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Protein

AP-4 complex subunit mu-1

Gene

Ap4m1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system (By similarity). It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons (PubMed:18341993). Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos. The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • asymmetric protein localization Source: UniProtKB
  • Golgi to endosome transport Source: UniProtKB
  • Golgi to lysosome transport Source: UniProtKB
  • intracellular protein transport Source: UniProtKB
  • protein localization to basolateral plasma membrane Source: UniProtKB
  • protein targeting Source: UniProtKB
  • protein targeting to lysosome Source: Ensembl
  • vesicle-mediated transport Source: MGI

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-432720. Lysosome Vesicle Biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
AP-4 complex subunit mu-1Curated
Alternative name(s):
AP-4 adaptor complex mu subunit
Adaptor-related protein complex 4 subunit mu-1
Mu subunit of AP-4
Mu-adaptin-related protein 2
Short name:
mu-ARP2
Mu4-adaptin
Short name:
mu4
Gene namesi
Name:Ap4m1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1337063. Ap4m1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001937881 – 449AP-4 complex subunit mu-1Add BLAST449

Proteomic databases

MaxQBiQ9JKC7.
PaxDbiQ9JKC7.
PRIDEiQ9JKC7.

PTM databases

iPTMnetiQ9JKC7.
PhosphoSitePlusiQ9JKC7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000019518.
CleanExiMM_AP4M1.
ExpressionAtlasiQ9JKC7. baseline and differential.
GenevisibleiQ9JKC7. MM.

Interactioni

Subunit structurei

Adaptor protein complex 4 (AP-4) is a heterotetramer composed of two large adaptins (epsilon-type subunit AP4E1 and beta-type subunit AP4B1), a medium adaptin (mu-type subunit AP4M1) and a small adaptin (sigma-type AP4S1). Interacts with tyrosine-based sorting signals on the cytoplasmic tail of cargo proteins such as APP, LAMP2 and NAGPA. Interacts with the C-terminal domain of GRID2 (By similarity). Interacts with GRIA1 and GRIA2; the interaction is indirect via CACNG3 (PubMed:18341993). Interacts with CACNG3; CACNG3 associates GRIA1 and GRIA2 with the adaptor protein complex 4 (AP-4) to target them to the somatodendritic compartment of neurons (PubMed:18341993).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019662.

Structurei

3D structure databases

ProteinModelPortaliQ9JKC7.
SMRiQ9JKC7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini184 – 448MHDPROSITE-ProRule annotationAdd BLAST265

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0937. Eukaryota.
ENOG410XPFS. LUCA.
GeneTreeiENSGT00530000062779.
HOGENOMiHOG000173245.
HOVERGENiHBG102734.
InParanoidiQ9JKC7.
KOiK12402.
OMAiIHIRHSG.
OrthoDBiEOG091G0ISV.
PhylomeDBiQ9JKC7.
TreeFamiTF329745.

Family and domain databases

InterProiView protein in InterPro
IPR036168. AP2_Mu_C_sf.
IPR001392. Clathrin_mu.
IPR018240. Clathrin_mu_CS.
IPR011012. Longin-like_dom_sf.
IPR028565. MHD.
PfamiView protein in Pfam
PF00928. Adap_comp_sub. 1 hit.
PIRSFiPIRSF005992. Clathrin_mu. 1 hit.
PRINTSiPR00314. CLATHRINADPT.
SUPFAMiSSF49447. SSF49447. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEiView protein in PROSITE
PS00991. CLAT_ADAPTOR_M_2. 1 hit.
PS51072. MHD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9JKC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISQFFILSS KGDPLIYKDF RGDSGGRDVA ELFYRKLTGL PGGESPVVMY
60 70 80 90 100
HGDRHFIHIR HSGLYLVATT LENVSPFSLL ELLSRLATLL GDYCGSLNEG
110 120 130 140 150
TISRNVALVY ELLDEVLDYG YVQTTSTEML RNFIQTEAVV SKPFSLFDLS
160 170 180 190 200
SVGLFGAETQ QNKVAPSSAA SRPVLSSRSD QSQKNEVFLD VVERLSVLIA
210 220 230 240 250
SNGSLLKVDV QGEIRLKSFL PSGSEICIGL TEEFCVGKSE LRGYGPGIRV
260 270 280 290 300
DEVSFHSSVN LDEFESHRIL RLQPPQGELT VMRYQLSDDL PSPLPFRLFP
310 320 330 340 350
SVQWDQGSGR LQVYLKLRCD LPPKSQALNI HLHLPLPRGV ISLSQELSSP
360 370 380 390 400
DQKAELGEGA LHWDLPRVQG GSQLSGLFQM DVPGLQGLPN HGPSPLGLGP
410 420 430 440
ASLSFELPRH TCSGLQVRFL RLSFSACGNA NPHKWVRHLS HSNAYVIRI
Length:449
Mass (Da):49,509
Last modified:October 1, 2000 - v1
Checksum:i579AEAE1F82B5D04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF242858 mRNA. Translation: AAF63513.1.
BC011174 mRNA. Translation: AAH11174.1.
CCDSiCCDS19794.1.
RefSeqiNP_067367.3. NM_021392.4.
UniGeneiMm.113205.
Mm.477097.

Genome annotation databases

EnsembliENSMUST00000019662; ENSMUSP00000019662; ENSMUSG00000019518.
GeneIDi11781.
KEGGimmu:11781.
UCSCiuc009aev.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiAP4M1_MOUSE
AccessioniPrimary (citable) accession number: Q9JKC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: November 22, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families