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Protein

Carboxylic ester hydrolase

Gene

Bche

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • acetylcholinesterase activity Source: Ensembl
  • choline binding Source: RGD
  • cholinesterase activity Source: RGD

GO - Biological processi

  • choline metabolic process Source: RGD
  • learning Source: RGD
  • negative regulation of cell proliferation Source: RGD
  • negative regulation of synaptic transmission Source: RGD
  • neuroblast differentiation Source: RGD
  • response to alkaloid Source: RGD
  • response to drug Source: RGD
  • response to folic acid Source: RGD
  • response to glucocorticoid Source: RGD
  • response to nutrient Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-RNO-422085. Synthesis, secretion, and deacylation of Ghrelin.

Protein family/group databases

ESTHERiratno-BCHE. BCHE.
MEROPSiS09.980.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxylic ester hydrolaseUniRule annotation (EC:3.1.1.-UniRule annotation)
Gene namesi
Name:BcheImported
ORF Names:rCG_62812Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi619996. Bche.

Subcellular locationi

GO - Cellular componenti

  • blood microparticle Source: Ensembl
  • endoplasmic reticulum lumen Source: RGD
  • extracellular space Source: RGD
  • membrane Source: RGD
  • nuclear envelope lumen Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2111475.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323UniRule annotationAdd
BLAST
Chaini24 – 597574Carboxylic ester hydrolaseUniRule annotationPRO_5006993921Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013279.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 545519COesteraseInterPro annotationAdd
BLAST
Domaini560 – 59536AChE_tetraInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the type-B carboxylesterase/lipase family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG4389. Eukaryota.
COG2272. LUCA.
GeneTreeiENSGT00760000118946.
HOGENOMiHOG000091866.
HOVERGENiHBG008839.
KOiK01050.
OMAiFLGSEMW.
OrthoDBiEOG789C9R.
TreeFamiTF315470.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR014788. AChE_tetra.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
IPR000997. Cholinesterase.
[Graphical view]
PfamiPF08674. AChE_tetra. 1 hit.
PF00135. COesterase. 1 hit.
[Graphical view]
PRINTSiPR00878. CHOLNESTRASE.
ProDomiPD415333. AChE_tetra. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JKC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTEIHFLLW ILLLCMLFGK SHTEEDVIIT TKTGRVRGLS MPILGGTVTA
60 70 80 90 100
FLGIPYAQPP LGSLRFKKPQ PLNKWPDVYN ATKYANSCYQ NIDQAFPGFQ
110 120 130 140 150
GSEMWNPNTN LSEDCLYLNV WIPVPKPKNA TVMVWVYGGG FQTGTSSLPV
160 170 180 190 200
YDGKFLTRVE RVIVVSMNYR VGALGFLAFP GNSEAPGNMG LFDQQLALQW
210 220 230 240 250
IQRNIAAFGG NPKSVTLFGE SAGAASVSLH LLCPQSYPLF TRAILESGSS
260 270 280 290 300
NAPWAVKHPE EARNRTLTLA KFIGCSKENE KEIITCLRSK DPQEILLNEK
310 320 330 340 350
LVLPSDSIRS INFGPTVDGD FLTDMPHTLL QLGKVKTAQI LVGVNKDEGT
360 370 380 390 400
AFLVYGAPGF SKDNDSLITR REFQEGLNMY FPGVSSLGKE AILFYYVDWL
410 420 430 440 450
GDQTPEVYRE AFDDIIGDYN IICPALEFTK KFAELEINAF FYYFEHRSSK
460 470 480 490 500
LPWPEWMGVM HGYEIEFVFG LPLERRVNYT RAEEIFSRSI MKTWANFAKY
510 520 530 540 550
GHPNGTQGNS TVWPVFTSTE QKYLTLNTEK SKINSKLRAP QCQFWRLFFP
560 570 580 590
KVLEITGDID EREQEWKAGF HRWSNYMMDW KNQFNDYTSK KETCTDL
Length:597
Mass (Da):67,777
Last modified:October 1, 2000 - v1
Checksum:i771204D166C7EEAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07011814 Genomic DNA. No translation available.
AABR07011815 Genomic DNA. No translation available.
AABR07011816 Genomic DNA. No translation available.
AABR07011817 Genomic DNA. No translation available.
AABR07011818 Genomic DNA. No translation available.
AABR07011819 Genomic DNA. No translation available.
AABR07011820 Genomic DNA. No translation available.
AABR07011821 Genomic DNA. No translation available.
AABR07011822 Genomic DNA. No translation available.
AF244349 mRNA. Translation: AAF44713.1.
CH473976 Genomic DNA. Translation: EDM00889.1.
RefSeqiNP_075231.1. NM_022942.1.
UniGeneiRn.48791.

Genome annotation databases

EnsembliENSRNOT00000013279; ENSRNOP00000013279; ENSRNOG00000009826.
GeneIDi65036.
KEGGirno:65036.
UCSCiRGD:619996. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07011814 Genomic DNA. No translation available.
AABR07011815 Genomic DNA. No translation available.
AABR07011816 Genomic DNA. No translation available.
AABR07011817 Genomic DNA. No translation available.
AABR07011818 Genomic DNA. No translation available.
AABR07011819 Genomic DNA. No translation available.
AABR07011820 Genomic DNA. No translation available.
AABR07011821 Genomic DNA. No translation available.
AABR07011822 Genomic DNA. No translation available.
AF244349 mRNA. Translation: AAF44713.1.
CH473976 Genomic DNA. Translation: EDM00889.1.
RefSeqiNP_075231.1. NM_022942.1.
UniGeneiRn.48791.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013279.

Chemistry

ChEMBLiCHEMBL2111475.

Protein family/group databases

ESTHERiratno-BCHE. BCHE.
MEROPSiS09.980.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000013279; ENSRNOP00000013279; ENSRNOG00000009826.
GeneIDi65036.
KEGGirno:65036.
UCSCiRGD:619996. rat.

Organism-specific databases

CTDi590.
RGDi619996. Bche.

Phylogenomic databases

eggNOGiKOG4389. Eukaryota.
COG2272. LUCA.
GeneTreeiENSGT00760000118946.
HOGENOMiHOG000091866.
HOVERGENiHBG008839.
KOiK01050.
OMAiFLGSEMW.
OrthoDBiEOG789C9R.
TreeFamiTF315470.

Enzyme and pathway databases

ReactomeiR-RNO-422085. Synthesis, secretion, and deacylation of Ghrelin.

Miscellaneous databases

NextBioi35576467.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR014788. AChE_tetra.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
IPR000997. Cholinesterase.
[Graphical view]
PfamiPF08674. AChE_tetra. 1 hit.
PF00135. COesterase. 1 hit.
[Graphical view]
PRINTSiPR00878. CHOLNESTRASE.
ProDomiPD415333. AChE_tetra. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Abundant tissue butyrylcholinesterase and its possible function in the acetylcholinesterase knockout mouse."
    Li B., Stribley J.A., Ticu A., Xie W., Schopfer L.M., Hammond P., Brimijoin S., Hinrichs S.H., Lockridge O.
    J. Neurochem. 75:1320-1331(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: HeartImported.
  2. Ticu A.M., Lockridge O., Bartels C.F.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: HeartImported.
  3. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  6. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ9JKC1_RAT
AccessioniPrimary (citable) accession number: Q9JKC1
Secondary accession number(s): F1LQK0
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: May 11, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.