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Q9JK37

- MYOZ1_MOUSE

UniProt

Q9JK37 - MYOZ1_MOUSE

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Protein
Myozenin-1
Gene
Myoz1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.2 Publications

GO - Molecular functioni

  1. protein binding Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Myozenin-1
Alternative name(s):
Calsarcin-2
Filamin-, actinin- and telethonin-binding protein
Protein FATZ
Gene namesi
Name:Myoz1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1929471. Myoz1.

Subcellular locationi

Nucleus By similarity. Cell projectionpseudopodium By similarity
Note: Localized to the nucleus and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2, FLNC and MYOT at the Z-lines of skeletal muscle By similarity.

GO - Cellular componenti

  1. actin cytoskeleton Source: MGI
  2. nucleus Source: UniProtKB-SubCell
  3. pseudopodium Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 296296Myozenin-1
PRO_0000111096Add
BLAST

Proteomic databases

MaxQBiQ9JK37.
PRIDEiQ9JK37.

PTM databases

PhosphoSiteiQ9JK37.

Expressioni

Tissue specificityi

Expressed primarily in skeletal muscle and specifically enriched in the gastrocnemius, which is composed predominantly of fast-twitch muscle fibers. Detected at lower levels in heart.2 Publications

Developmental stagei

At E9.5, expressed at significant levels in cardiac muscle with lower levels detected in skeletal muscle of tongue. At E15.5, cardiac expression is down-regulated and only weakly detected in atria, whereas skeletal muscle expression is more robust.1 Publication

Gene expression databases

BgeeiQ9JK37.
CleanExiMM_MYOZ1.
GenevestigatoriQ9JK37.

Interactioni

Subunit structurei

Interacts with ACTN2, ACTN3, FLNA, FLNB, FLNC, LDB3, PPP3CA and TCAP. Interacts via its C-terminal region with MYOT.By similarity1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9JK37.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi95 – 17278Gly-rich
Add
BLAST

Sequence similaritiesi

Belongs to the myozenin family.

Phylogenomic databases

eggNOGiNOG79996.
GeneTreeiENSGT00530000063184.
HOGENOMiHOG000030910.
HOVERGENiHBG071289.
InParanoidiQ9JK37.
OMAiMPKFDLG.
OrthoDBiEOG7B31NQ.
PhylomeDBiQ9JK37.
TreeFamiTF331748.

Family and domain databases

InterProiIPR008438. MYOZ.
[Graphical view]
PANTHERiPTHR15941. PTHR15941. 1 hit.
PfamiPF05556. Calsarcin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JK37-1 [UniParc]FASTAAdd to Basket

« Hide

MPLSGTPAPN KRRKSSKLIM ELTGGGRESS GLNLGKKISV PRDVMLEELS    50
LLTNRGSKMF KLRQMRVEKF IYENHPDVFS DSSMDHFQKF LPTVGGQLET 100
AGQGFSYGKG SSGGQAGSSG SAGQYGSDRH QQGSGFGAGG SGGPGGQAGG 150
GGAPGTVGLG EPGSGDQAGG DGKHVTVFKT YISPWDRAMG VDPQQKVELG 200
IDLLAYGAKA ELPKYKSFNR TAMPYGGYEK ASKRMTFQMP KFDLGPLLSE 250
PLVLYNQNLS NRPSFNRTPI PWLSSGEHVD YNVDVGIPLD GETEEL 296
Length:296
Mass (Da):31,457
Last modified:October 1, 2000 - v1
Checksum:iE9D16F4723B1EE83
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti100 – 1001T → A in BAB26059. 1 Publication
Sequence conflicti131 – 1311Q → H in BAC31092. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ005620 mRNA. Translation: CAB76836.1.
AY013298 mRNA. Translation: AAG38941.1.
AK009077 mRNA. Translation: BAB26059.1.
AK041896 mRNA. Translation: BAC31092.1.
BC024660 mRNA. Translation: AAH24660.1.
CCDSiCCDS36819.1.
RefSeqiNP_067483.1. NM_021508.3.
UniGeneiMm.439911.

Genome annotation databases

EnsembliENSMUST00000090469; ENSMUSP00000087955; ENSMUSG00000068697.
GeneIDi59011.
KEGGimmu:59011.
UCSCiuc007skd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ005620 mRNA. Translation: CAB76836.1 .
AY013298 mRNA. Translation: AAG38941.1 .
AK009077 mRNA. Translation: BAB26059.1 .
AK041896 mRNA. Translation: BAC31092.1 .
BC024660 mRNA. Translation: AAH24660.1 .
CCDSi CCDS36819.1.
RefSeqi NP_067483.1. NM_021508.3.
UniGenei Mm.439911.

3D structure databases

ProteinModelPortali Q9JK37.
ModBasei Search...

PTM databases

PhosphoSitei Q9JK37.

Proteomic databases

MaxQBi Q9JK37.
PRIDEi Q9JK37.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000090469 ; ENSMUSP00000087955 ; ENSMUSG00000068697 .
GeneIDi 59011.
KEGGi mmu:59011.
UCSCi uc007skd.1. mouse.

Organism-specific databases

CTDi 58529.
MGIi MGI:1929471. Myoz1.

Phylogenomic databases

eggNOGi NOG79996.
GeneTreei ENSGT00530000063184.
HOGENOMi HOG000030910.
HOVERGENi HBG071289.
InParanoidi Q9JK37.
OMAi MPKFDLG.
OrthoDBi EOG7B31NQ.
PhylomeDBi Q9JK37.
TreeFami TF331748.

Miscellaneous databases

ChiTaRSi MYOZ1. mouse.
NextBioi 314556.
PROi Q9JK37.
SOURCEi Search...

Gene expression databases

Bgeei Q9JK37.
CleanExi MM_MYOZ1.
Genevestigatori Q9JK37.

Family and domain databases

InterProi IPR008438. MYOZ.
[Graphical view ]
PANTHERi PTHR15941. PTHR15941. 1 hit.
Pfami PF05556. Calsarcin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Diaphragm.
  2. "Calsarcins, a novel family of sarcomeric calcineurin-binding proteins."
    Frey N., Richardson J.A., Olson E.N.
    Proc. Natl. Acad. Sci. U.S.A. 97:14632-14637(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH PPP3CA, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus and Tongue.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiMYOZ1_MOUSE
AccessioniPrimary (citable) accession number: Q9JK37
Secondary accession number(s): Q8C9L3, Q9D7N4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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