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Protein

AP-4 complex subunit mu-1

Gene

Ap4m1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the AP-4 complex, a novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. Plays a role in the intracellular trafficking of APP from the trans-Golgi network (TGN) to endosomes, and thereby inhibits amyloidogenic processing of APP (By similarity).By similarity

GO - Biological processi

  1. Golgi to endosome transport Source: UniProtKB
  2. intracellular protein transport Source: UniProtKB
  3. vesicle-mediated transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
AP-4 complex subunit mu-1
Alternative name(s):
AP-4 adaptor complex mu subunit
Adaptor-related protein complex 4 subunit mu-1
Mu subunit of AP-4
Mu-adaptin-related protein 2
Short name:
mu-ARP2
Mu4-adaptin
Short name:
mu4
Gene namesi
Name:Ap4m1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1337063. Ap4m1.

Subcellular locationi

Golgi apparatustrans-Golgi network By similarity. Membranecoated pit By similarity
Note: Associated with the trans-Golgi network. Found in soma and dendritic shafts of neuronal cells (By similarity).By similarity

GO - Cellular componenti

  1. clathrin adaptor complex Source: InterPro
  2. coated pit Source: UniProtKB-SubCell
  3. extracellular vesicular exosome Source: MGI
  4. trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Coated pit, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449AP-4 complex subunit mu-1PRO_0000193788Add
BLAST

Proteomic databases

MaxQBiQ9JKC7.
PaxDbiQ9JKC7.
PRIDEiQ9JKC7.

PTM databases

PhosphoSiteiQ9JKC7.

Expressioni

Gene expression databases

BgeeiQ9JKC7.
CleanExiMM_AP4M1.
ExpressionAtlasiQ9JKC7. baseline and differential.
GenevestigatoriQ9JKC7.

Interactioni

Subunit structurei

Adaptor protein complex 4 (AP-4) is a heterotetramer composed of two large adaptins (epsilon-type subunit AP4E1 and beta-type subunit AP4B1), a medium adaptin (mu-type subunit AP4M1) and a small adaptin (sigma-type AP4S1). Interacts with the C-terminal domain of GRID2. Interacts with tyrosine-based sorting signals on the cytoplasmic tail of cargo proteins, such as LAMP2 and APP (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9JKC7.
SMRiQ9JKC7. Positions 1-449.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini184 – 448265MHDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 MHD (mu homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG281769.
GeneTreeiENSGT00530000062779.
HOGENOMiHOG000173245.
HOVERGENiHBG102734.
InParanoidiQ9JKC7.
KOiK12402.
OMAiPGPPSHG.
OrthoDBiEOG78M01Z.
PhylomeDBiQ9JKC7.
TreeFamiTF329745.

Family and domain databases

InterProiIPR022775. AP_mu_sigma_su.
IPR001392. Clathrin_mu.
IPR008968. Clathrin_mu_C.
IPR018240. Clathrin_mu_CS.
IPR011012. Longin-like_dom.
IPR028565. MHD.
[Graphical view]
PfamiPF00928. Adap_comp_sub. 1 hit.
PF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
PIRSFiPIRSF005992. Clathrin_mu. 1 hit.
PRINTSiPR00314. CLATHRINADPT.
SUPFAMiSSF49447. SSF49447. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEiPS00991. CLAT_ADAPTOR_M_2. 1 hit.
PS51072. MHD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JKC7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MISQFFILSS KGDPLIYKDF RGDSGGRDVA ELFYRKLTGL PGGESPVVMY
60 70 80 90 100
HGDRHFIHIR HSGLYLVATT LENVSPFSLL ELLSRLATLL GDYCGSLNEG
110 120 130 140 150
TISRNVALVY ELLDEVLDYG YVQTTSTEML RNFIQTEAVV SKPFSLFDLS
160 170 180 190 200
SVGLFGAETQ QNKVAPSSAA SRPVLSSRSD QSQKNEVFLD VVERLSVLIA
210 220 230 240 250
SNGSLLKVDV QGEIRLKSFL PSGSEICIGL TEEFCVGKSE LRGYGPGIRV
260 270 280 290 300
DEVSFHSSVN LDEFESHRIL RLQPPQGELT VMRYQLSDDL PSPLPFRLFP
310 320 330 340 350
SVQWDQGSGR LQVYLKLRCD LPPKSQALNI HLHLPLPRGV ISLSQELSSP
360 370 380 390 400
DQKAELGEGA LHWDLPRVQG GSQLSGLFQM DVPGLQGLPN HGPSPLGLGP
410 420 430 440
ASLSFELPRH TCSGLQVRFL RLSFSACGNA NPHKWVRHLS HSNAYVIRI
Length:449
Mass (Da):49,509
Last modified:October 1, 2000 - v1
Checksum:i579AEAE1F82B5D04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF242858 mRNA. Translation: AAF63513.1.
BC011174 mRNA. Translation: AAH11174.1.
CCDSiCCDS19794.1.
RefSeqiNP_067367.3. NM_021392.4.
UniGeneiMm.113205.

Genome annotation databases

EnsembliENSMUST00000019662; ENSMUSP00000019662; ENSMUSG00000019518.
GeneIDi11781.
KEGGimmu:11781.
UCSCiuc009aev.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF242858 mRNA. Translation: AAF63513.1.
BC011174 mRNA. Translation: AAH11174.1.
CCDSiCCDS19794.1.
RefSeqiNP_067367.3. NM_021392.4.
UniGeneiMm.113205.

3D structure databases

ProteinModelPortaliQ9JKC7.
SMRiQ9JKC7. Positions 1-449.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ9JKC7.

Proteomic databases

MaxQBiQ9JKC7.
PaxDbiQ9JKC7.
PRIDEiQ9JKC7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019662; ENSMUSP00000019662; ENSMUSG00000019518.
GeneIDi11781.
KEGGimmu:11781.
UCSCiuc009aev.2. mouse.

Organism-specific databases

CTDi9179.
MGIiMGI:1337063. Ap4m1.

Phylogenomic databases

eggNOGiNOG281769.
GeneTreeiENSGT00530000062779.
HOGENOMiHOG000173245.
HOVERGENiHBG102734.
InParanoidiQ9JKC7.
KOiK12402.
OMAiPGPPSHG.
OrthoDBiEOG78M01Z.
PhylomeDBiQ9JKC7.
TreeFamiTF329745.

Miscellaneous databases

NextBioi279583.
PROiQ9JKC7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JKC7.
CleanExiMM_AP4M1.
ExpressionAtlasiQ9JKC7. baseline and differential.
GenevestigatoriQ9JKC7.

Family and domain databases

InterProiIPR022775. AP_mu_sigma_su.
IPR001392. Clathrin_mu.
IPR008968. Clathrin_mu_C.
IPR018240. Clathrin_mu_CS.
IPR011012. Longin-like_dom.
IPR028565. MHD.
[Graphical view]
PfamiPF00928. Adap_comp_sub. 1 hit.
PF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
PIRSFiPIRSF005992. Clathrin_mu. 1 hit.
PRINTSiPR00314. CLATHRINADPT.
SUPFAMiSSF49447. SSF49447. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEiPS00991. CLAT_ADAPTOR_M_2. 1 hit.
PS51072. MHD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mus musculus adaptor-related protein complex AP-4 mu4 subunit."
    Werner H., Nave K.-A.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.

Entry informationi

Entry nameiAP4M1_MOUSE
AccessioniPrimary (citable) accession number: Q9JKC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: February 4, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.