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Protein
Submitted name:

CD40 protein

Gene

Cd40

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • antigen binding Source: RGD
  • protein domain specific binding Source: RGD
  • receptor activity Source: InterPro

GO - Biological processi

  • B cell activation Source: InterPro
  • cellular response to erythropoietin Source: RGD
  • cellular response to interleukin-1 Source: RGD
  • cellular response to lipopolysaccharide Source: RGD
  • cellular response to tumor necrosis factor Source: RGD
  • inflammatory response Source: RGD
  • regulation of immune response Source: InterPro
  • response to bacterium Source: RGD
  • response to cobalamin Source: RGD
  • response to interferon-gamma Source: RGD
  • response to nutrient levels Source: RGD
  • response to peptide Source: RGD

Names & Taxonomyi

Protein namesi
Submitted name:
CD40 proteinImported
Gene namesi
Name:Cd40Imported
Synonyms:Tnfrsf5Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi619830. Cd40.

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: RGD
  • cytoplasm Source: RGD
  • external side of plasma membrane Source: InterPro
  • extracellular space Source: RGD
  • neuronal cell body Source: RGD
  • varicosity Source: RGD

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500433192024 – 169Sequence analysisAdd BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi38 ↔ 51PROSITE-ProRule annotation
Disulfide bondi41 ↔ 59PROSITE-ProRule annotation
Disulfide bondi62 ↔ 77PROSITE-ProRule annotation
Disulfide bondi125 ↔ 143PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Proteomic databases

PaxDbiQ9JKE0.

Interactioni

GO - Molecular functioni

  • protein domain specific binding Source: RGD

Structurei

3D structure databases

ProteinModelPortaliQ9JKE0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 59TNFR-CysInterPro annotationAdd BLAST35
Repeati25 – 59TNFR-CysPROSITE-ProRule annotationAdd BLAST35
Domaini61 – 103TNFR-CysInterPro annotationAdd BLAST43
Repeati61 – 103TNFR-CysPROSITE-ProRule annotationAdd BLAST43
Domaini104 – 143TNFR-CysInterPro annotationAdd BLAST40
Repeati104 – 143TNFR-CysPROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IY0H. Eukaryota.
ENOG4112DB5. LUCA.
HOVERGENiHBG005117.
PhylomeDBiQ9JKE0.

Family and domain databases

InterProiView protein in InterPro
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020435. TNFR_5.
PfamiView protein in Pfam
PF00020. TNFR_c6. 2 hits.
PRINTSiPR01922. TNFACTORR5.
SMARTiView protein in SMART
SM00208. TNFR. 3 hits.
PROSITEiView protein in PROSITE
PS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 3 hits.

Sequencei

Sequence statusi: Fragment.

Q9JKE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPLPQLCAL WGCLLTAVHL GQCVTCSDKQ YLQGGECCDL CQPGNRLVSH
60 70 80 90 100
CTALEKTQCQ PCDSGEFSAH WNREIRCHQH RHCELNQGLQ VKKEGTAVSD
110 120 130 140 150
TVCTCKEGQH CASKECETCA QHRPCGPGFG VVQMATETTD TVCQPCPVGF
160
FSNGSSLFEK CHPWTSCED
Length:169
Mass (Da):18,525
Last modified:June 1, 2001 - v2
Checksum:iF199D91EFA224A26
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei169Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF241231 mRNA. Translation: AAF43717.2.
UniGeneiRn.25180.

Genome annotation databases

UCSCiRGD:619830. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ9JKE0_RAT
AccessioniPrimary (citable) accession number: Q9JKE0
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: June 1, 2001
Last modified: July 5, 2017
This is version 73 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation