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Protein

p53 apoptosis effector related to PMP-22

Gene

Perp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway.2 Publications

GO - Biological processi

  • activation of cysteine-type endopeptidase activity Source: MGI
  • amelogenesis Source: MGI
  • desmosome organization Source: MGI
  • heterotypic cell-cell adhesion Source: MGI
  • intrinsic apoptotic signaling pathway by p53 class mediator Source: MGI
  • Notch signaling pathway Source: MGI
  • positive regulation of proteolysis Source: MGI
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
p53 apoptosis effector related to PMP-22
Alternative name(s):
Keratinocyte-associated protein 1
Short name:
KCP-1
Gene namesi
Name:Perp
Synonyms:Krtcap1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1929938. Perp.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221HelicalSequence analysisAdd
BLAST
Transmembranei81 – 10121HelicalSequence analysisAdd
BLAST
Transmembranei110 – 13021HelicalSequence analysisAdd
BLAST
Transmembranei151 – 17121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • desmosome Source: UniProtKB-SubCell
  • Golgi apparatus Source: MGI
  • integral component of plasma membrane Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 193193p53 apoptosis effector related to PMP-22PRO_0000226995Add
BLAST

Proteomic databases

PaxDbiQ9JK95.
PRIDEiQ9JK95.

Expressioni

Tissue specificityi

Expressed in the stratified squamous skin epithelium of the skin and the tongue, but not in simple epithelia (at protein level). Expressed in apoptotic cells.2 Publications

Developmental stagei

Expressed in developing skin during and after the stratification process from 9.5 to 15.5 dpc (at protein level). Expressed in ectoderm of the developing branchial arches and limb buds from the 9.5 to 10.5 dpc. Expressed in epithelia of the oral mucosa and skin from the 16.5 to 18.5 dpc.1 Publication

Inductioni

Up-regulated by UV irradiation, doxorubicin (DOX) and TP53 in embryo fibroblasts.1 Publication

Gene expression databases

BgeeiQ9JK95.
CleanExiMM_PERP.
GenevisibleiQ9JK95. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019998.

Structurei

3D structure databases

ProteinModelPortaliQ9JK95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM47 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4671. Eukaryota.
ENOG4111P5K. LUCA.
GeneTreeiENSGT00530000063484.
HOGENOMiHOG000057292.
HOVERGENiHBG061500.
InParanoidiQ9JK95.
KOiK10136.
OMAiTWAYGFG.
OrthoDBiEOG70CR8P.
PhylomeDBiQ9JK95.
TreeFamiTF312855.

Family and domain databases

InterProiIPR015664. P53_induced.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR14399. PTHR14399. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JK95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRCGLACER CRWILPLLLL SAIAFDIIAL AGRGWLQSSN HIQTSSLWWR
60 70 80 90 100
CFDEGGGSGS YDDGCQSLME YAWGRAAAAT LFCGFIILCI CFILSFFALC
110 120 130 140 150
GPQMLVFLRV IGGLLALAAI FQIISLVIYP VKYTQTFRLH DNPAVNYIYN
160 170 180 190
WAYGFGWAAT IILIGCSFFF CCLPNYEDDL LGAAKPRYFY PPA
Length:193
Mass (Da):21,567
Last modified:October 1, 2000 - v1
Checksum:iB1DD8A2AAC27A0AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF249870 mRNA. Translation: AAF64306.1.
AF251009 Genomic DNA. Translation: AAF70261.1.
AK003734 mRNA. Translation: BAB22968.1.
AK009184 mRNA. Translation: BAB26126.1.
AK009190 mRNA. Translation: BAB26130.1.
BC021772 mRNA. Translation: AAH21772.1.
CCDSiCCDS23714.1.
RefSeqiNP_071315.1. NM_022032.4.
UniGeneiMm.28209.

Genome annotation databases

EnsembliENSMUST00000019998; ENSMUSP00000019998; ENSMUSG00000019851.
GeneIDi64058.
KEGGimmu:64058.
UCSCiuc007emz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF249870 mRNA. Translation: AAF64306.1.
AF251009 Genomic DNA. Translation: AAF70261.1.
AK003734 mRNA. Translation: BAB22968.1.
AK009184 mRNA. Translation: BAB26126.1.
AK009190 mRNA. Translation: BAB26130.1.
BC021772 mRNA. Translation: AAH21772.1.
CCDSiCCDS23714.1.
RefSeqiNP_071315.1. NM_022032.4.
UniGeneiMm.28209.

3D structure databases

ProteinModelPortaliQ9JK95.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019998.

Proteomic databases

PaxDbiQ9JK95.
PRIDEiQ9JK95.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019998; ENSMUSP00000019998; ENSMUSG00000019851.
GeneIDi64058.
KEGGimmu:64058.
UCSCiuc007emz.1. mouse.

Organism-specific databases

CTDi64065.
MGIiMGI:1929938. Perp.

Phylogenomic databases

eggNOGiKOG4671. Eukaryota.
ENOG4111P5K. LUCA.
GeneTreeiENSGT00530000063484.
HOGENOMiHOG000057292.
HOVERGENiHBG061500.
InParanoidiQ9JK95.
KOiK10136.
OMAiTWAYGFG.
OrthoDBiEOG70CR8P.
PhylomeDBiQ9JK95.
TreeFamiTF312855.

Miscellaneous databases

ChiTaRSiPerp. mouse.
PROiQ9JK95.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JK95.
CleanExiMM_PERP.
GenevisibleiQ9JK95. MM.

Family and domain databases

InterProiIPR015664. P53_induced.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR14399. PTHR14399. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family."
    Attardi L.D., Reczek E.E., Cosmas C., Demicco E.G., McCurrach M.E., Lowe S.W., Jacks T.
    Genes Dev. 14:704-718(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-71, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Tongue.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and FVB/N.
    Tissue: Mammary tumor.
  4. Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Heart.

Entry informationi

Entry nameiPERP_MOUSE
AccessioniPrimary (citable) accession number: Q9JK95
Secondary accession number(s): Q9JI77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.