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Protein

Potassium voltage-gated channel subfamily KQT member 4

Gene

Kcnq4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea.

GO - Molecular functioni

  • voltage-gated potassium channel activity Source: MGI

GO - Biological processi

  • inner ear morphogenesis Source: MGI
  • negative regulation of synaptic transmission, dopaminergic Source: Ensembl
  • potassium ion transport Source: MGI
  • sensory perception of sound Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Hearing, Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiR-MMU-1296072. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily KQT member 4
Alternative name(s):
KQT-like 4
Potassium channel subunit alpha KvLQT4
Voltage-gated potassium channel subunit Kv7.4
Gene namesi
Name:Kcnq4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1926803. Kcnq4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9797CytoplasmicAdd
BLAST
Transmembranei98 – 11821Helical; Name=Segment S1Sequence analysisAdd
BLAST
Topological domaini119 – 13113ExtracellularAdd
BLAST
Transmembranei132 – 15221Helical; Name=Segment S2Sequence analysisAdd
BLAST
Topological domaini153 – 17220CytoplasmicAdd
BLAST
Transmembranei173 – 19321Helical; Name=Segment S3Sequence analysisAdd
BLAST
Topological domaini194 – 2018Extracellular
Transmembranei202 – 22423Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd
BLAST
Topological domaini225 – 23713CytoplasmicAdd
BLAST
Transmembranei238 – 25821Helical; Name=Segment S5Sequence analysisAdd
BLAST
Topological domaini259 – 27012ExtracellularAdd
BLAST
Intramembranei271 – 29222Pore-forming; Name=Segment H5Sequence analysisAdd
BLAST
Topological domaini293 – 2964Extracellular
Transmembranei297 – 31721Helical; Name=Segment S6Sequence analysisAdd
BLAST
Topological domaini318 – 695378CytoplasmicAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 696696Potassium voltage-gated channel subfamily KQT member 4PRO_0000054038Add
BLAST

Proteomic databases

PaxDbiQ9JK97.
PRIDEiQ9JK97.

PTM databases

iPTMnetiQ9JK97.
PhosphoSiteiQ9JK97.

Expressioni

Tissue specificityi

In the inner ear expressed in the outer sensory hair cells of the cochlea and in type I hair cells of the vestibular organs. Also expressed in the postsynaptic membrane of the calyx nerve endings innervating type I cells. In the brain expressed in neurons of many, but not all, nuclei of the central auditory pathway. Absent from most other brain regions.1 Publication

Gene expression databases

BgeeiQ9JK97.
GenevisibleiQ9JK97. MM.

Interactioni

Subunit structurei

Homotetramer. May form heteromultimers with KCNQ3 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030376.

Structurei

3D structure databases

ProteinModelPortaliQ9JK97.
SMRiQ9JK97. Positions 120-335, 525-550, 612-641.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni546 – 650105A-domain (Tetramerization)By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili610 – 64536Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi284 – 2896Selectivity filterBy similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.By similarity
The A-domain tail carries the major determinants of channel assembly specificity. Its coiled-coil region is Four-stranded (By similarity).By similarity

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1419. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00550000074513.
HOGENOMiHOG000220839.
HOVERGENiHBG059014.
InParanoidiQ9JK97.
KOiK04929.
OMAiWAFVYHV.
OrthoDBiEOG73804Z.
PhylomeDBiQ9JK97.
TreeFamiTF315186.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR003937. K_chnl_volt-dep_KCNQ.
IPR013821. K_chnl_volt-dep_KCNQ_C.
IPR015573. KCQN4.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 3 hits.
PTHR11537:SF4. PTHR11537:SF4. 3 hits.
PfamiPF00520. Ion_trans. 1 hit.
PF03520. KCNQ_channel. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01459. KCNQCHANNEL.

Sequencei

Sequence statusi: Complete.

Q9JK97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEAPPRRLG LGPPPGDAPR AELVALTAVQ SEQGEAGGGG SPRRLGLLGS
60 70 80 90 100
PLPPGAPLPG PGSGSGSACG GQRSSAAQKR YRRLQNWVYN VLERPRGWAF
110 120 130 140 150
VYHVFIFLLV FSCLVLSVLS TIQEHQELAN ECLLILEFVM IVVFGLEYII
160 170 180 190 200
RVWSAGCCCR YRGWQGRFRF ARKPFCVIDF IVFVASVAVI AAGTQGNIFA
210 220 230 240 250
TSALRSMRFL QILRMVRMDR RGGTWKLLGS VVYAHSKELI TAWYIGFLVL
260 270 280 290 300
IFASFLVYLA EKDANSDFSS YADSLWWGTI TLTTIGYGDK TPHTWLGRVL
310 320 330 340 350
AAGFALLGIS FFALPAGILG SGFALKVQEQ HRQKHFEKRR MPAANLIQAA
360 370 380 390 400
WRLYSTDTSR AYLTATWYYY DSILPSFREL ALLFEHIQRA RNGGLRPLEV
410 420 430 440 450
RRAPVPDGAP SRYPPVATCH RPGSASFCPG ESSRMGIKDR IRISSSQKRT
460 470 480 490 500
GPSKQHLAPP PIPTSPSSEQ VGEASSPSKV QKSWSFNDRT RFRASLRLKP
510 520 530 540 550
RCSAEEGPSE EVAEEKSYQC ELTVDDVMPA VKTVIRSVRI LKFLVAKRKF
560 570 580 590 600
KETLRPYDVK DVIEQYSAGH LDMLGRIKSL QARVDQIVGR GPGDRKTREK
610 620 630 640 650
GDKGPSDTEA VDEISMMGRV VKVEKQVQSI EHKLDLLLGF YSRCLRSGTS
660 670 680 690
ASLGTVQVPL FDPDITSDYH SPVDHEDISV SAQTLSISRS VSTNMD
Length:696
Mass (Da):77,057
Last modified:January 9, 2007 - v2
Checksum:i762B19DA32043E95
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti445 – 4451S → I in AAF66432 (PubMed:11042367).Curated
Sequence conflicti502 – 5021C → S in AAF66432 (PubMed:11042367).Curated
Sequence conflicti533 – 5331T → S in BAC30534 (PubMed:16141072).Curated
Sequence conflicti608 – 6081T → A in AAF66432 (PubMed:11042367).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL606924 Genomic DNA. Translation: CAM17003.1.
AK040190 mRNA. Translation: BAC30534.1.
AF249747 mRNA. Translation: AAF66432.1.
CCDSiCCDS38865.1.
RefSeqiNP_001074611.1. NM_001081142.1.
UniGeneiMm.249977.

Genome annotation databases

EnsembliENSMUST00000030376; ENSMUSP00000030376; ENSMUSG00000028631.
GeneIDi60613.
KEGGimmu:60613.
UCSCiuc008unm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL606924 Genomic DNA. Translation: CAM17003.1.
AK040190 mRNA. Translation: BAC30534.1.
AF249747 mRNA. Translation: AAF66432.1.
CCDSiCCDS38865.1.
RefSeqiNP_001074611.1. NM_001081142.1.
UniGeneiMm.249977.

3D structure databases

ProteinModelPortaliQ9JK97.
SMRiQ9JK97. Positions 120-335, 525-550, 612-641.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030376.

PTM databases

iPTMnetiQ9JK97.
PhosphoSiteiQ9JK97.

Proteomic databases

PaxDbiQ9JK97.
PRIDEiQ9JK97.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030376; ENSMUSP00000030376; ENSMUSG00000028631.
GeneIDi60613.
KEGGimmu:60613.
UCSCiuc008unm.1. mouse.

Organism-specific databases

CTDi9132.
MGIiMGI:1926803. Kcnq4.

Phylogenomic databases

eggNOGiKOG1419. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00550000074513.
HOGENOMiHOG000220839.
HOVERGENiHBG059014.
InParanoidiQ9JK97.
KOiK04929.
OMAiWAFVYHV.
OrthoDBiEOG73804Z.
PhylomeDBiQ9JK97.
TreeFamiTF315186.

Enzyme and pathway databases

ReactomeiR-MMU-1296072. Voltage gated Potassium channels.

Miscellaneous databases

PROiQ9JK97.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JK97.
GenevisibleiQ9JK97. MM.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR003937. K_chnl_volt-dep_KCNQ.
IPR013821. K_chnl_volt-dep_KCNQ_C.
IPR015573. KCQN4.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 3 hits.
PTHR11537:SF4. PTHR11537:SF4. 3 hits.
PfamiPF00520. Ion_trans. 1 hit.
PF03520. KCNQ_channel. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01459. KCNQCHANNEL.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 24-546.
    Strain: C57BL/6J.
    Tissue: Thymus.
  3. "Longitudinal gradients of KCNQ4 expression in spiral ganglion and cochlear hair cells correlate with progressive hearing loss in DFNA2(1)."
    Beisel K.W., Nelson N.C., Delimont D.C., Fritzsch B.
    Brain Res. Mol. Brain Res. 82:137-149(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 405-680.
    Strain: BALB/cJ.
    Tissue: Brain.
  4. "KCNQ4, a K+ channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway."
    Kharkovets T., Hardelin J.-P., Safieddine S., Schweizer M., El-Amraoui A., Petit C., Jentsch T.J.
    Proc. Natl. Acad. Sci. U.S.A. 97:4333-4338(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiKCNQ4_MOUSE
AccessioniPrimary (citable) accession number: Q9JK97
Secondary accession number(s): A2A7E8, Q8C9Y6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: January 9, 2007
Last modified: June 8, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.