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Q9JK72 (CCS_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Copper chaperone for superoxide dismutase
Alternative name(s):
Superoxide dismutase copper chaperone
Gene names
Name:Ccs
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length274 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Delivers copper to copper zinc superoxide dismutase (SOD1) By similarity.

Cofactor

Binds 2 copper ions per subunit By similarity.

Binds 1 zinc ion per subunit By similarity.

Subunit structure

Homodimer, and heterodimer with SOD1. Interacts with COMMD1 By similarity. Ref.1

Subcellular location

Cytoplasm By similarity.

Sequence similarities

In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.

Contains 1 HMA domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 274274Copper chaperone for superoxide dismutase
PRO_0000213546

Regions

Domain12 – 7564HMA
Region88 – 234147Superoxide dismutase-like

Sites

Metal binding221Copper 1 By similarity
Metal binding251Copper 1 By similarity
Metal binding1471Zinc By similarity
Metal binding1551Zinc By similarity
Metal binding1641Zinc By similarity
Metal binding1671Zinc By similarity
Metal binding2441Copper 2 By similarity
Metal binding2461Copper 2 By similarity

Amino acid modifications

Modified residue2671Phosphoserine By similarity
Disulfide bond141 ↔ 227 By similarity

Experimental info

Sequence conflict991V → I in AAI58587. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9JK72 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 55C95B72C808C800

FASTA27428,890
        10         20         30         40         50         60 
MASKSGDGGT MCALEFTVQM SCQSCVDAVH KTLKGAAGVQ NVEVQLENQM VLVQTTLPSQ 

        70         80         90        100        110        120 
EVQALLESTG RQAVLKGMGS SQLKNLGAAV AIMEGSGTVQ GVVRFLQLSS ELCLIEGTID 

       130        140        150        160        170        180 
GLEPGLHGLH VHQYGDLTKD CSSCGDHFNP DGASHGGPQD TDRHRGDLGN VHAEASGRAT 

       190        200        210        220        230        240 
FRIEDKQLKV WDVIGRSLVV DEGEDDLGRG GHPLSKVTGN SGKRLACGII ARSAGLFQNP 

       250        260        270 
KQICSCDGLT IWEERGRPIA GQGRKDSAQP PAHL

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of a copper chaperone for copper/zinc superoxide dismutase from the rat."
Hiromura M., Chino H., Sonoda T., Sakurai H.
Biochem. Biophys. Res. Commun. 275:394-400(2000) [PubMed: 10964676] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT.
Strain: Sprague-Dawley.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Spleen.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF255305 mRNA. Translation: AAF65572.1.
BC158586 mRNA. Translation: AAI58587.1.
IPIIPI00202139.
RefSeqNP_445877.1. NM_053425.1.
UniGeneRn.12311.

3D structure databases

ProteinModelPortalQ9JK72.
SMRQ9JK72. Positions 9-237.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9JK72. 1 interaction.
STRINGQ9JK72.

PTM databases

PhosphoSiteQ9JK72.

Proteomic databases

PRIDEQ9JK72.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000026670; ENSRNOP00000026670; ENSRNOG00000019691.
GeneID84485.
KEGGrno:84485.
UCSCNM_053425. rat.

Organism-specific databases

CTD9973.
RGD620403. Ccs.

Phylogenomic databases

eggNOGroNOG08275.
GeneTreeENSGT00530000063226.
HOVERGENHBG018933.
InParanoidQ9JK72.
OrthoDBEOG45TCNZ.
PhylomeDBQ9JK72.

Gene expression databases

ArrayExpressQ9JK72.
GenevestigatorQ9JK72.
GermOnlineENSRNOG00000019691. Rattus norvegicus.

Family and domain databases

InterProIPR006121. HeavyMe-assoc_HMA.
IPR024134. SOD_Cu/Zn_/chaperones.
IPR018152. SOD_Cu/Zn_BS.
IPR024142. SOD_Cu_chaperone.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
Gene3DG3DSA:2.60.40.200. SOD_Cu_Zn. 1 hit.
KOK04569.
PANTHERPTHR10003:SF27. PTHR10003:SF27. 1 hit.
PTHR10003. SOD_Cu_Zn. 1 hit.
PfamPF00403. HMA. 1 hit.
PF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSPR00068. CUZNDISMTASE.
SUPFAMSSF55008. HeavyMe_transpt. 1 hit.
SSF49329. SOD_Cu_Zn. 1 hit.
PROSITEPS01047. HMA_1. False negative.
PS50846. HMA_2. 1 hit.
PS00087. SOD_CU_ZN_1. False negative.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio617016.

Entry information

Entry nameCCS_RAT
AccessionPrimary (citable) accession number: Q9JK72
Secondary accession number(s): B0BMW1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: October 1, 2000
Last modified: November 16, 2011
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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