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Protein

High affinity copper uptake protein 1

Gene

Slc31a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

High-affinity, saturable copper transporter involved in dietary copper uptake.1 Publication

GO - Molecular functioni

  • copper ion transmembrane transporter activity Source: RGD
  • copper uptake transmembrane transporter activity Source: RGD

GO - Biological processi

  • cellular copper ion homeostasis Source: RGD
  • cellular response to cisplatin Source: RGD
  • copper ion import Source: RGD
  • copper ion import into cell Source: RGD
  • drug transmembrane transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Copper transport, Ion transport, Transport

Keywords - Ligandi

Copper

Enzyme and pathway databases

ReactomeiR-RNO-425410. Metal ion SLC transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity copper uptake protein 1
Alternative name(s):
Copper transporter 1
Short name:
rCTR1
Liver regeneration-related protein LRRGT00200
Solute carrier family 31 member 1
Gene namesi
Name:Slc31a1
Synonyms:Copt1, Ctr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi620059. Slc31a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6565ExtracellularSequence analysisAdd
BLAST
Transmembranei66 – 8621HelicalSequence analysisAdd
BLAST
Topological domaini87 – 12943CytoplasmicSequence analysisAdd
BLAST
Transmembranei130 – 15021HelicalSequence analysisAdd
BLAST
Topological domaini151 – 1533ExtracellularSequence analysis
Transmembranei154 – 17421HelicalSequence analysisAdd
BLAST
Topological domaini175 – 18713CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • late endosome Source: Ensembl
  • neuronal cell body Source: RGD
  • plasma membrane Source: RGD
  • recycling endosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 187187High affinity copper uptake protein 1PRO_0000195042Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi19 – 191N-linked (GlcNAc...)Sequence analysis
Glycosylationi30 – 301O-linked (GalNAc...)By similarity
Modified residuei111 – 1111PhosphothreonineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9JK41.
PRIDEiQ9JK41.

Expressioni

Gene expression databases

GenevisibleiQ9JK41. RN.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019544.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3386. Eukaryota.
ENOG4111I8D. LUCA.
GeneTreeiENSGT00530000063415.
HOGENOMiHOG000195393.
HOVERGENiHBG065767.
InParanoidiQ9JK41.
KOiK14686.
OMAiVGEVVHK.
OrthoDBiEOG7S220Q.
PhylomeDBiQ9JK41.

Family and domain databases

InterProiIPR007274. Cop_transporter.
[Graphical view]
PANTHERiPTHR12483. PTHR12483. 1 hit.
PfamiPF04145. Ctr. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JK41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRMNHMEMHH MGMNHTDDNI TMPPHQHPTT SASHSHEMMM PMTFYFGFKN
60 70 80 90 100
VDLLFSSLVI NTPGEMAGAF VAVFLLAMFY EGLKIAREGL LRKSQVSIRY
110 120 130 140 150
NSMPVPGPNG TILMETHKTV GQQMLSFPHL LQTVLHIIQV VISYFLMLIF
160 170 180
MTYNGYLCIA VAAGAGTGYF LFSWKKAVVV DITEHCH
Length:187
Mass (Da):21,129
Last modified:October 1, 2000 - v1
Checksum:i05CA4A45A543F5D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268030 mRNA. Translation: AAF72546.1.
AY539951 mRNA. Translation: AAS66291.1.
BC078745 mRNA. Translation: AAH78745.1.
RefSeqiNP_598284.1. NM_133600.1.
UniGeneiRn.2789.
Rn.95113.

Genome annotation databases

EnsembliENSRNOT00000019544; ENSRNOP00000019544; ENSRNOG00000014475.
GeneIDi171135.
KEGGirno:171135.
UCSCiRGD:620059. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268030 mRNA. Translation: AAF72546.1.
AY539951 mRNA. Translation: AAS66291.1.
BC078745 mRNA. Translation: AAH78745.1.
RefSeqiNP_598284.1. NM_133600.1.
UniGeneiRn.2789.
Rn.95113.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019544.

Proteomic databases

PaxDbiQ9JK41.
PRIDEiQ9JK41.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019544; ENSRNOP00000019544; ENSRNOG00000014475.
GeneIDi171135.
KEGGirno:171135.
UCSCiRGD:620059. rat.

Organism-specific databases

CTDi1317.
RGDi620059. Slc31a1.

Phylogenomic databases

eggNOGiKOG3386. Eukaryota.
ENOG4111I8D. LUCA.
GeneTreeiENSGT00530000063415.
HOGENOMiHOG000195393.
HOVERGENiHBG065767.
InParanoidiQ9JK41.
KOiK14686.
OMAiVGEVVHK.
OrthoDBiEOG7S220Q.
PhylomeDBiQ9JK41.

Enzyme and pathway databases

ReactomeiR-RNO-425410. Metal ion SLC transporters.

Miscellaneous databases

PROiQ9JK41.

Gene expression databases

GenevisibleiQ9JK41. RN.

Family and domain databases

InterProiIPR007274. Cop_transporter.
[Graphical view]
PANTHERiPTHR12483. PTHR12483. 1 hit.
PfamiPF04145. Ctr. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of rat copper transport protein 1."
    Chino H., Hiromura M., Sonoda T., Yasui H., Sakurai H.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. "Liver regeneration after PH."
    Xu C.S., Zhang L., Chang C.F., Han H.P., Wang G.P., Chai L.Q., Yuan J.Y., Yang K.J., Zhao L.F., Ma H., Wang L., Wang S.F., Xing X.K., Shen G.M., Shi J.B., Rahman S., Wang Q.N., Zhang J.B.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  4. "Ctr1 is an apical copper transporter in mammalian intestinal epithelial cells in vivo that is controlled at the level of protein stability."
    Nose Y., Wood L.K., Kim B.E., Prohaska J.R., Fry R.S., Spears J.W., Thiele D.J.
    J. Biol. Chem. 285:32385-32392(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiCOPT1_RAT
AccessioniPrimary (citable) accession number: Q9JK41
Secondary accession number(s): Q53YN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.