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Q9JKD8 (TBX21_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
T-box transcription factor TBX21

Short name=T-box protein 21
Alternative name(s):
T-cell-specific T-box transcription factor T-bet
Transcription factor TBLYM
Gene names
Name:Tbx21
Synonyms:Tbet, Tblym
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length530 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs By similarity.

Subcellular location

Nucleus.

Tissue specificity

T-cell specific.

Sequence similarities

Contains 1 T-box DNA-binding domain.

Ontologies

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 530530T-box transcription factor TBX21
PRO_0000184454

Regions

DNA binding140 – 325186T-box

Experimental info

Sequence conflict4821P → S in AAF00056. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9JKD8 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 07E4E9023A227FE8

FASTA53057,852
        10         20         30         40         50         60 
MGIVEPGCGD MLTGTEPMPS DEGRGPGADQ QHRFFYPEPG AQDPTDRRAG SSLGTPYSGG 

        70         80         90        100        110        120 
ALVPAAPGRF LGSFAYPPRA QVAGFPGPGE FFPPPAGAEG YPPVDGYPAP DPRAGLYPGP 

       130        140        150        160        170        180 
REDYALPAGL EVSGKLRVAL SNHLLWSKFN QHQTEMIITK QGRRMFPFLS FTVAGLEPTS 

       190        200        210        220        230        240 
HYRMFVDVVL VDQHHWRYQS GKWVQCGKAE GSMPGNRLYV HPDSPNTGAH WMRQEVSFGK 

       250        260        270        280        290        300 
LKLTNNKGAS NNVTQMIVLQ SLHKYQPRLH IVEVNDGEPE AACSASNTHV FTFQETQFIA 

       310        320        330        340        350        360 
VTAYQNAEIT QLKIDNNPFA KGFRENFESM YASVDTSVPS PPGPNCQLLG GDPFSPLLSN 

       370        380        390        400        410        420 
QYPVPSRFYP DLPGQPKDMI SQPYWLGTPR EHSYEAEFRA VSMKPTLLPS APGPTVPYYR 

       430        440        450        460        470        480 
GQDVLAPGAG WPVAPQYPPK MSPAGWFRPM RTLPMDPGLG SSEEQGSSPS LWPEVTSLQP 

       490        500        510        520        530 
EPSDSGLGEG DTKRRRISPY PSSGDSSSPA GAPSPFDKET EGQFYNYFPN 

« Hide

References

[1]"A novel transcription factor, T-bet, directs Th1 lineage commitment."
Szabo S.J., Kim S.T., Costa G.L., Zhang X., Fathman C.G., Glimcher L.H.
Cell 100:655-669(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning and characterization of a new member of the T-box gene family."
Zhang W.X., Yang S.Y.
Genomics 70:41-48(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF241242 mRNA. Translation: AAF61242.1.
AF093099 mRNA. Translation: AAF00056.1.
CCDSCCDS25315.1.
RefSeqNP_062380.2. NM_019507.2.
UniGeneMm.94519.

3D structure databases

ProteinModelPortalQ9JKD8.
SMRQ9JKD8. Positions 136-324.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid208321. 8 interactions.
IntActQ9JKD8. 3 interactions.
STRING10090.ENSMUSP00000001484.

PTM databases

PhosphoSiteQ9JKD8.

Proteomic databases

PRIDEQ9JKD8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000001484; ENSMUSP00000001484; ENSMUSG00000001444.
GeneID57765.
KEGGmmu:57765.
UCSCuc007ldr.2. mouse.

Organism-specific databases

CTD30009.
MGIMGI:1888984. Tbx21.

Phylogenomic databases

eggNOGNOG254024.
GeneTreeENSGT00740000115029.
HOGENOMHOG000218633.
HOVERGENHBG000578.
InParanoidQ9JKD8.
KOK10166.
OMAAPPGRFL.
OrthoDBEOG7C2R14.
PhylomeDBQ9JKD8.
TreeFamTF106341.

Gene expression databases

ArrayExpressQ9JKD8.
BgeeQ9JKD8.
CleanExMM_TBX21.
GenevestigatorQ9JKD8.

Family and domain databases

Gene3D2.60.40.820. 1 hit.
InterProIPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERPTHR11267. PTHR11267. 1 hit.
PfamPF00907. T-box. 1 hit.
[Graphical view]
PRINTSPR00937. TBOX.
SMARTSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMSSF49417. SSF49417. 1 hit.
PROSITEPS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio313936.
PROQ9JKD8.
SOURCESearch...

Entry information

Entry nameTBX21_MOUSE
AccessionPrimary (citable) accession number: Q9JKD8
Secondary accession number(s): Q9R0A6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot