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Protein

Partitioning defective 6 homolog gamma

Gene

Pard6g

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division

Enzyme and pathway databases

ReactomeiR-MMU-420029 Tight junction interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Partitioning defective 6 homolog gamma
Short name:
PAR-6 gamma
Short name:
PAR6A
Gene namesi
Name:Pard6g
Synonyms:Par6g
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2135606 Pard6g

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001125191 – 382Partitioning defective 6 homolog gammaAdd BLAST382

Proteomic databases

MaxQBiQ9JK84
PaxDbiQ9JK84
PRIDEiQ9JK84

PTM databases

iPTMnetiQ9JK84
PhosphoSitePlusiQ9JK84

Expressioni

Gene expression databases

BgeeiENSMUSG00000056214
GenevisibleiQ9JK84 MM

Interactioni

Subunit structurei

Interacts with PARD3 (Probable). Interacts with GTP-bound forms of CDC42, ARHQ/TC10 and RAC1 (By similarity). Interacts with the N-terminal part of PRKCI and PRKCZ (By similarity).By similarityCurated

Protein-protein interaction databases

BioGridi220281, 1 interactor
STRINGi10090.ENSMUSP00000069182

Structurei

3D structure databases

ProteinModelPortaliQ9JK84
SMRiQ9JK84
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 98PB1PROSITE-ProRule annotationAdd BLAST81
Domaini134 – 151Pseudo-CRIBAdd BLAST18
Domaini158 – 251PDZPROSITE-ProRule annotationAdd BLAST94

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 115Interaction with PRKCI and PRKCZBy similarityAdd BLAST115

Domaini

The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.By similarity

Sequence similaritiesi

Belongs to the PAR6 family.Curated

Phylogenomic databases

eggNOGiKOG3606 Eukaryota
ENOG410XRJ3 LUCA
GeneTreeiENSGT00390000005255
HOGENOMiHOG000231716
HOVERGENiHBG053509
InParanoidiQ9JK84
KOiK06093
OMAiISMPHDF
OrthoDBiEOG091G0FFH
PhylomeDBiQ9JK84
TreeFamiTF312899

Family and domain databases

CDDicd06403 PB1_Par6, 1 hit
InterProiView protein in InterPro
IPR034874 PAR-6_G
IPR000270 PB1_dom
IPR034868 PB1_Par6
IPR001478 PDZ
IPR036034 PDZ_sf
PANTHERiPTHR14102:SF3 PTHR14102:SF3, 1 hit
PfamiView protein in Pfam
PF00564 PB1, 1 hit
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00666 PB1, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS51745 PB1, 1 hit
PS50106 PDZ, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JK84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRSFHKSQT LRFYDCSAVE VKSKFGAEFR RFSLDRHKPG KFEDFYQLVV
60 70 80 90 100
HTHHISNTEV TIGYADVHGD LLPINNDDNF CKAVSSANPL LRVFIQKREE
110 120 130 140 150
ADHYSFGAGT LSRKKKVLVT LRDDGLRRRP HLNISMPHDF RPVSSIIDVD
160 170 180 190 200
ILPETHRRVR LYRHGYEKPL GFYIRDGTSV RVTPHGLEKV PGIFISRMVP
210 220 230 240 250
GGLAESTGLL AVNDEVLEVN GIEVAGKTLD QVTDMMIANS HNLIVTVKPA
260 270 280 290 300
NQRNNVVRSS RTSGSSVHST DSTTSHHSLP GAHVLQNSED VESDEEADIV
310 320 330 340 350
IEGALEPQHI PKTQAVPPGS LSRANGTSLA HGLHRRDMSL HSSGRESNGS
360 370 380
IHRFLSSLKP DPRHSLVLPQ GGVEEHGPAI TL
Length:382
Mass (Da):42,341
Last modified:October 1, 2000 - v1
Checksum:i9ED30843B8925533
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF252290 mRNA Translation: AAF71527.1
CCDSiCCDS29363.1
RefSeqiNP_444347.3, NM_053117.3
UniGeneiMm.24678

Genome annotation databases

EnsembliENSMUST00000070219; ENSMUSP00000069182; ENSMUSG00000056214
GeneIDi93737
KEGGimmu:93737
UCSCiuc008fsj.2 mouse

Similar proteinsi

Entry informationi

Entry nameiPAR6G_MOUSE
AccessioniPrimary (citable) accession number: Q9JK84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health