Q9JKK1 (STX6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Syntaxin-6

Gene names

Name:

Stx6

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in intracellular vesicle trafficking.
Subunit structure	Binds EEA1. Interacts with VPS45A and GOPC. Interacts with MARCH2 and MARCH3 By similarity. Identified in a complex containing STX6, STX13 and VAMP4 By similarity. This complex also includes VTI1A.
Subcellular location	Golgi apparatus membrane; Single-pass type IV membrane protein By similarity Ref.4.
Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR By similarity.
Sequence similarities	Belongs to the syntaxin family. Contains 1 t-SNARE coiled-coil homology domain.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Golgi apparatus Membrane
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	Golgi vesicle transport Inferred from electronic annotation. Source: InterPro endosome organization Inferred from mutant phenotype. Source: MGI intracellular protein transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW membrane fraction Inferred from direct assay. Source: MGI
Molecular function	SNAP receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9JKK1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9JKK1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     231-255: DRRQWCAIAILFAVLVVVLILFLVL → GNDVRQVKIQYLLFIWRLLPGERKT

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 255	255	Syntaxin-6		PRO_0000210209
Regions
	Topological domain	1 – 234	234	Cytoplasmic Potential
	Transmembrane	235 – 255	21	Helical; Anchor for type IV membrane protein; Potential
	Domain	163 – 225	63	t-SNARE coiled-coil homology
	Coiled coil	41 – 74	34	Potential
Amino acid modifications
	Modified residue	129	1	Phosphoserine By similarity
	Modified residue	152	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	231 – 255	25	DRRQW…LFLVL → GNDVRQVKIQYLLFIWRLLP GERKT in isoform 2.		VSP_016138

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 2CD91C02D23D28DE	FASTA	255	28,997
	10 20 30 40 50 60 MSMEDPFFVV KGEVQKAVNT AQGLFQRWTE LLQGPSAATR EEIDWTTNEL RNNLRSIEWD 70 80 90 100 110 120 LEDLDETISI VEANPRKFNL DATELSIRKA FITSTRQIVR DMKDQMSASS VQALAERKNR 130 140 150 160 170 180 QALLGDSSSQ SWNAGVADRY GRLDRELQLA NSHFIEEQQA QQQLIVEQQD EQLELVSGSI 190 200 210 220 230 240 GVLKNMSQRI GGELEEQAVM LDDFSHELES TQSRLDNVMK KLAKVSHMTS DRRQWCAIAI 250 LFAVLVVVLI LFLVL
	Isoform 2 [UniParc]. Checksum: CBE9A32C045803FC	FASTA	255	29,156
	10 20 30 40 50 60 MSMEDPFFVV KGEVQKAVNT AQGLFQRWTE LLQGPSAATR EEIDWTTNEL RNNLRSIEWD 70 80 90 100 110 120 LEDLDETISI VEANPRKFNL DATELSIRKA FITSTRQIVR DMKDQMSASS VQALAERKNR 130 140 150 160 170 180 QALLGDSSSQ SWNAGVADRY GRLDRELQLA NSHFIEEQQA QQQLIVEQQD EQLELVSGSI 190 200 210 220 230 240 GVLKNMSQRI GGELEEQAVM LDDFSHELES TQSRLDNVMK KLAKVSHMTS GNDVRQVKIQ 250 YLLFIWRLLP GERKT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mouse syntaxin 6." Low D.Y.H., Tang B.L., Hong W. Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Strain: C57BL/6J. Tissue: Embryonic stem cell, Testis and Tongue.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Mammary tumor.
[4]	"A 29-kilodalton Golgi soluble N-ethylmaleimide-sensitive factor attachment protein receptor (Vti1-rp2) implicated in protein trafficking in the secretory pathway." Xu Y., Wong S.H., Tang B.L., Subramaniam V.N., Zhang T., Hong W. J. Biol. Chem. 273:21783-21789(1998) [PubMed: 9705316] [Abstract] Cited for: IDENTIFICATION IN SNARE COMPLEX WITH VTI1A, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF237814 mRNA. Translation: AAF40221.1. AK009690 mRNA. Translation: BAB26441.1. AK019106 mRNA. Translation: BAB31549.1. AK031673 mRNA. Translation: BAC27505.1. AK044905 mRNA. Translation: BAC32135.1. AK049124 mRNA. Translation: BAC33556.1. BC029205 mRNA. Translation: AAH29205.1.
IPI	IPI00109506. IPI00123104.
RefSeq	NP_067408.1. NM_021433.3.
UniGene	Mm.465911. Mm.66264.
3D structure databases
ProteinModelPortal	Q9JKK1.
SMR	Q9JKK1. Positions 4-109, 170-232.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9JKK1. 1 interaction.
STRING	Q9JKK1.
PTM databases
PhosphoSite	Q9JKK1.
Proteomic databases
PRIDE	Q9JKK1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000027743; ENSMUSP00000027743; ENSMUSG00000026470. ENSMUST00000111779; ENSMUSP00000107409; ENSMUSG00000026470.
GeneID	58244.
KEGG	mmu:58244.
UCSC	uc007dbb.1. mouse. uc007dbc.1. mouse.
Organism-specific databases
CTD	10228.
MGI	MGI:1926235. Stx6.
Phylogenomic databases
GeneTree	ENSGT00390000008991.
HOVERGEN	HBG007194.
OMA	GQNWSTG.
OrthoDB	EOG45HRZ9.
Gene expression databases
ArrayExpress	Q9JKK1.
Bgee	Q9JKK1.
CleanEx	MM_STX6.
Genevestigator	Q9JKK1.
GermOnline	ENSMUSG00000026470. Mus musculus.
Family and domain databases
InterPro	IPR015260. Syntaxin-6_N. IPR006012. Syntaxin/epimorphin_CS. IPR010989. t-SNARE. IPR000727. T_SNARE_dom. [Graphical view]
KO	K08498.
Pfam	PF05739. SNARE. 1 hit. PF09177. Syntaxin-6_N. 1 hit. [Graphical view]
SMART	SM00397. t_SNARE. 1 hit. [Graphical view]
SUPFAM	SSF47661. t-snare. 1 hit.
PROSITE	PS00914. SYNTAXIN. 1 hit. PS50192. T_SNARE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	314297.
SOURCE	Search...

Entry information

Entry name

STX6_MOUSE

Accession

Primary (citable) accession number: Q9JKK1
Secondary accession number(s): Q9D3A1, Q9D729

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program