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Protein

Serpin I2

Gene

Serpini2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei357 – 3582Reactive bondBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.026.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin I2
Alternative name(s):
Serine protease inhibitor 14
Gene namesi
Name:Serpini2
Synonyms:Spi14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1915181. Serpini2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 405387Serpin I2PRO_0000032526Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi306 – 3061N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9JK88.
PaxDbiQ9JK88.
PRIDEiQ9JK88.

PTM databases

PhosphoSiteiQ9JK88.

Expressioni

Tissue specificityi

Expressed in pancreas.

Gene expression databases

BgeeiQ9JK88.
ExpressionAtlasiQ9JK88. baseline and differential.
GenevisibleiQ9JK88. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046943.

Structurei

3D structure databases

ProteinModelPortaliQ9JK88.
SMRiQ9JK88. Positions 23-393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118839.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiQ9JK88.
OMAiMESISTW.
OrthoDBiEOG7327PB.
PhylomeDBiQ9JK88.
TreeFamiTF343094.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JK88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKTILWSFL LFFSGSQTSR ATDQKIADFA VDLYKAISLS HKNNIIFSPL
60 70 80 90 100
GTTMLLGMVQ LGAKGKAQQQ ILKTLRMRGT PAGEEFSVLK SLFSAISKKK
110 120 130 140 150
QEFTFNLASA LYLQEGFIVK ETYLHSNKEF FQSATKLVDF LDAKTSAQAI
160 170 180 190 200
STWVESKTDG KIKNMFSEEE FGPLTRLVLV NAIYFKGDWK QKFRKEDTEM
210 220 230 240 250
TDFTKKDGST VKVPMMKALL RAQYGYFSQS SMTCQVLELP YKADEFSLVI
260 270 280 290 300
ILPTEDTSIE EVENQVTAPH VRRWFSELHE EEVEVSLPRF KIEQKLDLKE
310 320 330 340 350
ALYSLNVTEI FSGGCDLSGI TDSSEVYVSR VMQKVFFEIN EDGSEAAAST
360 370 380 390 400
GINIPAIMSL TQTQFLANHP FLFILKHIRT ESILFMGKVT DPDIQTTKGR

DLDSL
Length:405
Mass (Da):45,776
Last modified:October 1, 2000 - v1
Checksum:i04DF38BE8545DFA8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51I → M in BAB25079 (PubMed:16141072).Curated
Sequence conflicti195 – 1951K → T in BAB24976 (PubMed:16141072).Curated
Sequence conflicti207 – 2071D → S in BAB24976 (PubMed:16141072).Curated
Sequence conflicti212 – 2187KVPMMKA → RVPTDEV in BAB24976 (PubMed:16141072).Curated
Sequence conflicti246 – 2461F → Y in BAB24976 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251276 mRNA. Translation: AAF65821.1.
AK007347 mRNA. Translation: BAB24976.1.
AK007510 mRNA. Translation: BAB25079.1.
CCDSiCCDS17413.1.
RefSeqiNP_080736.2. NM_026460.3.
UniGeneiMm.259446.

Genome annotation databases

EnsembliENSMUST00000039047; ENSMUSP00000046943; ENSMUSG00000034139.
GeneIDi67931.
KEGGimmu:67931.
UCSCiuc008pna.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251276 mRNA. Translation: AAF65821.1.
AK007347 mRNA. Translation: BAB24976.1.
AK007510 mRNA. Translation: BAB25079.1.
CCDSiCCDS17413.1.
RefSeqiNP_080736.2. NM_026460.3.
UniGeneiMm.259446.

3D structure databases

ProteinModelPortaliQ9JK88.
SMRiQ9JK88. Positions 23-393.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046943.

Protein family/group databases

MEROPSiI04.026.

PTM databases

PhosphoSiteiQ9JK88.

Proteomic databases

MaxQBiQ9JK88.
PaxDbiQ9JK88.
PRIDEiQ9JK88.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039047; ENSMUSP00000046943; ENSMUSG00000034139.
GeneIDi67931.
KEGGimmu:67931.
UCSCiuc008pna.1. mouse.

Organism-specific databases

CTDi5276.
MGIiMGI:1915181. Serpini2.

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118839.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiQ9JK88.
OMAiMESISTW.
OrthoDBiEOG7327PB.
PhylomeDBiQ9JK88.
TreeFamiTF343094.

Miscellaneous databases

NextBioi325984.
PROiQ9JK88.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JK88.
ExpressionAtlasiQ9JK88. baseline and differential.
GenevisibleiQ9JK88. MM.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of mouse pancreas-specific serpin gene."
    Chang W.S., Lin S.C., Wu C.W.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pancreas.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Pancreas.

Entry informationi

Entry nameiSPI2_MOUSE
AccessioniPrimary (citable) accession number: Q9JK88
Secondary accession number(s): Q9D8Z3, Q9D955
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: October 1, 2000
Last modified: June 24, 2015
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.