Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glucosamine 6-phosphate N-acetyltransferase

Gene

Gnpnat1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Acetyl-CoA + D-glucosamine 6-phosphate = CoA + N-acetyl-D-glucosamine 6-phosphate.By similarity

Pathwayi: UDP-N-acetyl-alpha-D-glucosamine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I).
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glucosamine 6-phosphate N-acetyltransferase (Gnpnat1)
  2. Phosphoacetylglucosamine mutase (Pgm3), Phosphoacetylglucosamine mutase (Pgm3), Phosphoacetylglucosamine mutase (Pgm3), Phosphoacetylglucosamine mutase (Pgm3), Phosphoacetylglucosamine mutase (Pgm3), Phosphoacetylglucosamine mutase (Pgm3)
This subpathway is part of the pathway UDP-N-acetyl-alpha-D-glucosamine biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I), the pathway UDP-N-acetyl-alpha-D-glucosamine biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei61SubstrateBy similarity1
Binding sitei175SubstrateBy similarity1
Binding sitei181SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-13176
BRENDAi2.3.1.4 3474
ReactomeiR-MMU-446210 Synthesis of UDP-N-acetyl-glucosamine
SABIO-RKiQ9JK38
UniPathwayiUPA00113; UER00529

Names & Taxonomyi

Protein namesi
Recommended name:
Glucosamine 6-phosphate N-acetyltransferase (EC:2.3.1.4By similarity)
Alternative name(s):
Phosphoglucosamine acetylase
Phosphoglucosamine transacetylase
Protein EMeg32
Gene namesi
Name:Gnpnat1
Synonyms:Gna1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1858963 Gnpnat1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000745541 – 184Glucosamine 6-phosphate N-acetyltransferaseAdd BLAST184

Proteomic databases

EPDiQ9JK38
MaxQBiQ9JK38
PaxDbiQ9JK38
PeptideAtlasiQ9JK38
PRIDEiQ9JK38

PTM databases

iPTMnetiQ9JK38
PhosphoSitePlusiQ9JK38
SwissPalmiQ9JK38

Expressioni

Tissue specificityi

Ubiquitous. Shows a strong differential expression pattern in adult hematopoietic precursor cells.1 Publication

Developmental stagei

Widely expressed at early stages of embryonic development but is confined to bones, skin and the hematopoietic system at later developmental stages.1 Publication

Gene expression databases

BgeeiENSMUSG00000037722
CleanExiMM_GNPNAT1
GenevisibleiQ9JK38 MM

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi2076159 interactors.
IntActiQ9JK38 10 interactors.
STRINGi10090.ENSMUSP00000042860

Structurei

3D structure databases

ProteinModelPortaliQ9JK38
SMRiQ9JK38
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 184N-acetyltransferasePROSITE-ProRule annotationAdd BLAST146

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni108 – 111Substrate bindingBy similarity4
Regioni120 – 122Substrate bindingBy similarity3
Regioni130 – 135Acetyl-CoA bindingBy similarity6
Regioni151 – 152Substrate bindingBy similarity2
Regioni165 – 167Acetyl-CoA bindingBy similarity3

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3396 Eukaryota
COG0454 LUCA
GeneTreeiENSGT00390000008666
HOGENOMiHOG000106325
HOVERGENiHBG048986
InParanoidiQ9JK38
KOiK00621
OMAiVGCYKSI
OrthoDBiEOG091G0EMF
PhylomeDBiQ9JK38
TreeFamiTF313790

Family and domain databases

InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR000182 GNAT_dom
PfamiView protein in Pfam
PF00583 Acetyltransf_1, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS51186 GNAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JK38-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPDETPMFD PSLLKEVDWS QNTAIFSPAI SPTHPGEGLV LRPLCTADLN
60 70 80 90 100
KGFFKVLGQL TETGVVSPEQ FMKSFEHMKK SGDYYVTVVE DVTLGQIVAT
110 120 130 140 150
ATLIIEHKFI HSCAKRGRVE DVVVSDECRG KQLGKLLLST LTLLSKKLNC
160 170 180
YKITLECLPQ NVGFYKKFDY TVSEENYMCR RFLK
Length:184
Mass (Da):20,791
Last modified:October 1, 2000 - v1
Checksum:iC455BF12027BD8A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001006 mRNA Translation: CAA04463.1
AK018499 mRNA Translation: BAB31241.1
AK002466 mRNA Translation: BAB22120.1
AK007647 mRNA Translation: BAB25161.1
AK007722 mRNA Translation: BAB25212.1
AK007764 mRNA Translation: BAB25240.1
AK008566 mRNA Translation: BAB25749.1
AK011098 mRNA Translation: BAB27395.1
BC031116 mRNA Translation: AAH31116.1
CCDSiCCDS26976.1
RefSeqiNP_062298.1, NM_019425.2
XP_006519338.1, XM_006519275.2
XP_006519339.1, XM_006519276.3
UniGeneiMm.312945

Genome annotation databases

EnsembliENSMUST00000046191; ENSMUSP00000042860; ENSMUSG00000037722
ENSMUST00000227468; ENSMUSP00000154084; ENSMUSG00000037722
GeneIDi54342
KEGGimmu:54342
UCSCiuc007tgp.1 mouse

Similar proteinsi

Entry informationi

Entry nameiGNA1_MOUSE
AccessioniPrimary (citable) accession number: Q9JK38
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2000
Last modified: February 28, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome