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Protein

T-box transcription factor TBX21

Gene

Tbx21

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi140 – 325186T-boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding transcription factor activity Source: InterPro
  2. transcription regulatory region DNA binding Source: MGI

GO - Biological processi

  1. cellular response to organic substance Source: MGI
  2. lymphocyte migration Source: UniProtKB
  3. positive regulation of isotype switching to IgG isotypes Source: MGI
  4. positive regulation of transcription, DNA-templated Source: UniProtKB
  5. regulation of immune response Source: MGI
  6. response to virus Source: Ensembl
  7. T cell differentiation Source: MGI
  8. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-box transcription factor TBX21
Short name:
T-box protein 21
Alternative name(s):
T-cell-specific T-box transcription factor T-bet
Transcription factor TBLYM
Gene namesi
Name:Tbx21
Synonyms:Tbet, Tblym
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1888984. Tbx21.

Subcellular locationi

GO - Cellular componenti

  1. neuronal cell body Source: MGI
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530T-box transcription factor TBX21PRO_0000184454Add
BLAST

Proteomic databases

PRIDEiQ9JKD8.

PTM databases

PhosphoSiteiQ9JKD8.

Expressioni

Tissue specificityi

T-cell specific.

Gene expression databases

BgeeiQ9JKD8.
CleanExiMM_TBX21.
ExpressionAtlasiQ9JKD8. baseline and differential.
GenevestigatoriQ9JKD8.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Bcl6P411833EBI-3863870,EBI-6253762
Runx1Q033473EBI-3863870,EBI-3863873

Protein-protein interaction databases

BioGridi208321. 9 interactions.
IntActiQ9JKD8. 3 interactions.
STRINGi10090.ENSMUSP00000001484.

Structurei

3D structure databases

ProteinModelPortaliQ9JKD8.
SMRiQ9JKD8. Positions 136-324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 T-box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG254024.
GeneTreeiENSGT00740000115029.
HOGENOMiHOG000218633.
HOVERGENiHBG000578.
InParanoidiQ9JKD8.
KOiK10166.
OMAiAPPGRFL.
OrthoDBiEOG7C2R14.
PhylomeDBiQ9JKD8.
TreeFamiTF106341.

Family and domain databases

Gene3Di2.60.40.820. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERiPTHR11267. PTHR11267. 1 hit.
PfamiPF00907. T-box. 1 hit.
[Graphical view]
PRINTSiPR00937. TBOX.
SMARTiSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiPS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JKD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIVEPGCGD MLTGTEPMPS DEGRGPGADQ QHRFFYPEPG AQDPTDRRAG
60 70 80 90 100
SSLGTPYSGG ALVPAAPGRF LGSFAYPPRA QVAGFPGPGE FFPPPAGAEG
110 120 130 140 150
YPPVDGYPAP DPRAGLYPGP REDYALPAGL EVSGKLRVAL SNHLLWSKFN
160 170 180 190 200
QHQTEMIITK QGRRMFPFLS FTVAGLEPTS HYRMFVDVVL VDQHHWRYQS
210 220 230 240 250
GKWVQCGKAE GSMPGNRLYV HPDSPNTGAH WMRQEVSFGK LKLTNNKGAS
260 270 280 290 300
NNVTQMIVLQ SLHKYQPRLH IVEVNDGEPE AACSASNTHV FTFQETQFIA
310 320 330 340 350
VTAYQNAEIT QLKIDNNPFA KGFRENFESM YASVDTSVPS PPGPNCQLLG
360 370 380 390 400
GDPFSPLLSN QYPVPSRFYP DLPGQPKDMI SQPYWLGTPR EHSYEAEFRA
410 420 430 440 450
VSMKPTLLPS APGPTVPYYR GQDVLAPGAG WPVAPQYPPK MSPAGWFRPM
460 470 480 490 500
RTLPMDPGLG SSEEQGSSPS LWPEVTSLQP EPSDSGLGEG DTKRRRISPY
510 520 530
PSSGDSSSPA GAPSPFDKET EGQFYNYFPN
Length:530
Mass (Da):57,852
Last modified:October 1, 2000 - v1
Checksum:i07E4E9023A227FE8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti482 – 4821P → S in AAF00056 (PubMed:11087660).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF241242 mRNA. Translation: AAF61242.1.
AF093099 mRNA. Translation: AAF00056.1.
CCDSiCCDS25315.1.
RefSeqiNP_062380.2. NM_019507.2.
UniGeneiMm.94519.

Genome annotation databases

EnsembliENSMUST00000001484; ENSMUSP00000001484; ENSMUSG00000001444.
GeneIDi57765.
KEGGimmu:57765.
UCSCiuc007ldr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF241242 mRNA. Translation: AAF61242.1.
AF093099 mRNA. Translation: AAF00056.1.
CCDSiCCDS25315.1.
RefSeqiNP_062380.2. NM_019507.2.
UniGeneiMm.94519.

3D structure databases

ProteinModelPortaliQ9JKD8.
SMRiQ9JKD8. Positions 136-324.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208321. 9 interactions.
IntActiQ9JKD8. 3 interactions.
STRINGi10090.ENSMUSP00000001484.

PTM databases

PhosphoSiteiQ9JKD8.

Proteomic databases

PRIDEiQ9JKD8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001484; ENSMUSP00000001484; ENSMUSG00000001444.
GeneIDi57765.
KEGGimmu:57765.
UCSCiuc007ldr.2. mouse.

Organism-specific databases

CTDi30009.
MGIiMGI:1888984. Tbx21.

Phylogenomic databases

eggNOGiNOG254024.
GeneTreeiENSGT00740000115029.
HOGENOMiHOG000218633.
HOVERGENiHBG000578.
InParanoidiQ9JKD8.
KOiK10166.
OMAiAPPGRFL.
OrthoDBiEOG7C2R14.
PhylomeDBiQ9JKD8.
TreeFamiTF106341.

Miscellaneous databases

NextBioi313936.
PROiQ9JKD8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JKD8.
CleanExiMM_TBX21.
ExpressionAtlasiQ9JKD8. baseline and differential.
GenevestigatoriQ9JKD8.

Family and domain databases

Gene3Di2.60.40.820. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERiPTHR11267. PTHR11267. 1 hit.
PfamiPF00907. T-box. 1 hit.
[Graphical view]
PRINTSiPR00937. TBOX.
SMARTiSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiPS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A novel transcription factor, T-bet, directs Th1 lineage commitment."
    Szabo S.J., Kim S.T., Costa G.L., Zhang X., Fathman C.G., Glimcher L.H.
    Cell 100:655-669(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning and characterization of a new member of the T-box gene family."
    Zhang W.X., Yang S.Y.
    Genomics 70:41-48(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.

Entry informationi

Entry nameiTBX21_MOUSE
AccessioniPrimary (citable) accession number: Q9JKD8
Secondary accession number(s): Q9R0A6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: October 1, 2000
Last modified: February 4, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.