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Protein

Cell cycle exit and neuronal differentiation protein 1

Gene

Cend1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in neuroblastoma cell differentiation.By similarity

GO - Biological processi

  • adult walking behavior Source: MGI
  • cerebellar granular layer maturation Source: MGI
  • cerebellar Purkinje cell differentiation Source: MGI
  • negative regulation of cerebellar granule cell precursor proliferation Source: MGI
  • radial glia guided migration of cerebellar granule cell Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cell cycle exit and neuronal differentiation protein 1
Alternative name(s):
BM88 antigen
Gene namesi
Name:Cend1
Synonyms:Bm88
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1929898. Cend1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 124124CytoplasmicSequence analysisAdd
BLAST
Transmembranei125 – 14521Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST
Topological domaini146 – 1494ExtracellularSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 149149Cell cycle exit and neuronal differentiation protein 1PRO_0000064952Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei10 – 101PhosphoserineBy similarity
Modified residuei90 – 901PhosphoserineBy similarity
Modified residuei95 – 951PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9JKC6.
PaxDbiQ9JKC6.
PeptideAtlasiQ9JKC6.
PRIDEiQ9JKC6.

PTM databases

iPTMnetiQ9JKC6.
PhosphoSiteiQ9JKC6.

Expressioni

Gene expression databases

BgeeiQ9JKC6.
CleanExiMM_CEND1.
GenevisibleiQ9JKC6. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ9JKC6. 1 interaction.
MINTiMINT-4089274.
STRINGi10090.ENSMUSP00000081476.

Structurei

3D structure databases

ProteinModelPortaliQ9JKC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CEND1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JCHN. Eukaryota.
ENOG41114ZP. LUCA.
GeneTreeiENSGT00390000012831.
HOGENOMiHOG000081828.
HOVERGENiHBG081082.
InParanoidiQ9JKC6.
OMAiGPWPCEN.
OrthoDBiEOG7P02MQ.
PhylomeDBiQ9JKC6.
TreeFamiTF336209.

Family and domain databases

InterProiIPR020162. Cend1.
[Graphical view]
PfamiPF15677. CEND1. 1 hit.
[Graphical view]
ProDomiPD079544. Cend1. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q9JKC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESRGKSASS PKPDTKVPQA TAEAKATPAA DGKAPLTKPV KKDTQAEKQE
60 70 80 90 100
QAAAPGPAAT KKTPAKADPV LLNNHSNLKP APTVPAAPSS PDATSEPKGP
110 120 130 140
GDGAEEDESN TGGRGPWPCE NLTPLLVAGG VAVATIALIL GVAFLARKK
Length:149
Mass (Da):14,987
Last modified:October 1, 2000 - v1
Checksum:i88B252ED5DD1EE9B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti117 – 1171W → R in BAB23812 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF243130 mRNA. Translation: AAF62099.1.
AK005092 mRNA. Translation: BAB23812.1.
AK079045 mRNA. Translation: BAC37512.1.
BC023032 mRNA. Translation: AAH23032.1.
CCDSiCCDS22012.1.
RefSeqiNP_067291.1. NM_021316.4.
XP_006536280.1. XM_006536217.2.
UniGeneiMm.87027.

Genome annotation databases

EnsembliENSMUST00000084436; ENSMUSP00000081476; ENSMUSG00000060240.
ENSMUST00000124444; ENSMUSP00000118591; ENSMUSG00000060240.
ENSMUST00000137488; ENSMUSP00000123334; ENSMUSG00000060240.
ENSMUST00000164387; ENSMUSP00000131085; ENSMUSG00000060240.
GeneIDi57754.
KEGGimmu:57754.
UCSCiuc009kkx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF243130 mRNA. Translation: AAF62099.1.
AK005092 mRNA. Translation: BAB23812.1.
AK079045 mRNA. Translation: BAC37512.1.
BC023032 mRNA. Translation: AAH23032.1.
CCDSiCCDS22012.1.
RefSeqiNP_067291.1. NM_021316.4.
XP_006536280.1. XM_006536217.2.
UniGeneiMm.87027.

3D structure databases

ProteinModelPortaliQ9JKC6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JKC6. 1 interaction.
MINTiMINT-4089274.
STRINGi10090.ENSMUSP00000081476.

PTM databases

iPTMnetiQ9JKC6.
PhosphoSiteiQ9JKC6.

Proteomic databases

MaxQBiQ9JKC6.
PaxDbiQ9JKC6.
PeptideAtlasiQ9JKC6.
PRIDEiQ9JKC6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084436; ENSMUSP00000081476; ENSMUSG00000060240.
ENSMUST00000124444; ENSMUSP00000118591; ENSMUSG00000060240.
ENSMUST00000137488; ENSMUSP00000123334; ENSMUSG00000060240.
ENSMUST00000164387; ENSMUSP00000131085; ENSMUSG00000060240.
GeneIDi57754.
KEGGimmu:57754.
UCSCiuc009kkx.1. mouse.

Organism-specific databases

CTDi51286.
MGIiMGI:1929898. Cend1.

Phylogenomic databases

eggNOGiENOG410JCHN. Eukaryota.
ENOG41114ZP. LUCA.
GeneTreeiENSGT00390000012831.
HOGENOMiHOG000081828.
HOVERGENiHBG081082.
InParanoidiQ9JKC6.
OMAiGPWPCEN.
OrthoDBiEOG7P02MQ.
PhylomeDBiQ9JKC6.
TreeFamiTF336209.

Miscellaneous databases

ChiTaRSiCend1. mouse.
PROiQ9JKC6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JKC6.
CleanExiMM_CEND1.
GenevisibleiQ9JKC6. MM.

Family and domain databases

InterProiIPR020162. Cend1.
[Graphical view]
PfamiPF15677. CEND1. 1 hit.
[Graphical view]
ProDomiPD079544. Cend1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, expression and localization of human BM88 shows that it maps to chromosome 11p15.5, a region implicated in Beckwith-Wiedemann syndrome and tumorigenesis."
    Gaitanou M., Buanne P., Pappa C., Georgopoulou N., Mamalaki A., Tirone F., Matsas R.
    Biochem. J. 355:715-724(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum and Diencephalon.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Eye.
  4. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 43-61 AND 99-114, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6J.
    Tissue: Brain.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-95, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiCEND_MOUSE
AccessioniPrimary (citable) accession number: Q9JKC6
Secondary accession number(s): Q9DBA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.