Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9JK59

- Q9JK59_RAT

UniProt

Q9JK59 - Q9JK59_RAT

Protein
Submitted name:

BAK protein

Gene

Bak1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. BH domain binding Source: RGD
    2. chaperone binding Source: RGD
    3. heat shock protein binding Source: RGD
    4. protein binding Source: RGD
    5. protein heterodimerization activity Source: RGD
    6. protein homodimerization activity Source: RGD

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c Source: Ensembl
    2. aging Source: RGD
    3. apoptotic process Source: RGD
    4. apoptotic process involved in patterning of blood vessels Source: Ensembl
    5. B cell apoptotic process Source: Ensembl
    6. B cell homeostasis Source: Ensembl
    7. B cell negative selection Source: Ensembl
    8. blood vessel remodeling Source: Ensembl
    9. brain development Source: RGD
    10. cell proliferation Source: Ensembl
    11. cellular response to mechanical stimulus Source: Ensembl
    12. endocrine pancreas development Source: RGD
    13. establishment or maintenance of transmembrane electrochemical gradient Source: HGNC
    14. extrinsic apoptotic signaling pathway in absence of ligand Source: RefGenome
    15. fibroblast apoptotic process Source: Ensembl
    16. intrinsic apoptotic signaling pathway in response to DNA damage Source: RefGenome
    17. intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: Ensembl
    18. limb morphogenesis Source: Ensembl
    19. mitochondrial fusion Source: Ensembl
    20. myeloid cell homeostasis Source: Ensembl
    21. negative regulation of cell proliferation Source: RGD
    22. negative regulation of endoplasmic reticulum calcium ion concentration Source: Ensembl
    23. negative regulation of gene expression Source: RGD
    24. negative regulation of peptidyl-serine phosphorylation Source: Ensembl
    25. organ regeneration Source: RGD
    26. positive regulation of apoptotic process Source: RefGenome
    27. positive regulation of calcium ion transport into cytosol Source: Ensembl
    28. positive regulation of endoplasmic reticulum unfolded protein response Source: Ensembl
    29. positive regulation of proteolysis Source: Ensembl
    30. positive regulation of release of cytochrome c from mitochondria Source: RGD
    31. post-embryonic camera-type eye morphogenesis Source: Ensembl
    32. regulation of cell cycle Source: Ensembl
    33. regulation of mitochondrial membrane permeability Source: HGNC
    34. regulation of mitochondrial membrane potential Source: HGNC
    35. regulation of protein heterodimerization activity Source: Ensembl
    36. regulation of protein homodimerization activity Source: Ensembl
    37. release of cytochrome c from mitochondria Source: HGNC
    38. response to drug Source: RGD
    39. response to ethanol Source: RGD
    40. response to fungus Source: Ensembl
    41. response to gamma radiation Source: Ensembl
    42. response to hydrogen peroxide Source: RGD
    43. response to mycotoxin Source: Ensembl
    44. response to organic cyclic compound Source: RGD
    45. response to UV-C Source: RGD
    46. thymocyte apoptotic process Source: Ensembl
    47. vagina development Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    BAK proteinImported
    Submitted name:
    BCL2-antagonist/killer 1, isoform CRA_bImported
    Submitted name:
    Bak1 proteinImported
    Submitted name:
    Protein Bak1Imported
    Gene namesi
    Name:Bak1Imported
    Synonyms:BakImported
    ORF Names:rCG_60911Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 20

    Organism-specific databases

    RGDi621635. Bak1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: RGD
    2. endoplasmic reticulum Source: Ensembl
    3. membrane Source: RGD
    4. mitochondrial outer membrane Source: RefGenome
    5. mitochondrion Source: HGNC
    6. pore complex Source: HGNC

    Expressioni

    Gene expression databases

    GenevestigatoriQ9JK59.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000000576.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG145601.
    GeneTreeiENSGT00530000062935.
    HOGENOMiHOG000006521.
    HOVERGENiHBG002674.
    InParanoidiQ9JK59.
    KOiK14021.
    OMAiGDDINQR.
    OrthoDBiEOG70GMGD.
    TreeFamiTF315834.

    Family and domain databases

    InterProiIPR026308. BAK.
    IPR002475. Bcl2-like.
    IPR020717. Bcl2_BH1_motif_CS.
    IPR020726. Bcl2_BH2_motif_CS.
    IPR020728. Bcl2_BH3_motif_CS.
    IPR026298. Blc2_fam.
    [Graphical view]
    PANTHERiPTHR11256. PTHR11256. 1 hit.
    PTHR11256:SF41. PTHR11256:SF41. 1 hit.
    PfamiPF00452. Bcl-2. 1 hit.
    [Graphical view]
    PRINTSiPR01862. BCL2FAMILY.
    PROSITEiPS50062. BCL2_FAMILY. 1 hit.
    PS01080. BH1. 1 hit.
    PS01258. BH2. 1 hit.
    PS01259. BH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JK59-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASGQGPGPP KGDCDEALSA SEQQVAQDTE EVFRSYVFYL HQQEQETQGA    50
    AAPANPEMDN LSLEPNSVLG QVGRQLALIG DDINRRYDTE FQNLLEQLQP 100
    TAGNAYELFT KIASSLFKSG ISWGRVVALL GFGYRLALYV YQRGLTGFLG 150
    QVTCFLADII LHHYIARWIA QRGGWVAALS LRRDPILSVV VIFGVVLLGQ 200
    FVVHRFFRS 209
    Length:209
    Mass (Da):23,153
    Last modified:October 1, 2000 - v1
    Checksum:i2493B814B1972421
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06099908 Genomic DNA. No translation available.
    AF259504 mRNA. Translation: AAF71760.1.
    BC089784 mRNA. Translation: AAH89784.1.
    CH473988 Genomic DNA. Translation: EDL96872.1.
    RefSeqiNP_446264.1. NM_053812.1.
    XP_006256163.1. XM_006256101.1.
    UniGeneiRn.14598.

    Genome annotation databases

    EnsembliENSRNOT00000000576; ENSRNOP00000000576; ENSRNOG00000000485.
    GeneIDi116502.
    KEGGirno:116502.
    UCSCiRGD:621635. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06099908 Genomic DNA. No translation available.
    AF259504 mRNA. Translation: AAF71760.1 .
    BC089784 mRNA. Translation: AAH89784.1 .
    CH473988 Genomic DNA. Translation: EDL96872.1 .
    RefSeqi NP_446264.1. NM_053812.1.
    XP_006256163.1. XM_006256101.1.
    UniGenei Rn.14598.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000000576.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000000576 ; ENSRNOP00000000576 ; ENSRNOG00000000485 .
    GeneIDi 116502.
    KEGGi rno:116502.
    UCSCi RGD:621635. rat.

    Organism-specific databases

    CTDi 578.
    RGDi 621635. Bak1.

    Phylogenomic databases

    eggNOGi NOG145601.
    GeneTreei ENSGT00530000062935.
    HOGENOMi HOG000006521.
    HOVERGENi HBG002674.
    InParanoidi Q9JK59.
    KOi K14021.
    OMAi GDDINQR.
    OrthoDBi EOG70GMGD.
    TreeFami TF315834.

    Miscellaneous databases

    NextBioi 619109.
    PROi Q9JK59.

    Gene expression databases

    Genevestigatori Q9JK59.

    Family and domain databases

    InterProi IPR026308. BAK.
    IPR002475. Bcl2-like.
    IPR020717. Bcl2_BH1_motif_CS.
    IPR020726. Bcl2_BH2_motif_CS.
    IPR020728. Bcl2_BH3_motif_CS.
    IPR026298. Blc2_fam.
    [Graphical view ]
    PANTHERi PTHR11256. PTHR11256. 1 hit.
    PTHR11256:SF41. PTHR11256:SF41. 1 hit.
    Pfami PF00452. Bcl-2. 1 hit.
    [Graphical view ]
    PRINTSi PR01862. BCL2FAMILY.
    PROSITEi PS50062. BCL2_FAMILY. 1 hit.
    PS01080. BH1. 1 hit.
    PS01258. BH2. 1 hit.
    PS01259. BH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Bcl-2-related protein family gene expression during oligodendroglial differentiation."
      Itoh T., Itoh A., Pleasure D.
      J. Neurochem. 85:1500-1512(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Sprague-DawleyImported.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: SpleenImported.
    3. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    5. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    6. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiQ9JK59_RAT
    AccessioniPrimary (citable) accession number: Q9JK59
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2000
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3