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Q9JKC0

- CCL24_MOUSE

UniProt

Q9JKC0 - CCL24_MOUSE

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Protein

C-C motif chemokine 24

Gene

Ccl24

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Binds to CCR3 (By similarity).By similarity

GO - Molecular functioni

  1. cytokine activity Source: MGI

GO - Biological processi

  1. chemotaxis Source: MGI
  2. cytoskeleton organization Source: Ensembl
  3. eosinophil chemotaxis Source: Ensembl
  4. immune response Source: InterPro
  5. inflammatory response Source: UniProtKB-KW
  6. positive regulation of actin filament polymerization Source: Ensembl
  7. positive regulation of angiogenesis Source: BHF-UCL
  8. positive regulation of endothelial cell proliferation Source: Ensembl
  9. positive regulation of eosinophil migration Source: MGI
  10. positive regulation of inflammatory response Source: BHF-UCL
  11. positive regulation of Rac GTPase activity Source: Ensembl
  12. regulation of cell shape Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 24
Alternative name(s):
Eosinophil chemotactic protein 2
Eotaxin-2
Small-inducible cytokine A24
Gene namesi
Name:Ccl24
Synonyms:Scya24
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1928953. Ccl24.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 11993C-C motif chemokine 24PRO_0000005233Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 58By similarity
Disulfide bondi34 ↔ 74By similarity
Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Highest expression in jejunum and spleen. Lower levels found in liver and lung. No expression detected in kidney, thymus, brain or testis.1 Publication

Inductioni

By interleukin-4 and allergen challenge with A.fumigatus.1 Publication

Gene expression databases

BgeeiQ9JKC0.
CleanExiMM_CCL24.
ExpressionAtlasiQ9JKC0. baseline and differential.
GenevestigatoriQ9JKC0.

Structurei

3D structure databases

ProteinModelPortaliQ9JKC0.
SMRiQ9JKC0. Positions 27-97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG41621.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ9JKC0.
KOiK05514.
OMAiFCGDPKQ.
OrthoDBiEOG73BVG4.
PhylomeDBiQ9JKC0.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JKC0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGSATIVAG LLLLVACACC IFPIDSVTIP SSCCTSFISK KIPENRVVSY
60 70 80 90 100
QLANGSICPK AGVIFITKKG HKICTDPKLL WVQRHIQKLD AKKNQPSKGA
110
KAVRTKFAVQ RRRGNSTEV
Length:119
Mass (Da):12,871
Last modified:October 1, 2000 - v1
Checksum:i1EA921B3F13138A8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF244367 mRNA. Translation: AAF61736.1.
AF281075 mRNA. Translation: AAG32664.1.
BC065389 mRNA. Translation: AAH65389.1.
CCDSiCCDS19742.1.
RefSeqiNP_062523.1. NM_019577.4.
XP_006504507.1. XM_006504444.1.
XP_006504508.1. XM_006504445.1.
UniGeneiMm.31505.

Genome annotation databases

EnsembliENSMUST00000004936; ENSMUSP00000004936; ENSMUSG00000004814.
GeneIDi56221.
KEGGimmu:56221.
UCSCiuc008zyn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF244367 mRNA. Translation: AAF61736.1 .
AF281075 mRNA. Translation: AAG32664.1 .
BC065389 mRNA. Translation: AAH65389.1 .
CCDSi CCDS19742.1.
RefSeqi NP_062523.1. NM_019577.4.
XP_006504507.1. XM_006504444.1.
XP_006504508.1. XM_006504445.1.
UniGenei Mm.31505.

3D structure databases

ProteinModelPortali Q9JKC0.
SMRi Q9JKC0. Positions 27-97.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000004936 ; ENSMUSP00000004936 ; ENSMUSG00000004814 .
GeneIDi 56221.
KEGGi mmu:56221.
UCSCi uc008zyn.1. mouse.

Organism-specific databases

CTDi 6369.
MGIi MGI:1928953. Ccl24.

Phylogenomic databases

eggNOGi NOG41621.
GeneTreei ENSGT00730000110714.
HOGENOMi HOG000036685.
HOVERGENi HBG017871.
InParanoidi Q9JKC0.
KOi K05514.
OMAi FCGDPKQ.
OrthoDBi EOG73BVG4.
PhylomeDBi Q9JKC0.
TreeFami TF334888.

Miscellaneous databases

NextBioi 312098.
PROi Q9JKC0.
SOURCEi Search...

Gene expression databases

Bgeei Q9JKC0.
CleanExi MM_CCL24.
ExpressionAtlasi Q9JKC0. baseline and differential.
Genevestigatori Q9JKC0.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a mouse homolog of CC chemokine CCL24/MPIF-2/Eotaxin-2."
    Rossi D., Zlotnik A.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Murine eotaxin-2: a constitutive eosinophil chemokine induced by allergen challenge and IL-4 overexpression."
    Zimmermann N., Hogan S.P., Mishra A., Brandt E.B., Bodette T.R., Pope S.M., Finkelman F.D., Rothenberg M.E.
    J. Immunol. 165:5839-5846(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus.

Entry informationi

Entry nameiCCL24_MOUSE
AccessioniPrimary (citable) accession number: Q9JKC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3