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Q9JKK1

- STX6_MOUSE

UniProt

Q9JKK1 - STX6_MOUSE

Protein

Syntaxin-6

Gene

Stx6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Involved in intracellular vesicle trafficking.

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. SNAP receptor activity Source: RefGenome

    GO - Biological processi

    1. endosome organization Source: MGI
    2. Golgi vesicle transport Source: InterPro
    3. intracellular protein transport Source: RefGenome
    4. retrograde transport, endosome to Golgi Source: RefGenome
    5. vesicle fusion Source: RefGenome

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Syntaxin-6
    Gene namesi
    Name:Stx6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1926235. Stx6.

    Subcellular locationi

    GO - Cellular componenti

    1. early endosome Source: Ensembl
    2. Golgi apparatus Source: MGI
    3. Golgi membrane Source: UniProtKB-SubCell
    4. integral component of membrane Source: RefGenome
    5. membrane Source: MGI
    6. perinuclear region of cytoplasm Source: Ensembl
    7. recycling endosome Source: MGI
    8. SNARE complex Source: RefGenome
    9. trans-Golgi network Source: MGI
    10. trans-Golgi network membrane Source: MGI

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 255254Syntaxin-6PRO_0000210209Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei2 – 21PhosphoserineBy similarity
    Modified residuei152 – 1521PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9JKK1.
    PaxDbiQ9JKK1.
    PRIDEiQ9JKK1.

    PTM databases

    PhosphoSiteiQ9JKK1.

    Expressioni

    Gene expression databases

    BgeeiQ9JKK1.
    CleanExiMM_STX6.
    GenevestigatoriQ9JKK1.

    Interactioni

    Subunit structurei

    Binds EEA1. Interacts with VPS45A and GOPC. Interacts with MARCH2 and MARCH3 By similarity. Identified in a complex containing STX6, STX12 and VAMP4 By similarity. This complex also includes VTI1A.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi208415. 5 interactions.
    IntActiQ9JKK1. 4 interactions.
    MINTiMINT-4127329.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JKK1.
    SMRiQ9JKK1. Positions 4-109, 170-232.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 234233CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei235 – 25521Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini163 – 22563t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili41 – 7434Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the syntaxin family.Curated
    Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46901.
    GeneTreeiENSGT00390000008991.
    HOGENOMiHOG000237350.
    HOVERGENiHBG007194.
    KOiK08498.
    OMAiQVVREMK.
    OrthoDBiEOG7JHM7F.
    PhylomeDBiQ9JKK1.
    TreeFamiTF313254.

    Family and domain databases

    InterProiIPR015260. Syntaxin-6_N.
    IPR006012. Syntaxin/epimorphin_CS.
    IPR010989. t-SNARE.
    IPR000727. T_SNARE_dom.
    [Graphical view]
    PfamiPF05739. SNARE. 1 hit.
    PF09177. Syntaxin-6_N. 1 hit.
    [Graphical view]
    SMARTiSM00397. t_SNARE. 1 hit.
    [Graphical view]
    SUPFAMiSSF47661. SSF47661. 1 hit.
    PROSITEiPS00914. SYNTAXIN. 1 hit.
    PS50192. T_SNARE. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9JKK1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSMEDPFFVV KGEVQKAVNT AQGLFQRWTE LLQGPSAATR EEIDWTTNEL    50
    RNNLRSIEWD LEDLDETISI VEANPRKFNL DATELSIRKA FITSTRQIVR 100
    DMKDQMSASS VQALAERKNR QALLGDSSSQ SWNAGVADRY GRLDRELQLA 150
    NSHFIEEQQA QQQLIVEQQD EQLELVSGSI GVLKNMSQRI GGELEEQAVM 200
    LDDFSHELES TQSRLDNVMK KLAKVSHMTS DRRQWCAIAI LFAVLVVVLI 250
    LFLVL 255
    Length:255
    Mass (Da):28,997
    Last modified:October 1, 2000 - v1
    Checksum:i2CD91C02D23D28DE
    GO
    Isoform 2 (identifier: Q9JKK1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         231-255: DRRQWCAIAILFAVLVVVLILFLVL → GNDVRQVKIQYLLFIWRLLPGERKT

    Show »
    Length:255
    Mass (Da):29,156
    Checksum:iCBE9A32C045803FC
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei231 – 25525DRRQW…LFLVL → GNDVRQVKIQYLLFIWRLLP GERKT in isoform 2. 1 PublicationVSP_016138Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF237814 mRNA. Translation: AAF40221.1.
    AK009690 mRNA. Translation: BAB26441.1.
    AK019106 mRNA. Translation: BAB31549.1.
    AK031673 mRNA. Translation: BAC27505.1.
    AK044905 mRNA. Translation: BAC32135.1.
    AK049124 mRNA. Translation: BAC33556.1.
    BC029205 mRNA. Translation: AAH29205.1.
    CCDSiCCDS35741.1. [Q9JKK1-1]
    RefSeqiNP_067408.1. NM_021433.3. [Q9JKK1-1]
    UniGeneiMm.491299.
    Mm.66264.

    Genome annotation databases

    EnsembliENSMUST00000027743; ENSMUSP00000027743; ENSMUSG00000026470. [Q9JKK1-1]
    GeneIDi58244.
    KEGGimmu:58244.
    UCSCiuc007dbb.1. mouse. [Q9JKK1-1]
    uc007dbc.1. mouse. [Q9JKK1-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF237814 mRNA. Translation: AAF40221.1 .
    AK009690 mRNA. Translation: BAB26441.1 .
    AK019106 mRNA. Translation: BAB31549.1 .
    AK031673 mRNA. Translation: BAC27505.1 .
    AK044905 mRNA. Translation: BAC32135.1 .
    AK049124 mRNA. Translation: BAC33556.1 .
    BC029205 mRNA. Translation: AAH29205.1 .
    CCDSi CCDS35741.1. [Q9JKK1-1 ]
    RefSeqi NP_067408.1. NM_021433.3. [Q9JKK1-1 ]
    UniGenei Mm.491299.
    Mm.66264.

    3D structure databases

    ProteinModelPortali Q9JKK1.
    SMRi Q9JKK1. Positions 4-109, 170-232.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 208415. 5 interactions.
    IntActi Q9JKK1. 4 interactions.
    MINTi MINT-4127329.

    PTM databases

    PhosphoSitei Q9JKK1.

    Proteomic databases

    MaxQBi Q9JKK1.
    PaxDbi Q9JKK1.
    PRIDEi Q9JKK1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027743 ; ENSMUSP00000027743 ; ENSMUSG00000026470 . [Q9JKK1-1 ]
    GeneIDi 58244.
    KEGGi mmu:58244.
    UCSCi uc007dbb.1. mouse. [Q9JKK1-1 ]
    uc007dbc.1. mouse. [Q9JKK1-2 ]

    Organism-specific databases

    CTDi 10228.
    MGIi MGI:1926235. Stx6.

    Phylogenomic databases

    eggNOGi NOG46901.
    GeneTreei ENSGT00390000008991.
    HOGENOMi HOG000237350.
    HOVERGENi HBG007194.
    KOi K08498.
    OMAi QVVREMK.
    OrthoDBi EOG7JHM7F.
    PhylomeDBi Q9JKK1.
    TreeFami TF313254.

    Miscellaneous databases

    NextBioi 314297.
    PROi Q9JKK1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9JKK1.
    CleanExi MM_STX6.
    Genevestigatori Q9JKK1.

    Family and domain databases

    InterProi IPR015260. Syntaxin-6_N.
    IPR006012. Syntaxin/epimorphin_CS.
    IPR010989. t-SNARE.
    IPR000727. T_SNARE_dom.
    [Graphical view ]
    Pfami PF05739. SNARE. 1 hit.
    PF09177. Syntaxin-6_N. 1 hit.
    [Graphical view ]
    SMARTi SM00397. t_SNARE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47661. SSF47661. 1 hit.
    PROSITEi PS00914. SYNTAXIN. 1 hit.
    PS50192. T_SNARE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse syntaxin 6."
      Low D.Y.H., Tang B.L., Hong W.
      Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Embryonic stem cell, Testis and Tongue.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Mammary tumor.
    4. "A 29-kilodalton Golgi soluble N-ethylmaleimide-sensitive factor attachment protein receptor (Vti1-rp2) implicated in protein trafficking in the secretory pathway."
      Xu Y., Wong S.H., Tang B.L., Subramaniam V.N., Zhang T., Hong W.
      J. Biol. Chem. 273:21783-21789(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN SNARE COMPLEX WITH VTI1A, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiSTX6_MOUSE
    AccessioniPrimary (citable) accession number: Q9JKK1
    Secondary accession number(s): Q9D3A1, Q9D729
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3