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Q9JKD3 (SCAM5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified October 19, 2011. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Secretory carrier-associated membrane protein 5
Short name=Secretory carrier membrane protein 5
Gene names
Name:Scamp5
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length235 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery By similarity.

Subunit structure

Interacts (via C-terminal part) with SYT1 and SYT2; interaction with synaptotagmins making a link with the SNARE molecules. Interacts with SLC9A7 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein By similarity. Golgi apparatus › trans-Golgi network membrane; Multi-pass membrane protein By similarity. Recycling endosome membrane; Multi-pass membrane protein By similarity. Cytoplasmic vesicle › secretory vesicle › synaptic vesicle membrane; Multi-pass membrane protein. Note: Mainly localizes in Golgi apparatus membrane. Upon calcium-triggered exocytosis, it translocates to the cell membrane. Highly enriched in synaptic vesicles By similarity. Ref.1

Tissue specificity

Brain-specific. Ref.1

Developmental stage

Expressed late in development coincident with the elaboration of mature synapses.

Sequence similarities

Belongs to the SCAMP family. SCAMP5 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 235235Secretory carrier-associated membrane protein 5
PRO_0000191263

Regions

Topological domain1 – 3939Cytoplasmic Potential
Transmembrane40 – 6021Helical; Potential
Topological domain61 – 677Extracellular Potential
Transmembrane68 – 8821Helical; Potential
Topological domain89 – 10214Cytoplasmic Potential
Transmembrane103 – 12523Helical; Potential
Topological domain126 – 14823Extracellular Potential
Transmembrane149 – 16921Helical; Potential
Topological domain170 – 23566Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
Q9JKD3 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 5C2C25568FB1399F

FASTA23526,068
        10         20         30         40         50         60 
MAEKVNNFPP LPKFIPLKPC FYQDFEADIP PQHLSLTKRL YYLWMLNSVT LAVNLVGCLA 

        70         80         90        100        110        120 
WLIGGGGATN FGLAFLWLIL FTPCSYVCWF RPIYKAFKTD SSFSFMAFFF TFMAQLVISI 

       130        140        150        160        170        180 
IQAVGIPGWG VCGWIATISF FGTNIGSAVV MLIPTVMFTV VAVFSFIALS MVHKFYRGSG 

       190        200        210        220        230 
GSFSKAQEEW TTGAWKNPHV QQAAQNAAMG AAQGAMNQPQ TQYSATPNYT YSNEM

« Hide

References

« Hide 'large scale' references
[1]"Novel SCAMPs lacking NPF repeats: ubiquitous and synaptic vesicle-specific forms implicate SCAMPs in multiple membrane-trafficking functions."
Fernandez-Chacon R., Suedhof T.C.
J. Neurosci. 20:7941-7950(2000) [PubMed: 11050114] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Retina.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF241833 mRNA. Translation: AAF64491.1.
BC018613 mRNA. Translation: AAH18613.1.
IPIIPI00122865.
RefSeqNP_064666.1. NM_020270.2.
UniGeneMm.102278.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ9JKD3.

Proteomic databases

PRIDEQ9JKD3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000046587; ENSMUSP00000035898; ENSMUSG00000040722.
GeneID56807.
KEGGmmu:56807.
UCSCuc009puw.1. mouse.

Organism-specific databases

CTD192683.
MGIMGI:1928948. Scamp5.

Phylogenomic databases

eggNOGroNOG11211.
GeneTreeENSGT00390000014393.
HOGENOMHBG444815.
HOVERGENHBG071938.
InParanoidQ9JKD3.
OMASFFGTNI.
OrthoDBEOG451DRT.
PhylomeDBQ9JKD3.

Gene expression databases

ArrayExpressQ9JKD3.
BgeeQ9JKD3.
CleanExMM_SCAMP5.
GenevestigatorQ9JKD3.
GermOnlineENSMUSG00000040722. Mus musculus.

Family and domain databases

InterProIPR007273. SCAMP.
[Graphical view]
PANTHERPTHR10687. SCAMP. 1 hit.
PfamPF04144. SCAMP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio313357.
SOURCESearch...

Entry information

Entry nameSCAM5_MOUSE
AccessionPrimary (citable) accession number: Q9JKD3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2000
Last modified: October 19, 2011
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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