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Q9JK24

- P2R3C_MOUSE

UniProt

Q9JK24 - P2R3C_MOUSE

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Protein

Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma

Gene
Ppp2r3c, G5pr, MNCb-1932
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May regulate MCM3AP phosphorylation through phosphatase recruitment. May play a role in the activation-induced cell death of B-cells.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi286 – 297121 Reviewed predictionAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. protein binding Source: MGI

GO - Biological processi

  1. activation of protein kinase activity Source: MGI
  2. B cell homeostasis Source: MGI
  3. positive regulation of B cell differentiation Source: MGI
  4. regulation of antimicrobial humoral response Source: MGI
  5. regulation of B cell activation Source: MGI
  6. regulation of mitochondrial depolarization Source: MGI
  7. spleen development Source: MGI
  8. T cell homeostasis Source: MGI
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma
Alternative name(s):
Protein phosphatase subunit G5PR
Gene namesi
Name:Ppp2r3c
Synonyms:G5pr
ORF Names:MNCb-1932
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1930009. Ppp2r3c.

Subcellular locationi

Nucleus. Cytoplasm
Note: Excluded from the nucleoli. Localization is cell cycle-dependent. Localizes to the cytoplasm during cytokinesis.1 Publication

GO - Cellular componenti

  1. centrosome Source: Ensembl
  2. cytoplasm Source: UniProtKB-SubCell
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice display a reduction in the number of mature B-cells and an impaired B-cell proliferation upon B-Cell receptor cross-linking probably due to a loss of inhibition of BCR-induced apoptosis. G5pr overexpression protects B-cells from activation-induced cell death.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 453453Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gammaPRO_0000277834Add
BLAST

Proteomic databases

PRIDEiQ9JK24.

PTM databases

PhosphoSiteiQ9JK24.

Expressioni

Tissue specificityi

Expressed in all tissues tested including heart, brain, spleen, thymus, lung, liver, kidney and testis.1 Publication

Developmental stagei

Detected from 6 to 12 dpc in whole embryos and from 14 to 18 dpc in the heads of the embryos. Expressed in central nervous system, spine, face, pharynx, limbs and viscera at 11 dpc.1 Publication

Inductioni

Up-regulated upon B-cell receptor cross-linking.1 Publication

Gene expression databases

BgeeiQ9JK24.
GenevestigatoriQ9JK24.

Interactioni

Subunit structurei

Interacts with MCM3AP/GANP, PPP5C, and the phosphatase 2A core enzyme composed of the PPP2CA catalytic subunit and the constant regulatory subunit PPP2R1A.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9JK24.
SMRiQ9JK24. Positions 188-411.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini273 – 30836EF-hand 1Add
BLAST
Domaini341 – 37636EF-hand 2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi226 – 2294Poly-Phe

Sequence similaritiesi

Contains 2 EF-hand domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG279493.
GeneTreeiENSGT00530000063265.
HOGENOMiHOG000005699.
HOVERGENiHBG055242.
InParanoidiB2RR97.
KOiK11583.
OMAiQESNWFS.
OrthoDBiEOG7M6D73.
PhylomeDBiQ9JK24.
TreeFamiTF318412.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JK24-1 [UniParc]FASTAAdd to Basket

« Hide

MDWKDVLRRR LASPNTDPKR KKSEQELKDE EMDLFTKYYS EWKGGRKNTN    50
EFYKTIPRFY YRLPAEDEVL LQKLREESRA VFLQRKSREL LDNEELQNLW 100
FLLDKHQIPP MIGEEAMINY ENFLKVGEKA GPKCKQFFTA KVFAKLLHTD 150
SYGRISIMQF FNYVMRKVWL HQTRIGLSLY DVAGQGYLRE SDLENYILEL 200
IPTLPQLDGL EKSFYSFYVC TAVRKFFFFL DPLRTGKIKI QDILACSFLD 250
DLLELRDEEL SKESQETNWF SAPSALRVYG QYLNLDKDHN GMLSKEELSR 300
YGTATMTNVF LDRVFQECLT YDGEMDYKTY LDFVLALENR KEPAALQYIF 350
KLLDIENKGY LNVFSLNYFF RAIQELMKIH GQDPVSFQDV KDEIFDMVKP 400
KDPLKISLQD LINSNQGDTV TTILIDLNGF WTYENREALV ANDNENSADL 450
DDT 453
Length:453
Mass (Da):53,407
Last modified:March 1, 2001 - v2
Checksum:i8FD29927385EAD81
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti335 – 3351L → P in BAA95061. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ238247 mRNA. Translation: CAB88038.2.
AB041577 mRNA. Translation: BAA95061.1.
AK013403 mRNA. Translation: BAB28835.1.
AK028254 mRNA. Translation: BAC25845.1.
AK040589 mRNA. Translation: BAC30637.1.
AK087572 mRNA. Translation: BAC39933.1.
AK088240 mRNA. Translation: BAC40229.1.
BC024754 mRNA. Translation: AAH24754.1.
BC138295 mRNA. Translation: AAI38296.1.
BC138296 mRNA. Translation: AAI38297.1.
CCDSiCCDS36450.1.
RefSeqiNP_067504.2. NM_021529.3.
UniGeneiMm.427307.

Genome annotation databases

EnsembliENSMUST00000021410; ENSMUSP00000021410; ENSMUSG00000021022.
GeneIDi59032.
KEGGimmu:59032.
UCSCiuc007nom.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ238247 mRNA. Translation: CAB88038.2 .
AB041577 mRNA. Translation: BAA95061.1 .
AK013403 mRNA. Translation: BAB28835.1 .
AK028254 mRNA. Translation: BAC25845.1 .
AK040589 mRNA. Translation: BAC30637.1 .
AK087572 mRNA. Translation: BAC39933.1 .
AK088240 mRNA. Translation: BAC40229.1 .
BC024754 mRNA. Translation: AAH24754.1 .
BC138295 mRNA. Translation: AAI38296.1 .
BC138296 mRNA. Translation: AAI38297.1 .
CCDSi CCDS36450.1.
RefSeqi NP_067504.2. NM_021529.3.
UniGenei Mm.427307.

3D structure databases

ProteinModelPortali Q9JK24.
SMRi Q9JK24. Positions 188-411.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9JK24.

Proteomic databases

PRIDEi Q9JK24.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021410 ; ENSMUSP00000021410 ; ENSMUSG00000021022 .
GeneIDi 59032.
KEGGi mmu:59032.
UCSCi uc007nom.1. mouse.

Organism-specific databases

CTDi 55012.
MGIi MGI:1930009. Ppp2r3c.

Phylogenomic databases

eggNOGi NOG279493.
GeneTreei ENSGT00530000063265.
HOGENOMi HOG000005699.
HOVERGENi HBG055242.
InParanoidi B2RR97.
KOi K11583.
OMAi QESNWFS.
OrthoDBi EOG7M6D73.
PhylomeDBi Q9JK24.
TreeFami TF318412.

Miscellaneous databases

NextBioi 314626.
PROi Q9JK24.
SOURCEi Search...

Gene expression databases

Bgeei Q9JK24.
Genevestigatori Q9JK24.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "MCM3-binding GANP DNA-primase is associated with a novel phosphatase component G5PR."
    Kono Y., Maeda K., Kuwahara K., Yamamoto H., Miyamoto E., Yonezawa K., Takagi K., Sakaguchi N.
    Genes Cells 7:821-834(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH MCM3AP; PPP2CA; PPP2R1A AND PPP5C, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Tissue: B-cell.
  2. "Isolation of full-length cDNA clones from mouse brain cDNA library made by oligo-capping method."
    Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Embryo, Head, Oviduct and Thymus.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3.
    Tissue: Brain and Mammary tumor.
  5. "Defining a holoprosencephaly locus on human chromosome 14q13 and characterization of potential candidate genes."
    Kamnasaran D., Chen C.-P., Devriendt K., Mehta L., Cox D.W.
    Genomics 85:608-621(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
    Tissue: Brain.
  6. "Protein phosphatase subunit G5PR is needed for inhibition of B cell receptor-induced apoptosis."
    Xing Y., Igarashi H., Wang X., Sakaguchi N.
    J. Exp. Med. 202:707-719(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  7. "BCR-crosslinking induces a transcription of protein phosphatase component G5PR that is required for mature B-cell survival."
    Huq Ronny F.M., Igarashi H., Sakaguchi N.
    Biochem. Biophys. Res. Commun. 340:338-346(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.

Entry informationi

Entry nameiP2R3C_MOUSE
AccessioniPrimary (citable) accession number: Q9JK24
Secondary accession number(s): B2RR97, Q9CSA6, Q9JJD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi