ID   CLC6A_MOUSE             Reviewed;         209 AA.
AC   Q9JKF4; Q9JKF2; Q9JKF3;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-NOV-2009, entry version 66.
DE   RecName: Full=C-type lectin domain family 6 member A;
DE   AltName: Full=Dendritic cell-associated lectin 2;
DE   AltName: Full=DC-associated C-type lectin 2;
DE            Short=Dectin-2;
DE   AltName: Full=C-type lectin superfamily member 10;
GN   Name=Clec6a; Synonyms=Clec4n, Clecsf10, Dectin2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), AND TISSUE
RP   SPECIFICITY.
RC   STRAIN=BALB/c;
RX   PubMed=10766825; DOI=10.1074/jbc.275.16.11957;
RA   Ariizumi K., Shen G.-L., Shikano S., Ritter R. III, Zukas P.,
RA   Edelbaum D., Morita A., Takashima A.;
RT   "Cloning of a second dendritic cell-associated C-type lectin (dectin-
RT   2) and its alternatively spliced isoforms.";
RL   J. Biol. Chem. 275:11957-11963(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=FVB/N-3; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in regulating immune reactivity (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane
CC       protein (Probable).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1; Synonyms=Alpha;
CC         IsoId=Q9JKF4-1; Sequence=Displayed;
CC       Name=2; Synonyms=Beta;
CC         IsoId=Q9JKF4-2; Sequence=VSP_012846;
CC       Name=3; Synonyms=Gamma;
CC         IsoId=Q9JKF4-3; Sequence=VSP_012847;
CC   -!- TISSUE SPECIFICITY: Expressed by the XS52 DC (dendritic cell) line
CC       (at protein level). Expressed constitutively by the epidermis, and
CC       skin resident DC appear to be the major source of this expression.
CC       Expressed in the spleen and thymus. Expression was undetectable in
CC       non-DC lines, including macrophage lines (J774 and Raw), T-cell
CC       lines (7-17, HDK-1, and D10), B-cell hybridoma (5C5), a
CC       keratinocyte line (Pam 212), and a fibroblast line (NS01).
CC   -!- SIMILARITY: Contains 1 C-type lectin domain.
CC   -!- WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding;
CC       Note=Dectin-2;
CC       URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_361";
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DR   EMBL; AF240357; AAF67177.1; -; mRNA.
DR   EMBL; AF240358; AAF67178.1; -; mRNA.
DR   EMBL; AF240359; AAF67179.1; -; mRNA.
DR   EMBL; BC023008; AAH23008.1; -; mRNA.
DR   IPI; IPI00122937; -.
DR   IPI; IPI00122939; -.
DR   IPI; IPI00459254; -.
DR   RefSeq; NP_064385.1; -.
DR   UniGene; Mm.271782; -.
DR   HSSP; Q9H8F0; 1K9J.
DR   STRING; Q9JKF4; -.
DR   PRIDE; Q9JKF4; -.
DR   Ensembl; ENSMUST00000024118; ENSMUSP00000024118; ENSMUSG00000023349; Mus musculus.
DR   Ensembl; ENSMUST00000112554; ENSMUSP00000108173; ENSMUSG00000023349; Mus musculus.
DR   GeneID; 56620; -.
DR   KEGG; mmu:56620; -.
DR   UCSC; uc009dqe.1; mouse.
DR   UCSC; uc009dqf.1; mouse.
DR   CTD; 56620; -.
DR   MGI; MGI:1861231; Clec4n.
DR   HOGENOM; Q9JKF4; -.
DR   HOVERGEN; Q9JKF4; -.
DR   OMA; NDVFCDS; -.
DR   NextBio; 313047; -.
DR   ArrayExpress; Q9JKF4; -.
DR   Bgee; Q9JKF4; -.
DR   CleanEx; MM_CLEC4N; -.
DR   Genevestigator; Q9JKF4; -.
DR   GermOnline; ENSMUSG00000023349; Mus musculus.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005529; F:sugar binding; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR002353; AntifreezeII.
DR   InterPro; IPR001304; C-type_lectin.
DR   InterPro; IPR016186; C-type_lectin-like.
DR   InterPro; IPR018378; C-type_lectin_CS.
DR   Gene3D; G3DSA:3.10.100.10; C-type_lectin-like; 1.
DR   Pfam; PF00059; Lectin_C; 1.
DR   PRINTS; PR00356; ANTIFREEZEII.
DR   SMART; SM00034; CLECT; 1.
DR   PROSITE; PS00615; C_TYPE_LECTIN_1; 1.
DR   PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Disulfide bond; Glycoprotein; Immune response;
KW   Lectin; Membrane; Signal-anchor; Transmembrane.
FT   CHAIN         1    209       C-type lectin domain family 6 member A.
FT                                /FTId=PRO_0000046636.
FT   TOPO_DOM      1     20       Cytoplasmic (Potential).
FT   TRANSMEM     21     43       Signal-anchor for type II membrane
FT                                protein (Potential).
FT   TOPO_DOM     44    209       Extracellular (Potential).
FT   DOMAIN       86    203       C-type lectin.
FT   CARBOHYD    131    131       N-linked (GlcNAc...) (Potential).
FT   DISULFID     79     90       By similarity.
FT   DISULFID    107    202       By similarity.
FT   DISULFID    176    194       By similarity.
FT   VAR_SEQ      39     72       Missing (in isoform 2).
FT                                /FTId=VSP_012846.
FT   VAR_SEQ     142    182       Missing (in isoform 3).
FT                                /FTId=VSP_012847.
SQ   SEQUENCE   209 AA;  24324 MW;  7AB8BDC0DB1EA5ED CRC64;
     MVQERQSQGK GVCWTLRLWS AAVISMLLLS TCFIASCVVT YQFIMDQPSR RLYELHTYHS
     SLTCFSEGTM VSEKMWGCCP NHWKSFGSSC YLISTKENFW STSEQNCVQM GAHLVVINTE
     AEQNFITQQL NESLSYFLGL SDPQGNGKWQ WIDDTPFSQN VRFWHPHEPN LPEERCVSIV
     YWNPSKWGWN DVFCDSKHNS ICEMKKIYL
//