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Protein

Claudin-5

Gene

Cldn5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space.By similarity

GO - Molecular functioni

  • identical protein binding Source: UniProtKB
  • structural molecule activity Source: RGD

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-5
Gene namesi
Name:Cldn5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi68431 Cldn5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 81ExtracellularSequence analysisAdd BLAST53
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 123CytoplasmicSequence analysisAdd BLAST21
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Topological domaini145 – 160ExtracellularSequence analysisAdd BLAST16
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Topological domaini182 – 218CytoplasmicSequence analysisAdd BLAST37

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447471 – 218Claudin-5Add BLAST218

Proteomic databases

PaxDbiQ9JKD6

PTM databases

iPTMnetiQ9JKD6
PhosphoSitePlusiQ9JKD6

Expressioni

Gene expression databases

BgeeiENSRNOG00000045811
GenevisibleiQ9JKD6 RN

Interactioni

Subunit structurei

Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity). Interacts with MPDZ.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064048

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni217 – 218Interactions with TJP1, TJP2 and TJP3By similarity2

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJT1 Eukaryota
ENOG410Y9S8 LUCA
GeneTreeiENSGT00760000118928
HOVERGENiHBG000643
InParanoidiQ9JKD6
KOiK06087
OMAiCLVGWVG
OrthoDBiEOG091G0MMR
PhylomeDBiQ9JKD6

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003551 Claudin5
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01380 CLAUDIN5
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JKD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSAALEILG LVLCLVGWVG LILACGLPMW QVTAFLDHNI VTAQTTWKGL
60 70 80 90 100
WMSCVVQSTG HMQCKVYESV LALSAEVQAA RALTVGAVLL ALVALFVTLT
110 120 130 140 150
GAQCTTCVAP GPVKARVALT GGALYALCGL LALVPLCWFA NIVVREFYDP
160 170 180 190 200
TVPVSQKYEL GAALYIGWAA SALLMCGGGL VCCGAWVCTG RPEFSFPVKY
210
SAPRRTTANG DYDKKNYV
Length:218
Mass (Da):23,072
Last modified:April 12, 2005 - v2
Checksum:i93A316815D8D7F3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082073 mRNA Translation: AAH82073.1
AF241260 mRNA Translation: AAF73425.1
RefSeqiNP_113889.1, NM_031701.2
UniGeneiRn.17420

Genome annotation databases

EnsembliENSRNOT00000071806; ENSRNOP00000064048; ENSRNOG00000045811
GeneIDi65131
KEGGirno:65131

Similar proteinsi

Entry informationi

Entry nameiCLD5_RAT
AccessioniPrimary (citable) accession number: Q9JKD6
Secondary accession number(s): Q66H22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: April 12, 2005
Last modified: May 23, 2018
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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