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Protein

Syntaxin-6

Gene

Stx6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in intracellular vesicle trafficking.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6811438. Intra-Golgi traffic.
R-MMU-6811440. Retrograde transport at the Trans-Golgi-Network.

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-6
Gene namesi
Name:Stx6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1926235. Stx6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 234CytoplasmicSequence analysisAdd BLAST233
Transmembranei235 – 255Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002102092 – 255Syntaxin-6Add BLAST254

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1
Modified residuei129PhosphoserineBy similarity1
Modified residuei152PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9JKK1.
PRIDEiQ9JKK1.

PTM databases

iPTMnetiQ9JKK1.
PhosphoSitePlusiQ9JKK1.
SwissPalmiQ9JKK1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026470.
CleanExiMM_STX6.
ExpressionAtlasiQ9JKK1. baseline and differential.
GenevisibleiQ9JKK1. MM.

Interactioni

Subunit structurei

Binds EEA1. Interacts with VPS45A and GOPC. Interacts with MARCH2 and MARCH3 (By similarity). Identified in a complex containing STX6, STX12 and VAMP4 (By similarity). This complex also includes VTI1A.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi208415. 7 interactors.
CORUMiQ9JKK1.
IntActiQ9JKK1. 5 interactors.
MINTiQ9JKK1.
STRINGi10090.ENSMUSP00000027743.

Structurei

3D structure databases

ProteinModelPortaliQ9JKK1.
SMRiQ9JKK1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini163 – 225t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili41 – 74Sequence analysisAdd BLAST34

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3202. Eukaryota.
ENOG410ZZA3. LUCA.
GeneTreeiENSGT00390000008991.
HOGENOMiHOG000237350.
HOVERGENiHBG007194.
InParanoidiQ9JKK1.
KOiK08498.
OMAiWARNELK.
OrthoDBiEOG091G0KE5.
PhylomeDBiQ9JKK1.
TreeFamiTF313254.

Family and domain databases

InterProiView protein in InterPro
IPR010989. SNARE.
IPR015260. Syntaxin-6_N.
IPR006012. Syntaxin/epimorphin_CS.
IPR000727. T_SNARE_dom.
PfamiView protein in Pfam
PF05739. SNARE. 1 hit.
PF09177. Syntaxin-6_N. 1 hit.
SMARTiView protein in SMART
SM00397. t_SNARE. 1 hit.
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiView protein in PROSITE
PS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9JKK1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSMEDPFFVV KGEVQKAVNT AQGLFQRWTE LLQGPSAATR EEIDWTTNEL
60 70 80 90 100
RNNLRSIEWD LEDLDETISI VEANPRKFNL DATELSIRKA FITSTRQIVR
110 120 130 140 150
DMKDQMSASS VQALAERKNR QALLGDSSSQ SWNAGVADRY GRLDRELQLA
160 170 180 190 200
NSHFIEEQQA QQQLIVEQQD EQLELVSGSI GVLKNMSQRI GGELEEQAVM
210 220 230 240 250
LDDFSHELES TQSRLDNVMK KLAKVSHMTS DRRQWCAIAI LFAVLVVVLI

LFLVL
Length:255
Mass (Da):28,997
Last modified:October 1, 2000 - v1
Checksum:i2CD91C02D23D28DE
GO
Isoform 2 (identifier: Q9JKK1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     231-255: DRRQWCAIAILFAVLVVVLILFLVL → GNDVRQVKIQYLLFIWRLLPGERKT

Show »
Length:255
Mass (Da):29,156
Checksum:iCBE9A32C045803FC
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016138231 – 255DRRQW…LFLVL → GNDVRQVKIQYLLFIWRLLP GERKT in isoform 2. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237814 mRNA. Translation: AAF40221.1.
AK009690 mRNA. Translation: BAB26441.1.
AK019106 mRNA. Translation: BAB31549.1.
AK031673 mRNA. Translation: BAC27505.1.
AK044905 mRNA. Translation: BAC32135.1.
AK049124 mRNA. Translation: BAC33556.1.
BC029205 mRNA. Translation: AAH29205.1.
CCDSiCCDS35741.1. [Q9JKK1-1]
RefSeqiNP_067408.1. NM_021433.3. [Q9JKK1-1]
UniGeneiMm.491299.
Mm.66264.

Genome annotation databases

EnsembliENSMUST00000027743; ENSMUSP00000027743; ENSMUSG00000026470. [Q9JKK1-1]
ENSMUST00000195302; ENSMUSP00000142089; ENSMUSG00000026470. [Q9JKK1-2]
GeneIDi58244.
KEGGimmu:58244.
UCSCiuc007dbb.1. mouse. [Q9JKK1-1]
uc007dbc.1. mouse. [Q9JKK1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSTX6_MOUSE
AccessioniPrimary (citable) accession number: Q9JKK1
Secondary accession number(s): Q9D3A1, Q9D729
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2000
Last modified: February 28, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome