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Q9JK37

- MYOZ1_MOUSE

UniProt

Q9JK37 - MYOZ1_MOUSE

Protein

Myozenin-1

Gene

Myoz1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.2 PublicationsCurated

    GO - Molecular functioni

    1. protein binding Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myozenin-1
    Alternative name(s):
    Calsarcin-2
    Filamin-, actinin- and telethonin-binding protein
    Protein FATZ
    Gene namesi
    Name:Myoz1Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1929471. Myoz1.

    Subcellular locationi

    Nucleus By similarity. Cell projectionpseudopodium By similarity
    Note: Localized to the nucleus and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2, FLNC and MYOT at the Z-lines of skeletal muscle By similarity.By similarity

    GO - Cellular componenti

    1. actin cytoskeleton Source: MGI
    2. nucleus Source: UniProtKB-SubCell
    3. pseudopodium Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell projection, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 296296Myozenin-1PRO_0000111096Add
    BLAST

    Proteomic databases

    MaxQBiQ9JK37.
    PRIDEiQ9JK37.

    PTM databases

    PhosphoSiteiQ9JK37.

    Expressioni

    Tissue specificityi

    Expressed primarily in skeletal muscle and specifically enriched in the gastrocnemius, which is composed predominantly of fast-twitch muscle fibers. Detected at lower levels in heart.2 Publications

    Developmental stagei

    At E9.5, expressed at significant levels in cardiac muscle with lower levels detected in skeletal muscle of tongue. At E15.5, cardiac expression is down-regulated and only weakly detected in atria, whereas skeletal muscle expression is more robust.1 Publication

    Gene expression databases

    BgeeiQ9JK37.
    CleanExiMM_MYOZ1.
    GenevestigatoriQ9JK37.

    Interactioni

    Subunit structurei

    Interacts with ACTN2, ACTN3, FLNA, FLNB, FLNC, LDB3, PPP3CA and TCAP. Interacts via its C-terminal region with MYOT.By similarity1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JK37.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi95 – 17278Gly-richSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the myozenin family.Curated

    Phylogenomic databases

    eggNOGiNOG79996.
    GeneTreeiENSGT00530000063184.
    HOGENOMiHOG000030910.
    HOVERGENiHBG071289.
    InParanoidiQ9JK37.
    OMAiMPKFDLG.
    OrthoDBiEOG7B31NQ.
    PhylomeDBiQ9JK37.
    TreeFamiTF331748.

    Family and domain databases

    InterProiIPR008438. MYOZ.
    [Graphical view]
    PANTHERiPTHR15941. PTHR15941. 1 hit.
    PfamiPF05556. Calsarcin. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JK37-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLSGTPAPN KRRKSSKLIM ELTGGGRESS GLNLGKKISV PRDVMLEELS    50
    LLTNRGSKMF KLRQMRVEKF IYENHPDVFS DSSMDHFQKF LPTVGGQLET 100
    AGQGFSYGKG SSGGQAGSSG SAGQYGSDRH QQGSGFGAGG SGGPGGQAGG 150
    GGAPGTVGLG EPGSGDQAGG DGKHVTVFKT YISPWDRAMG VDPQQKVELG 200
    IDLLAYGAKA ELPKYKSFNR TAMPYGGYEK ASKRMTFQMP KFDLGPLLSE 250
    PLVLYNQNLS NRPSFNRTPI PWLSSGEHVD YNVDVGIPLD GETEEL 296
    Length:296
    Mass (Da):31,457
    Last modified:October 1, 2000 - v1
    Checksum:iE9D16F4723B1EE83
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti100 – 1001T → A in BAB26059. (PubMed:16141072)Curated
    Sequence conflicti131 – 1311Q → H in BAC31092. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ005620 mRNA. Translation: CAB76836.1.
    AY013298 mRNA. Translation: AAG38941.1.
    AK009077 mRNA. Translation: BAB26059.1.
    AK041896 mRNA. Translation: BAC31092.1.
    BC024660 mRNA. Translation: AAH24660.1.
    CCDSiCCDS36819.1.
    RefSeqiNP_067483.1. NM_021508.3.
    UniGeneiMm.439911.

    Genome annotation databases

    EnsembliENSMUST00000090469; ENSMUSP00000087955; ENSMUSG00000068697.
    GeneIDi59011.
    KEGGimmu:59011.
    UCSCiuc007skd.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ005620 mRNA. Translation: CAB76836.1 .
    AY013298 mRNA. Translation: AAG38941.1 .
    AK009077 mRNA. Translation: BAB26059.1 .
    AK041896 mRNA. Translation: BAC31092.1 .
    BC024660 mRNA. Translation: AAH24660.1 .
    CCDSi CCDS36819.1.
    RefSeqi NP_067483.1. NM_021508.3.
    UniGenei Mm.439911.

    3D structure databases

    ProteinModelPortali Q9JK37.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9JK37.

    Proteomic databases

    MaxQBi Q9JK37.
    PRIDEi Q9JK37.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000090469 ; ENSMUSP00000087955 ; ENSMUSG00000068697 .
    GeneIDi 59011.
    KEGGi mmu:59011.
    UCSCi uc007skd.1. mouse.

    Organism-specific databases

    CTDi 58529.
    MGIi MGI:1929471. Myoz1.

    Phylogenomic databases

    eggNOGi NOG79996.
    GeneTreei ENSGT00530000063184.
    HOGENOMi HOG000030910.
    HOVERGENi HBG071289.
    InParanoidi Q9JK37.
    OMAi MPKFDLG.
    OrthoDBi EOG7B31NQ.
    PhylomeDBi Q9JK37.
    TreeFami TF331748.

    Miscellaneous databases

    ChiTaRSi MYOZ1. mouse.
    NextBioi 314556.
    PROi Q9JK37.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9JK37.
    CleanExi MM_MYOZ1.
    Genevestigatori Q9JK37.

    Family and domain databases

    InterProi IPR008438. MYOZ.
    [Graphical view ]
    PANTHERi PTHR15941. PTHR15941. 1 hit.
    Pfami PF05556. Calsarcin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: DiaphragmImported.
    2. "Calsarcins, a novel family of sarcomeric calcineurin-binding proteins."
      Frey N., Richardson J.A., Olson E.N.
      Proc. Natl. Acad. Sci. U.S.A. 97:14632-14637(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH PPP3CA, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6JImported.
      Tissue: ThymusImported and TongueImported.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/NImported.
      Tissue: Mammary glandImported.

    Entry informationi

    Entry nameiMYOZ1_MOUSE
    AccessioniPrimary (citable) accession number: Q9JK37
    Secondary accession number(s): Q8C9L3, Q9D7N4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3