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Q9JK88

- SPI2_MOUSE

UniProt

Q9JK88 - SPI2_MOUSE

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Protein

Serpin I2

Gene

Serpini2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei357 – 3582Reactive bondBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: RefGenome

GO - Biological processi

  1. negative regulation of endopeptidase activity Source: RefGenome
  2. regulation of cell adhesion Source: Ensembl
  3. regulation of proteolysis Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.026.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin I2
Alternative name(s):
Serine protease inhibitor 14
Gene namesi
Name:Serpini2
Synonyms:Spi14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1915181. Serpini2.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 405387Serpin I2PRO_0000032526Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi306 – 3061N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9JK88.
PaxDbiQ9JK88.
PRIDEiQ9JK88.

PTM databases

PhosphoSiteiQ9JK88.

Expressioni

Tissue specificityi

Expressed in pancreas.

Gene expression databases

BgeeiQ9JK88.
ExpressionAtlasiQ9JK88. differential.
GenevestigatoriQ9JK88.

Structurei

3D structure databases

ProteinModelPortaliQ9JK88.
SMRiQ9JK88. Positions 23-393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118789.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiQ9JK88.
OMAiAQQILKW.
OrthoDBiEOG7327PB.
PhylomeDBiQ9JK88.
TreeFamiTF343094.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JK88 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKTILWSFL LFFSGSQTSR ATDQKIADFA VDLYKAISLS HKNNIIFSPL
60 70 80 90 100
GTTMLLGMVQ LGAKGKAQQQ ILKTLRMRGT PAGEEFSVLK SLFSAISKKK
110 120 130 140 150
QEFTFNLASA LYLQEGFIVK ETYLHSNKEF FQSATKLVDF LDAKTSAQAI
160 170 180 190 200
STWVESKTDG KIKNMFSEEE FGPLTRLVLV NAIYFKGDWK QKFRKEDTEM
210 220 230 240 250
TDFTKKDGST VKVPMMKALL RAQYGYFSQS SMTCQVLELP YKADEFSLVI
260 270 280 290 300
ILPTEDTSIE EVENQVTAPH VRRWFSELHE EEVEVSLPRF KIEQKLDLKE
310 320 330 340 350
ALYSLNVTEI FSGGCDLSGI TDSSEVYVSR VMQKVFFEIN EDGSEAAAST
360 370 380 390 400
GINIPAIMSL TQTQFLANHP FLFILKHIRT ESILFMGKVT DPDIQTTKGR

DLDSL
Length:405
Mass (Da):45,776
Last modified:October 1, 2000 - v1
Checksum:i04DF38BE8545DFA8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51I → M in BAB25079. (PubMed:16141072)Curated
Sequence conflicti195 – 1951K → T in BAB24976. (PubMed:16141072)Curated
Sequence conflicti207 – 2071D → S in BAB24976. (PubMed:16141072)Curated
Sequence conflicti212 – 2187KVPMMKA → RVPTDEV in BAB24976. (PubMed:16141072)Curated
Sequence conflicti246 – 2461F → Y in BAB24976. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF251276 mRNA. Translation: AAF65821.1.
AK007347 mRNA. Translation: BAB24976.1.
AK007510 mRNA. Translation: BAB25079.1.
CCDSiCCDS17413.1.
RefSeqiNP_080736.2. NM_026460.3.
UniGeneiMm.259446.

Genome annotation databases

EnsembliENSMUST00000039047; ENSMUSP00000046943; ENSMUSG00000034139.
GeneIDi67931.
KEGGimmu:67931.
UCSCiuc008pna.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF251276 mRNA. Translation: AAF65821.1 .
AK007347 mRNA. Translation: BAB24976.1 .
AK007510 mRNA. Translation: BAB25079.1 .
CCDSi CCDS17413.1.
RefSeqi NP_080736.2. NM_026460.3.
UniGenei Mm.259446.

3D structure databases

ProteinModelPortali Q9JK88.
SMRi Q9JK88. Positions 23-393.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi I04.026.

PTM databases

PhosphoSitei Q9JK88.

Proteomic databases

MaxQBi Q9JK88.
PaxDbi Q9JK88.
PRIDEi Q9JK88.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000039047 ; ENSMUSP00000046943 ; ENSMUSG00000034139 .
GeneIDi 67931.
KEGGi mmu:67931.
UCSCi uc008pna.1. mouse.

Organism-specific databases

CTDi 5276.
MGIi MGI:1915181. Serpini2.

Phylogenomic databases

eggNOGi COG4826.
GeneTreei ENSGT00760000118789.
HOGENOMi HOG000238519.
HOVERGENi HBG005957.
InParanoidi Q9JK88.
OMAi AQQILKW.
OrthoDBi EOG7327PB.
PhylomeDBi Q9JK88.
TreeFami TF343094.

Miscellaneous databases

NextBioi 325984.
PROi Q9JK88.
SOURCEi Search...

Gene expression databases

Bgeei Q9JK88.
ExpressionAtlasi Q9JK88. differential.
Genevestigatori Q9JK88.

Family and domain databases

InterProi IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
PROSITEi PS00284. SERPIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of mouse pancreas-specific serpin gene."
    Chang W.S., Lin S.C., Wu C.W.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pancreas.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Pancreas.

Entry informationi

Entry nameiSPI2_MOUSE
AccessioniPrimary (citable) accession number: Q9JK88
Secondary accession number(s): Q9D8Z3, Q9D955
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3