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Protein

Cell surface A33 antigen

Gene

Gpa33

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in cell-cell recognition and signaling.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cell surface A33 antigen
Alternative name(s):
Glycoprotein A33
Short name:
mA33
Gene namesi
Name:Gpa33
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1891703. Gpa33.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 235ExtracellularSequence analysisAdd BLAST214
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 319CytoplasmicSequence analysisAdd BLAST63

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001477122 – 319Cell surface A33 antigenAdd BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 117PROSITE-ProRule annotation
Glycosylationi99N-linked (GlcNAc...)Sequence analysis1
Glycosylationi112N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi146 ↔ 222PROSITE-ProRule annotation
Disulfide bondi162 ↔ 211PROSITE-ProRule annotation
Glycosylationi200N-linked (GlcNAc...)Sequence analysis1
Glycosylationi223N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Palmitoylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQBiQ9JKA5.
PaxDbiQ9JKA5.
PeptideAtlasiQ9JKA5.
PRIDEiQ9JKA5.

PTM databases

PhosphoSitePlusiQ9JKA5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000000544.
CleanExiMM_GPA33.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060147.

Structurei

3D structure databases

ProteinModelPortaliQ9JKA5.
SMRiQ9JKA5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 134Ig-like V-typeAdd BLAST113
Domaini140 – 227Ig-like C2-typeAdd BLAST88

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi258 – 261Poly-Cys4

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWKU. Eukaryota.
ENOG410YJEV. LUCA.
HOGENOMiHOG000112779.
HOVERGENiHBG051792.
InParanoidiQ9JKA5.
KOiK06790.
PhylomeDBiQ9JKA5.
TreeFamiTF330875.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JKA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGKAGSVVW MLCAIWVAAD ALTVETTQDI LRAARGRSVT LPCTYNTYVS
60 70 80 90 100
DREGFIQWDK LLRSQTERVV TWNFVTKKYI YGNRYENRVR VSNDAELSNA
110 120 130 140 150
SITIDQLTMD DNGTYECSVS LMSDQDVNAK SRVRLLVLVP PSKPDCSIQG
160 170 180 190 200
EMVIGNNIQL TCHSAEGSPS PQYSWKSYNA QNQQRPLTQP VSGEPLLLKN
210 220 230 240 250
ISTETAGYYI CTSSNDVGIE SCNITVAPRP PSMNIALYAG IAGGVFVALI
260 270 280 290 300
IIGVIVYCCC CREKDDKDQD REDARPNRAA YQVPKKEQKE ISRGREDEDD
310
HRHEDRWSSG RSTPDQPFQ
Length:319
Mass (Da):35,692
Last modified:April 26, 2004 - v2
Checksum:iA37C8DB4BF685C3A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12L → F in AAF65818 (PubMed:10960348).Curated1
Sequence conflicti244G → S in AAF65818 (PubMed:10960348).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF247659 mRNA. Translation: AAF65818.1.
BC008528 mRNA. Translation: AAH08528.1.
CCDSiCCDS15447.1.
RefSeqiNP_067623.1. NM_021610.1.
UniGeneiMm.46357.

Genome annotation databases

GeneIDi59290.
KEGGimmu:59290.
UCSCiuc007dkj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF247659 mRNA. Translation: AAF65818.1.
BC008528 mRNA. Translation: AAH08528.1.
CCDSiCCDS15447.1.
RefSeqiNP_067623.1. NM_021610.1.
UniGeneiMm.46357.

3D structure databases

ProteinModelPortaliQ9JKA5.
SMRiQ9JKA5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060147.

PTM databases

PhosphoSitePlusiQ9JKA5.

Proteomic databases

MaxQBiQ9JKA5.
PaxDbiQ9JKA5.
PeptideAtlasiQ9JKA5.
PRIDEiQ9JKA5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi59290.
KEGGimmu:59290.
UCSCiuc007dkj.1. mouse.

Organism-specific databases

CTDi10223.
MGIiMGI:1891703. Gpa33.

Phylogenomic databases

eggNOGiENOG410IWKU. Eukaryota.
ENOG410YJEV. LUCA.
HOGENOMiHOG000112779.
HOVERGENiHBG051792.
InParanoidiQ9JKA5.
KOiK06790.
PhylomeDBiQ9JKA5.
TreeFamiTF330875.

Miscellaneous databases

PROiQ9JKA5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000544.
CleanExiMM_GPA33.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPA33_MOUSE
AccessioniPrimary (citable) accession number: Q9JKA5
Secondary accession number(s): Q922D5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: November 2, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.