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Protein

High affinity copper uptake protein 1

Gene

Slc31a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

High-affinity, saturable copper transporter involved in dietary copper uptake.1 Publication

GO - Molecular functioni

  • copper ion transmembrane transporter activity Source: RGD
  • copper uptake transmembrane transporter activity Source: RGD

GO - Biological processi

  • cellular copper ion homeostasis Source: RGD
  • cellular response to cisplatin Source: RGD
  • copper ion import Source: RGD
  • copper ion import into cell Source: RGD
  • drug transmembrane transport Source: RGD

Keywordsi

Biological processCopper transport, Ion transport, Transport
LigandCopper

Enzyme and pathway databases

ReactomeiR-RNO-425410. Metal ion SLC transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity copper uptake protein 1
Alternative name(s):
Copper transporter 1
Short name:
rCTR1
Liver regeneration-related protein LRRGT00200
Solute carrier family 31 member 1
Gene namesi
Name:Slc31a1
Synonyms:Copt1, Ctr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi620059. Slc31a1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 65ExtracellularSequence analysisAdd BLAST65
Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Topological domaini87 – 129CytoplasmicSequence analysisAdd BLAST43
Transmembranei130 – 150HelicalSequence analysisAdd BLAST21
Topological domaini151 – 153ExtracellularSequence analysis3
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Topological domaini175 – 187CytoplasmicSequence analysisAdd BLAST13

GO - Cellular componenti

  • cytoplasm Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • late endosome Source: Ensembl
  • neuronal cell body Source: RGD
  • plasma membrane Source: RGD
  • recycling endosome Source: Ensembl

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001950421 – 187High affinity copper uptake protein 1Add BLAST187

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi19N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi30O-linked (GalNAc...) threonineBy similarity1
Modified residuei111PhosphothreonineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9JK41.
PRIDEiQ9JK41.

PTM databases

PhosphoSitePlusiQ9JK41.

Expressioni

Gene expression databases

BgeeiENSRNOG00000014475.
GenevisibleiQ9JK41. RN.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019544.

Structurei

3D structure databases

SMRiQ9JK41.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3386. Eukaryota.
ENOG4111I8D. LUCA.
GeneTreeiENSGT00530000063415.
HOGENOMiHOG000195393.
HOVERGENiHBG065767.
InParanoidiQ9JK41.
KOiK14686.
OMAiVGEVVHK.
OrthoDBiEOG091G0VVR.
PhylomeDBiQ9JK41.

Family and domain databases

InterProiView protein in InterPro
IPR007274. Cop_transporter.
PANTHERiPTHR12483. PTHR12483. 1 hit.
PfamiView protein in Pfam
PF04145. Ctr. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9JK41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRMNHMEMHH MGMNHTDDNI TMPPHQHPTT SASHSHEMMM PMTFYFGFKN
60 70 80 90 100
VDLLFSSLVI NTPGEMAGAF VAVFLLAMFY EGLKIAREGL LRKSQVSIRY
110 120 130 140 150
NSMPVPGPNG TILMETHKTV GQQMLSFPHL LQTVLHIIQV VISYFLMLIF
160 170 180
MTYNGYLCIA VAAGAGTGYF LFSWKKAVVV DITEHCH
Length:187
Mass (Da):21,129
Last modified:October 1, 2000 - v1
Checksum:i05CA4A45A543F5D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268030 mRNA. Translation: AAF72546.1.
AY539951 mRNA. Translation: AAS66291.1.
BC078745 mRNA. Translation: AAH78745.1.
RefSeqiNP_598284.1. NM_133600.1.
UniGeneiRn.2789.
Rn.95113.

Genome annotation databases

EnsembliENSRNOT00000019544; ENSRNOP00000019544; ENSRNOG00000014475.
GeneIDi171135.
KEGGirno:171135.
UCSCiRGD:620059. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268030 mRNA. Translation: AAF72546.1.
AY539951 mRNA. Translation: AAS66291.1.
BC078745 mRNA. Translation: AAH78745.1.
RefSeqiNP_598284.1. NM_133600.1.
UniGeneiRn.2789.
Rn.95113.

3D structure databases

SMRiQ9JK41.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019544.

PTM databases

PhosphoSitePlusiQ9JK41.

Proteomic databases

PaxDbiQ9JK41.
PRIDEiQ9JK41.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019544; ENSRNOP00000019544; ENSRNOG00000014475.
GeneIDi171135.
KEGGirno:171135.
UCSCiRGD:620059. rat.

Organism-specific databases

CTDi1317.
RGDi620059. Slc31a1.

Phylogenomic databases

eggNOGiKOG3386. Eukaryota.
ENOG4111I8D. LUCA.
GeneTreeiENSGT00530000063415.
HOGENOMiHOG000195393.
HOVERGENiHBG065767.
InParanoidiQ9JK41.
KOiK14686.
OMAiVGEVVHK.
OrthoDBiEOG091G0VVR.
PhylomeDBiQ9JK41.

Enzyme and pathway databases

ReactomeiR-RNO-425410. Metal ion SLC transporters.

Miscellaneous databases

PROiPR:Q9JK41.

Gene expression databases

BgeeiENSRNOG00000014475.
GenevisibleiQ9JK41. RN.

Family and domain databases

InterProiView protein in InterPro
IPR007274. Cop_transporter.
PANTHERiPTHR12483. PTHR12483. 1 hit.
PfamiView protein in Pfam
PF04145. Ctr. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOPT1_RAT
AccessioniPrimary (citable) accession number: Q9JK41
Secondary accession number(s): Q53YN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: May 10, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.