Q9JK64 (Q9JK64_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Multidrug resistance protein 1a EMBL AAF69007.1

Submitted name:
RCG41085 EMBL EDL84318.1
Submitted name:
Uncharacterized protein Ensembl ENSRNOP00000011166

Gene names

Name:	Abcb1a Ensembl ENSRNOP00000011166 RGD 619951
Synonyms:	Pgy1 EMBL AAF69007.1
ORF Names:	rCG_41085 EMBL EDL84318.1

Organism

Rattus norvegicus (Rat) EMBL AAF69007.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	1272 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the ABC transporter superfamily. RuleBase RU000684

Ontologies

Keywords
Domain	Repeat SAAS SAAS017940
Ligand	ATP-binding RuleBase RU000684 Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	circadian rhythm Inferred from expression pattern. Source: RGD drug transmembrane transport Inferred from direct assay. Source: RGD lactation Inferred from expression pattern. Source: RGD negative regulation of cell death Inferred from mutant phenotype. Source: RGD response to cadmium ion Inferred from expression pattern. Source: RGD response to hypoxia Inferred from expression pattern. Source: RGD response to organic cyclic compound Inferred from expression pattern. Source: RGD response to vitamin D Inferred from expression pattern. Source: RGD
Cellular component	Golgi membrane Inferred from Biological aspect of Ancestor. Source: RefGenome apical plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome integral to membrane Inferred from Biological aspect of Ancestor. Source: RefGenome intercellular canaliculus Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Inferred from Biological aspect of Ancestor. Source: RefGenome protein binding Inferred from physical interaction. Source: RGD
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9JK64 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: B5C1DF89DFC986C5	FASTA	1,272	140,327
	10 20 30 40 50 60 MELEEDLNGR ADKNFSKMGK KSKKEKKEKK PAVSVLTMFR YAGWLDRFYM LLGTLAAIIH 70 80 90 100 110 120 GIALPLMMLV FGDMTDSFAN VGNNRSMSFY NATDIYAKLE DEMTTYAYYY TGIGAGVLIV 130 140 150 160 170 180 AYIQVSLWCL AAGRQIHKIR QKFFHAIMNQ EIGWFDVHDV GELNTRLTDD VSKINEGIGD 190 200 210 220 230 240 KIGMFFQAMA TFFGGFIIGF TRGWKLTLVI LAISPVLGLS AGIWAKILSS FTDKELQAYA 250 260 270 280 290 300 KAGAVAEEVL AAIRTVIAFG GQKKELERYN NNLEEAKRLG IKKAITANIS MGAAFLLIYA 310 320 330 340 350 360 SYALAFWYGT SLVISKEYTI GQVLTVFFSV LIGAFSVGQA SPNIEAFANA RGAAYEVFSI 370 380 390 400 410 420 IDNKPSIDSF SKSGHKPDNI QGNLEFKNIH FSYPSRKDVQ ILKGLNLKVK SGQTVALVGN 430 440 450 460 470 480 SGCGKSTTVQ LLQRLYDPIE GEVSIDGQDI RTINVRYLRE IIGVVSQEPV LFATTIAENI 490 500 510 520 530 540 RYGRENVTMD EIEKAVKEAN AYDFIMKLPH KFDTLVGERG AQLSGGQKQR IAIARALVRN 550 560 570 580 590 600 PKILLLDEAT SALDTESEAV VQAALDKARE GRTTIVIAHR LSTVRNADVI AGFDGGVIVE 610 620 630 640 650 660 QGNHDELMRE KGIYFKLVMT QTAGNEIELG NEACESKDGI DNVDMSSKDS GSSLIRRRST 670 680 690 700 710 720 RKSIRGPHDQ DGELSTKEAL DDDVPPASFW RILKLNSTEW PYFVVGVFCA IINGGLQPAF 730 740 750 760 770 780 SIIFSKVVGV FTKNDTPEIQ RQNSNLFSLL FLILGIISFI TFFLQGFTFG KAGEILTKRL 790 800 810 820 830 840 RYMVFKSMLR QDISWFDDPK NTTGALTTRL ANDAAQVKGA TGSRLAVITQ NIANLGTGII 850 860 870 880 890 900 ISLIYGWQLT LLLLAIVPII AIAGVVEMKM LSGQALKDKK ELEGSGKIAT EAIENFRTVV 910 920 930 940 950 960 SLTREQKFET MYAQSLQIPY RNALKKAHVF GITFSFTQAM MYFSYAACFR FGAYLVAREL 970 980 990 1000 1010 1020 MTFENVLLVF SAIVFGAMAV GQVSSFAPDY AKAKVSASHI IRIIEKIPEI DSYSTEGLKP 1030 1040 1050 1060 1070 1080 NMLEGNVKFN GVMFNYPTRP NIPVLQGLSL EVKKGQTLAL VGSSGCGKST VVQLLERFYD 1090 1100 1110 1120 1130 1140 PMAGTVFLDG KEIKQLNVQW LRAHLGIVSQ EPILFDCSIA ENIAYGDNSR VVSHEEIVKA 1150 1160 1170 1180 1190 1200 AKEANIHQFI DSLPEKYNTR VGDKGTQLSG GQKQRIAIAR ALVRQPHILL LDEATSALDT 1210 1220 1230 1240 1250 1260 ESEKVVQEAL DKAREGRTCI VIAHRLSTIQ NADLIVVIQN GQVKEHGTHQ QLLAQKGIYF 1270 SMVSVQAGAK RS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the Brown Norway rat yields insights into mammalian evolution." Rat Genome Sequencing Project Consortium Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S. Nature 428:493-521(2004) [PubMed: 15057822] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Brown Norway Ensembl ENSRNOP00000011166.
[2]	"Gene and alternative splicing annotation with AIR." Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G. Genome Res. 15:54-66(2005) [PubMed: 15632090] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDL84318.1.
[3]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Brown Norway Ensembl ENSRNOP00000011166.
[4]	"Cloning and functional characterization of the rat multidrug resistance protein Mdr1a." Hooiveld G.J.E.J., Wilms J.W.J., Hagenbuch B., Jansen P.L.M., Meijer D.K.F., Muller M. Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Wistar EMBL AAF69007.1. Tissue: Liver EMBL AAF69007.1.
[5]	Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. , Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDL84318.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF257746 mRNA. Translation: AAF69007.1. CH474013 Genomic DNA. Translation: EDL84318.1.
IPI	IPI00470287.
RefSeq	NP_596892.1. NM_133401.1.
UniGene	Rn.154810.
3D structure databases
HSSP	HSSP built from PDB template 1MT0 based on UniProtKB P08716.
ProteinModelPortal	Q9JK64.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9JK64.
Proteomic databases
PRIDE	Q9JK64.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000011166; ENSRNOP00000011166; ENSRNOG00000008012.
GeneID	170913.
KEGG	rno:170913.
UCSC	NM_133401. rat.
Organism-specific databases
CTD	18671.
RGD	619951. Abcb1a.
Phylogenomic databases
GeneTree	ENSGT00530000062896.
HOVERGEN	HBG080809.
InParanoid	Q9JK64.
OMA	EEEMTTY.
PhylomeDB	Q9JK64.
Gene expression databases
ArrayExpress	Q9JK64.
Genevestigator	Q9JK64.
Family and domain databases
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR001140. ABC_transptr_TM_dom. IPR011527. ABC_transptrTM_dom_typ1. IPR003593. ATPase_AAA+_core. [Graphical view]
KO	K05658.
Pfam	PF00664. ABC_membrane. 2 hits. PF00005. ABC_tran. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
SUPFAM	SSF90123. ABC_TM_1. 2 hits.
PROSITE	PS50929. ABC_TM1F. 2 hits. PS00211. ABC_TRANSPORTER_1. 2 hits. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	621381.

Entry information

Entry name

Q9JK64_RAT

Accession

Primary (citable) accession number: Q9JK64

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2000
Last sequence update:	October 1, 2000
Last modified:	November 16, 2011
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)