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Q9JK59

- Q9JK59_RAT

UniProt

Q9JK59 - Q9JK59_RAT

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Protein
Submitted name:

BAK protein

Gene

Bak1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. BH domain binding Source: RGD
  2. chaperone binding Source: RGD
  3. heat shock protein binding Source: RGD
  4. protein heterodimerization activity Source: RGD
  5. protein homodimerization activity Source: RGD

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c Source: Ensembl
  2. aging Source: RGD
  3. apoptotic process Source: RGD
  4. apoptotic process involved in patterning of blood vessels Source: Ensembl
  5. B cell apoptotic process Source: Ensembl
  6. B cell homeostasis Source: Ensembl
  7. B cell negative selection Source: Ensembl
  8. blood vessel remodeling Source: Ensembl
  9. brain development Source: RGD
  10. cell proliferation Source: Ensembl
  11. cellular response to mechanical stimulus Source: Ensembl
  12. endocrine pancreas development Source: RGD
  13. establishment or maintenance of transmembrane electrochemical gradient Source: HGNC
  14. extrinsic apoptotic signaling pathway in absence of ligand Source: RefGenome
  15. fibroblast apoptotic process Source: Ensembl
  16. intrinsic apoptotic signaling pathway in response to DNA damage Source: RefGenome
  17. intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: Ensembl
  18. limb morphogenesis Source: Ensembl
  19. mitochondrial fusion Source: Ensembl
  20. myeloid cell homeostasis Source: Ensembl
  21. negative regulation of cell proliferation Source: RGD
  22. negative regulation of endoplasmic reticulum calcium ion concentration Source: Ensembl
  23. negative regulation of gene expression Source: RGD
  24. negative regulation of peptidyl-serine phosphorylation Source: Ensembl
  25. organ regeneration Source: RGD
  26. positive regulation of apoptotic process Source: RefGenome
  27. positive regulation of calcium ion transport into cytosol Source: Ensembl
  28. positive regulation of endoplasmic reticulum unfolded protein response Source: Ensembl
  29. positive regulation of proteolysis Source: Ensembl
  30. positive regulation of release of cytochrome c from mitochondria Source: RGD
  31. post-embryonic camera-type eye morphogenesis Source: Ensembl
  32. regulation of cell cycle Source: Ensembl
  33. regulation of mitochondrial membrane permeability Source: HGNC
  34. regulation of mitochondrial membrane potential Source: HGNC
  35. regulation of protein heterodimerization activity Source: Ensembl
  36. regulation of protein homodimerization activity Source: Ensembl
  37. release of cytochrome c from mitochondria Source: HGNC
  38. response to drug Source: RGD
  39. response to ethanol Source: RGD
  40. response to fungus Source: Ensembl
  41. response to gamma radiation Source: Ensembl
  42. response to hydrogen peroxide Source: RGD
  43. response to mycotoxin Source: Ensembl
  44. response to organic cyclic compound Source: RGD
  45. response to UV-C Source: RGD
  46. thymocyte apoptotic process Source: Ensembl
  47. vagina development Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_258150. Activation and oligomerization of BAK protein.

Names & Taxonomyi

Protein namesi
Submitted name:
BAK proteinImported
Submitted name:
BCL2-antagonist/killer 1, isoform CRA_bImported
Submitted name:
Bak1 proteinImported
Submitted name:
Protein Bak1Imported
Gene namesi
Name:Bak1Imported
Synonyms:BakImported
ORF Names:rCG_60911Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 20

Organism-specific databases

RGDi621635. Bak1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: RGD
  2. endoplasmic reticulum Source: Ensembl
  3. membrane Source: RGD
  4. mitochondrial outer membrane Source: RefGenome
  5. mitochondrion Source: HGNC
  6. pore complex Source: HGNC
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ9JK59.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000576.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG145601.
GeneTreeiENSGT00530000062935.
HOGENOMiHOG000006521.
HOVERGENiHBG002674.
KOiK14021.
OMAiGDDINQR.
OrthoDBiEOG70GMGD.
TreeFamiTF315834.

Family and domain databases

InterProiIPR026308. BAK.
IPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR020728. Bcl2_BH3_motif_CS.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF41. PTHR11256:SF41. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PRINTSiPR01862. BCL2FAMILY.
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
PS01259. BH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JK59-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASGQGPGPP KGDCDEALSA SEQQVAQDTE EVFRSYVFYL HQQEQETQGA
60 70 80 90 100
AAPANPEMDN LSLEPNSVLG QVGRQLALIG DDINRRYDTE FQNLLEQLQP
110 120 130 140 150
TAGNAYELFT KIASSLFKSG ISWGRVVALL GFGYRLALYV YQRGLTGFLG
160 170 180 190 200
QVTCFLADII LHHYIARWIA QRGGWVAALS LRRDPILSVV VIFGVVLLGQ

FVVHRFFRS
Length:209
Mass (Da):23,153
Last modified:October 1, 2000 - v1
Checksum:i2493B814B1972421
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06099908 Genomic DNA. No translation available.
AF259504 mRNA. Translation: AAF71760.1.
BC089784 mRNA. Translation: AAH89784.1.
CH473988 Genomic DNA. Translation: EDL96872.1.
RefSeqiNP_446264.1. NM_053812.1.
XP_006256163.1. XM_006256101.2.
UniGeneiRn.14598.

Genome annotation databases

EnsembliENSRNOT00000000576; ENSRNOP00000000576; ENSRNOG00000000485.
GeneIDi116502.
KEGGirno:116502.
UCSCiRGD:621635. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06099908 Genomic DNA. No translation available.
AF259504 mRNA. Translation: AAF71760.1 .
BC089784 mRNA. Translation: AAH89784.1 .
CH473988 Genomic DNA. Translation: EDL96872.1 .
RefSeqi NP_446264.1. NM_053812.1.
XP_006256163.1. XM_006256101.2.
UniGenei Rn.14598.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000000576.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000000576 ; ENSRNOP00000000576 ; ENSRNOG00000000485 .
GeneIDi 116502.
KEGGi rno:116502.
UCSCi RGD:621635. rat.

Organism-specific databases

CTDi 578.
RGDi 621635. Bak1.

Phylogenomic databases

eggNOGi NOG145601.
GeneTreei ENSGT00530000062935.
HOGENOMi HOG000006521.
HOVERGENi HBG002674.
KOi K14021.
OMAi GDDINQR.
OrthoDBi EOG70GMGD.
TreeFami TF315834.

Enzyme and pathway databases

Reactomei REACT_258150. Activation and oligomerization of BAK protein.

Miscellaneous databases

NextBioi 619109.
PROi Q9JK59.

Gene expression databases

Genevestigatori Q9JK59.

Family and domain databases

InterProi IPR026308. BAK.
IPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR020728. Bcl2_BH3_motif_CS.
IPR026298. Blc2_fam.
[Graphical view ]
PANTHERi PTHR11256. PTHR11256. 1 hit.
PTHR11256:SF41. PTHR11256:SF41. 1 hit.
Pfami PF00452. Bcl-2. 1 hit.
[Graphical view ]
PRINTSi PR01862. BCL2FAMILY.
PROSITEi PS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
PS01259. BH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Bcl-2-related protein family gene expression during oligodendroglial differentiation."
    Itoh T., Itoh A., Pleasure D.
    J. Neurochem. 85:1500-1512(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: SpleenImported.
  3. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  6. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ9JK59_RAT
AccessioniPrimary (citable) accession number: Q9JK59
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3