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Protein

Prolargin

Gene

Prelp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May anchor basement membranes to the underlying connective tissue.By similarity

GO - Molecular functioni

GO - Biological processi

  • cell aging Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-2022854. Keratan sulfate biosynthesis.
R-MMU-2022857. Keratan sulfate degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Prolargin
Alternative name(s):
Proline-arginine-rich end leucine-rich repeat protein
Gene namesi
Name:Prelp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2151110. Prelp.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 378357ProlarginPRO_0000032745Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence analysis
Glycosylationi285 – 2851N-linked (GlcNAc...)Sequence analysis
Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence analysis
Glycosylationi323 – 3231N-linked (GlcNAc...)Sequence analysis
Disulfide bondi328 ↔ 369By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9JK53.
PaxDbiQ9JK53.
PRIDEiQ9JK53.

PTM databases

PhosphoSiteiQ9JK53.

Expressioni

Tissue specificityi

Expressed in cartilage throughout both fetal development and postnatal life. It is also expressed in the developing embryo prior to skeletogenesis. In adult, highest expression in lung, lower levels in cardiac and skeletal muscle.

Gene expression databases

BgeeiENSMUSG00000041577.
CleanExiMM_PRELP.
ExpressionAtlasiQ9JK53. baseline and differential.
GenevisibleiQ9JK53. MM.

Interactioni

Subunit structurei

Binds the basement membrane heparan sulfate proteoglycan perlecan and triple helical collagens type I and type II.By similarity

Protein-protein interaction databases

IntActiQ9JK53. 1 interaction.
MINTiMINT-4108557.
STRINGi10090.ENSMUSP00000048803.

Structurei

3D structure databases

ProteinModelPortaliQ9JK53.
SMRiQ9JK53. Positions 68-359.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati91 – 11020LRR 1Add
BLAST
Repeati111 – 13424LRR 2Add
BLAST
Repeati135 – 15824LRR 3Add
BLAST
Repeati159 – 17921LRR 4Add
BLAST
Repeati180 – 20324LRR 5Add
BLAST
Repeati204 – 22926LRR 6Add
BLAST
Repeati230 – 25021LRR 7Add
BLAST
Repeati251 – 27424LRR 8Add
BLAST
Repeati275 – 29925LRR 9Add
BLAST
Repeati300 – 31920LRR 10Add
BLAST
Repeati320 – 35839LRR 11Add
BLAST
Repeati359 – 37820LRR 12Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi69 – 8517Cys-richAdd
BLAST
Compositional biasi193 – 1986Poly-Leu

Domaini

The basic N-terminal Arg/Pro-rich binds heparin and heparan sulfate. Binds collagens type I and type II through its leucine-rich repeat domain (By similarity).By similarity

Sequence similaritiesi

Contains 12 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118969.
HOGENOMiHOG000234447.
HOVERGENiHBG108061.
InParanoidiQ9JK53.
KOiK08125.
OMAiRKMPPKV.
OrthoDBiEOG091G09Q0.
PhylomeDBiQ9JK53.
TreeFamiTF334562.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
IPR027216. Prolargin.
[Graphical view]
PANTHERiPTHR24373:SF152. PTHR24373:SF152. 1 hit.
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 8 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JK53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRASFFWLLP LLLILASVAQ GQPTRPKPGI RRKPKPRPTP RFPQAPEPAE
60 70 80 90 100
PTDLPPPLPP GPPSVFPDCP RECYCPPDFP SALYCDSRNL RRVPVIPPRI
110 120 130 140 150
HYLYLQNNFI TELPLESFQN ATGLRWVNLD NNRIRKVDQR VLGKLPSLAF
160 170 180 190 200
LYMEKNQLEE VPSALPRNLE QLRLSQNLIS RIPPGVFSKL ENLLLLDLQH
210 220 230 240 250
NRLSDGVFKA DTFQGLKNLM QLNLAHNILR KMPPKVPQAI HQLYLDSNKI
260 270 280 290 300
ETIPNGYFKD FPNLAFIRMN YNKLSDRGLP KNSFNISNLL VLHLSHNKIS
310 320 330 340 350
NVPAISNKLE HLYLNNNSIE KINGTQICPN NLVAFHDFSS DLENVPHLRY
360 370
LRLDGNFLKP PIPLDLMMCF RLLQSVVI
Length:378
Mass (Da):43,293
Last modified:June 1, 2001 - v2
Checksum:i81654FB9D5F55186
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF261888, AF261887 Genomic DNA. Translation: AAF72994.2.
BC019775 mRNA. Translation: AAH19775.1.
CCDSiCCDS15300.1.
RefSeqiNP_473418.3. NM_054077.4.
XP_006529147.1. XM_006529084.2.
XP_006529148.1. XM_006529085.2.
UniGeneiMm.214514.

Genome annotation databases

EnsembliENSMUST00000048432; ENSMUSP00000048803; ENSMUSG00000041577.
GeneIDi116847.
KEGGimmu:116847.
UCSCiuc007crc.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF261888, AF261887 Genomic DNA. Translation: AAF72994.2.
BC019775 mRNA. Translation: AAH19775.1.
CCDSiCCDS15300.1.
RefSeqiNP_473418.3. NM_054077.4.
XP_006529147.1. XM_006529084.2.
XP_006529148.1. XM_006529085.2.
UniGeneiMm.214514.

3D structure databases

ProteinModelPortaliQ9JK53.
SMRiQ9JK53. Positions 68-359.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JK53. 1 interaction.
MINTiMINT-4108557.
STRINGi10090.ENSMUSP00000048803.

PTM databases

PhosphoSiteiQ9JK53.

Proteomic databases

MaxQBiQ9JK53.
PaxDbiQ9JK53.
PRIDEiQ9JK53.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048432; ENSMUSP00000048803; ENSMUSG00000041577.
GeneIDi116847.
KEGGimmu:116847.
UCSCiuc007crc.3. mouse.

Organism-specific databases

CTDi5549.
MGIiMGI:2151110. Prelp.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118969.
HOGENOMiHOG000234447.
HOVERGENiHBG108061.
InParanoidiQ9JK53.
KOiK08125.
OMAiRKMPPKV.
OrthoDBiEOG091G09Q0.
PhylomeDBiQ9JK53.
TreeFamiTF334562.

Enzyme and pathway databases

ReactomeiR-MMU-2022854. Keratan sulfate biosynthesis.
R-MMU-2022857. Keratan sulfate degradation.

Miscellaneous databases

PROiQ9JK53.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041577.
CleanExiMM_PRELP.
ExpressionAtlasiQ9JK53. baseline and differential.
GenevisibleiQ9JK53. MM.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
IPR027216. Prolargin.
[Graphical view]
PANTHERiPTHR24373:SF152. PTHR24373:SF152. 1 hit.
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 8 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 10 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRELP_MOUSE
AccessioniPrimary (citable) accession number: Q9JK53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.