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Protein

Carboxylic ester hydrolase

Gene

Bche

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • acetylcholinesterase activity Source: Ensembl
  • choline binding Source: RGD
  • cholinesterase activity Source: RGD
  • identical protein binding Source: Ensembl

GO - Biological processi

  • choline metabolic process Source: RGD
  • learning Source: RGD
  • negative regulation of cell proliferation Source: RGD
  • negative regulation of synaptic transmission Source: RGD
  • neuroblast differentiation Source: RGD
  • response to alkaloid Source: RGD
  • response to drug Source: RGD
  • response to folic acid Source: RGD
  • response to glucocorticoid Source: RGD
  • response to nutrient Source: RGD

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-RNO-422085. Synthesis, secretion, and deacylation of Ghrelin.

Protein family/group databases

ESTHERiratno-BCHE. BCHE.
MEROPSiS09.980.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxylic ester hydrolaseUniRule annotation (EC:3.1.1.-UniRule annotation)
Gene namesi
Name:BcheImported
ORF Names:rCG_62812Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi619996. Bche.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3403.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23UniRule annotationAdd BLAST23
ChainiPRO_501075493024 – 597Carboxylic ester hydrolaseUniRule annotationAdd BLAST574

PTM databases

iPTMnetiQ9JKC1.
PhosphoSitePlusiQ9JKC1.

Expressioni

Gene expression databases

BgeeiENSRNOG00000009826.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013279.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 545COesteraseInterPro annotationAdd BLAST519
Domaini560 – 595AChE_tetraInterPro annotationAdd BLAST36

Sequence similaritiesi

Belongs to the type-B carboxylesterase/lipase family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG4389. Eukaryota.
COG2272. LUCA.
GeneTreeiENSGT00760000118946.
HOGENOMiHOG000091866.
HOVERGENiHBG008839.
KOiK01050.
OMAiGNNAFFY.
OrthoDBiEOG091G0I4G.
TreeFamiTF315470.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR014788. AChE_tetra.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
IPR000997. Cholinesterase.
PfamiView protein in Pfam
PF08674. AChE_tetra. 1 hit.
PF00135. COesterase. 1 hit.
PRINTSiPR00878. CHOLNESTRASE.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD415333. AChE_tetra. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiView protein in PROSITE
PS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9JKC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTEIHFLLW ILLLCMLFGK SHTEEDVIIT TKTGRVRGLS MPILGGTVTA
60 70 80 90 100
FLGIPYAQPP LGSLRFKKPQ PLNKWPDVYN ATKYANSCYQ NIDQAFPGFQ
110 120 130 140 150
GSEMWNPNTN LSEDCLYLNV WIPVPKPKNA TVMVWVYGGG FQTGTSSLPV
160 170 180 190 200
YDGKFLTRVE RVIVVSMNYR VGALGFLAFP GNSEAPGNMG LFDQQLALQW
210 220 230 240 250
IQRNIAAFGG NPKSVTLFGE SAGAASVSLH LLCPQSYPLF TRAILESGSS
260 270 280 290 300
NAPWAVKHPE EARNRTLTLA KFIGCSKENE KEIITCLRSK DPQEILLNEK
310 320 330 340 350
LVLPSDSIRS INFGPTVDGD FLTDMPHTLL QLGKVKTAQI LVGVNKDEGT
360 370 380 390 400
AFLVYGAPGF SKDNDSLITR REFQEGLNMY FPGVSSLGKE AILFYYVDWL
410 420 430 440 450
GDQTPEVYRE AFDDIIGDYN IICPALEFTK KFAELEINAF FYYFEHRSSK
460 470 480 490 500
LPWPEWMGVM HGYEIEFVFG LPLERRVNYT RAEEIFSRSI MKTWANFAKY
510 520 530 540 550
GHPNGTQGNS TVWPVFTSTE QKYLTLNTEK SKINSKLRAP QCQFWRLFFP
560 570 580 590
KVLEITGDID EREQEWKAGF HRWSNYMMDW KNQFNDYTSK KETCTDL
Length:597
Mass (Da):67,777
Last modified:October 1, 2000 - v1
Checksum:i771204D166C7EEAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07011814 Genomic DNA. No translation available.
AABR07011815 Genomic DNA. No translation available.
AABR07011816 Genomic DNA. No translation available.
AABR07011817 Genomic DNA. No translation available.
AABR07011818 Genomic DNA. No translation available.
AABR07011819 Genomic DNA. No translation available.
AABR07011820 Genomic DNA. No translation available.
AABR07011821 Genomic DNA. No translation available.
AABR07011822 Genomic DNA. No translation available.
AF244349 mRNA. Translation: AAF44713.1.
CH473976 Genomic DNA. Translation: EDM00889.1.
RefSeqiNP_075231.1. NM_022942.1.
UniGeneiRn.48791.

Genome annotation databases

EnsembliENSRNOT00000013279; ENSRNOP00000013279; ENSRNOG00000009826.
GeneIDi65036.
KEGGirno:65036.
UCSCiRGD:619996. rat.

Entry informationi

Entry nameiQ9JKC1_RAT
AccessioniPrimary (citable) accession number: Q9JKC1
Secondary accession number(s): F1LQK0
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: October 25, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported