7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206139. 1 interactor.
IntActiQ9JKK7. 4 interactors.
MINTiMINT-5200854.
STRINGi10090.ENSMUSP00000069956.

PTM databases

iPTMnetiQ9JKK7.
PhosphoSitePlusiQ9JKK7.

Proteomic databases

PaxDbiQ9JKK7.
PeptideAtlasiQ9JKK7.
PRIDEiQ9JKK7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064433; ENSMUSP00000069956; ENSMUSG00000032186. [Q9JKK7-1]
ENSMUST00000098552; ENSMUSP00000096152; ENSMUSG00000032186. [Q9JKK7-1]
ENSMUST00000164100; ENSMUSP00000126739; ENSMUSG00000032186. [Q9JKK7-1]
GeneIDi50876.
KEGGimmu:50876.
UCSCiuc009qsj.1. mouse. [Q9JKK7-1]
uc009qsp.1. mouse. [Q9JKK7-2]

Organism-specific databases

CTDi29767.
MGIiMGI:1355335. Tmod2.

Phylogenomic databases

eggNOGiKOG3735. Eukaryota.
ENOG410YAHM. LUCA.
GeneTreeiENSGT00760000119226.
HOGENOMiHOG000261624.
HOVERGENiHBG056172.
InParanoidiQ9JKK7.
KOiK10370.
OMAiTHVKTFS.
OrthoDBiEOG091G0C3H.
PhylomeDBiQ9JKK7.
TreeFamiTF315841.

Miscellaneous databases

ChiTaRSiTmod2. mouse.
PROiQ9JKK7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032186.
CleanExiMM_TMOD2.
GenevisibleiQ9JKK7. MM.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR004934. TMOD.
IPR030130. TMOD2.
[Graphical view]
PANTHERiPTHR10901. PTHR10901. 1 hit.
PTHR10901:SF15. PTHR10901:SF15. 1 hit.
PfamiPF03250. Tropomodulin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTMOD2_MOUSE
AccessioniPrimary (citable) accession number: Q9JKK7
Secondary accession number(s): Q3UH50
, Q8BGX9, Q9CUK4, Q9JLH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: May 1, 2007
Last modified: November 2, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.