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Protein

Heat shock protein beta-8

Gene

Hspb8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Displays temperature-dependent chaperone activity.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Enzyme and pathway databases

ReactomeiR-MMU-3371571. HSF1-dependent transactivation.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein beta-8
Short name:
HspB8
Alternative name(s):
Alpha-crystallin C chain
Small stress protein-like protein HSP22
Gene namesi
Name:Hspb8
Synonyms:Cryac, Hsp22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2135756. Hspb8.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Translocates to nuclear foci during heat shock.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001259471 – 196Heat shock protein beta-8Add BLAST196

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24PhosphoserineBy similarity1
Modified residuei57PhosphoserineBy similarity1
Modified residuei63PhosphothreonineBy similarity1
Modified residuei71Asymmetric dimethylarginineCombined sources1
Modified residuei78Asymmetric dimethylarginineCombined sources1
Modified residuei87PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ9JK92.
PaxDbiQ9JK92.
PeptideAtlasiQ9JK92.
PRIDEiQ9JK92.

PTM databases

iPTMnetiQ9JK92.
PhosphoSitePlusiQ9JK92.

Expressioni

Tissue specificityi

Highly expressed in skeletal muscle, heart, uterus, liver, lung and ovary. Low levels found in stomach and brain. Not detected in small intestine, large intestine, kidney, spleen and testis. In the ovary, expression is concentrated in the endometrium and in the connective tissue between the circular and longitudinal muscles of the myometrium.1 Publication

Developmental stagei

Detected in developing heart throughout embryonic development but only detected in developing liver close to time of birth. In the adult ovary, expression is highest during decidualization and early pregnancy.1 Publication

Inductioni

By progesterone.1 Publication

Gene expression databases

BgeeiENSMUSG00000041548.
CleanExiMM_HSPB8.
GenevisibleiQ9JK92. MM.

Interactioni

Subunit structurei

Monomer. Interacts with HSPB1 (By similarity). Interacts with DNAJB6 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9JK92. 2 interactors.
MINTiMINT-4098152.
STRINGi10090.ENSMUSP00000037007.

Structurei

3D structure databases

ProteinModelPortaliQ9JK92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
GeneTreeiENSGT00760000119238.
HOGENOMiHOG000233955.
HOVERGENiHBG054766.
InParanoidiQ9JK92.
KOiK08879.
OMAiQTPPYYL.
OrthoDBiEOG091G0USC.
PhylomeDBiQ9JK92.
TreeFamiTF105049.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JK92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADGQLPFPC SYPSRLRRDP FRDSPLSSRL LDDGFGMDPF PDDLTAPWPE
60 70 80 90 100
WALPRLSSAW PGTLRSGMVP RGPPATARFG VPAEGRSPPP FPGEPWKVCV
110 120 130 140 150
NVHSFKPEEL MVKTKDGYVE VSGKHEEKQQ EGGIVSKNFT KKIQLPAEVD
160 170 180 190
PATVFASLSP EGLLIIEAPQ VPPYSPFGES SFNNELPQDN QEVTCS
Length:196
Mass (Da):21,533
Last modified:October 1, 2000 - v1
Checksum:iADE847E9E70D7DAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250139 mRNA. Translation: AAF65563.1.
AF273453 mRNA. Translation: AAG00233.1.
AK005052 mRNA. Translation: BAB23778.1.
BC011219 mRNA. Translation: AAH11219.1.
CCDSiCCDS19600.1.
RefSeqiNP_109629.1. NM_030704.3.
UniGeneiMm.21549.

Genome annotation databases

EnsembliENSMUST00000036991; ENSMUSP00000037007; ENSMUSG00000041548.
GeneIDi80888.
KEGGimmu:80888.
UCSCiuc008zez.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250139 mRNA. Translation: AAF65563.1.
AF273453 mRNA. Translation: AAG00233.1.
AK005052 mRNA. Translation: BAB23778.1.
BC011219 mRNA. Translation: AAH11219.1.
CCDSiCCDS19600.1.
RefSeqiNP_109629.1. NM_030704.3.
UniGeneiMm.21549.

3D structure databases

ProteinModelPortaliQ9JK92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JK92. 2 interactors.
MINTiMINT-4098152.
STRINGi10090.ENSMUSP00000037007.

PTM databases

iPTMnetiQ9JK92.
PhosphoSitePlusiQ9JK92.

Proteomic databases

MaxQBiQ9JK92.
PaxDbiQ9JK92.
PeptideAtlasiQ9JK92.
PRIDEiQ9JK92.

Protocols and materials databases

DNASUi80888.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036991; ENSMUSP00000037007; ENSMUSG00000041548.
GeneIDi80888.
KEGGimmu:80888.
UCSCiuc008zez.1. mouse.

Organism-specific databases

CTDi26353.
MGIiMGI:2135756. Hspb8.

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
GeneTreeiENSGT00760000119238.
HOGENOMiHOG000233955.
HOVERGENiHBG054766.
InParanoidiQ9JK92.
KOiK08879.
OMAiQTPPYYL.
OrthoDBiEOG091G0USC.
PhylomeDBiQ9JK92.
TreeFamiTF105049.

Enzyme and pathway databases

ReactomeiR-MMU-3371571. HSF1-dependent transactivation.

Miscellaneous databases

PROiQ9JK92.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041548.
CleanExiMM_HSPB8.
GenevisibleiQ9JK92. MM.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHSPB8_MOUSE
AccessioniPrimary (citable) accession number: Q9JK92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.