Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9JKD8

- TBX21_MOUSE

UniProt

Q9JKD8 - TBX21_MOUSE

Protein

T-box transcription factor TBX21

Gene

Tbx21

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi140 – 325186T-boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. sequence-specific DNA binding transcription factor activity Source: InterPro
    3. transcription regulatory region DNA binding Source: Ensembl

    GO - Biological processi

    1. cellular response to organic substance Source: MGI
    2. lymphocyte migration Source: UniProtKB
    3. positive regulation of isotype switching to IgG isotypes Source: MGI
    4. positive regulation of transcription, DNA-templated Source: UniProtKB
    5. regulation of immune response Source: MGI
    6. response to virus Source: Ensembl
    7. T cell differentiation Source: MGI
    8. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    T-box transcription factor TBX21
    Short name:
    T-box protein 21
    Alternative name(s):
    T-cell-specific T-box transcription factor T-bet
    Transcription factor TBLYM
    Gene namesi
    Name:Tbx21
    Synonyms:Tbet, Tblym
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1888984. Tbx21.

    Subcellular locationi

    GO - Cellular componenti

    1. neuronal cell body Source: MGI
    2. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 530530T-box transcription factor TBX21PRO_0000184454Add
    BLAST

    Proteomic databases

    PRIDEiQ9JKD8.

    PTM databases

    PhosphoSiteiQ9JKD8.

    Expressioni

    Tissue specificityi

    T-cell specific.

    Gene expression databases

    ArrayExpressiQ9JKD8.
    BgeeiQ9JKD8.
    CleanExiMM_TBX21.
    GenevestigatoriQ9JKD8.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Bcl6P411833EBI-3863870,EBI-6253762
    Runx1Q033473EBI-3863870,EBI-3863873

    Protein-protein interaction databases

    BioGridi208321. 9 interactions.
    IntActiQ9JKD8. 3 interactions.
    STRINGi10090.ENSMUSP00000001484.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JKD8.
    SMRiQ9JKD8. Positions 136-324.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 T-box DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG254024.
    GeneTreeiENSGT00740000115029.
    HOGENOMiHOG000218633.
    HOVERGENiHBG000578.
    InParanoidiQ9JKD8.
    KOiK10166.
    OMAiAPPGRFL.
    OrthoDBiEOG7C2R14.
    PhylomeDBiQ9JKD8.
    TreeFamiTF106341.

    Family and domain databases

    Gene3Di2.60.40.820. 1 hit.
    InterProiIPR008967. p53-like_TF_DNA-bd.
    IPR001699. TF_T-box.
    IPR018186. TF_T-box_CS.
    [Graphical view]
    PANTHERiPTHR11267. PTHR11267. 1 hit.
    PfamiPF00907. T-box. 1 hit.
    [Graphical view]
    PRINTSiPR00937. TBOX.
    SMARTiSM00425. TBOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF49417. SSF49417. 1 hit.
    PROSITEiPS01283. TBOX_1. 1 hit.
    PS01264. TBOX_2. 1 hit.
    PS50252. TBOX_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JKD8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGIVEPGCGD MLTGTEPMPS DEGRGPGADQ QHRFFYPEPG AQDPTDRRAG    50
    SSLGTPYSGG ALVPAAPGRF LGSFAYPPRA QVAGFPGPGE FFPPPAGAEG 100
    YPPVDGYPAP DPRAGLYPGP REDYALPAGL EVSGKLRVAL SNHLLWSKFN 150
    QHQTEMIITK QGRRMFPFLS FTVAGLEPTS HYRMFVDVVL VDQHHWRYQS 200
    GKWVQCGKAE GSMPGNRLYV HPDSPNTGAH WMRQEVSFGK LKLTNNKGAS 250
    NNVTQMIVLQ SLHKYQPRLH IVEVNDGEPE AACSASNTHV FTFQETQFIA 300
    VTAYQNAEIT QLKIDNNPFA KGFRENFESM YASVDTSVPS PPGPNCQLLG 350
    GDPFSPLLSN QYPVPSRFYP DLPGQPKDMI SQPYWLGTPR EHSYEAEFRA 400
    VSMKPTLLPS APGPTVPYYR GQDVLAPGAG WPVAPQYPPK MSPAGWFRPM 450
    RTLPMDPGLG SSEEQGSSPS LWPEVTSLQP EPSDSGLGEG DTKRRRISPY 500
    PSSGDSSSPA GAPSPFDKET EGQFYNYFPN 530
    Length:530
    Mass (Da):57,852
    Last modified:October 1, 2000 - v1
    Checksum:i07E4E9023A227FE8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti482 – 4821P → S in AAF00056. (PubMed:11087660)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF241242 mRNA. Translation: AAF61242.1.
    AF093099 mRNA. Translation: AAF00056.1.
    CCDSiCCDS25315.1.
    RefSeqiNP_062380.2. NM_019507.2.
    UniGeneiMm.94519.

    Genome annotation databases

    EnsembliENSMUST00000001484; ENSMUSP00000001484; ENSMUSG00000001444.
    GeneIDi57765.
    KEGGimmu:57765.
    UCSCiuc007ldr.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF241242 mRNA. Translation: AAF61242.1 .
    AF093099 mRNA. Translation: AAF00056.1 .
    CCDSi CCDS25315.1.
    RefSeqi NP_062380.2. NM_019507.2.
    UniGenei Mm.94519.

    3D structure databases

    ProteinModelPortali Q9JKD8.
    SMRi Q9JKD8. Positions 136-324.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 208321. 9 interactions.
    IntActi Q9JKD8. 3 interactions.
    STRINGi 10090.ENSMUSP00000001484.

    PTM databases

    PhosphoSitei Q9JKD8.

    Proteomic databases

    PRIDEi Q9JKD8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000001484 ; ENSMUSP00000001484 ; ENSMUSG00000001444 .
    GeneIDi 57765.
    KEGGi mmu:57765.
    UCSCi uc007ldr.2. mouse.

    Organism-specific databases

    CTDi 30009.
    MGIi MGI:1888984. Tbx21.

    Phylogenomic databases

    eggNOGi NOG254024.
    GeneTreei ENSGT00740000115029.
    HOGENOMi HOG000218633.
    HOVERGENi HBG000578.
    InParanoidi Q9JKD8.
    KOi K10166.
    OMAi APPGRFL.
    OrthoDBi EOG7C2R14.
    PhylomeDBi Q9JKD8.
    TreeFami TF106341.

    Miscellaneous databases

    NextBioi 313936.
    PROi Q9JKD8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9JKD8.
    Bgeei Q9JKD8.
    CleanExi MM_TBX21.
    Genevestigatori Q9JKD8.

    Family and domain databases

    Gene3Di 2.60.40.820. 1 hit.
    InterProi IPR008967. p53-like_TF_DNA-bd.
    IPR001699. TF_T-box.
    IPR018186. TF_T-box_CS.
    [Graphical view ]
    PANTHERi PTHR11267. PTHR11267. 1 hit.
    Pfami PF00907. T-box. 1 hit.
    [Graphical view ]
    PRINTSi PR00937. TBOX.
    SMARTi SM00425. TBOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49417. SSF49417. 1 hit.
    PROSITEi PS01283. TBOX_1. 1 hit.
    PS01264. TBOX_2. 1 hit.
    PS50252. TBOX_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel transcription factor, T-bet, directs Th1 lineage commitment."
      Szabo S.J., Kim S.T., Costa G.L., Zhang X., Fathman C.G., Glimcher L.H.
      Cell 100:655-669(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning and characterization of a new member of the T-box gene family."
      Zhang W.X., Yang S.Y.
      Genomics 70:41-48(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.

    Entry informationi

    Entry nameiTBX21_MOUSE
    AccessioniPrimary (citable) accession number: Q9JKD8
    Secondary accession number(s): Q9R0A6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 12, 2005
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3