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Protein

AP-3 complex subunit mu-1

Gene

Ap3m1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.1 Publication

GO - Molecular functioni

GO - Biological processi

  • anterograde axon cargo transport Source: UniProtKB
  • anterograde synaptic vesicle transport Source: UniProtKB
  • intracellular protein transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_275351. Association of TriC/CCT with target proteins during biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
AP-3 complex subunit mu-1
Alternative name(s):
AP-3 adaptor complex mu3A subunit
Adaptor-related protein complex 3 subunit mu-1
Mu-adaptin 3A
Mu3A-adaptin
Gene namesi
Name:Ap3m1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1929212. Ap3m1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 418418AP-3 complex subunit mu-1PRO_0000193782Add
BLAST

Proteomic databases

MaxQBiQ9JKC8.
PaxDbiQ9JKC8.
PRIDEiQ9JKC8.

PTM databases

PhosphoSiteiQ9JKC8.

Expressioni

Gene expression databases

BgeeiQ9JKC8.
CleanExiMM_AP3M1.
ExpressionAtlasiQ9JKC8. baseline and differential.
GenevisibleiQ9JKC8. MM.

Interactioni

Subunit structurei

Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2). Interacts with AGAP1. AP-3 associates with the BLOC-1 complex.1 Publication

Protein-protein interaction databases

IntActiQ9JKC8. 1 interaction.
STRINGi10090.ENSMUSP00000117346.

Structurei

3D structure databases

ProteinModelPortaliQ9JKC8.
SMRiQ9JKC8. Positions 4-418.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini176 – 417242MHDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 MHD (mu homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG298719.
GeneTreeiENSGT00530000062779.
HOGENOMiHOG000234366.
HOVERGENiHBG104910.
InParanoidiQ9JKC8.
KOiK12398.
OMAiHMPKAVL.
OrthoDBiEOG79KPF6.
TreeFamiTF315187.

Family and domain databases

InterProiIPR022775. AP_mu_sigma_su.
IPR001392. Clathrin_mu.
IPR018240. Clathrin_mu_CS.
IPR011012. Longin-like_dom.
IPR028565. MHD.
[Graphical view]
PfamiPF00928. Adap_comp_sub. 1 hit.
PF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
PIRSFiPIRSF005992. Clathrin_mu. 1 hit.
PRINTSiPR00314. CLATHRINADPT.
SUPFAMiSSF49447. SSF49447. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEiPS00990. CLAT_ADAPTOR_M_1. 1 hit.
PS00991. CLAT_ADAPTOR_M_2. 1 hit.
PS51072. MHD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JKC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIHSLFLINC SGDIFLEKHW KSVVSQSVCD YFFEAQEKAA DVENVPPVIS
60 70 80 90 100
TPHHYLISIY RDKLFFVSVI QTEVPPLFVI EFLHRVADTF QDYFGECSEA
110 120 130 140 150
AIKDNVVIVY ELLEEMLDNG FPLATESNIL KELIKPPTIL RSVVNSITGS
160 170 180 190 200
SNVGDTLPTG QLSNIPWRRA GVKYTNNEAY FDVVEEIDAI IDKSGSTVFA
210 220 230 240 250
EIQGVIDACI KLSGMPDLSL SFMNPRLLDD VSFHPCIRFK RWESERVLSF
260 270 280 290 300
IPPDGNFRLI SYRVSSQNLV AIPVYVKHSI SFKENSSCGR FDITIGPKQN
310 320 330 340 350
MGKTIEGITV TVHMPKVVLN MNLTPTQGSY TFDPVTKVLA WDVGKITPQK
360 370 380 390 400
LPSLKGLVNL QSGAPKPEEN PNLNIQFKIQ QLAISGLKVN RLDMYGEKYK
410
PFKGVKYVTK AGKFQVRT
Length:418
Mass (Da):46,936
Last modified:October 1, 2000 - v1
Checksum:i69EC322D820C47D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF242857 mRNA. Translation: AAF63512.1.
BC024595 mRNA. Translation: AAH24595.1.
BC090983 mRNA. Translation: AAH90983.1.
CCDSiCCDS26861.1.
RefSeqiNP_061299.3. NM_018829.4.
XP_006519355.1. XM_006519292.1.
XP_006519356.1. XM_006519293.1.
UniGeneiMm.376269.

Genome annotation databases

EnsembliENSMUST00000154460; ENSMUSP00000117346; ENSMUSG00000021824.
GeneIDi55946.
KEGGimmu:55946.
UCSCiuc007sla.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF242857 mRNA. Translation: AAF63512.1.
BC024595 mRNA. Translation: AAH24595.1.
BC090983 mRNA. Translation: AAH90983.1.
CCDSiCCDS26861.1.
RefSeqiNP_061299.3. NM_018829.4.
XP_006519355.1. XM_006519292.1.
XP_006519356.1. XM_006519293.1.
UniGeneiMm.376269.

3D structure databases

ProteinModelPortaliQ9JKC8.
SMRiQ9JKC8. Positions 4-418.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JKC8. 1 interaction.
STRINGi10090.ENSMUSP00000117346.

PTM databases

PhosphoSiteiQ9JKC8.

Proteomic databases

MaxQBiQ9JKC8.
PaxDbiQ9JKC8.
PRIDEiQ9JKC8.

Protocols and materials databases

DNASUi55946.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000154460; ENSMUSP00000117346; ENSMUSG00000021824.
GeneIDi55946.
KEGGimmu:55946.
UCSCiuc007sla.2. mouse.

Organism-specific databases

CTDi26985.
MGIiMGI:1929212. Ap3m1.

Phylogenomic databases

eggNOGiNOG298719.
GeneTreeiENSGT00530000062779.
HOGENOMiHOG000234366.
HOVERGENiHBG104910.
InParanoidiQ9JKC8.
KOiK12398.
OMAiHMPKAVL.
OrthoDBiEOG79KPF6.
TreeFamiTF315187.

Enzyme and pathway databases

ReactomeiREACT_275351. Association of TriC/CCT with target proteins during biosynthesis.

Miscellaneous databases

ChiTaRSiAp3m1. mouse.
NextBioi311634.
PROiQ9JKC8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JKC8.
CleanExiMM_AP3M1.
ExpressionAtlasiQ9JKC8. baseline and differential.
GenevisibleiQ9JKC8. MM.

Family and domain databases

InterProiIPR022775. AP_mu_sigma_su.
IPR001392. Clathrin_mu.
IPR018240. Clathrin_mu_CS.
IPR011012. Longin-like_dom.
IPR028565. MHD.
[Graphical view]
PfamiPF00928. Adap_comp_sub. 1 hit.
PF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
PIRSFiPIRSF005992. Clathrin_mu. 1 hit.
PRINTSiPR00314. CLATHRINADPT.
SUPFAMiSSF49447. SSF49447. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEiPS00990. CLAT_ADAPTOR_M_1. 1 hit.
PS00991. CLAT_ADAPTOR_M_2. 1 hit.
PS51072. MHD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse medium chain clathrin adaptor protein mu3A."
    Werner H., Nave K.-A.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland and Testis.
  3. "Specific regulation of the adaptor protein complex AP-3 by the Arf GAP AGAP1."
    Nie Z., Boehm M., Boja E.S., Vass W.C., Bonifacino J.S., Fales H.M., Randazzo P.A.
    Dev. Cell 5:513-521(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH AGAP1.
  4. "The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse."
    Larimore J., Tornieri K., Ryder P.V., Gokhale A., Zlatic S.A., Craige B., Lee J.D., Talbot K., Pare J.F., Smith Y., Faundez V.
    Mol. Biol. Cell 22:4854-4867(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ASSOCIATION WITH THE BLOC-1 COMPLEX.

Entry informationi

Entry nameiAP3M1_MOUSE
AccessioniPrimary (citable) accession number: Q9JKC8
Secondary accession number(s): Q5BKQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: October 1, 2000
Last modified: July 22, 2015
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.