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Q9JKD8

- TBX21_MOUSE

UniProt

Q9JKD8 - TBX21_MOUSE

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Protein
T-box transcription factor TBX21
Gene
Tbx21, Tbet, Tblym
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi140 – 325186T-box
Add
BLAST

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. sequence-specific DNA binding transcription factor activity Source: InterPro
  3. transcription regulatory region DNA binding Source: Ensembl

GO - Biological processi

  1. T cell differentiation Source: MGI
  2. cellular response to organic substance Source: MGI
  3. lymphocyte migration Source: UniProtKB
  4. positive regulation of isotype switching to IgG isotypes Source: MGI
  5. positive regulation of transcription, DNA-templated Source: UniProtKB
  6. regulation of immune response Source: MGI
  7. response to virus Source: Ensembl
  8. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-box transcription factor TBX21
Short name:
T-box protein 21
Alternative name(s):
T-cell-specific T-box transcription factor T-bet
Transcription factor TBLYM
Gene namesi
Name:Tbx21
Synonyms:Tbet, Tblym
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1888984. Tbx21.

Subcellular locationi

GO - Cellular componenti

  1. neuronal cell body Source: MGI
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530T-box transcription factor TBX21
PRO_0000184454Add
BLAST

Proteomic databases

PRIDEiQ9JKD8.

PTM databases

PhosphoSiteiQ9JKD8.

Expressioni

Tissue specificityi

T-cell specific.

Gene expression databases

ArrayExpressiQ9JKD8.
BgeeiQ9JKD8.
CleanExiMM_TBX21.
GenevestigatoriQ9JKD8.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Bcl6P411833EBI-3863870,EBI-6253762
Runx1Q033473EBI-3863870,EBI-3863873

Protein-protein interaction databases

BioGridi208321. 8 interactions.
IntActiQ9JKD8. 3 interactions.
STRINGi10090.ENSMUSP00000001484.

Structurei

3D structure databases

ProteinModelPortaliQ9JKD8.
SMRiQ9JKD8. Positions 136-324.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG254024.
GeneTreeiENSGT00740000115029.
HOGENOMiHOG000218633.
HOVERGENiHBG000578.
InParanoidiQ9JKD8.
KOiK10166.
OMAiAPPGRFL.
OrthoDBiEOG7C2R14.
PhylomeDBiQ9JKD8.
TreeFamiTF106341.

Family and domain databases

Gene3Di2.60.40.820. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERiPTHR11267. PTHR11267. 1 hit.
PfamiPF00907. T-box. 1 hit.
[Graphical view]
PRINTSiPR00937. TBOX.
SMARTiSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiPS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JKD8-1 [UniParc]FASTAAdd to Basket

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MGIVEPGCGD MLTGTEPMPS DEGRGPGADQ QHRFFYPEPG AQDPTDRRAG    50
SSLGTPYSGG ALVPAAPGRF LGSFAYPPRA QVAGFPGPGE FFPPPAGAEG 100
YPPVDGYPAP DPRAGLYPGP REDYALPAGL EVSGKLRVAL SNHLLWSKFN 150
QHQTEMIITK QGRRMFPFLS FTVAGLEPTS HYRMFVDVVL VDQHHWRYQS 200
GKWVQCGKAE GSMPGNRLYV HPDSPNTGAH WMRQEVSFGK LKLTNNKGAS 250
NNVTQMIVLQ SLHKYQPRLH IVEVNDGEPE AACSASNTHV FTFQETQFIA 300
VTAYQNAEIT QLKIDNNPFA KGFRENFESM YASVDTSVPS PPGPNCQLLG 350
GDPFSPLLSN QYPVPSRFYP DLPGQPKDMI SQPYWLGTPR EHSYEAEFRA 400
VSMKPTLLPS APGPTVPYYR GQDVLAPGAG WPVAPQYPPK MSPAGWFRPM 450
RTLPMDPGLG SSEEQGSSPS LWPEVTSLQP EPSDSGLGEG DTKRRRISPY 500
PSSGDSSSPA GAPSPFDKET EGQFYNYFPN 530
Length:530
Mass (Da):57,852
Last modified:October 1, 2000 - v1
Checksum:i07E4E9023A227FE8
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti482 – 4821P → S in AAF00056. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF241242 mRNA. Translation: AAF61242.1.
AF093099 mRNA. Translation: AAF00056.1.
CCDSiCCDS25315.1.
RefSeqiNP_062380.2. NM_019507.2.
UniGeneiMm.94519.

Genome annotation databases

EnsembliENSMUST00000001484; ENSMUSP00000001484; ENSMUSG00000001444.
GeneIDi57765.
KEGGimmu:57765.
UCSCiuc007ldr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF241242 mRNA. Translation: AAF61242.1 .
AF093099 mRNA. Translation: AAF00056.1 .
CCDSi CCDS25315.1.
RefSeqi NP_062380.2. NM_019507.2.
UniGenei Mm.94519.

3D structure databases

ProteinModelPortali Q9JKD8.
SMRi Q9JKD8. Positions 136-324.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 208321. 8 interactions.
IntActi Q9JKD8. 3 interactions.
STRINGi 10090.ENSMUSP00000001484.

PTM databases

PhosphoSitei Q9JKD8.

Proteomic databases

PRIDEi Q9JKD8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000001484 ; ENSMUSP00000001484 ; ENSMUSG00000001444 .
GeneIDi 57765.
KEGGi mmu:57765.
UCSCi uc007ldr.2. mouse.

Organism-specific databases

CTDi 30009.
MGIi MGI:1888984. Tbx21.

Phylogenomic databases

eggNOGi NOG254024.
GeneTreei ENSGT00740000115029.
HOGENOMi HOG000218633.
HOVERGENi HBG000578.
InParanoidi Q9JKD8.
KOi K10166.
OMAi APPGRFL.
OrthoDBi EOG7C2R14.
PhylomeDBi Q9JKD8.
TreeFami TF106341.

Miscellaneous databases

NextBioi 313936.
PROi Q9JKD8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9JKD8.
Bgeei Q9JKD8.
CleanExi MM_TBX21.
Genevestigatori Q9JKD8.

Family and domain databases

Gene3Di 2.60.40.820. 1 hit.
InterProi IPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view ]
PANTHERi PTHR11267. PTHR11267. 1 hit.
Pfami PF00907. T-box. 1 hit.
[Graphical view ]
PRINTSi PR00937. TBOX.
SMARTi SM00425. TBOX. 1 hit.
[Graphical view ]
SUPFAMi SSF49417. SSF49417. 1 hit.
PROSITEi PS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A novel transcription factor, T-bet, directs Th1 lineage commitment."
    Szabo S.J., Kim S.T., Costa G.L., Zhang X., Fathman C.G., Glimcher L.H.
    Cell 100:655-669(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning and characterization of a new member of the T-box gene family."
    Zhang W.X., Yang S.Y.
    Genomics 70:41-48(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.

Entry informationi

Entry nameiTBX21_MOUSE
AccessioniPrimary (citable) accession number: Q9JKD8
Secondary accession number(s): Q9R0A6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi