T-box transcription factor TBX21 - Mus musculus (Mouse)

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Q9JKD8 (TBX21_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 88. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
T-box transcription factor TBX21
Short name=T-box protein 21

Alternative name(s):
T-cell-specific T-box transcription factor T-bet
Transcription factor TBLYM

Gene names

Name:	Tbx21
Synonyms:	Tbet, Tblym

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	530 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs By similarity.
Subcellular location	Nucleus.
Tissue specificity	T-cell specific.
Sequence similarities	Contains 1 T-box DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	T cell differentiation Inferred from mutant phenotype PubMed 20399120. Source: MGI lymphocyte migration Inferred from mutant phenotype PubMed 19805038. Source: UniProtKB positive regulation of isotype switching to IgG isotypes Inferred from mutant phenotype PubMed 12882831. Source: MGI positive regulation of transcription, DNA-dependent Inferred from mutant phenotype PubMed 19805038. Source: UniProtKB response to virus Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	neuronal cell body Inferred from direct assay PubMed 15677725. Source: MGI nucleus Inferred from direct assay PubMed 21752992. Source: MGI
Molecular_function	sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro transcription regulatory region DNA binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Bcl6	P41183	3	EBI-3863870,EBI-6253762
Runx1	Q03347	3	EBI-3863870,EBI-3863873

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 530

530

T-box transcription factor TBX21

PRO_0000184454

Regions

DNA binding

140 – 325

186

T-box

Experimental info

Sequence conflict

482

P → S in AAF00056. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

Q9JKD8 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 07E4E9023A227FE8
Show »

FASTA

530

57,852

        10         20         30         40         50         60 
MGIVEPGCGD MLTGTEPMPS DEGRGPGADQ QHRFFYPEPG AQDPTDRRAG SSLGTPYSGG 

        70         80         90        100        110        120 
ALVPAAPGRF LGSFAYPPRA QVAGFPGPGE FFPPPAGAEG YPPVDGYPAP DPRAGLYPGP 

       130        140        150        160        170        180 
REDYALPAGL EVSGKLRVAL SNHLLWSKFN QHQTEMIITK QGRRMFPFLS FTVAGLEPTS 

       190        200        210        220        230        240 
HYRMFVDVVL VDQHHWRYQS GKWVQCGKAE GSMPGNRLYV HPDSPNTGAH WMRQEVSFGK 

       250        260        270        280        290        300 
LKLTNNKGAS NNVTQMIVLQ SLHKYQPRLH IVEVNDGEPE AACSASNTHV FTFQETQFIA 

       310        320        330        340        350        360 
VTAYQNAEIT QLKIDNNPFA KGFRENFESM YASVDTSVPS PPGPNCQLLG GDPFSPLLSN 

       370        380        390        400        410        420 
QYPVPSRFYP DLPGQPKDMI SQPYWLGTPR EHSYEAEFRA VSMKPTLLPS APGPTVPYYR 

       430        440        450        460        470        480 
GQDVLAPGAG WPVAPQYPPK MSPAGWFRPM RTLPMDPGLG SSEEQGSSPS LWPEVTSLQP 

       490        500        510        520        530 
EPSDSGLGEG DTKRRRISPY PSSGDSSSPA GAPSPFDKET EGQFYNYFPN

« Hide

References

[1]	"A novel transcription factor, T-bet, directs Th1 lineage commitment." Szabo S.J., Kim S.T., Costa G.L., Zhang X., Fathman C.G., Glimcher L.H. Cell 100:655-669(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning and characterization of a new member of the T-box gene family." Zhang W.X., Yang S.Y. Genomics 70:41-48(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF241242 mRNA. Translation: AAF61242.1. AF093099 mRNA. Translation: AAF00056.1.
IPI	IPI00311393.
RefSeq	NP_062380.2. NM_019507.2.
UniGene	Mm.490611.
3D structure databases
ProteinModelPortal	Q9JKD8.
SMR	Q9JKD8. Positions 136-324.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9JKD8. 3 interactions.
STRING	10090.ENSMUSP00000001484.
PTM databases
PhosphoSite	Q9JKD8.
Proteomic databases
PRIDE	Q9JKD8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000001484; ENSMUSP00000001484; ENSMUSG00000001444.
GeneID	57765.
KEGG	mmu:57765.
Organism-specific databases
CTD	30009.
MGI	MGI:1888984. Tbx21.
Phylogenomic databases
eggNOG	NOG254024.
GeneTree	ENSGT00690000102082.
HOGENOM	HOG000218633.
HOVERGEN	HBG000578.
InParanoid	Q9JKD8.
KO	K10166.
OMA	MPASDEG.
OrthoDB	EOG47WNNQ.
Gene expression databases
ArrayExpress	Q9JKD8.
Bgee	Q9JKD8.
CleanEx	MM_TBX21.
Genevestigator	Q9JKD8.
GermOnline	ENSMUSG00000001444. Mus musculus.
Family and domain databases
Gene3D	2.60.40.820. 1 hit.
InterPro	IPR008967. p53-like_TF_DNA-bd. IPR001699. TF_T-box. IPR018186. TF_T-box_CS. [Graphical view]
PANTHER	PTHR11267. PTHR11267. 1 hit.
Pfam	PF00907. T-box. 1 hit. [Graphical view]
PRINTS	PR00937. TBOX.
SMART	SM00425. TBOX. 1 hit. [Graphical view]
SUPFAM	SSF49417. P53_like_DNA_bnd. 1 hit.
PROSITE	PS01283. TBOX_1. 1 hit. PS01264. TBOX_2. 1 hit. PS50252. TBOX_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	313936.
SOURCE	Search...

Entry information

Entry name

TBX21_MOUSE

Accession

Primary (citable) accession number: Q9JKD8
Secondary accession number(s): Q9R0A6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 12, 2005
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents