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Protein

Partitioning defective 6 homolog gamma

Gene

Pard6g

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Enzyme and pathway databases

ReactomeiR-MMU-420029. Tight junction interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Partitioning defective 6 homolog gamma
Short name:
PAR-6 gamma
Short name:
PAR6A
Gene namesi
Name:Pard6g
Synonyms:Par6g
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2135606. Pard6g.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Partitioning defective 6 homolog gammaPRO_0000112519Add
BLAST

Proteomic databases

MaxQBiQ9JK84.
PaxDbiQ9JK84.
PRIDEiQ9JK84.

PTM databases

iPTMnetiQ9JK84.
PhosphoSiteiQ9JK84.

Expressioni

Gene expression databases

BgeeiENSMUSG00000056214.
GenevisibleiQ9JK84. MM.

Interactioni

Subunit structurei

Interacts with PARD3 (Probable). Interacts with GTP-bound forms of CDC42, ARHQ/TC10 and RAC1 (By similarity). Interacts with the N-terminal part of PRKCI and PRKCZ (By similarity).By similarityCurated

Protein-protein interaction databases

BioGridi220281. 1 interaction.
STRINGi10090.ENSMUSP00000069182.

Structurei

3D structure databases

ProteinModelPortaliQ9JK84.
SMRiQ9JK84. Positions 17-98, 134-254.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 9881PB1PROSITE-ProRule annotationAdd
BLAST
Domaini134 – 15118Pseudo-CRIBAdd
BLAST
Domaini158 – 25194PDZPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 115115Interaction with PRKCI and PRKCZBy similarityAdd
BLAST

Domaini

The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.By similarity

Sequence similaritiesi

Belongs to the PAR6 family.Curated
Contains 1 PB1 domain.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 pseudo-CRIB domain.Curated

Phylogenomic databases

eggNOGiKOG3606. Eukaryota.
ENOG410XRJ3. LUCA.
GeneTreeiENSGT00390000005255.
HOGENOMiHOG000231716.
HOVERGENiHBG053509.
InParanoidiQ9JK84.
KOiK06093.
OMAiHRHGCEK.
OrthoDBiEOG091G0FFH.
PhylomeDBiQ9JK84.
TreeFamiTF312899.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR000270. PB1_dom.
IPR001478. PDZ.
[Graphical view]
PfamiPF00564. PB1. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00666. PB1. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS51745. PB1. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JK84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRSFHKSQT LRFYDCSAVE VKSKFGAEFR RFSLDRHKPG KFEDFYQLVV
60 70 80 90 100
HTHHISNTEV TIGYADVHGD LLPINNDDNF CKAVSSANPL LRVFIQKREE
110 120 130 140 150
ADHYSFGAGT LSRKKKVLVT LRDDGLRRRP HLNISMPHDF RPVSSIIDVD
160 170 180 190 200
ILPETHRRVR LYRHGYEKPL GFYIRDGTSV RVTPHGLEKV PGIFISRMVP
210 220 230 240 250
GGLAESTGLL AVNDEVLEVN GIEVAGKTLD QVTDMMIANS HNLIVTVKPA
260 270 280 290 300
NQRNNVVRSS RTSGSSVHST DSTTSHHSLP GAHVLQNSED VESDEEADIV
310 320 330 340 350
IEGALEPQHI PKTQAVPPGS LSRANGTSLA HGLHRRDMSL HSSGRESNGS
360 370 380
IHRFLSSLKP DPRHSLVLPQ GGVEEHGPAI TL
Length:382
Mass (Da):42,341
Last modified:October 1, 2000 - v1
Checksum:i9ED30843B8925533
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF252290 mRNA. Translation: AAF71527.1.
CCDSiCCDS29363.1.
RefSeqiNP_444347.3. NM_053117.3.
UniGeneiMm.24678.

Genome annotation databases

EnsembliENSMUST00000070219; ENSMUSP00000069182; ENSMUSG00000056214.
GeneIDi93737.
KEGGimmu:93737.
UCSCiuc008fsj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF252290 mRNA. Translation: AAF71527.1.
CCDSiCCDS29363.1.
RefSeqiNP_444347.3. NM_053117.3.
UniGeneiMm.24678.

3D structure databases

ProteinModelPortaliQ9JK84.
SMRiQ9JK84. Positions 17-98, 134-254.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi220281. 1 interaction.
STRINGi10090.ENSMUSP00000069182.

PTM databases

iPTMnetiQ9JK84.
PhosphoSiteiQ9JK84.

Proteomic databases

MaxQBiQ9JK84.
PaxDbiQ9JK84.
PRIDEiQ9JK84.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070219; ENSMUSP00000069182; ENSMUSG00000056214.
GeneIDi93737.
KEGGimmu:93737.
UCSCiuc008fsj.2. mouse.

Organism-specific databases

CTDi84552.
MGIiMGI:2135606. Pard6g.

Phylogenomic databases

eggNOGiKOG3606. Eukaryota.
ENOG410XRJ3. LUCA.
GeneTreeiENSGT00390000005255.
HOGENOMiHOG000231716.
HOVERGENiHBG053509.
InParanoidiQ9JK84.
KOiK06093.
OMAiHRHGCEK.
OrthoDBiEOG091G0FFH.
PhylomeDBiQ9JK84.
TreeFamiTF312899.

Enzyme and pathway databases

ReactomeiR-MMU-420029. Tight junction interactions.

Miscellaneous databases

PROiQ9JK84.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000056214.
GenevisibleiQ9JK84. MM.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR000270. PB1_dom.
IPR001478. PDZ.
[Graphical view]
PfamiPF00564. PB1. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00666. PB1. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS51745. PB1. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAR6G_MOUSE
AccessioniPrimary (citable) accession number: Q9JK84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.