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Protein

Syntaxin-6

Gene

Stx6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in intracellular vesicle trafficking.

GO - Molecular functioni

  1. SNAP receptor activity Source: GO_Central
  2. syntaxin binding Source: MGI

GO - Biological processi

  1. endosome organization Source: MGI
  2. Golgi ribbon formation Source: MGI
  3. Golgi vesicle transport Source: InterPro
  4. intracellular protein transport Source: GO_Central
  5. regulation of protein localization Source: MGI
  6. retrograde transport, endosome to Golgi Source: MGI
  7. vesicle fusion Source: MGI
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-6
Gene namesi
Name:Stx6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1926235. Stx6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 234233CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei235 – 25521Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. early endosome Source: MGI
  2. Golgi apparatus Source: MGI
  3. Golgi membrane Source: UniProtKB-SubCell
  4. integral component of membrane Source: GO_Central
  5. membrane Source: MGI
  6. perinuclear region of cytoplasm Source: MGI
  7. recycling endosome Source: MGI
  8. SNARE complex Source: MGI
  9. trans-Golgi network Source: MGI
  10. trans-Golgi network membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 255254Syntaxin-6PRO_0000210209Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei2 – 21PhosphoserineBy similarity
Modified residuei152 – 1521PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9JKK1.
PaxDbiQ9JKK1.
PRIDEiQ9JKK1.

PTM databases

PhosphoSiteiQ9JKK1.

Expressioni

Gene expression databases

BgeeiQ9JKK1.
CleanExiMM_STX6.
ExpressionAtlasiQ9JKK1. baseline and differential.
GenevestigatoriQ9JKK1.

Interactioni

Subunit structurei

Binds EEA1. Interacts with VPS45A and GOPC. Interacts with MARCH2 and MARCH3 (By similarity). Identified in a complex containing STX6, STX12 and VAMP4 (By similarity). This complex also includes VTI1A.By similarity1 Publication

Protein-protein interaction databases

BioGridi208415. 7 interactions.
IntActiQ9JKK1. 4 interactions.
MINTiMINT-4127329.

Structurei

3D structure databases

ProteinModelPortaliQ9JKK1.
SMRiQ9JKK1. Positions 4-109, 170-232.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini163 – 22563t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili41 – 7434Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46901.
GeneTreeiENSGT00390000008991.
HOGENOMiHOG000237350.
HOVERGENiHBG007194.
InParanoidiQ9JKK1.
KOiK08498.
OMAiQVVREMK.
OrthoDBiEOG7JHM7F.
PhylomeDBiQ9JKK1.
TreeFamiTF313254.

Family and domain databases

InterProiIPR015260. Syntaxin-6_N.
IPR006012. Syntaxin/epimorphin_CS.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
PF09177. Syntaxin-6_N. 1 hit.
[Graphical view]
SMARTiSM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9JKK1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSMEDPFFVV KGEVQKAVNT AQGLFQRWTE LLQGPSAATR EEIDWTTNEL
60 70 80 90 100
RNNLRSIEWD LEDLDETISI VEANPRKFNL DATELSIRKA FITSTRQIVR
110 120 130 140 150
DMKDQMSASS VQALAERKNR QALLGDSSSQ SWNAGVADRY GRLDRELQLA
160 170 180 190 200
NSHFIEEQQA QQQLIVEQQD EQLELVSGSI GVLKNMSQRI GGELEEQAVM
210 220 230 240 250
LDDFSHELES TQSRLDNVMK KLAKVSHMTS DRRQWCAIAI LFAVLVVVLI

LFLVL
Length:255
Mass (Da):28,997
Last modified:October 1, 2000 - v1
Checksum:i2CD91C02D23D28DE
GO
Isoform 2 (identifier: Q9JKK1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     231-255: DRRQWCAIAILFAVLVVVLILFLVL → GNDVRQVKIQYLLFIWRLLPGERKT

Show »
Length:255
Mass (Da):29,156
Checksum:iCBE9A32C045803FC
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei231 – 25525DRRQW…LFLVL → GNDVRQVKIQYLLFIWRLLP GERKT in isoform 2. 1 PublicationVSP_016138Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237814 mRNA. Translation: AAF40221.1.
AK009690 mRNA. Translation: BAB26441.1.
AK019106 mRNA. Translation: BAB31549.1.
AK031673 mRNA. Translation: BAC27505.1.
AK044905 mRNA. Translation: BAC32135.1.
AK049124 mRNA. Translation: BAC33556.1.
BC029205 mRNA. Translation: AAH29205.1.
CCDSiCCDS35741.1. [Q9JKK1-1]
RefSeqiNP_067408.1. NM_021433.3. [Q9JKK1-1]
UniGeneiMm.491299.
Mm.66264.

Genome annotation databases

EnsembliENSMUST00000027743; ENSMUSP00000027743; ENSMUSG00000026470. [Q9JKK1-1]
ENSMUST00000195302; ENSMUSP00000142089; ENSMUSG00000026470. [Q9JKK1-2]
GeneIDi58244.
KEGGimmu:58244.
UCSCiuc007dbb.1. mouse. [Q9JKK1-1]
uc007dbc.1. mouse. [Q9JKK1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237814 mRNA. Translation: AAF40221.1.
AK009690 mRNA. Translation: BAB26441.1.
AK019106 mRNA. Translation: BAB31549.1.
AK031673 mRNA. Translation: BAC27505.1.
AK044905 mRNA. Translation: BAC32135.1.
AK049124 mRNA. Translation: BAC33556.1.
BC029205 mRNA. Translation: AAH29205.1.
CCDSiCCDS35741.1. [Q9JKK1-1]
RefSeqiNP_067408.1. NM_021433.3. [Q9JKK1-1]
UniGeneiMm.491299.
Mm.66264.

3D structure databases

ProteinModelPortaliQ9JKK1.
SMRiQ9JKK1. Positions 4-109, 170-232.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208415. 7 interactions.
IntActiQ9JKK1. 4 interactions.
MINTiMINT-4127329.

PTM databases

PhosphoSiteiQ9JKK1.

Proteomic databases

MaxQBiQ9JKK1.
PaxDbiQ9JKK1.
PRIDEiQ9JKK1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027743; ENSMUSP00000027743; ENSMUSG00000026470. [Q9JKK1-1]
ENSMUST00000195302; ENSMUSP00000142089; ENSMUSG00000026470. [Q9JKK1-2]
GeneIDi58244.
KEGGimmu:58244.
UCSCiuc007dbb.1. mouse. [Q9JKK1-1]
uc007dbc.1. mouse. [Q9JKK1-2]

Organism-specific databases

CTDi10228.
MGIiMGI:1926235. Stx6.

Phylogenomic databases

eggNOGiNOG46901.
GeneTreeiENSGT00390000008991.
HOGENOMiHOG000237350.
HOVERGENiHBG007194.
InParanoidiQ9JKK1.
KOiK08498.
OMAiQVVREMK.
OrthoDBiEOG7JHM7F.
PhylomeDBiQ9JKK1.
TreeFamiTF313254.

Miscellaneous databases

NextBioi314297.
PROiQ9JKK1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JKK1.
CleanExiMM_STX6.
ExpressionAtlasiQ9JKK1. baseline and differential.
GenevestigatoriQ9JKK1.

Family and domain databases

InterProiIPR015260. Syntaxin-6_N.
IPR006012. Syntaxin/epimorphin_CS.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
PF09177. Syntaxin-6_N. 1 hit.
[Graphical view]
SMARTiSM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse syntaxin 6."
    Low D.Y.H., Tang B.L., Hong W.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Embryonic stem cell, Testis and Tongue.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Mammary tumor.
  4. "A 29-kilodalton Golgi soluble N-ethylmaleimide-sensitive factor attachment protein receptor (Vti1-rp2) implicated in protein trafficking in the secretory pathway."
    Xu Y., Wong S.H., Tang B.L., Subramaniam V.N., Zhang T., Hong W.
    J. Biol. Chem. 273:21783-21789(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN SNARE COMPLEX WITH VTI1A, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiSTX6_MOUSE
AccessioniPrimary (citable) accession number: Q9JKK1
Secondary accession number(s): Q9D3A1, Q9D729
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2000
Last modified: March 4, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.