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Protein
Submitted name:

BAK protein

Gene

Bak1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. BH domain binding Source: RGD
  2. chaperone binding Source: RGD
  3. heat shock protein binding Source: RGD
  4. protein heterodimerization activity Source: RGD
  5. protein homodimerization activity Source: RGD

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c Source: Ensembl
  2. aging Source: RGD
  3. apoptotic process Source: RGD
  4. apoptotic process involved in patterning of blood vessels Source: Ensembl
  5. B cell apoptotic process Source: Ensembl
  6. B cell homeostasis Source: Ensembl
  7. B cell negative selection Source: Ensembl
  8. blood vessel remodeling Source: Ensembl
  9. brain development Source: RGD
  10. cell proliferation Source: Ensembl
  11. cellular response to mechanical stimulus Source: Ensembl
  12. endocrine pancreas development Source: RGD
  13. establishment or maintenance of transmembrane electrochemical gradient Source: HGNC
  14. extrinsic apoptotic signaling pathway in absence of ligand Source: GO_Central
  15. fibroblast apoptotic process Source: Ensembl
  16. intrinsic apoptotic signaling pathway in response to DNA damage Source: GO_Central
  17. intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: Ensembl
  18. limb morphogenesis Source: Ensembl
  19. mitochondrial fusion Source: Ensembl
  20. myeloid cell homeostasis Source: Ensembl
  21. negative regulation of cell proliferation Source: RGD
  22. negative regulation of endoplasmic reticulum calcium ion concentration Source: Ensembl
  23. negative regulation of gene expression Source: RGD
  24. negative regulation of peptidyl-serine phosphorylation Source: Ensembl
  25. organ regeneration Source: RGD
  26. positive regulation of apoptotic process Source: GO_Central
  27. positive regulation of calcium ion transport into cytosol Source: Ensembl
  28. positive regulation of endoplasmic reticulum unfolded protein response Source: Ensembl
  29. positive regulation of release of cytochrome c from mitochondria Source: RGD
  30. post-embryonic camera-type eye morphogenesis Source: Ensembl
  31. regulation of cell cycle Source: Ensembl
  32. regulation of mitochondrial membrane permeability Source: HGNC
  33. regulation of mitochondrial membrane potential Source: HGNC
  34. regulation of protein heterodimerization activity Source: Ensembl
  35. regulation of protein homodimerization activity Source: Ensembl
  36. release of cytochrome c from mitochondria Source: HGNC
  37. response to drug Source: RGD
  38. response to ethanol Source: RGD
  39. response to fungus Source: Ensembl
  40. response to gamma radiation Source: Ensembl
  41. response to hydrogen peroxide Source: RGD
  42. response to mycotoxin Source: Ensembl
  43. response to organic cyclic compound Source: RGD
  44. response to UV-C Source: RGD
  45. thymocyte apoptotic process Source: Ensembl
  46. vagina development Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_309451. Activation and oligomerization of BAK protein.

Names & Taxonomyi

Protein namesi
Submitted name:
BAK proteinImported
Submitted name:
BCL2-antagonist/killer 1, isoform CRA_bImported
Submitted name:
Bak1 proteinImported
Submitted name:
Protein Bak1Imported
Gene namesi
Name:Bak1Imported
Synonyms:BakImported
ORF Names:rCG_60911Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi621635. Bak1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: RGD
  2. endoplasmic reticulum Source: Ensembl
  3. membrane Source: RGD
  4. mitochondrial outer membrane Source: GO_Central
  5. mitochondrion Source: HGNC
  6. pore complex Source: HGNC
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ9JK59.
PRIDEiQ9JK59.

Expressioni

Gene expression databases

GenevestigatoriQ9JK59.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000576.

Structurei

3D structure databases

ProteinModelPortaliQ9JK59.
SMRiQ9JK59. Positions 19-181.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG145601.
GeneTreeiENSGT00530000062935.
HOGENOMiHOG000006521.
HOVERGENiHBG002674.
InParanoidiQ9JK59.
KOiK14021.
OMAiFQAMLQH.
OrthoDBiEOG70GMGD.
PhylomeDBiQ9JK59.
TreeFamiTF315834.

Family and domain databases

InterProiIPR026308. BAK.
IPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR020728. Bcl2_BH3_motif_CS.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF41. PTHR11256:SF41. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PRINTSiPR01862. BCL2FAMILY.
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
PS01259. BH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JK59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGQGPGPP KGDCDEALSA SEQQVAQDTE EVFRSYVFYL HQQEQETQGA
60 70 80 90 100
AAPANPEMDN LSLEPNSVLG QVGRQLALIG DDINRRYDTE FQNLLEQLQP
110 120 130 140 150
TAGNAYELFT KIASSLFKSG ISWGRVVALL GFGYRLALYV YQRGLTGFLG
160 170 180 190 200
QVTCFLADII LHHYIARWIA QRGGWVAALS LRRDPILSVV VIFGVVLLGQ

FVVHRFFRS
Length:209
Mass (Da):23,153
Last modified:September 30, 2000 - v1
Checksum:i2493B814B1972421
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06099908 Genomic DNA. No translation available.
AF259504 mRNA. Translation: AAF71760.1.
BC089784 mRNA. Translation: AAH89784.1.
CH473988 Genomic DNA. Translation: EDL96872.1.
RefSeqiNP_446264.1. NM_053812.1.
XP_006256163.1. XM_006256101.2.
UniGeneiRn.14598.

Genome annotation databases

EnsembliENSRNOT00000000576; ENSRNOP00000000576; ENSRNOG00000000485.
GeneIDi116502.
KEGGirno:116502.
UCSCiRGD:621635. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06099908 Genomic DNA. No translation available.
AF259504 mRNA. Translation: AAF71760.1.
BC089784 mRNA. Translation: AAH89784.1.
CH473988 Genomic DNA. Translation: EDL96872.1.
RefSeqiNP_446264.1. NM_053812.1.
XP_006256163.1. XM_006256101.2.
UniGeneiRn.14598.

3D structure databases

ProteinModelPortaliQ9JK59.
SMRiQ9JK59. Positions 19-181.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000576.

Proteomic databases

PaxDbiQ9JK59.
PRIDEiQ9JK59.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000000576; ENSRNOP00000000576; ENSRNOG00000000485.
GeneIDi116502.
KEGGirno:116502.
UCSCiRGD:621635. rat.

Organism-specific databases

CTDi578.
RGDi621635. Bak1.

Phylogenomic databases

eggNOGiNOG145601.
GeneTreeiENSGT00530000062935.
HOGENOMiHOG000006521.
HOVERGENiHBG002674.
InParanoidiQ9JK59.
KOiK14021.
OMAiFQAMLQH.
OrthoDBiEOG70GMGD.
PhylomeDBiQ9JK59.
TreeFamiTF315834.

Enzyme and pathway databases

ReactomeiREACT_309451. Activation and oligomerization of BAK protein.

Miscellaneous databases

NextBioi619109.
PROiQ9JK59.

Gene expression databases

GenevestigatoriQ9JK59.

Family and domain databases

InterProiIPR026308. BAK.
IPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR020728. Bcl2_BH3_motif_CS.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF41. PTHR11256:SF41. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PRINTSiPR01862. BCL2FAMILY.
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
PS01259. BH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Bcl-2-related protein family gene expression during oligodendroglial differentiation."
    Itoh T., Itoh A., Pleasure D.
    J. Neurochem. 85:1500-1512(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: SpleenImported.
  3. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  6. Ensembl
    Submitted (JAN-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ9JK59_RAT
AccessioniPrimary (citable) accession number: Q9JK59
Entry historyi
Integrated into UniProtKB/TrEMBL: September 30, 2000
Last sequence update: September 30, 2000
Last modified: March 31, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.