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Protein

Carboxylic ester hydrolase

Gene

Bche

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • acetylcholinesterase activity Source: RGD
  • choline binding Source: RGD
  • cholinesterase activity Source: RGD
  • identical protein binding Source: RGD

GO - Biological processi

  • choline metabolic process Source: RGD
  • learning Source: RGD
  • negative regulation of cell proliferation Source: RGD
  • negative regulation of synaptic transmission Source: RGD
  • neuroblast differentiation Source: RGD
  • response to alkaloid Source: RGD
  • response to drug Source: RGD
  • response to folic acid Source: RGD
  • response to glucocorticoid Source: RGD
  • response to nutrient Source: RGD

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-RNO-112311 Neurotransmitter clearance
R-RNO-1483191 Synthesis of PC
R-RNO-422085 Synthesis, secretion, and deacylation of Ghrelin

Protein family/group databases

ESTHERiratno-BCHE BCHE
MEROPSiS09.980

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxylic ester hydrolaseUniRule annotation (EC:3.1.1.-UniRule annotation)
Gene namesi
Name:BcheImported
ORF Names:rCG_62812Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi619996 Bche

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3403

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23UniRule annotationAdd BLAST23
ChainiPRO_501398388524 – 597Carboxylic ester hydrolaseUniRule annotationAdd BLAST574

Expressioni

Gene expression databases

BgeeiENSRNOG00000009826

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013279

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 545COesteraseInterPro annotationAdd BLAST519
Domaini560 – 595AChE_tetraInterPro annotationAdd BLAST36

Sequence similaritiesi

Belongs to the type-B carboxylesterase/lipase family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG4389 Eukaryota
COG2272 LUCA
GeneTreeiENSGT00760000118946
HOGENOMiHOG000091866
HOVERGENiHBG008839
KOiK01050
OMAiGNNAFFY
OrthoDBiEOG091G0I4G
TreeFamiTF315470

Family and domain databases

Gene3Di3.40.50.18201 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR014788 AChE_tetra
IPR002018 CarbesteraseB
IPR019826 Carboxylesterase_B_AS
IPR019819 Carboxylesterase_B_CS
IPR000997 Cholinesterase
PfamiView protein in Pfam
PF08674 AChE_tetra, 1 hit
PF00135 COesterase, 1 hit
PRINTSiPR00878 CHOLNESTRASE
ProDomiView protein in ProDom or Entries sharing at least one domain
PD415333 AChE_tetra, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00122 CARBOXYLESTERASE_B_1, 1 hit
PS00941 CARBOXYLESTERASE_B_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JKC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTEIHFLLW ILLLCMLFGK SHTEEDVIIT TKTGRVRGLS MPILGGTVTA
60 70 80 90 100
FLGIPYAQPP LGSLRFKKPQ PLNKWPDVYN ATKYANSCYQ NIDQAFPGFQ
110 120 130 140 150
GSEMWNPNTN LSEDCLYLNV WIPVPKPKNA TVMVWVYGGG FQTGTSSLPV
160 170 180 190 200
YDGKFLTRVE RVIVVSMNYR VGALGFLAFP GNSEAPGNMG LFDQQLALQW
210 220 230 240 250
IQRNIAAFGG NPKSVTLFGE SAGAASVSLH LLCPQSYPLF TRAILESGSS
260 270 280 290 300
NAPWAVKHPE EARNRTLTLA KFIGCSKENE KEIITCLRSK DPQEILLNEK
310 320 330 340 350
LVLPSDSIRS INFGPTVDGD FLTDMPHTLL QLGKVKTAQI LVGVNKDEGT
360 370 380 390 400
AFLVYGAPGF SKDNDSLITR REFQEGLNMY FPGVSSLGKE AILFYYVDWL
410 420 430 440 450
GDQTPEVYRE AFDDIIGDYN IICPALEFTK KFAELEINAF FYYFEHRSSK
460 470 480 490 500
LPWPEWMGVM HGYEIEFVFG LPLERRVNYT RAEEIFSRSI MKTWANFAKY
510 520 530 540 550
GHPNGTQGNS TVWPVFTSTE QKYLTLNTEK SKINSKLRAP QCQFWRLFFP
560 570 580 590
KVLEITGDID EREQEWKAGF HRWSNYMMDW KNQFNDYTSK KETCTDL
Length:597
Mass (Da):67,777
Last modified:October 1, 2000 - v1
Checksum:i771204D166C7EEAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07011814 Genomic DNA No translation available.
AABR07011815 Genomic DNA No translation available.
AABR07011816 Genomic DNA No translation available.
AABR07011817 Genomic DNA No translation available.
AABR07011818 Genomic DNA No translation available.
AABR07011819 Genomic DNA No translation available.
AABR07011820 Genomic DNA No translation available.
AABR07011821 Genomic DNA No translation available.
AABR07011822 Genomic DNA No translation available.
AF244349 mRNA Translation: AAF44713.1
CH473976 Genomic DNA Translation: EDM00889.1
RefSeqiNP_075231.1, NM_022942.1
UniGeneiRn.48791

Genome annotation databases

EnsembliENSRNOT00000013279; ENSRNOP00000013279; ENSRNOG00000009826
GeneIDi65036
KEGGirno:65036
UCSCiRGD:619996 rat

Similar proteinsi

Entry informationi

Entry nameiQ9JKC1_RAT
AccessioniPrimary (citable) accession number: Q9JKC1
Secondary accession number(s): F1LQK0
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported