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Protein

Dexamethasone-induced Ras-related protein 1

Gene

Rasd1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi31 – 388GTPBy similarity
Nucleotide bindingi78 – 825GTPBy similarity
Nucleotide bindingi145 – 1484GTPBy similarity

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • nitric oxide mediated signal transduction Source: RGD
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dexamethasone-induced Ras-related protein 1
Gene namesi
Name:Rasd1
Synonyms:Dexras1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi619727. Rasd1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB
  • plasma membrane Source: UniProtKB-SubCell
  • sarcoplasmic reticulum Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi178 – 1781A → V: Constituvely active mutant. Does not affect interaction with APBB1/FE65. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 277277Dexamethasone-induced Ras-related protein 1PRO_0000082719Add
BLAST
Propeptidei278 – 2803Removed in mature formBy similarityPRO_0000281374

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei11 – 111S-nitrosocysteineBy similarity
Modified residuei277 – 2771Cysteine methyl esterBy similarity
Lipidationi277 – 2771S-farnesyl cysteineBy similarity

Post-translational modificationi

S-nitrosylation stimulates guanine-nucleotide exchange activity.By similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation, S-nitrosylation

Proteomic databases

PaxDbiQ9JKF8.

Expressioni

Tissue specificityi

Prominently found in brain at both mRNA and protein levels. Moderate expression in testis and lung. Slightly expressed in heart, spleen, skeletal muscle, liver and kidney.1 Publication

Gene expression databases

GenevisibleiQ9JKF8. RN.

Interactioni

Subunit structurei

Forms a ternary complex with CAPON and NOS1. Component of a complex, at least composed of APBB1, RASD1/DEXRAS1 and APP. Interacts with APBB1/FE65. Forms.2 Publications

Protein-protein interaction databases

MINTiMINT-150992.
STRINGi10116.ENSRNOP00000004475.

Structurei

3D structure databases

ProteinModelPortaliQ9JKF8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi53 – 619Effector region

Sequence similaritiesi

Belongs to the small GTPase superfamily. RasD family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121857.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ9JKF8.
KOiK07843.
OMAiFYREVEQ.
OrthoDBiEOG7M0NSN.
PhylomeDBiQ9JKF8.
TreeFamiTF316238.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JKF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLAAMIKKM CPSDSELSIP AKNCYRMVIL GSSKVGKTAI VSRFLTGRFE
60 70 80 90 100
DAYTPTIEDF HRKFYSIRGE VYQLDILDTS GNHPFPAMRR LSILTGDVFI
110 120 130 140 150
LVFSLDNRDS FEEVQRLKQQ ILDTKSCLKN KTKENVDVPL VICGNKGDRD
160 170 180 190 200
FYREVEQREI EQLVGDDPQR CAYFEISAKK NSSLDQMFRA LFAMAKLPSE
210 220 230 240 250
MSPDLHRKVS VQYCDVLHKK ALRNKKLLRA GSGGGGDHGD AFGILAPFAR
260 270 280
RPSVHSDLMY IREKTSVSSQ AKDKERCVIS
Length:280
Mass (Da):31,714
Last modified:October 1, 2000 - v1
Checksum:iE551203186B8F9D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF239157 mRNA. Translation: AAF43090.1.
BC099136 mRNA. Translation: AAH99136.1.
RefSeqiNP_001257883.1. NM_001270954.1.
XP_008766093.1. XM_008767871.1.
XP_008766094.1. XM_008767872.1.
XP_008766095.1. XM_008767873.1.
UniGeneiRn.54720.

Genome annotation databases

EnsembliENSRNOT00000004475; ENSRNOP00000004475; ENSRNOG00000003348.
GeneIDi64455.
KEGGirno:64455.
UCSCiRGD:619727. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF239157 mRNA. Translation: AAF43090.1.
BC099136 mRNA. Translation: AAH99136.1.
RefSeqiNP_001257883.1. NM_001270954.1.
XP_008766093.1. XM_008767871.1.
XP_008766094.1. XM_008767872.1.
XP_008766095.1. XM_008767873.1.
UniGeneiRn.54720.

3D structure databases

ProteinModelPortaliQ9JKF8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-150992.
STRINGi10116.ENSRNOP00000004475.

Proteomic databases

PaxDbiQ9JKF8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004475; ENSRNOP00000004475; ENSRNOG00000003348.
GeneIDi64455.
KEGGirno:64455.
UCSCiRGD:619727. rat.

Organism-specific databases

CTDi51655.
RGDi619727. Rasd1.

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121857.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ9JKF8.
KOiK07843.
OMAiFYREVEQ.
OrthoDBiEOG7M0NSN.
PhylomeDBiQ9JKF8.
TreeFamiTF316238.

Miscellaneous databases

PROiQ9JKF8.

Gene expression databases

GenevisibleiQ9JKF8. RN.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON."
    Fang M., Jaffrey S.R., Sawa A., Ye K., Luo X., Snyder S.H.
    Neuron 28:183-193(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH CAPON AND NOS1, TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcription."
    Lau K.-F., Chan W.-M., Perkinton M.S., Tudor E.L., Chang R.C.C., Chan H.-Y., McLoughlin D.M., Miller C.C.J.
    J. Biol. Chem. 283:34728-34737(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, IDENTIFICATION IN A COMPLEX WITH APBB1 AND APP, INTERACTION WITH APBB1, MUTAGENESIS OF ALA-178.

Entry informationi

Entry nameiRASD1_RAT
AccessioniPrimary (citable) accession number: Q9JKF8
Secondary accession number(s): Q4KLL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.