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Q9JKC7

- AP4M1_MOUSE

UniProt

Q9JKC7 - AP4M1_MOUSE

Protein

AP-4 complex subunit mu-1

Gene

Ap4m1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Component of the AP-4 complex, a novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. Plays a role in the intracellular trafficking of APP from the trans-Golgi network (TGN) to endosomes, and thereby inhibits amyloidogenic processing of APP By similarity.By similarity

    GO - Biological processi

    1. Golgi to endosome transport Source: UniProtKB
    2. intracellular protein transport Source: UniProtKB
    3. vesicle-mediated transport Source: MGI

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AP-4 complex subunit mu-1
    Alternative name(s):
    AP-4 adaptor complex mu subunit
    Adaptor-related protein complex 4 subunit mu-1
    Mu subunit of AP-4
    Mu-adaptin-related protein 2
    Short name:
    mu-ARP2
    Mu4-adaptin
    Short name:
    mu4
    Gene namesi
    Name:Ap4m1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1337063. Ap4m1.

    Subcellular locationi

    Golgi apparatustrans-Golgi network By similarity. Membranecoated pit By similarity
    Note: Associated with the trans-Golgi network. Found in soma and dendritic shafts of neuronal cells By similarity.By similarity

    GO - Cellular componenti

    1. clathrin adaptor complex Source: InterPro
    2. coated pit Source: UniProtKB-SubCell
    3. trans-Golgi network Source: UniProtKB

    Keywords - Cellular componenti

    Coated pit, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 449449AP-4 complex subunit mu-1PRO_0000193788Add
    BLAST

    Proteomic databases

    PaxDbiQ9JKC7.
    PRIDEiQ9JKC7.

    PTM databases

    PhosphoSiteiQ9JKC7.

    Expressioni

    Gene expression databases

    BgeeiQ9JKC7.
    CleanExiMM_AP4M1.
    GenevestigatoriQ9JKC7.

    Interactioni

    Subunit structurei

    Adaptor protein complex 4 (AP-4) is a heterotetramer composed of two large adaptins (epsilon-type subunit AP4E1 and beta-type subunit AP4B1), a medium adaptin (mu-type subunit AP4M1) and a small adaptin (sigma-type AP4S1). Interacts with the C-terminal domain of GRID2. Interacts with tyrosine-based sorting signals on the cytoplasmic tail of cargo proteins, such as LAMP2 and APP By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JKC7.
    SMRiQ9JKC7. Positions 1-449.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini184 – 448265MHDPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 MHD (mu homology) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG281769.
    GeneTreeiENSGT00530000062779.
    HOGENOMiHOG000173245.
    HOVERGENiHBG102734.
    InParanoidiQ9JKC7.
    KOiK12402.
    OMAiGLQIRFL.
    OrthoDBiEOG78M01Z.
    PhylomeDBiQ9JKC7.
    TreeFamiTF329745.

    Family and domain databases

    InterProiIPR022775. AP_mu_sigma_su.
    IPR001392. Clathrin_mu.
    IPR008968. Clathrin_mu_C.
    IPR018240. Clathrin_mu_CS.
    IPR011012. Longin-like_dom.
    IPR028565. MHD.
    [Graphical view]
    PfamiPF00928. Adap_comp_sub. 1 hit.
    PF01217. Clat_adaptor_s. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005992. Clathrin_mu. 1 hit.
    PRINTSiPR00314. CLATHRINADPT.
    SUPFAMiSSF49447. SSF49447. 1 hit.
    SSF64356. SSF64356. 1 hit.
    PROSITEiPS00991. CLAT_ADAPTOR_M_2. 1 hit.
    PS51072. MHD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JKC7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MISQFFILSS KGDPLIYKDF RGDSGGRDVA ELFYRKLTGL PGGESPVVMY    50
    HGDRHFIHIR HSGLYLVATT LENVSPFSLL ELLSRLATLL GDYCGSLNEG 100
    TISRNVALVY ELLDEVLDYG YVQTTSTEML RNFIQTEAVV SKPFSLFDLS 150
    SVGLFGAETQ QNKVAPSSAA SRPVLSSRSD QSQKNEVFLD VVERLSVLIA 200
    SNGSLLKVDV QGEIRLKSFL PSGSEICIGL TEEFCVGKSE LRGYGPGIRV 250
    DEVSFHSSVN LDEFESHRIL RLQPPQGELT VMRYQLSDDL PSPLPFRLFP 300
    SVQWDQGSGR LQVYLKLRCD LPPKSQALNI HLHLPLPRGV ISLSQELSSP 350
    DQKAELGEGA LHWDLPRVQG GSQLSGLFQM DVPGLQGLPN HGPSPLGLGP 400
    ASLSFELPRH TCSGLQVRFL RLSFSACGNA NPHKWVRHLS HSNAYVIRI 449
    Length:449
    Mass (Da):49,509
    Last modified:October 1, 2000 - v1
    Checksum:i579AEAE1F82B5D04
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF242858 mRNA. Translation: AAF63513.1.
    BC011174 mRNA. Translation: AAH11174.1.
    CCDSiCCDS19794.1.
    RefSeqiNP_067367.3. NM_021392.4.
    UniGeneiMm.113205.

    Genome annotation databases

    EnsembliENSMUST00000019662; ENSMUSP00000019662; ENSMUSG00000019518.
    GeneIDi11781.
    KEGGimmu:11781.
    UCSCiuc009aev.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF242858 mRNA. Translation: AAF63513.1 .
    BC011174 mRNA. Translation: AAH11174.1 .
    CCDSi CCDS19794.1.
    RefSeqi NP_067367.3. NM_021392.4.
    UniGenei Mm.113205.

    3D structure databases

    ProteinModelPortali Q9JKC7.
    SMRi Q9JKC7. Positions 1-449.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9JKC7.

    Proteomic databases

    PaxDbi Q9JKC7.
    PRIDEi Q9JKC7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000019662 ; ENSMUSP00000019662 ; ENSMUSG00000019518 .
    GeneIDi 11781.
    KEGGi mmu:11781.
    UCSCi uc009aev.2. mouse.

    Organism-specific databases

    CTDi 9179.
    MGIi MGI:1337063. Ap4m1.

    Phylogenomic databases

    eggNOGi NOG281769.
    GeneTreei ENSGT00530000062779.
    HOGENOMi HOG000173245.
    HOVERGENi HBG102734.
    InParanoidi Q9JKC7.
    KOi K12402.
    OMAi GLQIRFL.
    OrthoDBi EOG78M01Z.
    PhylomeDBi Q9JKC7.
    TreeFami TF329745.

    Miscellaneous databases

    NextBioi 279583.
    PROi Q9JKC7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9JKC7.
    CleanExi MM_AP4M1.
    Genevestigatori Q9JKC7.

    Family and domain databases

    InterProi IPR022775. AP_mu_sigma_su.
    IPR001392. Clathrin_mu.
    IPR008968. Clathrin_mu_C.
    IPR018240. Clathrin_mu_CS.
    IPR011012. Longin-like_dom.
    IPR028565. MHD.
    [Graphical view ]
    Pfami PF00928. Adap_comp_sub. 1 hit.
    PF01217. Clat_adaptor_s. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005992. Clathrin_mu. 1 hit.
    PRINTSi PR00314. CLATHRINADPT.
    SUPFAMi SSF49447. SSF49447. 1 hit.
    SSF64356. SSF64356. 1 hit.
    PROSITEi PS00991. CLAT_ADAPTOR_M_2. 1 hit.
    PS51072. MHD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mus musculus adaptor-related protein complex AP-4 mu4 subunit."
      Werner H., Nave K.-A.
      Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon.

    Entry informationi

    Entry nameiAP4M1_MOUSE
    AccessioniPrimary (citable) accession number: Q9JKC7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3