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Q9JK30

- ORC3_MOUSE

UniProt

Q9JK30 - ORC3_MOUSE

Protein

Origin recognition complex subunit 3

Gene

Orc3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication By similarity. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. DNA replication Source: MGI
    2. neural precursor cell proliferation Source: MGI

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_204269. E2F-enabled inhibition of pre-replication complex formation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Origin recognition complex subunit 3
    Alternative name(s):
    Origin recognition complex subunit Latheo
    Gene namesi
    Name:Orc3
    Synonyms:Orc3l
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1354944. Orc3.

    Subcellular locationi

    GO - Cellular componenti

    1. nuclear origin of replication recognition complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 715715Origin recognition complex subunit 3PRO_0000127084Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei523 – 5231PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9JK30.
    PRIDEiQ9JK30.

    PTM databases

    PhosphoSiteiQ9JK30.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9JK30.
    BgeeiQ9JK30.
    GenevestigatoriQ9JK30.

    Interactioni

    Subunit structurei

    Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase By similarity.By similarity

    Protein-protein interaction databases

    BioGridi206124. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JK30.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ORC3 family.Curated

    Phylogenomic databases

    eggNOGiNOG296366.
    GeneTreeiENSGT00390000011376.
    HOGENOMiHOG000047785.
    HOVERGENiHBG007599.
    InParanoidiQ9JK30.
    KOiK02605.
    OMAiCFVFKPN.
    OrthoDBiEOG78PV8B.
    PhylomeDBiQ9JK30.
    TreeFamiTF101093.

    Family and domain databases

    InterProiIPR016024. ARM-type_fold.
    IPR020795. ORC3.
    [Graphical view]
    PANTHERiPTHR12748. PTHR12748. 1 hit.
    PfamiPF07034. ORC3_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 4 hits.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9JK30-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MHTGPRTMAT SSVSKGCFVF KPDFKKRKVF VPIEDYFNNE ELDSEDSKLR    50
    FETYSLLWQR MKSETEQLQE ELNENLFDNL VDFLQKSHPE FQKNSRDWGS 100
    QMKFREIPTA ALILGVNVTD HDVILRSLTE TLQNNVTPYV VSLQAKDCPD 150
    VKHFLQKFTS QLMDCCVDRH SKEVTSGKAL KKTNYSMDSL CSWYSAVTQK 200
    ADHKVTIKKR TASGHWRSPP VVLILKSMES FTSKVLQDFI TISSQHLHEF 250
    PLILIFGIAT SPVIIHRLLP HSVSSLLCVE LFQSLSCEQH LTVVLDKLLL 300
    TPQFPFKLSK KALQVLTNIF LYHDFSIQSF IKGIKLSLLE HFYSQPLSVL 350
    CCDLSEAKKR VNVFSVSQCE NIRRLPSFRR YVENQPLGKQ VALLTNETFL 400
    KEKTQSLLED LHVYHINYFL VLRCLHNFTS SLPKYPLGRQ IRELYCTCLE 450
    KKIWDSEEYK SALQLLRMLA KDELVSILQR CIEVLDSSTE KQLGNTTQKI 500
    KDFLTQFQNL DADSKEEEDA CGSQPKGLQK TDLYHLQKSL LEMKELRRTK 550
    KPTKFEMLRE NVMNFIDNLV RDYLLPPESQ PLHEVVYFSA ANTLREHLNA 600
    APRIALHTAL NNPYYYLKNE ELEGCIPNTA PDICIAYKLH LECSLLINLV 650
    DWAEAFATVV TAAEKMDANS TVSEEMSEVI HARFIRAVSE LELLGFIKPT 700
    KQKTDHVARL TWGGC 715
    Length:715
    Mass (Da):82,342
    Last modified:October 1, 2000 - v1
    Checksum:i1E915A719A2E33EB
    GO
    Isoform 2 (identifier: Q9JK30-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         512-512: Missing.

    Note: Contains a phosphoserine at position 522.

    Show »
    Length:714
    Mass (Da):82,271
    Checksum:i13E9EDC7B01D1C7E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti114 – 1141L → F in BAC39695. (PubMed:16141072)Curated
    Sequence conflicti212 – 2121A → P in BAD91665. (PubMed:15634681)Curated
    Sequence conflicti212 – 2121A → P in AAH61252. (PubMed:15489334)Curated
    Sequence conflicti360 – 3601R → G in BAC32339. (PubMed:16141072)Curated
    Sequence conflicti645 – 6451L → R in BAD91665. (PubMed:15634681)Curated
    Sequence conflicti645 – 6451L → R in AAH61252. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei512 – 5121Missing in isoform 2. 2 PublicationsVSP_026407

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ132830 mRNA. Translation: CAB76399.1.
    AB190257 mRNA. Translation: BAD91665.2.
    AK045388 mRNA. Translation: BAC32339.1.
    AK086579 mRNA. Translation: BAC39695.1.
    AL807397, AL928738 Genomic DNA. Translation: CAM16474.1.
    AL807397, AL928738 Genomic DNA. Translation: CAM16475.1.
    AL928738, AL807397 Genomic DNA. Translation: CAM26869.1.
    AL928738, AL807397 Genomic DNA. Translation: CAM26870.1.
    BC061252 mRNA. Translation: AAH61252.1.
    CCDSiCCDS18028.1. [Q9JK30-1]
    CCDS51137.1. [Q9JK30-2]
    RefSeqiNP_001153035.1. NM_001159563.1. [Q9JK30-2]
    NP_056639.3. NM_015824.4. [Q9JK30-1]
    UniGeneiMm.399624.

    Genome annotation databases

    EnsembliENSMUST00000048706; ENSMUSP00000048319; ENSMUSG00000040044. [Q9JK30-1]
    ENSMUST00000108142; ENSMUSP00000103777; ENSMUSG00000040044. [Q9JK30-2]
    GeneIDi50793.
    KEGGimmu:50793.
    UCSCiuc008sgb.2. mouse. [Q9JK30-1]
    uc008sgd.1. mouse. [Q9JK30-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ132830 mRNA. Translation: CAB76399.1 .
    AB190257 mRNA. Translation: BAD91665.2 .
    AK045388 mRNA. Translation: BAC32339.1 .
    AK086579 mRNA. Translation: BAC39695.1 .
    AL807397 , AL928738 Genomic DNA. Translation: CAM16474.1 .
    AL807397 , AL928738 Genomic DNA. Translation: CAM16475.1 .
    AL928738 , AL807397 Genomic DNA. Translation: CAM26869.1 .
    AL928738 , AL807397 Genomic DNA. Translation: CAM26870.1 .
    BC061252 mRNA. Translation: AAH61252.1 .
    CCDSi CCDS18028.1. [Q9JK30-1 ]
    CCDS51137.1. [Q9JK30-2 ]
    RefSeqi NP_001153035.1. NM_001159563.1. [Q9JK30-2 ]
    NP_056639.3. NM_015824.4. [Q9JK30-1 ]
    UniGenei Mm.399624.

    3D structure databases

    ProteinModelPortali Q9JK30.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 206124. 1 interaction.

    PTM databases

    PhosphoSitei Q9JK30.

    Proteomic databases

    PaxDbi Q9JK30.
    PRIDEi Q9JK30.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000048706 ; ENSMUSP00000048319 ; ENSMUSG00000040044 . [Q9JK30-1 ]
    ENSMUST00000108142 ; ENSMUSP00000103777 ; ENSMUSG00000040044 . [Q9JK30-2 ]
    GeneIDi 50793.
    KEGGi mmu:50793.
    UCSCi uc008sgb.2. mouse. [Q9JK30-1 ]
    uc008sgd.1. mouse. [Q9JK30-2 ]

    Organism-specific databases

    CTDi 23595.
    MGIi MGI:1354944. Orc3.

    Phylogenomic databases

    eggNOGi NOG296366.
    GeneTreei ENSGT00390000011376.
    HOGENOMi HOG000047785.
    HOVERGENi HBG007599.
    InParanoidi Q9JK30.
    KOi K02605.
    OMAi CFVFKPN.
    OrthoDBi EOG78PV8B.
    PhylomeDBi Q9JK30.
    TreeFami TF101093.

    Enzyme and pathway databases

    Reactomei REACT_204269. E2F-enabled inhibition of pre-replication complex formation.

    Miscellaneous databases

    ChiTaRSi ORC3. mouse.
    NextBioi 307789.
    PROi Q9JK30.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9JK30.
    Bgeei Q9JK30.
    Genevestigatori Q9JK30.

    Family and domain databases

    InterProi IPR016024. ARM-type_fold.
    IPR020795. ORC3.
    [Graphical view ]
    PANTHERi PTHR12748. PTHR12748. 1 hit.
    Pfami PF07034. ORC3_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 4 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Identification and chromosomal localization of murine ORC3, a new member of the mouse origin recognition complex."
      Springer J., Nanda I., Hoehn K., Schmid M., Grummt F.
      Cytogenet. Cell Genet. 87:245-251(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Novel splicing variant of mouse Orc1 is deficient in nuclear translocation and resistant for proteasome-mediated degradation."
      Miyake Y., Mizuno T., Yanagi K., Hanaoka F.
      J. Biol. Chem. 280:12643-12652(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Corpora quadrigemina and Head.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Pituitary.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-522 (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiORC3_MOUSE
    AccessioniPrimary (citable) accession number: Q9JK30
    Secondary accession number(s): A2AMF4
    , A2AMF5, Q6P8H2, Q8BR83, Q8C395
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3