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Q9JKK1 (STX6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Syntaxin-6
Gene names
Name:Stx6
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length255 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in intracellular vesicle trafficking.

Subunit structure

Binds EEA1. Interacts with VPS45A and GOPC. Interacts with MARCH2 and MARCH3 By similarity. Identified in a complex containing STX6, STX12 and VAMP4 By similarity. This complex also includes VTI1A. Ref.4

Subcellular location

Golgi apparatus membrane; Single-pass type IV membrane protein By similarity Ref.4.

Sequence similarities

Belongs to the syntaxin family.

Contains 1 t-SNARE coiled-coil homology domain.

Ontologies

Keywords
   Biological processProtein transport
Transport
   Cellular componentGolgi apparatus
Membrane
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
Transmembrane
Transmembrane helix
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processGolgi vesicle transport

Inferred from electronic annotation. Source: InterPro

endosome organization

Inferred from mutant phenotype PubMed 14668490. Source: MGI

intracellular protein transport

Inferred from Biological aspect of Ancestor. Source: RefGenome

retrograde transport, endosome to Golgi

Inferred from Biological aspect of Ancestor. Source: RefGenome

vesicle fusion

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Cellular_componentGolgi apparatus

Inferred from direct assay PubMed 15800058PubMed 22783020PubMed 23485813. Source: MGI

Golgi membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

SNARE complex

Inferred from Biological aspect of Ancestor. Source: RefGenome

early endosome

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

membrane

Inferred from direct assay PubMed 15886206. Source: MGI

perinuclear region of cytoplasm

Inferred from electronic annotation. Source: Ensembl

recycling endosome

Inferred from sequence orthology PubMed 23269685. Source: MGI

trans-Golgi network

Inferred from direct assay PubMed 17003038PubMed 17003121. Source: MGI

trans-Golgi network membrane

Inferred from direct assay PubMed 19338761. Source: MGI

   Molecular_functionSNAP receptor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

protein binding

Inferred from physical interaction PubMed 14668490. Source: MGI

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9JKK1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9JKK1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     231-255: DRRQWCAIAILFAVLVVVLILFLVL → GNDVRQVKIQYLLFIWRLLPGERKT

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 255254Syntaxin-6
PRO_0000210209

Regions

Topological domain2 – 234233Cytoplasmic Potential
Transmembrane235 – 25521Helical; Anchor for type IV membrane protein; Potential
Domain163 – 22563t-SNARE coiled-coil homology
Coiled coil41 – 7434 Potential

Amino acid modifications

Modified residue21N-acetylserine By similarity
Modified residue21Phosphoserine By similarity
Modified residue1521Phosphoserine By similarity

Natural variations

Alternative sequence231 – 25525DRRQW…LFLVL → GNDVRQVKIQYLLFIWRLLP GERKT in isoform 2.
VSP_016138

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 2CD91C02D23D28DE

FASTA25528,997
        10         20         30         40         50         60 
MSMEDPFFVV KGEVQKAVNT AQGLFQRWTE LLQGPSAATR EEIDWTTNEL RNNLRSIEWD 

        70         80         90        100        110        120 
LEDLDETISI VEANPRKFNL DATELSIRKA FITSTRQIVR DMKDQMSASS VQALAERKNR 

       130        140        150        160        170        180 
QALLGDSSSQ SWNAGVADRY GRLDRELQLA NSHFIEEQQA QQQLIVEQQD EQLELVSGSI 

       190        200        210        220        230        240 
GVLKNMSQRI GGELEEQAVM LDDFSHELES TQSRLDNVMK KLAKVSHMTS DRRQWCAIAI 

       250 
LFAVLVVVLI LFLVL 

« Hide

Isoform 2 [UniParc].

Checksum: CBE9A32C045803FC
Show »

FASTA25529,156

References

« Hide 'large scale' references
[1]"Mouse syntaxin 6."
Low D.Y.H., Tang B.L., Hong W.
Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J.
Tissue: Embryonic stem cell, Testis and Tongue.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Mammary tumor.
[4]"A 29-kilodalton Golgi soluble N-ethylmaleimide-sensitive factor attachment protein receptor (Vti1-rp2) implicated in protein trafficking in the secretory pathway."
Xu Y., Wong S.H., Tang B.L., Subramaniam V.N., Zhang T., Hong W.
J. Biol. Chem. 273:21783-21789(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN SNARE COMPLEX WITH VTI1A, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF237814 mRNA. Translation: AAF40221.1.
AK009690 mRNA. Translation: BAB26441.1.
AK019106 mRNA. Translation: BAB31549.1.
AK031673 mRNA. Translation: BAC27505.1.
AK044905 mRNA. Translation: BAC32135.1.
AK049124 mRNA. Translation: BAC33556.1.
BC029205 mRNA. Translation: AAH29205.1.
CCDSCCDS35741.1. [Q9JKK1-1]
RefSeqNP_067408.1. NM_021433.3. [Q9JKK1-1]
UniGeneMm.491299.
Mm.66264.

3D structure databases

ProteinModelPortalQ9JKK1.
SMRQ9JKK1. Positions 4-109, 170-232.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid208415. 5 interactions.
IntActQ9JKK1. 4 interactions.
MINTMINT-4127329.

PTM databases

PhosphoSiteQ9JKK1.

Proteomic databases

MaxQBQ9JKK1.
PaxDbQ9JKK1.
PRIDEQ9JKK1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000027743; ENSMUSP00000027743; ENSMUSG00000026470. [Q9JKK1-1]
GeneID58244.
KEGGmmu:58244.
UCSCuc007dbb.1. mouse. [Q9JKK1-1]
uc007dbc.1. mouse. [Q9JKK1-2]

Organism-specific databases

CTD10228.
MGIMGI:1926235. Stx6.

Phylogenomic databases

eggNOGNOG46901.
GeneTreeENSGT00390000008991.
HOGENOMHOG000237350.
HOVERGENHBG007194.
KOK08498.
OMAQVVREMK.
OrthoDBEOG7JHM7F.
PhylomeDBQ9JKK1.
TreeFamTF313254.

Gene expression databases

BgeeQ9JKK1.
CleanExMM_STX6.
GenevestigatorQ9JKK1.

Family and domain databases

InterProIPR015260. Syntaxin-6_N.
IPR006012. Syntaxin/epimorphin_CS.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamPF05739. SNARE. 1 hit.
PF09177. Syntaxin-6_N. 1 hit.
[Graphical view]
SMARTSM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMSSF47661. SSF47661. 1 hit.
PROSITEPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio314297.
PROQ9JKK1.
SOURCESearch...

Entry information

Entry nameSTX6_MOUSE
AccessionPrimary (citable) accession number: Q9JKK1
Secondary accession number(s): Q9D3A1, Q9D729
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot