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Protein

Mesogenin-1

Gene

Msgn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in specifying the paraxial, but not dorsal, mesoderm. May regulate the expression of T-box transcription factors required for mesoderm formation and differentiation.2 Publications

GO - Molecular functioni

  • chromatin binding Source: MGI
  • DNA binding Source: UniProtKB-KW
  • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding Source: MGI

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • segment specification Source: MGI
  • somitogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mesogenin-1
Alternative name(s):
Paraxial mesoderm-specific mesogenin1
pMesogenin1
Short name:
pMsgn1
Gene namesi
Name:Msgn1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1860483. Msgn1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mutant animals die during gestation. Premature death starts around 10.5 dpc. Severe morphological abnormalities, such as enlarged tailbud, kinked neural tube posterior to forelimb buds and reduced tissue mass in the interlimb domain become obvious at 9.0 dpc and thereafter. Head and anterior body structures, including the developing heart, appeared normal. In the trunk posterior to the forelimbs, there are no identifiable somites or segment patterning, although the anterior-most somites appeared normal, with decreases in somite size and disruption of myotomal patterning in somites 8-11. There are no detectable somites beyond somite 11. At 11.5 dpc, myotomes are absent from the trunk at the interlimb level and at 12.5 dpc, muscle is absent from the hindlimbs. The few fetuses surviving beyond 14.5 and 17.5 pdc lack a tail and show a grossly normal, but very thin body with relatively normal forelimbs and hindlimbs. At this stage, all vertebrae posterior to cervical level together with ribs are absent, while all cervical vertebrae are present, although the most posterior ones are sometimes malformed and fused. Other trunk skeletal structures that originate from lateral mesoderm, such as the sternum and scapula, form quite normally.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 188188Mesogenin-1PRO_0000330029Add
BLAST

Proteomic databases

PaxDbiQ9JK54.
PRIDEiQ9JK54.

PTM databases

iPTMnetiQ9JK54.
PhosphoSiteiQ9JK54.

Expressioni

Developmental stagei

Specifically expressed in unsegmented paraxial mesoderm and its immediate progenitors and sharply down-regulated in presumptive somites. Not detectable at 6.5 dpc. At 7.5 dpc, expressed mainly in the posterior region of the embryo, lateral to the primitive streak where presumptive progenitors of paraxial mesoderm reside. Expression is largely excluded from the midline of the primitive streak. No expression is detected in the anterior part of the embryo. At 9.0 dpc, highly expressed in the caudal presomitic mesoderm. At 11.5 dpc, the primitive streak completely regresses, expression is observed exclusively in the tailbud. Expression remains in the tailbud until 13.5 dpc and begins to disappear between 13.5 and 14.5 dpc when the tailbud loses its potential to provide paraxial mesoderm cells.1 Publication

Gene expression databases

BgeeiQ9JK54.
GenevisibleiQ9JK54. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055001.

Structurei

3D structure databases

ProteinModelPortaliQ9JK54.
SMRiQ9JK54. Positions 117-174.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini118 – 17255bHLHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4029. Eukaryota.
ENOG411227D. LUCA.
GeneTreeiENSGT00530000063712.
HOGENOMiHOG000070445.
HOVERGENiHBG105692.
InParanoidiQ9JK54.
KOiK09077.
OMAiSSWDWKN.
OrthoDBiEOG7P5T36.
PhylomeDBiQ9JK54.
TreeFamiTF325707.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JK54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNLGETFLS LEDGLDSSDT AGLLASWDWK SRARPLELVQ ESPTQSLSPA
60 70 80 90 100
PSLESYSEVA LPCGHSGAST GGSDGYGSHE AAGLVELDYS MLAFQPPYLH
110 120 130 140 150
TAGGLKGQKG SKVKMSVQRR RKASEREKLR MRTLADALHT LRNYLPPVYS
160 170 180
QRGQPLTKIQ TLKYTIKYIG ELTDLLNSSG REPRPQSV
Length:188
Mass (Da):20,553
Last modified:October 1, 2000 - v1
Checksum:iB31A67067630E322
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF261105 mRNA. Translation: AAF70375.1.
BC116996 mRNA. Translation: AAI16997.1.
CCDSiCCDS25814.1.
RefSeqiNP_062417.1. NM_019544.1.
UniGeneiMm.117113.

Genome annotation databases

EnsembliENSMUST00000049877; ENSMUSP00000055001; ENSMUSG00000047002.
GeneIDi56184.
KEGGimmu:56184.
UCSCiuc007nau.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF261105 mRNA. Translation: AAF70375.1.
BC116996 mRNA. Translation: AAI16997.1.
CCDSiCCDS25814.1.
RefSeqiNP_062417.1. NM_019544.1.
UniGeneiMm.117113.

3D structure databases

ProteinModelPortaliQ9JK54.
SMRiQ9JK54. Positions 117-174.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055001.

PTM databases

iPTMnetiQ9JK54.
PhosphoSiteiQ9JK54.

Proteomic databases

PaxDbiQ9JK54.
PRIDEiQ9JK54.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049877; ENSMUSP00000055001; ENSMUSG00000047002.
GeneIDi56184.
KEGGimmu:56184.
UCSCiuc007nau.1. mouse.

Organism-specific databases

CTDi343930.
MGIiMGI:1860483. Msgn1.

Phylogenomic databases

eggNOGiKOG4029. Eukaryota.
ENOG411227D. LUCA.
GeneTreeiENSGT00530000063712.
HOGENOMiHOG000070445.
HOVERGENiHBG105692.
InParanoidiQ9JK54.
KOiK09077.
OMAiSSWDWKN.
OrthoDBiEOG7P5T36.
PhylomeDBiQ9JK54.
TreeFamiTF325707.

Miscellaneous databases

PROiQ9JK54.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JK54.
GenevisibleiQ9JK54. MM.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The bHLH class protein pMesogenin1 can specify paraxial mesoderm phenotypes."
    Yoon J.K., Moon R.T., Wold B.
    Dev. Biol. 222:376-391(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "The bHLH regulator pMesogenin1 is required for maturation and segmentation of paraxial mesoderm."
    Yoon J.K., Wold B.
    Genes Dev. 14:3204-3214(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiMSGN1_MOUSE
AccessioniPrimary (citable) accession number: Q9JK54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.