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Protein

Partitioning defective 6 homolog beta

Gene

Pard6b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.2 Publications

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division

Enzyme and pathway databases

ReactomeiR-MMU-420029 Tight junction interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Partitioning defective 6 homolog beta
Short name:
PAR-6 beta
Short name:
PAR-6B
Gene namesi
Name:Pard6b
Synonyms:Par6b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2135605 Pard6b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Tight junction

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi133 – 134IS → AA: Does not abolish interaction with CDC42 and ARHQ. 1 Publication2
Mutagenesisi136P → A: Abolishes interaction with ARHQ, but not the interaction with CDC42; when associated with A-139. 1 Publication1
Mutagenesisi139F → A: Abolishes interaction with ARHQ, but not the interaction with CDC42; when associated with A-136. 1 Publication1
Mutagenesisi167 – 170KPLG → AAAA: Strongly reduces interaction with PARD3. Does not abolish interaction with CDC42 and ARHQ. 1 Publication4
Mutagenesisi235M → W: Prevents interaction with MPP5. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001125171 – 371Partitioning defective 6 homolog betaAdd BLAST371

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineCombined sources1
Modified residuei11PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9JK83
PeptideAtlasiQ9JK83
PRIDEiQ9JK83

PTM databases

iPTMnetiQ9JK83
PhosphoSitePlusiQ9JK83

Expressioni

Tissue specificityi

Expressed in pancreas and in both adult and fetal kidney. Weakly expressed in placenta and lung. Not expressed in other tissues.

Gene expression databases

BgeeiENSMUSG00000044641
GenevisibleiQ9JK83 MM

Interactioni

Subunit structurei

Interacts with PARD3. Interacts with GTP-bound forms of CDC42, ARHQ/TC10 and RAC1. Interacts with the N-terminal part of PRKCI and PRKCZ. Part of a complex with PARD3, CDC42 or RAC1 and PRKCI or PRKCZ. Part of a complex with LLGL1 and PRKCI. Interacts with ALS2CR19. Interacts with ECT2 (By similarity). Interacts with MPP5.By similarity4 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi208398, 12 interactors
CORUMiQ9JK83
IntActiQ9JK83, 17 interactors
MINTiQ9JK83
STRINGi10090.ENSMUSP00000052619

Structurei

Secondary structure

1371
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi137 – 146Combined sources10
Beta strandi156 – 160Combined sources5
Beta strandi171 – 182Combined sources12
Beta strandi185 – 197Combined sources13
Helixi202 – 206Combined sources5
Beta strandi214 – 218Combined sources5
Beta strandi221 – 223Combined sources3
Helixi228 – 237Combined sources10
Turni238 – 240Combined sources3
Beta strandi241 – 247Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NF3X-ray2.10C/D126-253[»]
ProteinModelPortaliQ9JK83
SMRiQ9JK83
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9JK83

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 96PB1PROSITE-ProRule annotationAdd BLAST81
Domaini133 – 150Pseudo-CRIBAdd BLAST18
Domaini157 – 250PDZPROSITE-ProRule annotationAdd BLAST94

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni126 – 253Interaction with PARD3 and CDC421 PublicationAdd BLAST128

Domaini

The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.1 Publication
The PDZ domain mediates the interaction with MPP5.1 Publication

Sequence similaritiesi

Belongs to the PAR6 family.Curated

Phylogenomic databases

eggNOGiKOG3606 Eukaryota
ENOG410XRJ3 LUCA
GeneTreeiENSGT00390000005255
HOGENOMiHOG000231716
HOVERGENiHBG053509
InParanoidiQ9JK83
KOiK06093
OMAiIQFLILY
OrthoDBiEOG091G0FFH
TreeFamiTF312899

Family and domain databases

CDDicd06403 PB1_Par6, 1 hit
InterProiView protein in InterPro
IPR034873 PAR-6B
IPR000270 PB1_dom
IPR034868 PB1_Par6
IPR001478 PDZ
IPR036034 PDZ_sf
PANTHERiPTHR14102:SF4 PTHR14102:SF4, 1 hit
PfamiView protein in Pfam
PF00564 PB1, 1 hit
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00666 PB1, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS51745 PB1, 1 hit
PS50106 PDZ, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9JK83-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNRGHRHGAS SGCLGTMEVK SKFGAEFRRF SLERSKPGKF EEFYGLLQHV
60 70 80 90 100
HKIPNVDVLV GYADIHGDLL PINNDDNYHK AVSTANPLLR IFIQKKEEAD
110 120 130 140 150
YSAFGTDTLI RKKNMLSNVL RPDNHRKKPH IVISMPQDFR PVSSIIDVDI
160 170 180 190 200
LPETHRRVRL YKYGTEKPLG FYIRDGSSVR VTPHGLEKVP GIFISRLVPG
210 220 230 240 250
GLAQSTGLLA VNDEVLEVNG IEVSGKSLDQ VTDMMIANSR NLIITVRPAN
260 270 280 290 300
QRNNVVRNSR TSGSSSQSTD NSLLGFPQQV EASFEPEDQD SDEDDIIIED
310 320 330 340 350
SGEPQQIPKA TPAQSLESLT QIELSFESGQ NGFSPPQDTS LVPVPGSLDT
360 370
ELESRAPDQK LLEEDGTIIT L
Length:371
Mass (Da):41,067
Last modified:July 27, 2011 - v2
Checksum:i664C7D25262494A9
GO
Isoform 2 (identifier: Q9JK83-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     298-298: I → C
     299-371: Missing.

Note: No experimental confirmation available.
Show »
Length:298
Mass (Da):33,267
Checksum:i842E7B79CE012070
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13C → W in AAH25147 (PubMed:15489334).Curated1
Sequence conflicti70L → P in AAF71528 (PubMed:10934474).Curated1
Sequence conflicti161Y → C in AAF71528 (PubMed:10934474).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007460298I → C in isoform 2. 1 Publication1
Alternative sequenceiVSP_007461299 – 371Missing in isoform 2. 1 PublicationAdd BLAST73

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF252291 mRNA Translation: AAF71528.1
AL831766 Genomic DNA Translation: CAM17536.1
CH466551 Genomic DNA Translation: EDL06536.1
BC025147 mRNA Translation: AAH25147.1
CCDSiCCDS17108.1 [Q9JK83-1]
RefSeqiNP_067384.2, NM_021409.2 [Q9JK83-1]
UniGeneiMm.292834

Genome annotation databases

EnsembliENSMUST00000052125; ENSMUSP00000052619; ENSMUSG00000044641 [Q9JK83-1]
GeneIDi58220
KEGGimmu:58220
UCSCiuc008oao.2 mouse [Q9JK83-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPAR6B_MOUSE
AccessioniPrimary (citable) accession number: Q9JK83
Secondary accession number(s): A2ANX8, Q8R3J8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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