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Protein

Triggering receptor expressed on myeloid cells 1

Gene

Trem1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cell migration Source: MGI
  • chemokine metabolic process Source: MGI
  • cytokine metabolic process Source: MGI
  • cytokine secretion involved in immune response Source: MGI
  • mitophagy in response to mitochondrial depolarization Source: MGI
  • neutrophil chemotaxis Source: MGI
  • neutrophil extravasation Source: MGI
  • neutrophil mediated killing of gram-negative bacterium Source: MGI
  • positive regulation of defense response to virus by host Source: MGI
  • xenophagy Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-MMU-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-MMU-202733. Cell surface interactions at the vascular wall.
R-MMU-2172127. DAP12 interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Triggering receptor expressed on myeloid cells 1
Short name:
TREM-1
Alternative name(s):
CD_antigen: CD354
Gene namesi
Name:Trem1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1930005. Trem1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 202182ExtracellularSequence analysisAdd
BLAST
Transmembranei203 – 22321HelicalSequence analysisAdd
BLAST
Topological domaini224 – 2307CytoplasmicSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 230210Triggering receptor expressed on myeloid cells 1PRO_0000042797Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 113Combined sources1 Publication
Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9JKE2.
PRIDEiQ9JKE2.
TopDownProteomicsiQ9JKE2.

PTM databases

PhosphoSiteiQ9JKE2.

Expressioni

Gene expression databases

BgeeiQ9JKE2.
CleanExiMM_TREM1.
ExpressionAtlasiQ9JKE2. baseline and differential.
GenevisibleiQ9JKE2. MM.

Interactioni

Subunit structurei

Interacts with TYROBP/DAP12 (By similarity). Monomer.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038636.

Structurei

Secondary structure

1
230
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi27 – 326Combined sources
Beta strandi37 – 426Combined sources
Helixi45 – 484Combined sources
Beta strandi51 – 577Combined sources
Beta strandi65 – 695Combined sources
Beta strandi78 – 825Combined sources
Beta strandi85 – 906Combined sources
Helixi91 – 933Combined sources
Beta strandi95 – 1006Combined sources
Helixi105 – 1073Combined sources
Beta strandi109 – 1168Combined sources
Beta strandi129 – 1346Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1U9KX-ray1.76A/B21-134[»]
ProteinModelPortaliQ9JKE2.
SMRiQ9JKE2. Positions 25-134.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9JKE2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 124104Ig-like V-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J3SD. Eukaryota.
ENOG4111ABH. LUCA.
GeneTreeiENSGT00470000042299.
HOGENOMiHOG000130964.
HOVERGENiHBG068403.
InParanoidiQ9JKE2.
KOiK14362.
OMAiPVFNIVI.
PhylomeDBiQ9JKE2.
TreeFamiTF339293.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JKE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKAGLWGLL CVFFVSEVKA AIVLEEERYD LVEGQTLTVK CPFNIMKYAN
60 70 80 90 100
SQKAWQRLPD GKEPLTLVVT QRPFTRPSEV HMGKFTLKHD PSEAMLQVQM
110 120 130 140 150
TDLQVTDSGL YRCVIYHPPN DPVVLFHPVR LVVTKGSSDV FTPVIIPITR
160 170 180 190 200
LTERPILITT KYSPSDTTTT RSLPKPTAVV SSPGLGVTII NGTDADSVST
210 220 230
SSVTISVICG LLSKSLVFII LFIVTKRTFG
Length:230
Mass (Da):25,409
Last modified:October 1, 2000 - v1
Checksum:i51A1B7FD095A1990
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti92 – 921S → T in BAE42651 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF241219 mRNA. Translation: AAF69834.1.
AK089439 mRNA. Translation: BAC40884.1.
AK171753 mRNA. Translation: BAE42651.1.
CCDSiCCDS28860.1.
RefSeqiNP_067381.1. NM_021406.5.
UniGeneiMm.248352.

Genome annotation databases

EnsembliENSMUST00000048782; ENSMUSP00000038636; ENSMUSG00000042265.
GeneIDi58217.
KEGGimmu:58217.
UCSCiuc029tij.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF241219 mRNA. Translation: AAF69834.1.
AK089439 mRNA. Translation: BAC40884.1.
AK171753 mRNA. Translation: BAE42651.1.
CCDSiCCDS28860.1.
RefSeqiNP_067381.1. NM_021406.5.
UniGeneiMm.248352.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1U9KX-ray1.76A/B21-134[»]
ProteinModelPortaliQ9JKE2.
SMRiQ9JKE2. Positions 25-134.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038636.

PTM databases

PhosphoSiteiQ9JKE2.

Proteomic databases

PaxDbiQ9JKE2.
PRIDEiQ9JKE2.
TopDownProteomicsiQ9JKE2.

Protocols and materials databases

DNASUi58217.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048782; ENSMUSP00000038636; ENSMUSG00000042265.
GeneIDi58217.
KEGGimmu:58217.
UCSCiuc029tij.2. mouse.

Organism-specific databases

CTDi54210.
MGIiMGI:1930005. Trem1.

Phylogenomic databases

eggNOGiENOG410J3SD. Eukaryota.
ENOG4111ABH. LUCA.
GeneTreeiENSGT00470000042299.
HOGENOMiHOG000130964.
HOVERGENiHBG068403.
InParanoidiQ9JKE2.
KOiK14362.
OMAiPVFNIVI.
PhylomeDBiQ9JKE2.
TreeFamiTF339293.

Enzyme and pathway databases

ReactomeiR-MMU-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-MMU-202733. Cell surface interactions at the vascular wall.
R-MMU-2172127. DAP12 interactions.

Miscellaneous databases

EvolutionaryTraceiQ9JKE2.
PROiQ9JKE2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JKE2.
CleanExiMM_TREM1.
ExpressionAtlasiQ9JKE2. baseline and differential.
GenevisibleiQ9JKE2. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes."
    Bouchon A., Dietrich J., Colonna M.
    J. Immunol. 164:4991-4995(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Dendritic cell and Spleen.
  3. "Crystal structure of mouse triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.76 A."
    Kelker M.S., Debler E.W., Wilson I.A.
    J. Mol. Biol. 344:1175-1181(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.76 ANGSTROMS) OF 21-134, SUBUNIT, DISULFIDE BOND.

Entry informationi

Entry nameiTREM1_MOUSE
AccessioniPrimary (citable) accession number: Q9JKE2
Secondary accession number(s): Q3TAL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.