Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9JK24

- P2R3C_MOUSE

UniProt

Q9JK24 - P2R3C_MOUSE

Protein

Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma

Gene

Ppp2r3c

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (01 Mar 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May regulate MCM3AP phosphorylation through phosphatase recruitment. May play a role in the activation-induced cell death of B-cells.3 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi286 – 297121Sequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. protein binding Source: MGI

    GO - Biological processi

    1. activation of protein kinase activity Source: MGI
    2. B cell homeostasis Source: MGI
    3. positive regulation of B cell differentiation Source: MGI
    4. regulation of antimicrobial humoral response Source: MGI
    5. regulation of B cell activation Source: MGI
    6. regulation of mitochondrial depolarization Source: MGI
    7. spleen development Source: MGI
    8. T cell homeostasis Source: MGI

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma
    Alternative name(s):
    Protein phosphatase subunit G5PR
    Gene namesi
    Name:Ppp2r3c
    Synonyms:G5pr
    ORF Names:MNCb-1932
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1930009. Ppp2r3c.

    Subcellular locationi

    Nucleus 1 Publication. Cytoplasm 1 Publication
    Note: Excluded from the nucleoli. Localization is cell cycle-dependent. Localizes to the cytoplasm during cytokinesis.

    GO - Cellular componenti

    1. centrosome Source: Ensembl
    2. cytoplasm Source: UniProtKB-SubCell
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Mice display a reduction in the number of mature B-cells and an impaired B-cell proliferation upon B-Cell receptor cross-linking probably due to a loss of inhibition of BCR-induced apoptosis. G5pr overexpression protects B-cells from activation-induced cell death.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 453453Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gammaPRO_0000277834Add
    BLAST

    Proteomic databases

    PRIDEiQ9JK24.

    PTM databases

    PhosphoSiteiQ9JK24.

    Expressioni

    Tissue specificityi

    Expressed in all tissues tested including heart, brain, spleen, thymus, lung, liver, kidney and testis.1 Publication

    Developmental stagei

    Detected from 6 to 12 dpc in whole embryos and from 14 to 18 dpc in the heads of the embryos. Expressed in central nervous system, spine, face, pharynx, limbs and viscera at 11 dpc.1 Publication

    Inductioni

    Up-regulated upon B-cell receptor cross-linking.1 Publication

    Gene expression databases

    BgeeiQ9JK24.
    GenevestigatoriQ9JK24.

    Interactioni

    Subunit structurei

    Interacts with MCM3AP/GANP, PPP5C, and the phosphatase 2A core enzyme composed of the PPP2CA catalytic subunit and the constant regulatory subunit PPP2R1A.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JK24.
    SMRiQ9JK24. Positions 188-411.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini273 – 30836EF-hand 1Add
    BLAST
    Domaini341 – 37636EF-hand 2Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi226 – 2294Poly-Phe

    Sequence similaritiesi

    Contains 2 EF-hand domains.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG279493.
    GeneTreeiENSGT00530000063265.
    HOGENOMiHOG000005699.
    HOVERGENiHBG055242.
    InParanoidiB2RR97.
    KOiK11583.
    OMAiQESNWFS.
    OrthoDBiEOG7M6D73.
    PhylomeDBiQ9JK24.
    TreeFamiTF318412.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JK24-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDWKDVLRRR LASPNTDPKR KKSEQELKDE EMDLFTKYYS EWKGGRKNTN    50
    EFYKTIPRFY YRLPAEDEVL LQKLREESRA VFLQRKSREL LDNEELQNLW 100
    FLLDKHQIPP MIGEEAMINY ENFLKVGEKA GPKCKQFFTA KVFAKLLHTD 150
    SYGRISIMQF FNYVMRKVWL HQTRIGLSLY DVAGQGYLRE SDLENYILEL 200
    IPTLPQLDGL EKSFYSFYVC TAVRKFFFFL DPLRTGKIKI QDILACSFLD 250
    DLLELRDEEL SKESQETNWF SAPSALRVYG QYLNLDKDHN GMLSKEELSR 300
    YGTATMTNVF LDRVFQECLT YDGEMDYKTY LDFVLALENR KEPAALQYIF 350
    KLLDIENKGY LNVFSLNYFF RAIQELMKIH GQDPVSFQDV KDEIFDMVKP 400
    KDPLKISLQD LINSNQGDTV TTILIDLNGF WTYENREALV ANDNENSADL 450
    DDT 453
    Length:453
    Mass (Da):53,407
    Last modified:March 1, 2001 - v2
    Checksum:i8FD29927385EAD81
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti335 – 3351L → P in BAA95061. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ238247 mRNA. Translation: CAB88038.2.
    AB041577 mRNA. Translation: BAA95061.1.
    AK013403 mRNA. Translation: BAB28835.1.
    AK028254 mRNA. Translation: BAC25845.1.
    AK040589 mRNA. Translation: BAC30637.1.
    AK087572 mRNA. Translation: BAC39933.1.
    AK088240 mRNA. Translation: BAC40229.1.
    BC024754 mRNA. Translation: AAH24754.1.
    BC138295 mRNA. Translation: AAI38296.1.
    BC138296 mRNA. Translation: AAI38297.1.
    CCDSiCCDS36450.1.
    RefSeqiNP_067504.2. NM_021529.3.
    UniGeneiMm.427307.

    Genome annotation databases

    EnsembliENSMUST00000021410; ENSMUSP00000021410; ENSMUSG00000021022.
    GeneIDi59032.
    KEGGimmu:59032.
    UCSCiuc007nom.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ238247 mRNA. Translation: CAB88038.2 .
    AB041577 mRNA. Translation: BAA95061.1 .
    AK013403 mRNA. Translation: BAB28835.1 .
    AK028254 mRNA. Translation: BAC25845.1 .
    AK040589 mRNA. Translation: BAC30637.1 .
    AK087572 mRNA. Translation: BAC39933.1 .
    AK088240 mRNA. Translation: BAC40229.1 .
    BC024754 mRNA. Translation: AAH24754.1 .
    BC138295 mRNA. Translation: AAI38296.1 .
    BC138296 mRNA. Translation: AAI38297.1 .
    CCDSi CCDS36450.1.
    RefSeqi NP_067504.2. NM_021529.3.
    UniGenei Mm.427307.

    3D structure databases

    ProteinModelPortali Q9JK24.
    SMRi Q9JK24. Positions 188-411.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9JK24.

    Proteomic databases

    PRIDEi Q9JK24.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021410 ; ENSMUSP00000021410 ; ENSMUSG00000021022 .
    GeneIDi 59032.
    KEGGi mmu:59032.
    UCSCi uc007nom.1. mouse.

    Organism-specific databases

    CTDi 55012.
    MGIi MGI:1930009. Ppp2r3c.

    Phylogenomic databases

    eggNOGi NOG279493.
    GeneTreei ENSGT00530000063265.
    HOGENOMi HOG000005699.
    HOVERGENi HBG055242.
    InParanoidi B2RR97.
    KOi K11583.
    OMAi QESNWFS.
    OrthoDBi EOG7M6D73.
    PhylomeDBi Q9JK24.
    TreeFami TF318412.

    Miscellaneous databases

    NextBioi 314626.
    PROi Q9JK24.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9JK24.
    Genevestigatori Q9JK24.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "MCM3-binding GANP DNA-primase is associated with a novel phosphatase component G5PR."
      Kono Y., Maeda K., Kuwahara K., Yamamoto H., Miyamoto E., Yonezawa K., Takagi K., Sakaguchi N.
      Genes Cells 7:821-834(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH MCM3AP; PPP2CA; PPP2R1A AND PPP5C, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
      Tissue: B-cell.
    2. "Isolation of full-length cDNA clones from mouse brain cDNA library made by oligo-capping method."
      Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.
      Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Embryo, Head, Oviduct and Thymus.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N-3.
      Tissue: Brain and Mammary tumor.
    5. "Defining a holoprosencephaly locus on human chromosome 14q13 and characterization of potential candidate genes."
      Kamnasaran D., Chen C.-P., Devriendt K., Mehta L., Cox D.W.
      Genomics 85:608-621(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.
      Tissue: Brain.
    6. "Protein phosphatase subunit G5PR is needed for inhibition of B cell receptor-induced apoptosis."
      Xing Y., Igarashi H., Wang X., Sakaguchi N.
      J. Exp. Med. 202:707-719(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    7. "BCR-crosslinking induces a transcription of protein phosphatase component G5PR that is required for mature B-cell survival."
      Huq Ronny F.M., Igarashi H., Sakaguchi N.
      Biochem. Biophys. Res. Commun. 340:338-346(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.

    Entry informationi

    Entry nameiP2R3C_MOUSE
    AccessioniPrimary (citable) accession number: Q9JK24
    Secondary accession number(s): B2RR97, Q9CSA6, Q9JJD2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 20, 2007
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3