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Q9JKC8

- AP3M1_MOUSE

UniProt

Q9JKC8 - AP3M1_MOUSE

Protein

AP-3 complex subunit mu-1

Gene

Ap3m1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.1 Publication

    GO - Biological processi

    1. anterograde axon cargo transport Source: UniProtKB
    2. anterograde synaptic vesicle transport Source: UniProtKB
    3. intracellular protein transport Source: InterPro

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AP-3 complex subunit mu-1
    Alternative name(s):
    AP-3 adaptor complex mu3A subunit
    Adaptor-related protein complex 3 subunit mu-1
    Mu-adaptin 3A
    Mu3A-adaptin
    Gene namesi
    Name:Ap3m1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1929212. Ap3m1.

    Subcellular locationi

    Golgi apparatus. Cytoplasmic vesicle membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
    Note: Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.By similarity

    GO - Cellular componenti

    1. clathrin adaptor complex Source: InterPro
    2. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
    3. Golgi apparatus Source: UniProtKB-SubCell
    4. lysosomal membrane Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 418418AP-3 complex subunit mu-1PRO_0000193782Add
    BLAST

    Proteomic databases

    MaxQBiQ9JKC8.
    PaxDbiQ9JKC8.
    PRIDEiQ9JKC8.

    PTM databases

    PhosphoSiteiQ9JKC8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9JKC8.
    BgeeiQ9JKC8.
    CleanExiMM_AP3M1.
    GenevestigatoriQ9JKC8.

    Interactioni

    Subunit structurei

    Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2). Interacts with AGAP1. AP-3 associates with the BLOC-1 complex.1 Publication

    Protein-protein interaction databases

    IntActiQ9JKC8. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JKC8.
    SMRiQ9JKC8. Positions 4-418.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini176 – 417242MHDPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 MHD (mu homology) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG298719.
    GeneTreeiENSGT00530000062779.
    HOGENOMiHOG000234366.
    HOVERGENiHBG104910.
    InParanoidiQ9JKC8.
    KOiK12398.
    OMAiHMPKAVL.
    OrthoDBiEOG79KPF6.
    TreeFamiTF315187.

    Family and domain databases

    InterProiIPR022775. AP_mu_sigma_su.
    IPR001392. Clathrin_mu.
    IPR008968. Clathrin_mu_C.
    IPR018240. Clathrin_mu_CS.
    IPR011012. Longin-like_dom.
    IPR028565. MHD.
    [Graphical view]
    PfamiPF00928. Adap_comp_sub. 1 hit.
    PF01217. Clat_adaptor_s. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005992. Clathrin_mu. 1 hit.
    PRINTSiPR00314. CLATHRINADPT.
    SUPFAMiSSF49447. SSF49447. 1 hit.
    SSF64356. SSF64356. 1 hit.
    PROSITEiPS00990. CLAT_ADAPTOR_M_1. 1 hit.
    PS00991. CLAT_ADAPTOR_M_2. 1 hit.
    PS51072. MHD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JKC8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIHSLFLINC SGDIFLEKHW KSVVSQSVCD YFFEAQEKAA DVENVPPVIS    50
    TPHHYLISIY RDKLFFVSVI QTEVPPLFVI EFLHRVADTF QDYFGECSEA 100
    AIKDNVVIVY ELLEEMLDNG FPLATESNIL KELIKPPTIL RSVVNSITGS 150
    SNVGDTLPTG QLSNIPWRRA GVKYTNNEAY FDVVEEIDAI IDKSGSTVFA 200
    EIQGVIDACI KLSGMPDLSL SFMNPRLLDD VSFHPCIRFK RWESERVLSF 250
    IPPDGNFRLI SYRVSSQNLV AIPVYVKHSI SFKENSSCGR FDITIGPKQN 300
    MGKTIEGITV TVHMPKVVLN MNLTPTQGSY TFDPVTKVLA WDVGKITPQK 350
    LPSLKGLVNL QSGAPKPEEN PNLNIQFKIQ QLAISGLKVN RLDMYGEKYK 400
    PFKGVKYVTK AGKFQVRT 418
    Length:418
    Mass (Da):46,936
    Last modified:October 1, 2000 - v1
    Checksum:i69EC322D820C47D3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF242857 mRNA. Translation: AAF63512.1.
    BC024595 mRNA. Translation: AAH24595.1.
    BC090983 mRNA. Translation: AAH90983.1.
    CCDSiCCDS26861.1.
    RefSeqiNP_061299.3. NM_018829.4.
    XP_006519355.1. XM_006519292.1.
    XP_006519356.1. XM_006519293.1.
    UniGeneiMm.376269.

    Genome annotation databases

    EnsembliENSMUST00000154460; ENSMUSP00000117346; ENSMUSG00000021824.
    GeneIDi55946.
    KEGGimmu:55946.
    UCSCiuc007sla.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF242857 mRNA. Translation: AAF63512.1 .
    BC024595 mRNA. Translation: AAH24595.1 .
    BC090983 mRNA. Translation: AAH90983.1 .
    CCDSi CCDS26861.1.
    RefSeqi NP_061299.3. NM_018829.4.
    XP_006519355.1. XM_006519292.1.
    XP_006519356.1. XM_006519293.1.
    UniGenei Mm.376269.

    3D structure databases

    ProteinModelPortali Q9JKC8.
    SMRi Q9JKC8. Positions 4-418.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9JKC8. 1 interaction.

    PTM databases

    PhosphoSitei Q9JKC8.

    Proteomic databases

    MaxQBi Q9JKC8.
    PaxDbi Q9JKC8.
    PRIDEi Q9JKC8.

    Protocols and materials databases

    DNASUi 55946.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000154460 ; ENSMUSP00000117346 ; ENSMUSG00000021824 .
    GeneIDi 55946.
    KEGGi mmu:55946.
    UCSCi uc007sla.2. mouse.

    Organism-specific databases

    CTDi 26985.
    MGIi MGI:1929212. Ap3m1.

    Phylogenomic databases

    eggNOGi NOG298719.
    GeneTreei ENSGT00530000062779.
    HOGENOMi HOG000234366.
    HOVERGENi HBG104910.
    InParanoidi Q9JKC8.
    KOi K12398.
    OMAi HMPKAVL.
    OrthoDBi EOG79KPF6.
    TreeFami TF315187.

    Miscellaneous databases

    ChiTaRSi AP3M1. mouse.
    NextBioi 311634.
    PROi Q9JKC8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9JKC8.
    Bgeei Q9JKC8.
    CleanExi MM_AP3M1.
    Genevestigatori Q9JKC8.

    Family and domain databases

    InterProi IPR022775. AP_mu_sigma_su.
    IPR001392. Clathrin_mu.
    IPR008968. Clathrin_mu_C.
    IPR018240. Clathrin_mu_CS.
    IPR011012. Longin-like_dom.
    IPR028565. MHD.
    [Graphical view ]
    Pfami PF00928. Adap_comp_sub. 1 hit.
    PF01217. Clat_adaptor_s. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005992. Clathrin_mu. 1 hit.
    PRINTSi PR00314. CLATHRINADPT.
    SUPFAMi SSF49447. SSF49447. 1 hit.
    SSF64356. SSF64356. 1 hit.
    PROSITEi PS00990. CLAT_ADAPTOR_M_1. 1 hit.
    PS00991. CLAT_ADAPTOR_M_2. 1 hit.
    PS51072. MHD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse medium chain clathrin adaptor protein mu3A."
      Werner H., Nave K.-A.
      Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland and Testis.
    3. "Specific regulation of the adaptor protein complex AP-3 by the Arf GAP AGAP1."
      Nie Z., Boehm M., Boja E.S., Vass W.C., Bonifacino J.S., Fales H.M., Randazzo P.A.
      Dev. Cell 5:513-521(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH AGAP1.
    4. "The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse."
      Larimore J., Tornieri K., Ryder P.V., Gokhale A., Zlatic S.A., Craige B., Lee J.D., Talbot K., Pare J.F., Smith Y., Faundez V.
      Mol. Biol. Cell 22:4854-4867(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, ASSOCIATION WITH THE BLOC-1 COMPLEX.

    Entry informationi

    Entry nameiAP3M1_MOUSE
    AccessioniPrimary (citable) accession number: Q9JKC8
    Secondary accession number(s): Q5BKQ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3