Q9JKD8 (TBX21_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
T-box transcription factor TBX21
Short name=T-box protein 21

Alternative name(s):
T-cell-specific T-box transcription factor T-bet
Transcription factor TBLYM

Gene names

Name:	Tbx21
Synonyms:	Tbet, Tblym

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	530 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs By similarity.
Subcellular location	Nucleus.
Tissue specificity	T-cell specific.
Sequence similarities	Contains 1 T-box DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	lymphocyte migration Inferred from mutant phenotype. Source: UniProtKB positive regulation of isotype switching to IgG isotypes Inferred from mutant phenotype. Source: MGI positive regulation of transcription, DNA-dependent Inferred from mutant phenotype. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	neuronal cell body Inferred from direct assay. Source: MGI nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction. Source: IntAct sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Runx1	Q03347	3	EBI-3863870,EBI-3863873

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 530	530	T-box transcription factor TBX21		PRO_0000184454
Regions
	DNA binding	140 – 325	186	T-box
Experimental info
	Sequence conflict	482	1	P → S in AAF00056. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9JKD8 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 07E4E9023A227FE8	FASTA	530	57,852
	10 20 30 40 50 60 MGIVEPGCGD MLTGTEPMPS DEGRGPGADQ QHRFFYPEPG AQDPTDRRAG SSLGTPYSGG 70 80 90 100 110 120 ALVPAAPGRF LGSFAYPPRA QVAGFPGPGE FFPPPAGAEG YPPVDGYPAP DPRAGLYPGP 130 140 150 160 170 180 REDYALPAGL EVSGKLRVAL SNHLLWSKFN QHQTEMIITK QGRRMFPFLS FTVAGLEPTS 190 200 210 220 230 240 HYRMFVDVVL VDQHHWRYQS GKWVQCGKAE GSMPGNRLYV HPDSPNTGAH WMRQEVSFGK 250 260 270 280 290 300 LKLTNNKGAS NNVTQMIVLQ SLHKYQPRLH IVEVNDGEPE AACSASNTHV FTFQETQFIA 310 320 330 340 350 360 VTAYQNAEIT QLKIDNNPFA KGFRENFESM YASVDTSVPS PPGPNCQLLG GDPFSPLLSN 370 380 390 400 410 420 QYPVPSRFYP DLPGQPKDMI SQPYWLGTPR EHSYEAEFRA VSMKPTLLPS APGPTVPYYR 430 440 450 460 470 480 GQDVLAPGAG WPVAPQYPPK MSPAGWFRPM RTLPMDPGLG SSEEQGSSPS LWPEVTSLQP 490 500 510 520 530 EPSDSGLGEG DTKRRRISPY PSSGDSSSPA GAPSPFDKET EGQFYNYFPN

References

[1]	"A novel transcription factor, T-bet, directs Th1 lineage commitment." Szabo S.J., Kim S.T., Costa G.L., Zhang X., Fathman C.G., Glimcher L.H. Cell 100:655-669(2000) [PubMed: 10761931] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning and characterization of a new member of the T-box gene family." Zhang W.X., Yang S.Y. Genomics 70:41-48(2000) [PubMed: 11087660] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF241242 mRNA. Translation: AAF61242.1. AF093099 mRNA. Translation: AAF00056.1.
IPI	IPI00311393.
RefSeq	NP_062380.2. NM_019507.2.
3D structure databases
ProteinModelPortal	Q9JKD8.
SMR	Q9JKD8. Positions 135-325.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9JKD8. 2 interactions.
STRING	Q9JKD8.
PTM databases
PhosphoSite	Q9JKD8.
Proteomic databases
PRIDE	Q9JKD8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000001484; ENSMUSP00000001484; ENSMUSG00000001444.
GeneID	57765.
KEGG	mmu:57765.
NMPDR	fig|10090.3.peg.25155.
Organism-specific databases
CTD	30009.
MGI	MGI:1888984. Tbx21.
Phylogenomic databases
GeneTree	ENSGT00590000082772.
HOGENOM	HBG443799.
HOVERGEN	HBG000578.
InParanoid	Q9JKD8.
OMA	MPASDEG.
OrthoDB	EOG47WNNQ.
PhylomeDB	Q9JKD8.
Gene expression databases
ArrayExpress	Q9JKD8.
Bgee	Q9JKD8.
CleanEx	MM_TBX21.
Genevestigator	Q9JKD8.
GermOnline	ENSMUSG00000001444. Mus musculus.
Family and domain databases
InterPro	IPR008967. p53-like_TF_DNA-bd. IPR001699. TF_T-box. IPR018186. TF_T-box_CS. [Graphical view]
Gene3D	G3DSA:2.60.40.820. TF_T-box. 1 hit.
KO	K10166.
PANTHER	PTHR11267. TF_T-box. 1 hit.
Pfam	PF00907. T-box. 1 hit. [Graphical view]
PRINTS	PR00937. TBOX.
SMART	SM00425. TBOX. 1 hit. [Graphical view]
SUPFAM	SSF49417. P53_like_DNA_bnd. 1 hit.
PROSITE	PS01283. TBOX_1. 1 hit. PS01264. TBOX_2. 1 hit. PS50252. TBOX_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	313936.
SOURCE	Search...

Entry information

Entry name

TBX21_MOUSE

Accession

Primary (citable) accession number: Q9JKD8
Secondary accession number(s): Q9R0A6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 12, 2005
Last sequence update:	October 1, 2000
Last modified:	December 14, 2011
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program