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Q9JK88

- SPI2_MOUSE

UniProt

Q9JK88 - SPI2_MOUSE

Protein

Serpin I2

Gene

Serpini2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei357 – 3582Reactive bondBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: RefGenome

    GO - Biological processi

    1. negative regulation of endopeptidase activity Source: RefGenome
    2. regulation of cell adhesion Source: Ensembl
    3. regulation of proteolysis Source: RefGenome

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Protein family/group databases

    MEROPSiI04.026.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serpin I2
    Alternative name(s):
    Serine protease inhibitor 14
    Gene namesi
    Name:Serpini2
    Synonyms:Spi14
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1915181. Serpini2.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular space Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 405387Serpin I2PRO_0000032526Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi306 – 3061N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ9JK88.
    PaxDbiQ9JK88.
    PRIDEiQ9JK88.

    PTM databases

    PhosphoSiteiQ9JK88.

    Expressioni

    Tissue specificityi

    Expressed in pancreas.

    Gene expression databases

    ArrayExpressiQ9JK88.
    BgeeiQ9JK88.
    GenevestigatoriQ9JK88.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JK88.
    SMRiQ9JK88. Positions 23-393.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serpin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4826.
    GeneTreeiENSGT00740000115014.
    HOGENOMiHOG000238519.
    HOVERGENiHBG005957.
    InParanoidiQ9JK88.
    OMAiAQQILKW.
    OrthoDBiEOG7327PB.
    PhylomeDBiQ9JK88.
    TreeFamiTF343094.

    Family and domain databases

    InterProiIPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9JK88-1 [UniParc]FASTAAdd to Basket

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    MNKTILWSFL LFFSGSQTSR ATDQKIADFA VDLYKAISLS HKNNIIFSPL    50
    GTTMLLGMVQ LGAKGKAQQQ ILKTLRMRGT PAGEEFSVLK SLFSAISKKK 100
    QEFTFNLASA LYLQEGFIVK ETYLHSNKEF FQSATKLVDF LDAKTSAQAI 150
    STWVESKTDG KIKNMFSEEE FGPLTRLVLV NAIYFKGDWK QKFRKEDTEM 200
    TDFTKKDGST VKVPMMKALL RAQYGYFSQS SMTCQVLELP YKADEFSLVI 250
    ILPTEDTSIE EVENQVTAPH VRRWFSELHE EEVEVSLPRF KIEQKLDLKE 300
    ALYSLNVTEI FSGGCDLSGI TDSSEVYVSR VMQKVFFEIN EDGSEAAAST 350
    GINIPAIMSL TQTQFLANHP FLFILKHIRT ESILFMGKVT DPDIQTTKGR 400
    DLDSL 405
    Length:405
    Mass (Da):45,776
    Last modified:October 1, 2000 - v1
    Checksum:i04DF38BE8545DFA8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti5 – 51I → M in BAB25079. (PubMed:16141072)Curated
    Sequence conflicti195 – 1951K → T in BAB24976. (PubMed:16141072)Curated
    Sequence conflicti207 – 2071D → S in BAB24976. (PubMed:16141072)Curated
    Sequence conflicti212 – 2187KVPMMKA → RVPTDEV in BAB24976. (PubMed:16141072)Curated
    Sequence conflicti246 – 2461F → Y in BAB24976. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF251276 mRNA. Translation: AAF65821.1.
    AK007347 mRNA. Translation: BAB24976.1.
    AK007510 mRNA. Translation: BAB25079.1.
    CCDSiCCDS17413.1.
    RefSeqiNP_080736.2. NM_026460.3.
    UniGeneiMm.259446.

    Genome annotation databases

    EnsembliENSMUST00000039047; ENSMUSP00000046943; ENSMUSG00000034139.
    GeneIDi67931.
    KEGGimmu:67931.
    UCSCiuc008pna.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF251276 mRNA. Translation: AAF65821.1 .
    AK007347 mRNA. Translation: BAB24976.1 .
    AK007510 mRNA. Translation: BAB25079.1 .
    CCDSi CCDS17413.1.
    RefSeqi NP_080736.2. NM_026460.3.
    UniGenei Mm.259446.

    3D structure databases

    ProteinModelPortali Q9JK88.
    SMRi Q9JK88. Positions 23-393.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I04.026.

    PTM databases

    PhosphoSitei Q9JK88.

    Proteomic databases

    MaxQBi Q9JK88.
    PaxDbi Q9JK88.
    PRIDEi Q9JK88.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000039047 ; ENSMUSP00000046943 ; ENSMUSG00000034139 .
    GeneIDi 67931.
    KEGGi mmu:67931.
    UCSCi uc008pna.1. mouse.

    Organism-specific databases

    CTDi 5276.
    MGIi MGI:1915181. Serpini2.

    Phylogenomic databases

    eggNOGi COG4826.
    GeneTreei ENSGT00740000115014.
    HOGENOMi HOG000238519.
    HOVERGENi HBG005957.
    InParanoidi Q9JK88.
    OMAi AQQILKW.
    OrthoDBi EOG7327PB.
    PhylomeDBi Q9JK88.
    TreeFami TF343094.

    Miscellaneous databases

    NextBioi 325984.
    PROi Q9JK88.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9JK88.
    Bgeei Q9JK88.
    Genevestigatori Q9JK88.

    Family and domain databases

    InterProi IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of mouse pancreas-specific serpin gene."
      Chang W.S., Lin S.C., Wu C.W.
      Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pancreas.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Pancreas.

    Entry informationi

    Entry nameiSPI2_MOUSE
    AccessioniPrimary (citable) accession number: Q9JK88
    Secondary accession number(s): Q9D8Z3, Q9D955
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3