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Protein

Claudin-5

Gene

Cldn5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space.By similarity

GO - Molecular functioni

  • identical protein binding Source: UniProtKB
  • structural molecule activity Source: RGD

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-5
Gene namesi
Name:Cldn5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi68431. Cldn5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77CytoplasmicSequence analysis
Transmembranei8 – 2821HelicalSequence analysisAdd
BLAST
Topological domaini29 – 8153ExtracellularSequence analysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence analysisAdd
BLAST
Topological domaini103 – 12321CytoplasmicSequence analysisAdd
BLAST
Transmembranei124 – 14421HelicalSequence analysisAdd
BLAST
Topological domaini145 – 16016ExtracellularSequence analysisAdd
BLAST
Transmembranei161 – 18121HelicalSequence analysisAdd
BLAST
Topological domaini182 – 21837CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • bicellular tight junction Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • paranode region of axon Source: RGD
  • plasma membrane Source: UniProtKB-SubCell
  • Schmidt-Lanterman incisure Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 218218Claudin-5PRO_0000144747Add
BLAST

Proteomic databases

PaxDbiQ9JKD6.

PTM databases

iPTMnetiQ9JKD6.
PhosphoSiteiQ9JKD6.

Expressioni

Gene expression databases

BgeeiENSRNOG00000045811.
GenevisibleiQ9JKD6. RN.

Interactioni

Subunit structurei

Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity). Interacts with MPDZ.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064048.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni217 – 2182Interactions with TJP1, TJP2 and TJP3By similarity

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJT1. Eukaryota.
ENOG410Y9S8. LUCA.
GeneTreeiENSGT00760000118928.
HOVERGENiHBG000643.
InParanoidiQ9JKD6.
KOiK06087.
OMAiLVCCGAW.
OrthoDBiEOG091G0MMR.
PhylomeDBiQ9JKD6.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003551. Claudin5.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01380. CLAUDIN5.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JKD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSAALEILG LVLCLVGWVG LILACGLPMW QVTAFLDHNI VTAQTTWKGL
60 70 80 90 100
WMSCVVQSTG HMQCKVYESV LALSAEVQAA RALTVGAVLL ALVALFVTLT
110 120 130 140 150
GAQCTTCVAP GPVKARVALT GGALYALCGL LALVPLCWFA NIVVREFYDP
160 170 180 190 200
TVPVSQKYEL GAALYIGWAA SALLMCGGGL VCCGAWVCTG RPEFSFPVKY
210
SAPRRTTANG DYDKKNYV
Length:218
Mass (Da):23,072
Last modified:April 12, 2005 - v2
Checksum:i93A316815D8D7F3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082073 mRNA. Translation: AAH82073.1.
AF241260 mRNA. Translation: AAF73425.1.
RefSeqiNP_113889.1. NM_031701.2.
UniGeneiRn.17420.

Genome annotation databases

EnsembliENSRNOT00000071806; ENSRNOP00000064048; ENSRNOG00000045811.
GeneIDi65131.
KEGGirno:65131.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082073 mRNA. Translation: AAH82073.1.
AF241260 mRNA. Translation: AAF73425.1.
RefSeqiNP_113889.1. NM_031701.2.
UniGeneiRn.17420.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064048.

PTM databases

iPTMnetiQ9JKD6.
PhosphoSiteiQ9JKD6.

Proteomic databases

PaxDbiQ9JKD6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000071806; ENSRNOP00000064048; ENSRNOG00000045811.
GeneIDi65131.
KEGGirno:65131.

Organism-specific databases

CTDi7122.
RGDi68431. Cldn5.

Phylogenomic databases

eggNOGiENOG410IJT1. Eukaryota.
ENOG410Y9S8. LUCA.
GeneTreeiENSGT00760000118928.
HOVERGENiHBG000643.
InParanoidiQ9JKD6.
KOiK06087.
OMAiLVCCGAW.
OrthoDBiEOG091G0MMR.
PhylomeDBiQ9JKD6.

Miscellaneous databases

PROiQ9JKD6.

Gene expression databases

BgeeiENSRNOG00000045811.
GenevisibleiQ9JKD6. RN.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003551. Claudin5.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01380. CLAUDIN5.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLD5_RAT
AccessioniPrimary (citable) accession number: Q9JKD6
Secondary accession number(s): Q66H22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: April 12, 2005
Last modified: September 7, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.