Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9JK24 (P2R3C_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma
Alternative name(s):
Protein phosphatase subunit G5PR
Gene names
Name:Ppp2r3c
Synonyms:G5pr
ORF Names:MNCb-1932
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length453 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May regulate MCM3AP phosphorylation through phosphatase recruitment. May play a role in the activation-induced cell death of B-cells. Ref.1 Ref.6 Ref.7

Subunit structure

Interacts with MCM3AP/GANP, PPP5C, and the phosphatase 2A core enzyme composed of the PPP2CA catalytic subunit and the constant regulatory subunit PPP2R1A. Ref.1

Subcellular location

Nucleus. Cytoplasm. Note: Excluded from the nucleoli. Localization is cell cycle-dependent. Localizes to the cytoplasm during cytokinesis. Ref.1

Tissue specificity

Expressed in all tissues tested including heart, brain, spleen, thymus, lung, liver, kidney and testis. Ref.1

Developmental stage

Detected from 6 to 12 dpc in whole embryos and from 14 to 18 dpc in the heads of the embryos. Expressed in central nervous system, spine, face, pharynx, limbs and viscera at 11 dpc. Ref.5

Induction

Up-regulated upon B-cell receptor cross-linking. Ref.7

Disruption phenotype

Mice display a reduction in the number of mature B-cells and an impaired B-cell proliferation upon B-Cell receptor cross-linking probably due to a loss of inhibition of BCR-induced apoptosis. G5pr overexpression protects B-cells from activation-induced cell death. Ref.6

Sequence similarities

Contains 2 EF-hand domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 453453Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma
PRO_0000277834

Regions

Domain273 – 30836EF-hand 1
Domain341 – 37636EF-hand 2
Calcium binding286 – 297121 Potential
Compositional bias226 – 2294Poly-Phe

Experimental info

Sequence conflict3351L → P in BAA95061. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9JK24 [UniParc].

Last modified March 1, 2001. Version 2.
Checksum: 8FD29927385EAD81

FASTA45353,407
        10         20         30         40         50         60 
MDWKDVLRRR LASPNTDPKR KKSEQELKDE EMDLFTKYYS EWKGGRKNTN EFYKTIPRFY 

        70         80         90        100        110        120 
YRLPAEDEVL LQKLREESRA VFLQRKSREL LDNEELQNLW FLLDKHQIPP MIGEEAMINY 

       130        140        150        160        170        180 
ENFLKVGEKA GPKCKQFFTA KVFAKLLHTD SYGRISIMQF FNYVMRKVWL HQTRIGLSLY 

       190        200        210        220        230        240 
DVAGQGYLRE SDLENYILEL IPTLPQLDGL EKSFYSFYVC TAVRKFFFFL DPLRTGKIKI 

       250        260        270        280        290        300 
QDILACSFLD DLLELRDEEL SKESQETNWF SAPSALRVYG QYLNLDKDHN GMLSKEELSR 

       310        320        330        340        350        360 
YGTATMTNVF LDRVFQECLT YDGEMDYKTY LDFVLALENR KEPAALQYIF KLLDIENKGY 

       370        380        390        400        410        420 
LNVFSLNYFF RAIQELMKIH GQDPVSFQDV KDEIFDMVKP KDPLKISLQD LINSNQGDTV 

       430        440        450 
TTILIDLNGF WTYENREALV ANDNENSADL DDT 

« Hide

References

« Hide 'large scale' references
[1]"MCM3-binding GANP DNA-primase is associated with a novel phosphatase component G5PR."
Kono Y., Maeda K., Kuwahara K., Yamamoto H., Miyamoto E., Yonezawa K., Takagi K., Sakaguchi N.
Genes Cells 7:821-834(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH MCM3AP; PPP2CA; PPP2R1A AND PPP5C, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
Tissue: B-cell.
[2]"Isolation of full-length cDNA clones from mouse brain cDNA library made by oligo-capping method."
Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.
Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Embryo, Head, Oviduct and Thymus.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N-3.
Tissue: Brain and Mammary tumor.
[5]"Defining a holoprosencephaly locus on human chromosome 14q13 and characterization of potential candidate genes."
Kamnasaran D., Chen C.-P., Devriendt K., Mehta L., Cox D.W.
Genomics 85:608-621(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: DEVELOPMENTAL STAGE.
Tissue: Brain.
[6]"Protein phosphatase subunit G5PR is needed for inhibition of B cell receptor-induced apoptosis."
Xing Y., Igarashi H., Wang X., Sakaguchi N.
J. Exp. Med. 202:707-719(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DISRUPTION PHENOTYPE.
[7]"BCR-crosslinking induces a transcription of protein phosphatase component G5PR that is required for mature B-cell survival."
Huq Ronny F.M., Igarashi H., Sakaguchi N.
Biochem. Biophys. Res. Commun. 340:338-346(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INDUCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ238247 mRNA. Translation: CAB88038.2.
AB041577 mRNA. Translation: BAA95061.1.
AK013403 mRNA. Translation: BAB28835.1.
AK028254 mRNA. Translation: BAC25845.1.
AK040589 mRNA. Translation: BAC30637.1.
AK087572 mRNA. Translation: BAC39933.1.
AK088240 mRNA. Translation: BAC40229.1.
BC024754 mRNA. Translation: AAH24754.1.
BC138295 mRNA. Translation: AAI38296.1.
BC138296 mRNA. Translation: AAI38297.1.
CCDSCCDS36450.1.
RefSeqNP_067504.2. NM_021529.3.
UniGeneMm.427307.

3D structure databases

ProteinModelPortalQ9JK24.
SMRQ9JK24. Positions 188-411.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9JK24.

Proteomic databases

PRIDEQ9JK24.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000021410; ENSMUSP00000021410; ENSMUSG00000021022.
GeneID59032.
KEGGmmu:59032.
UCSCuc007nom.1. mouse.

Organism-specific databases

CTD55012.
MGIMGI:1930009. Ppp2r3c.

Phylogenomic databases

eggNOGNOG279493.
GeneTreeENSGT00530000063265.
HOGENOMHOG000005699.
HOVERGENHBG055242.
InParanoidB2RR97.
KOK11583.
OMAQESNWFS.
OrthoDBEOG7M6D73.
PhylomeDBQ9JK24.
TreeFamTF318412.

Gene expression databases

BgeeQ9JK24.
GenevestigatorQ9JK24.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio314626.
PROQ9JK24.
SOURCESearch...

Entry information

Entry nameP2R3C_MOUSE
AccessionPrimary (citable) accession number: Q9JK24
Secondary accession number(s): B2RR97, Q9CSA6, Q9JJD2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot