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Q9JK37 (MYOZ1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myozenin-1
Alternative name(s):
Calsarcin-2
Filamin-, actinin- and telethonin-binding protein
Protein FATZ
Gene names
Name:Myoz1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length296 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. Ref.1 Ref.2

Subunit structure

Interacts with ACTN2, ACTN3, FLNA, FLNB, FLNC, LDB3, PPP3CA and TCAP. Interacts via its C-terminal region with MYOT. Ref.2 UniProtKB Q9NP98

Subcellular location

Nucleus By similarity. Cell projectionpseudopodium By similarity. Note: Localized to the nucleus and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2, FLNC and MYOT at the Z-lines of skeletal muscle By similarity.

Tissue specificity

Expressed primarily in skeletal muscle and specifically enriched in the gastrocnemius, which is composed predominantly of fast-twitch muscle fibers. Detected at lower levels in heart. Ref.1 Ref.2

Developmental stage

At E9.5, expressed at significant levels in cardiac muscle with lower levels detected in skeletal muscle of tongue. At E15.5, cardiac expression is down-regulated and only weakly detected in atria, whereas skeletal muscle expression is more robust. Ref.2

Sequence similarities

Belongs to the myozenin family.

Ontologies

Keywords
   Cellular componentCell projection
Nucleus
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentactin cytoskeleton

Inferred from direct assay Ref.2. Source: MGI

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

pseudopodium

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotein binding

Inferred from physical interaction Ref.2. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 296296Myozenin-1
PRO_0000111096

Regions

Compositional bias95 – 17278Gly-rich

Experimental info

Sequence conflict1001T → A in BAB26059. Ref.3
Sequence conflict1311Q → H in BAC31092. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9JK37 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: E9D16F4723B1EE83

FASTA29631,457
        10         20         30         40         50         60 
MPLSGTPAPN KRRKSSKLIM ELTGGGRESS GLNLGKKISV PRDVMLEELS LLTNRGSKMF 

        70         80         90        100        110        120 
KLRQMRVEKF IYENHPDVFS DSSMDHFQKF LPTVGGQLET AGQGFSYGKG SSGGQAGSSG 

       130        140        150        160        170        180 
SAGQYGSDRH QQGSGFGAGG SGGPGGQAGG GGAPGTVGLG EPGSGDQAGG DGKHVTVFKT 

       190        200        210        220        230        240 
YISPWDRAMG VDPQQKVELG IDLLAYGAKA ELPKYKSFNR TAMPYGGYEK ASKRMTFQMP 

       250        260        270        280        290 
KFDLGPLLSE PLVLYNQNLS NRPSFNRTPI PWLSSGEHVD YNVDVGIPLD GETEEL 

« Hide

References

« Hide 'large scale' references
[1]"FATZ, a filamin-, actinin-, and telethonin-binding protein of the Z-disc of skeletal muscle."
Faulkner G., Pallavicini A., Comelli A., Salamon M., Bortoletto G., Ievolella C., Trevisan S., Kojic' S., Dalla Vecchia F., Laveder P., Valle G., Lanfranchi G.
J. Biol. Chem. 275:41234-41242(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Diaphragm.
[2]"Calsarcins, a novel family of sarcomeric calcineurin-binding proteins."
Frey N., Richardson J.A., Olson E.N.
Proc. Natl. Acad. Sci. U.S.A. 97:14632-14637(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH PPP3CA, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Thymus and Tongue.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ005620 mRNA. Translation: CAB76836.1.
AY013298 mRNA. Translation: AAG38941.1.
AK009077 mRNA. Translation: BAB26059.1.
AK041896 mRNA. Translation: BAC31092.1.
BC024660 mRNA. Translation: AAH24660.1.
CCDSCCDS36819.1.
RefSeqNP_067483.1. NM_021508.3.
UniGeneMm.439911.

3D structure databases

ProteinModelPortalQ9JK37.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9JK37.

Proteomic databases

MaxQBQ9JK37.
PRIDEQ9JK37.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000090469; ENSMUSP00000087955; ENSMUSG00000068697.
GeneID59011.
KEGGmmu:59011.
UCSCuc007skd.1. mouse.

Organism-specific databases

CTD58529.
MGIMGI:1929471. Myoz1.

Phylogenomic databases

eggNOGNOG79996.
GeneTreeENSGT00530000063184.
HOGENOMHOG000030910.
HOVERGENHBG071289.
InParanoidQ9JK37.
OMAMPKFDLG.
OrthoDBEOG7B31NQ.
PhylomeDBQ9JK37.
TreeFamTF331748.

Gene expression databases

BgeeQ9JK37.
CleanExMM_MYOZ1.
GenevestigatorQ9JK37.

Family and domain databases

InterProIPR008438. MYOZ.
[Graphical view]
PANTHERPTHR15941. PTHR15941. 1 hit.
PfamPF05556. Calsarcin. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMYOZ1. mouse.
NextBio314556.
PROQ9JK37.
SOURCESearch...

Entry information

Entry nameMYOZ1_MOUSE
AccessionPrimary (citable) accession number: Q9JK37
Secondary accession number(s): Q8C9L3, Q9D7N4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot