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Protein

Triggering receptor expressed on myeloid cells 1

Gene

Trem1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cell migration Source: MGI
  • chemokine metabolic process Source: MGI
  • cytokine metabolic process Source: MGI
  • cytokine secretion involved in immune response Source: MGI
  • mitophagy in response to mitochondrial depolarization Source: Ensembl
  • neutrophil chemotaxis Source: MGI
  • neutrophil extravasation Source: MGI
  • neutrophil mediated killing of gram-negative bacterium Source: MGI
  • positive regulation of defense response to virus by host Source: Ensembl
  • xenophagy Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-MMU-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-MMU-202733. Cell surface interactions at the vascular wall.
R-MMU-2172127. DAP12 interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Triggering receptor expressed on myeloid cells 1
Short name:
TREM-1
Alternative name(s):
CD_antigen: CD354
Gene namesi
Name:Trem1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1930005. Trem1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 202ExtracellularSequence analysisAdd BLAST182
Transmembranei203 – 223HelicalSequence analysisAdd BLAST21
Topological domaini224 – 230CytoplasmicSequence analysis7

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000004279721 – 230Triggering receptor expressed on myeloid cells 1Add BLAST210

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 113Combined sources1 Publication
Glycosylationi191N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9JKE2.
PRIDEiQ9JKE2.
TopDownProteomicsiQ9JKE2.

PTM databases

PhosphoSitePlusiQ9JKE2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000042265.
CleanExiMM_TREM1.
ExpressionAtlasiQ9JKE2. baseline and differential.
GenevisibleiQ9JKE2. MM.

Interactioni

Subunit structurei

Interacts with TYROBP/DAP12 (By similarity). Monomer.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038636.

Structurei

Secondary structure

1230
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 32Combined sources6
Beta strandi37 – 42Combined sources6
Helixi45 – 48Combined sources4
Beta strandi51 – 57Combined sources7
Beta strandi65 – 69Combined sources5
Beta strandi78 – 82Combined sources5
Beta strandi85 – 90Combined sources6
Helixi91 – 93Combined sources3
Beta strandi95 – 100Combined sources6
Helixi105 – 107Combined sources3
Beta strandi109 – 116Combined sources8
Beta strandi129 – 134Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1U9KX-ray1.76A/B21-134[»]
ProteinModelPortaliQ9JKE2.
SMRiQ9JKE2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9JKE2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 124Ig-like V-typeAdd BLAST104

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J3SD. Eukaryota.
ENOG4111ABH. LUCA.
GeneTreeiENSGT00470000042299.
HOGENOMiHOG000130964.
HOVERGENiHBG068403.
InParanoidiQ9JKE2.
KOiK14362.
OMAiPVFNIVI.
OrthoDBiEOG091G0W1B.
PhylomeDBiQ9JKE2.
TreeFamiTF339293.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JKE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKAGLWGLL CVFFVSEVKA AIVLEEERYD LVEGQTLTVK CPFNIMKYAN
60 70 80 90 100
SQKAWQRLPD GKEPLTLVVT QRPFTRPSEV HMGKFTLKHD PSEAMLQVQM
110 120 130 140 150
TDLQVTDSGL YRCVIYHPPN DPVVLFHPVR LVVTKGSSDV FTPVIIPITR
160 170 180 190 200
LTERPILITT KYSPSDTTTT RSLPKPTAVV SSPGLGVTII NGTDADSVST
210 220 230
SSVTISVICG LLSKSLVFII LFIVTKRTFG
Length:230
Mass (Da):25,409
Last modified:October 1, 2000 - v1
Checksum:i51A1B7FD095A1990
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti92S → T in BAE42651 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF241219 mRNA. Translation: AAF69834.1.
AK089439 mRNA. Translation: BAC40884.1.
AK171753 mRNA. Translation: BAE42651.1.
CCDSiCCDS28860.1.
RefSeqiNP_067381.1. NM_021406.5.
UniGeneiMm.248352.

Genome annotation databases

EnsembliENSMUST00000048782; ENSMUSP00000038636; ENSMUSG00000042265.
GeneIDi58217.
KEGGimmu:58217.
UCSCiuc029tij.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF241219 mRNA. Translation: AAF69834.1.
AK089439 mRNA. Translation: BAC40884.1.
AK171753 mRNA. Translation: BAE42651.1.
CCDSiCCDS28860.1.
RefSeqiNP_067381.1. NM_021406.5.
UniGeneiMm.248352.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1U9KX-ray1.76A/B21-134[»]
ProteinModelPortaliQ9JKE2.
SMRiQ9JKE2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038636.

PTM databases

PhosphoSitePlusiQ9JKE2.

Proteomic databases

PaxDbiQ9JKE2.
PRIDEiQ9JKE2.
TopDownProteomicsiQ9JKE2.

Protocols and materials databases

DNASUi58217.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048782; ENSMUSP00000038636; ENSMUSG00000042265.
GeneIDi58217.
KEGGimmu:58217.
UCSCiuc029tij.2. mouse.

Organism-specific databases

CTDi54210.
MGIiMGI:1930005. Trem1.

Phylogenomic databases

eggNOGiENOG410J3SD. Eukaryota.
ENOG4111ABH. LUCA.
GeneTreeiENSGT00470000042299.
HOGENOMiHOG000130964.
HOVERGENiHBG068403.
InParanoidiQ9JKE2.
KOiK14362.
OMAiPVFNIVI.
OrthoDBiEOG091G0W1B.
PhylomeDBiQ9JKE2.
TreeFamiTF339293.

Enzyme and pathway databases

ReactomeiR-MMU-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-MMU-202733. Cell surface interactions at the vascular wall.
R-MMU-2172127. DAP12 interactions.

Miscellaneous databases

EvolutionaryTraceiQ9JKE2.
PROiQ9JKE2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042265.
CleanExiMM_TREM1.
ExpressionAtlasiQ9JKE2. baseline and differential.
GenevisibleiQ9JKE2. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTREM1_MOUSE
AccessioniPrimary (citable) accession number: Q9JKE2
Secondary accession number(s): Q3TAL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.