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Q9JKC0

- CCL24_MOUSE

UniProt

Q9JKC0 - CCL24_MOUSE

Protein

C-C motif chemokine 24

Gene

Ccl24

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Binds to CCR3 By similarity.By similarity

    GO - Molecular functioni

    1. cytokine activity Source: MGI

    GO - Biological processi

    1. chemotaxis Source: MGI
    2. cytoskeleton organization Source: Ensembl
    3. eosinophil chemotaxis Source: Ensembl
    4. immune response Source: InterPro
    5. inflammatory response Source: UniProtKB-KW
    6. positive regulation of actin filament polymerization Source: Ensembl
    7. positive regulation of angiogenesis Source: BHF-UCL
    8. positive regulation of endothelial cell proliferation Source: Ensembl
    9. positive regulation of eosinophil migration Source: MGI
    10. positive regulation of inflammatory response Source: BHF-UCL
    11. positive regulation of Rac GTPase activity Source: Ensembl
    12. regulation of cell shape Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 24
    Alternative name(s):
    Eosinophil chemotactic protein 2
    Eotaxin-2
    Small-inducible cytokine A24
    Gene namesi
    Name:Ccl24
    Synonyms:Scya24
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1928953. Ccl24.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 11993C-C motif chemokine 24PRO_0000005233Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 58By similarity
    Disulfide bondi34 ↔ 74By similarity
    Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Expressioni

    Tissue specificityi

    Highest expression in jejunum and spleen. Lower levels found in liver and lung. No expression detected in kidney, thymus, brain or testis.1 Publication

    Inductioni

    By interleukin-4 and allergen challenge with A.fumigatus.1 Publication

    Gene expression databases

    ArrayExpressiQ9JKC0.
    BgeeiQ9JKC0.
    CleanExiMM_CCL24.
    GenevestigatoriQ9JKC0.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JKC0.
    SMRiQ9JKC0. Positions 27-97.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG41621.
    GeneTreeiENSGT00730000110714.
    HOGENOMiHOG000036685.
    HOVERGENiHBG017871.
    InParanoidiQ9JKC0.
    KOiK05514.
    OMAiFCGDPKQ.
    OrthoDBiEOG73BVG4.
    PhylomeDBiQ9JKC0.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9JKC0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGSATIVAG LLLLVACACC IFPIDSVTIP SSCCTSFISK KIPENRVVSY    50
    QLANGSICPK AGVIFITKKG HKICTDPKLL WVQRHIQKLD AKKNQPSKGA 100
    KAVRTKFAVQ RRRGNSTEV 119
    Length:119
    Mass (Da):12,871
    Last modified:October 1, 2000 - v1
    Checksum:i1EA921B3F13138A8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF244367 mRNA. Translation: AAF61736.1.
    AF281075 mRNA. Translation: AAG32664.1.
    BC065389 mRNA. Translation: AAH65389.1.
    CCDSiCCDS19742.1.
    RefSeqiNP_062523.1. NM_019577.4.
    XP_006504507.1. XM_006504444.1.
    XP_006504508.1. XM_006504445.1.
    UniGeneiMm.31505.

    Genome annotation databases

    EnsembliENSMUST00000004936; ENSMUSP00000004936; ENSMUSG00000004814.
    GeneIDi56221.
    KEGGimmu:56221.
    UCSCiuc008zyn.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF244367 mRNA. Translation: AAF61736.1 .
    AF281075 mRNA. Translation: AAG32664.1 .
    BC065389 mRNA. Translation: AAH65389.1 .
    CCDSi CCDS19742.1.
    RefSeqi NP_062523.1. NM_019577.4.
    XP_006504507.1. XM_006504444.1.
    XP_006504508.1. XM_006504445.1.
    UniGenei Mm.31505.

    3D structure databases

    ProteinModelPortali Q9JKC0.
    SMRi Q9JKC0. Positions 27-97.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000004936 ; ENSMUSP00000004936 ; ENSMUSG00000004814 .
    GeneIDi 56221.
    KEGGi mmu:56221.
    UCSCi uc008zyn.1. mouse.

    Organism-specific databases

    CTDi 6369.
    MGIi MGI:1928953. Ccl24.

    Phylogenomic databases

    eggNOGi NOG41621.
    GeneTreei ENSGT00730000110714.
    HOGENOMi HOG000036685.
    HOVERGENi HBG017871.
    InParanoidi Q9JKC0.
    KOi K05514.
    OMAi FCGDPKQ.
    OrthoDBi EOG73BVG4.
    PhylomeDBi Q9JKC0.
    TreeFami TF334888.

    Miscellaneous databases

    NextBioi 312098.
    PROi Q9JKC0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9JKC0.
    Bgeei Q9JKC0.
    CleanExi MM_CCL24.
    Genevestigatori Q9JKC0.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a mouse homolog of CC chemokine CCL24/MPIF-2/Eotaxin-2."
      Rossi D., Zlotnik A.
      Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Murine eotaxin-2: a constitutive eosinophil chemokine induced by allergen challenge and IL-4 overexpression."
      Zimmermann N., Hogan S.P., Mishra A., Brandt E.B., Bodette T.R., Pope S.M., Finkelman F.D., Rothenberg M.E.
      J. Immunol. 165:5839-5846(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Thymus.

    Entry informationi

    Entry nameiCCL24_MOUSE
    AccessioniPrimary (citable) accession number: Q9JKC0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3