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Q9JKE3 (SCAM5_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified October 19, 2011. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Secretory carrier-associated membrane protein 5
Short name=Secretory carrier membrane protein 5
Gene names
Name:Scamp5
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length235 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery By similarity.

Subunit structure

Interacts (via C-terminal part) with SYT1 and SYT2; interaction with synaptotagmins making a link with the SNARE molecules. Interacts with SLC9A7 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity. Golgi apparatus membrane; Multi-pass membrane protein By similarity. Golgi apparatus › trans-Golgi network membrane; Multi-pass membrane protein By similarity. Recycling endosome membrane; Multi-pass membrane protein By similarity. Cytoplasmic vesicle › secretory vesicle › synaptic vesicle membrane; Multi-pass membrane protein By similarity. Note: Mainly localizes in Golgi apparatus membrane. Upon calcium-triggered exocytosis, it translocates to the cell membrane. Highly enriched in synaptic vesicles By similarity.

Sequence similarities

Belongs to the SCAMP family. SCAMP5 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 235235Secretory carrier-associated membrane protein 5
PRO_0000191264

Regions

Topological domain1 – 3939Cytoplasmic Potential
Transmembrane40 – 6021Helical; Potential
Topological domain61 – 677Extracellular Potential
Transmembrane68 – 8821Helical; Potential
Topological domain89 – 10214Cytoplasmic Potential
Transmembrane103 – 12523Helical; Potential
Topological domain126 – 14823Extracellular Potential
Transmembrane149 – 16921Helical; Potential
Topological domain170 – 23566Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
Q9JKE3 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 5C2C35578FB1399F

FASTA23526,098
        10         20         30         40         50         60 
MAEKVNNFPP LPKFIPLKPC FYQDFEADIP PQHLSLTKRL YYLWMLNSVT LAVNLVGCLA 

        70         80         90        100        110        120 
WLIGGGGATN FGLAFLWLIL FTPCSYVCWF RPIYKAFKTD SSFSFMAFFF TFMAQLVISI 

       130        140        150        160        170        180 
IQAVGIPGWG VCGWIATISF FGTNIGSAVV MLIPTVMFTV VAVFSFIALS MVHKFYRGSG 

       190        200        210        220        230 
GSFSKAQEEW TTGAWKNPHV QQAAQNAAMG AAQGAMNQPQ TQYSTTPNYT YSNEM

« Hide

References

[1]"Novel SCAMPs lacking NPF repeats: ubiquitous and synaptic vesicle-specific forms implicate SCAMPs in multiple membrane-trafficking functions."
Fernandez-Chacon R., Suedhof T.C.
J. Neurosci. 20:7941-7950(2000) [PubMed: 11050114] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF240784 mRNA. Translation: AAF64466.1.
IPIIPI00202535.
RefSeqNP_113914.1. NM_031726.1.
UniGeneRn.24420.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID65171.
KEGGrno:65171.

Organism-specific databases

CTD192683.
RGD68356. Scamp5.

Phylogenomic databases

eggNOGmaNOG18425.
HOVERGENHBG071938.

Gene expression databases

GenevestigatorQ9JKE3.

Family and domain databases

InterProIPR007273. SCAMP.
[Graphical view]
PANTHERPTHR10687. SCAMP. 1 hit.
PfamPF04144. SCAMP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio614061.

Entry information

Entry nameSCAM5_RAT
AccessionPrimary (citable) accession number: Q9JKE3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2000
Last modified: October 19, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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