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Protein

C-C motif chemokine 24

Gene

Ccl24

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Binds to CCR3 (By similarity).By similarity

GO - Molecular functioni

  • chemokine activity Source: MGI
  • cytokine activity Source: MGI

GO - Biological processi

  • chemotaxis Source: MGI
  • cytoskeleton organization Source: MGI
  • eosinophil chemotaxis Source: MGI
  • immune response Source: InterPro
  • inflammatory response Source: UniProtKB-KW
  • positive regulation of actin filament polymerization Source: MGI
  • positive regulation of angiogenesis Source: BHF-UCL
  • positive regulation of cell migration Source: MGI
  • positive regulation of endothelial cell proliferation Source: MGI
  • positive regulation of eosinophil migration Source: MGI
  • positive regulation of GTPase activity Source: MGI
  • positive regulation of inflammatory response Source: BHF-UCL
  • regulation of cell shape Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 24
Alternative name(s):
Eosinophil chemotactic protein 2
Eotaxin-2
Small-inducible cytokine A24
Gene namesi
Name:Ccl24
Synonyms:Scya24
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1928953. Ccl24.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 11993C-C motif chemokine 24PRO_0000005233Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 58By similarity
Disulfide bondi34 ↔ 74By similarity
Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Highest expression in jejunum and spleen. Lower levels found in liver and lung. No expression detected in kidney, thymus, brain or testis.1 Publication

Inductioni

By interleukin-4 and allergen challenge with A.fumigatus.1 Publication

Gene expression databases

BgeeiQ9JKC0.
CleanExiMM_CCL24.
ExpressionAtlasiQ9JKC0. baseline and differential.
GenevestigatoriQ9JKC0.

Structurei

3D structure databases

ProteinModelPortaliQ9JKC0.
SMRiQ9JKC0. Positions 27-97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG41621.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ9JKC0.
KOiK05514.
OMAiFCGDPKQ.
OrthoDBiEOG73BVG4.
PhylomeDBiQ9JKC0.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JKC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGSATIVAG LLLLVACACC IFPIDSVTIP SSCCTSFISK KIPENRVVSY
60 70 80 90 100
QLANGSICPK AGVIFITKKG HKICTDPKLL WVQRHIQKLD AKKNQPSKGA
110
KAVRTKFAVQ RRRGNSTEV
Length:119
Mass (Da):12,871
Last modified:October 1, 2000 - v1
Checksum:i1EA921B3F13138A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF244367 mRNA. Translation: AAF61736.1.
AF281075 mRNA. Translation: AAG32664.1.
BC065389 mRNA. Translation: AAH65389.1.
CCDSiCCDS19742.1.
RefSeqiNP_062523.1. NM_019577.4.
XP_006504507.1. XM_006504444.2.
XP_006504508.1. XM_006504445.2.
UniGeneiMm.31505.

Genome annotation databases

EnsembliENSMUST00000004936; ENSMUSP00000004936; ENSMUSG00000004814.
GeneIDi56221.
KEGGimmu:56221.
UCSCiuc008zyn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF244367 mRNA. Translation: AAF61736.1.
AF281075 mRNA. Translation: AAG32664.1.
BC065389 mRNA. Translation: AAH65389.1.
CCDSiCCDS19742.1.
RefSeqiNP_062523.1. NM_019577.4.
XP_006504507.1. XM_006504444.2.
XP_006504508.1. XM_006504445.2.
UniGeneiMm.31505.

3D structure databases

ProteinModelPortaliQ9JKC0.
SMRiQ9JKC0. Positions 27-97.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000004936; ENSMUSP00000004936; ENSMUSG00000004814.
GeneIDi56221.
KEGGimmu:56221.
UCSCiuc008zyn.1. mouse.

Organism-specific databases

CTDi6369.
MGIiMGI:1928953. Ccl24.

Phylogenomic databases

eggNOGiNOG41621.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ9JKC0.
KOiK05514.
OMAiFCGDPKQ.
OrthoDBiEOG73BVG4.
PhylomeDBiQ9JKC0.
TreeFamiTF334888.

Miscellaneous databases

NextBioi312098.
PROiQ9JKC0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JKC0.
CleanExiMM_CCL24.
ExpressionAtlasiQ9JKC0. baseline and differential.
GenevestigatoriQ9JKC0.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a mouse homolog of CC chemokine CCL24/MPIF-2/Eotaxin-2."
    Rossi D., Zlotnik A.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Murine eotaxin-2: a constitutive eosinophil chemokine induced by allergen challenge and IL-4 overexpression."
    Zimmermann N., Hogan S.P., Mishra A., Brandt E.B., Bodette T.R., Pope S.M., Finkelman F.D., Rothenberg M.E.
    J. Immunol. 165:5839-5846(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus.

Entry informationi

Entry nameiCCL24_MOUSE
AccessioniPrimary (citable) accession number: Q9JKC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: May 27, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.