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Q9JK30

- ORC3_MOUSE

UniProt

Q9JK30 - ORC3_MOUSE

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Protein

Origin recognition complex subunit 3

Gene

Orc3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity). Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 (By similarity).By similarity

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA replication Source: MGI
  2. neural precursor cell proliferation Source: MGI
Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_204269. E2F-enabled inhibition of pre-replication complex formation.
REACT_230841. Assembly of the pre-replicative complex.
REACT_232236. Activation of ATR in response to replication stress.
REACT_236939. Removal of licensing factors from origins.
REACT_244558. CDT1 association with the CDC6:ORC:origin complex.
REACT_245230. Orc1 removal from chromatin.
REACT_247969. Assembly of the ORC complex at the origin of replication.
REACT_254983. Activation of the pre-replicative complex.
REACT_259974. CDC6 association with the ORC:origin complex.
REACT_262002. Association of licensing factors with the pre-replicative complex.

Names & Taxonomyi

Protein namesi
Recommended name:
Origin recognition complex subunit 3
Alternative name(s):
Origin recognition complex subunit Latheo
Gene namesi
Name:Orc3
Synonyms:Orc3l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1354944. Orc3.

Subcellular locationi

GO - Cellular componenti

  1. nuclear origin of replication recognition complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 715715Origin recognition complex subunit 3PRO_0000127084Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei523 – 5231PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9JK30.
PaxDbiQ9JK30.
PRIDEiQ9JK30.

PTM databases

PhosphoSiteiQ9JK30.

Expressioni

Gene expression databases

BgeeiQ9JK30.
ExpressionAtlasiQ9JK30. baseline and differential.
GenevestigatoriQ9JK30.

Interactioni

Subunit structurei

Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase (By similarity).By similarity

Protein-protein interaction databases

BioGridi206124. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9JK30.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ORC3 family.Curated

Phylogenomic databases

eggNOGiNOG296366.
GeneTreeiENSGT00390000011376.
HOGENOMiHOG000047785.
HOVERGENiHBG007599.
InParanoidiQ9JK30.
KOiK02605.
OMAiCFVFKPN.
OrthoDBiEOG78PV8B.
PhylomeDBiQ9JK30.
TreeFamiTF101093.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR020795. ORC3.
[Graphical view]
PANTHERiPTHR12748. PTHR12748. 1 hit.
PfamiPF07034. ORC3_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9JK30-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHTGPRTMAT SSVSKGCFVF KPDFKKRKVF VPIEDYFNNE ELDSEDSKLR
60 70 80 90 100
FETYSLLWQR MKSETEQLQE ELNENLFDNL VDFLQKSHPE FQKNSRDWGS
110 120 130 140 150
QMKFREIPTA ALILGVNVTD HDVILRSLTE TLQNNVTPYV VSLQAKDCPD
160 170 180 190 200
VKHFLQKFTS QLMDCCVDRH SKEVTSGKAL KKTNYSMDSL CSWYSAVTQK
210 220 230 240 250
ADHKVTIKKR TASGHWRSPP VVLILKSMES FTSKVLQDFI TISSQHLHEF
260 270 280 290 300
PLILIFGIAT SPVIIHRLLP HSVSSLLCVE LFQSLSCEQH LTVVLDKLLL
310 320 330 340 350
TPQFPFKLSK KALQVLTNIF LYHDFSIQSF IKGIKLSLLE HFYSQPLSVL
360 370 380 390 400
CCDLSEAKKR VNVFSVSQCE NIRRLPSFRR YVENQPLGKQ VALLTNETFL
410 420 430 440 450
KEKTQSLLED LHVYHINYFL VLRCLHNFTS SLPKYPLGRQ IRELYCTCLE
460 470 480 490 500
KKIWDSEEYK SALQLLRMLA KDELVSILQR CIEVLDSSTE KQLGNTTQKI
510 520 530 540 550
KDFLTQFQNL DADSKEEEDA CGSQPKGLQK TDLYHLQKSL LEMKELRRTK
560 570 580 590 600
KPTKFEMLRE NVMNFIDNLV RDYLLPPESQ PLHEVVYFSA ANTLREHLNA
610 620 630 640 650
APRIALHTAL NNPYYYLKNE ELEGCIPNTA PDICIAYKLH LECSLLINLV
660 670 680 690 700
DWAEAFATVV TAAEKMDANS TVSEEMSEVI HARFIRAVSE LELLGFIKPT
710
KQKTDHVARL TWGGC
Length:715
Mass (Da):82,342
Last modified:October 1, 2000 - v1
Checksum:i1E915A719A2E33EB
GO
Isoform 2 (identifier: Q9JK30-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     512-512: Missing.

Note: Contains a phosphoserine at position 522.

Show »
Length:714
Mass (Da):82,271
Checksum:i13E9EDC7B01D1C7E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti114 – 1141L → F in BAC39695. (PubMed:16141072)Curated
Sequence conflicti212 – 2121A → P in BAD91665. (PubMed:15634681)Curated
Sequence conflicti212 – 2121A → P in AAH61252. (PubMed:15489334)Curated
Sequence conflicti360 – 3601R → G in BAC32339. (PubMed:16141072)Curated
Sequence conflicti645 – 6451L → R in BAD91665. (PubMed:15634681)Curated
Sequence conflicti645 – 6451L → R in AAH61252. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei512 – 5121Missing in isoform 2. 2 PublicationsVSP_026407

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132830 mRNA. Translation: CAB76399.1.
AB190257 mRNA. Translation: BAD91665.2.
AK045388 mRNA. Translation: BAC32339.1.
AK086579 mRNA. Translation: BAC39695.1.
AL807397, AL928738 Genomic DNA. Translation: CAM16474.1.
AL807397, AL928738 Genomic DNA. Translation: CAM16475.1.
AL928738, AL807397 Genomic DNA. Translation: CAM26869.1.
AL928738, AL807397 Genomic DNA. Translation: CAM26870.1.
BC061252 mRNA. Translation: AAH61252.1.
CCDSiCCDS18028.1. [Q9JK30-1]
CCDS51137.1. [Q9JK30-2]
RefSeqiNP_001153035.1. NM_001159563.1. [Q9JK30-2]
NP_056639.3. NM_015824.4. [Q9JK30-1]
UniGeneiMm.399624.

Genome annotation databases

EnsembliENSMUST00000048706; ENSMUSP00000048319; ENSMUSG00000040044. [Q9JK30-1]
ENSMUST00000108142; ENSMUSP00000103777; ENSMUSG00000040044. [Q9JK30-2]
GeneIDi50793.
KEGGimmu:50793.
UCSCiuc008sgb.2. mouse. [Q9JK30-1]
uc008sgd.1. mouse. [Q9JK30-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132830 mRNA. Translation: CAB76399.1 .
AB190257 mRNA. Translation: BAD91665.2 .
AK045388 mRNA. Translation: BAC32339.1 .
AK086579 mRNA. Translation: BAC39695.1 .
AL807397 , AL928738 Genomic DNA. Translation: CAM16474.1 .
AL807397 , AL928738 Genomic DNA. Translation: CAM16475.1 .
AL928738 , AL807397 Genomic DNA. Translation: CAM26869.1 .
AL928738 , AL807397 Genomic DNA. Translation: CAM26870.1 .
BC061252 mRNA. Translation: AAH61252.1 .
CCDSi CCDS18028.1. [Q9JK30-1 ]
CCDS51137.1. [Q9JK30-2 ]
RefSeqi NP_001153035.1. NM_001159563.1. [Q9JK30-2 ]
NP_056639.3. NM_015824.4. [Q9JK30-1 ]
UniGenei Mm.399624.

3D structure databases

ProteinModelPortali Q9JK30.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 206124. 1 interaction.

PTM databases

PhosphoSitei Q9JK30.

Proteomic databases

MaxQBi Q9JK30.
PaxDbi Q9JK30.
PRIDEi Q9JK30.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000048706 ; ENSMUSP00000048319 ; ENSMUSG00000040044 . [Q9JK30-1 ]
ENSMUST00000108142 ; ENSMUSP00000103777 ; ENSMUSG00000040044 . [Q9JK30-2 ]
GeneIDi 50793.
KEGGi mmu:50793.
UCSCi uc008sgb.2. mouse. [Q9JK30-1 ]
uc008sgd.1. mouse. [Q9JK30-2 ]

Organism-specific databases

CTDi 23595.
MGIi MGI:1354944. Orc3.

Phylogenomic databases

eggNOGi NOG296366.
GeneTreei ENSGT00390000011376.
HOGENOMi HOG000047785.
HOVERGENi HBG007599.
InParanoidi Q9JK30.
KOi K02605.
OMAi CFVFKPN.
OrthoDBi EOG78PV8B.
PhylomeDBi Q9JK30.
TreeFami TF101093.

Enzyme and pathway databases

Reactomei REACT_204269. E2F-enabled inhibition of pre-replication complex formation.
REACT_230841. Assembly of the pre-replicative complex.
REACT_232236. Activation of ATR in response to replication stress.
REACT_236939. Removal of licensing factors from origins.
REACT_244558. CDT1 association with the CDC6:ORC:origin complex.
REACT_245230. Orc1 removal from chromatin.
REACT_247969. Assembly of the ORC complex at the origin of replication.
REACT_254983. Activation of the pre-replicative complex.
REACT_259974. CDC6 association with the ORC:origin complex.
REACT_262002. Association of licensing factors with the pre-replicative complex.

Miscellaneous databases

ChiTaRSi Orc3. mouse.
NextBioi 307789.
PROi Q9JK30.
SOURCEi Search...

Gene expression databases

Bgeei Q9JK30.
ExpressionAtlasi Q9JK30. baseline and differential.
Genevestigatori Q9JK30.

Family and domain databases

InterProi IPR016024. ARM-type_fold.
IPR020795. ORC3.
[Graphical view ]
PANTHERi PTHR12748. PTHR12748. 1 hit.
Pfami PF07034. ORC3_N. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 4 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and chromosomal localization of murine ORC3, a new member of the mouse origin recognition complex."
    Springer J., Nanda I., Hoehn K., Schmid M., Grummt F.
    Cytogenet. Cell Genet. 87:245-251(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Novel splicing variant of mouse Orc1 is deficient in nuclear translocation and resistant for proteasome-mediated degradation."
    Miyake Y., Mizuno T., Yanagi K., Hanaoka F.
    J. Biol. Chem. 280:12643-12652(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Corpora quadrigemina and Head.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Pituitary.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-522 (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiORC3_MOUSE
AccessioniPrimary (citable) accession number: Q9JK30
Secondary accession number(s): A2AMF4
, A2AMF5, Q6P8H2, Q8BR83, Q8C395
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3