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Protein

AT-rich interactive domain-containing protein 4B

Gene

Arid4b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
AT-rich interactive domain-containing protein 4B
Short name:
ARID domain-containing protein 4B
Alternative name(s):
180 kDa Sin3-associated polypeptide
Short name:
Sin3-associated polypeptide p180
Histone deacetylase complex subunit SAP180
Retinoblastoma-binding protein 1-like 1
Gene namesi
Name:Arid4b
Synonyms:Rbbp1l1, Sap180
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619919. Arid4b.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12281228AT-rich interactive domain-containing protein 4BPRO_0000282865Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei276 – 2761PhosphoserineBy similarity
Modified residuei295 – 2951PhosphoserineCombined sources
Modified residuei296 – 2961PhosphoserineCombined sources
Cross-linki428 – 428Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei579 – 5791PhosphoserineBy similarity
Modified residuei581 – 5811PhosphoserineCombined sources
Modified residuei588 – 5881PhosphoserineCombined sources
Modified residuei630 – 6301PhosphoserineBy similarity
Modified residuei691 – 6911PhosphoserineBy similarity
Modified residuei703 – 7031PhosphoserineCombined sources
Modified residuei706 – 7061PhosphothreonineCombined sources
Modified residuei930 – 9301PhosphoserineBy similarity
Modified residuei942 – 9421PhosphothreonineBy similarity
Modified residuei1066 – 10661PhosphothreonineBy similarity
Modified residuei1068 – 10681PhosphoserineBy similarity
Modified residuei1069 – 10691PhosphoserineBy similarity
Modified residuei1071 – 10711PhosphoserineBy similarity
Modified residuei1075 – 10751PhosphoserineBy similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9JKB5.
PRIDEiQ9JKB5.

PTM databases

iPTMnetiQ9JKB5.

Interactioni

Subunit structurei

Component of a Sin3A corepressor complex consisting of SIN3A, SAP130, SUDS3/SAP45, SAP180, HDAC1 and HDAC2.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022445.

Structurei

3D structure databases

ProteinModelPortaliQ9JKB5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini306 – 39893ARIDPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1141 – 118646Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi154 – 1596Poly-Ser
Compositional biasi268 – 31043Glu-richAdd
BLAST
Compositional biasi1011 – 10177Poly-Ser
Compositional biasi1187 – 121933Ser-richAdd
BLAST

Domaini

The C-terminus mediates interaction with mSin3A corepressor complex.By similarity
The N-terminus is involved in transcriptional repression by HDAC-independent mechanisms.By similarity
The ARID domain is involved in stabilizing the mSin3A corepressor complex on DNA.By similarity

Sequence similaritiesi

Contains 1 ARID domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2744. Eukaryota.
KOG3001. Eukaryota.
ENOG410Y2AP. LUCA.
HOGENOMiHOG000015398.
HOVERGENiHBG058247.
InParanoidiQ9JKB5.
KOiK19195.
PhylomeDBiQ9JKB5.

Family and domain databases

Gene3Di1.10.150.60. 1 hit.
InterProiIPR028853. ARID4B.
IPR001606. ARID_dom.
IPR012603. RBB1NT.
IPR002999. Tudor.
[Graphical view]
PANTHERiPTHR13964:SF24. PTHR13964:SF24. 1 hit.
PfamiPF01388. ARID. 1 hit.
PF08169. RBB1NT. 1 hit.
[Graphical view]
SMARTiSM00501. BRIGHT. 1 hit.
SM00333. TUDOR. 1 hit.
[Graphical view]
SUPFAMiSSF46774. SSF46774. 1 hit.
PROSITEiPS51011. ARID. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JKB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKALDEPPYL TVGTDVSAKY RGAFCEAKIK TAKRLVKVKV TFRHDSSTVE
60 70 80 90 100
VQDDHIKGPL KVGAIVEVKN LDGAYQEAVI NKLTDASWYT VVFDDGDEKT
110 120 130 140 150
LRRSSLCLKG ERHFAESETL DQLPLTNPEH FGTPVIGKKT NRGRRSNHIP
160 170 180 190 200
EEESSSSSSD DDEDDRKQTD ELLGKVVCVD YISLDKKKAL WFPALVVCPD
210 220 230 240 250
CSDEIAVKKD NILVRSFKDG KFTSVPRKDV HEITSDTAPK PDAVLKQAFD
260 270 280 290 300
QALEFHKSRT IPANWKTELK EDSSSSEAEE EEEEEDDEKE KEDNSSEEEE
310 320 330 340 350
EIEPFPEERE NFLQQLYKFM EDRGTPINKR PVLGYRNLNL FKLFRLVHKL
360 370 380 390 400
GGFDNIESGA VWKQVYQDLG IPVLNSAAGY NVKCAYKKYL YGFEEYCRSA
410 420 430 440 450
NIDFQMALPE KVLNKPCKDC ENKEIKVKEE SDAEIKEVNV EDSKNMIPKE
460 470 480 490 500
ETPAEDESER KENIKPSLGS KKGLLECIPA QSDQEKEANI TKLEEKESLE
510 520 530 540 550
DKDGATARAE EALSTEVDAE EEQARSGYDE WIKADKIVRP ADKNVPKIKH
560 570 580 590 600
RKKIKNKLDK EKDRDEKYSP KNCKLRRLSK SPFQSNPSPE MVSKLDLADA
610 620 630 640 650
KNSDTGHIKS IEITSILNGL QASESSAEDS EQEEERCAQD PESSSKDESK
660 670 680 690 700
VEHSAHSRSE LISKEELSSP SLLEENKVHP DLVIAKTVSK SPERLRKDVE
710 720 730 740 750
AISEDTDFEE EDEITKKRKD VKKDTTDKAL KPQTKTWGKD RYCIQTNCLQ
760 770 780 790 800
SGSPGKKEDR TKSKEPLCTG NSSNSSSDED EEEKSKAKMT PTKKYNGLEE
810 820 830 840 850
KRKSLRTTSF YSGFSEVAEK RIKLLNNSDE RLQNNRAKDR KDVWSSIQGQ
860 870 880 890 900
WPKKTLKELF SDSDTEAAAS PPHAAPDEGT VEESLQTVAE EESCSPNMEL
910 920 930 940 950
EKPLPTSVDS KPVEEKPLEV SDRKTEFPSS GSNSVLNTPP TTPESPSSVT
960 970 980 990 1000
VTETSQQQSS VTVSVPLPPN QEEVRSIKSE TDSTIEVDSV VGELQDLQSE
1010 1020 1030 1040 1050
GNSSPAGFNA SVSSSSSNQP EPEHPEKACT GQKRVKDTQG VGSSSKKQKR
1060 1070 1080 1090 1100
SHKATVVNNK KKGKGTNSSD SEDLSAGESV TKTQAIKSVP TGMKTHNSKS
1110 1120 1130 1140 1150
PARIQSPGKC GKNGDKDPDL KEPSNRLPKV YKWSFQMSDL ENMTSAERIS
1160 1170 1180 1190 1200
ILQEKLQEIR KHYLSLKSEV ASIDRRRKRL KKKERESAAT SSSSSSPSSS
1210 1220
SITAAVMLTL AEPSMSSASQ NGMSVECR
Length:1,228
Mass (Da):137,080
Last modified:October 1, 2000 - v1
Checksum:iDE50F198D9E46C6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF245512 mRNA. Translation: AAF61271.1.
RefSeqiNP_445873.1. NM_053421.1.
UniGeneiRn.47249.

Genome annotation databases

GeneIDi84481.
KEGGirno:84481.
UCSCiRGD:619919. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF245512 mRNA. Translation: AAF61271.1.
RefSeqiNP_445873.1. NM_053421.1.
UniGeneiRn.47249.

3D structure databases

ProteinModelPortaliQ9JKB5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022445.

PTM databases

iPTMnetiQ9JKB5.

Proteomic databases

PaxDbiQ9JKB5.
PRIDEiQ9JKB5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi84481.
KEGGirno:84481.
UCSCiRGD:619919. rat.

Organism-specific databases

CTDi51742.
RGDi619919. Arid4b.

Phylogenomic databases

eggNOGiKOG2744. Eukaryota.
KOG3001. Eukaryota.
ENOG410Y2AP. LUCA.
HOGENOMiHOG000015398.
HOVERGENiHBG058247.
InParanoidiQ9JKB5.
KOiK19195.
PhylomeDBiQ9JKB5.

Miscellaneous databases

PROiQ9JKB5.

Family and domain databases

Gene3Di1.10.150.60. 1 hit.
InterProiIPR028853. ARID4B.
IPR001606. ARID_dom.
IPR012603. RBB1NT.
IPR002999. Tudor.
[Graphical view]
PANTHERiPTHR13964:SF24. PTHR13964:SF24. 1 hit.
PfamiPF01388. ARID. 1 hit.
PF08169. RBB1NT. 1 hit.
[Graphical view]
SMARTiSM00501. BRIGHT. 1 hit.
SM00333. TUDOR. 1 hit.
[Graphical view]
SUPFAMiSSF46774. SSF46774. 1 hit.
PROSITEiPS51011. ARID. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Upregulation of rat homolog of human retinoblastoma-binding protein (RBBP1) in substantia nigra following developmental striatal target injury."
    Kholodilov N.G., Neystat M., Burke R.E.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-295; SER-296; SER-581; SER-588; SER-703 AND THR-706, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiARI4B_RAT
AccessioniPrimary (citable) accession number: Q9JKB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.