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Protein

Arf-GAP with dual PH domain-containing protein 2

Gene

Adap2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Binding of phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4-bisphosphate occurs at a much lower affinity. Possesses a stoichiometry of two binding sites for InsP4 with identical affinity (By similarity).By similarityCurated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri25 – 48C4-typePROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

  • 1-phosphatidylinositol binding Source: RGD
  • GTPase activator activity Source: UniProtKB-KW
  • inositol 1,3,4,5 tetrakisphosphate binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • phosphatidylinositol-3,4,5-trisphosphate binding Source: UniProtKB
  • phosphatidylinositol-3,4-bisphosphate binding Source: UniProtKB
  • phosphatidylinositol-4,5-bisphosphate binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionGTPase activation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Arf-GAP with dual PH domain-containing protein 2
Alternative name(s):
Centaurin-alpha-2
Short name:
Cnt-a2
Gene namesi
Name:Adap2
Synonyms:Centa2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708487 Adap2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi151R → C: Almost complete loss of InsP4 binding. 1 Publication1
Mutagenesisi275R → C: No loss of InsP4 binding. Almost complete loss of InsP4 binding; when associated with C-151. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000742081 – 376Arf-GAP with dual PH domain-containing protein 2Add BLAST376

Proteomic databases

PaxDbiQ9JK15
PRIDEiQ9JK15

PTM databases

PhosphoSitePlusiQ9JK15

Expressioni

Tissue specificityi

Expressed in many tissues, with highest levels in fat, heart and skeletal muscle. Also detected in kidney, liver and lung.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053112

Structurei

3D structure databases

ProteinModelPortaliQ9JK15
SMRiQ9JK15
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 130Arf-GAPPROSITE-ProRule annotationAdd BLAST122
Domaini131 – 232PH 1PROSITE-ProRule annotationAdd BLAST102
Domaini254 – 360PH 2PROSITE-ProRule annotationAdd BLAST107

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri25 – 48C4-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0703 Eukaryota
COG5347 LUCA
HOGENOMiHOG000006719
HOVERGENiHBG050888
InParanoidiQ9JK15
PhylomeDBiQ9JK15

Family and domain databases

CDDicd13252 PH1_ADAP, 1 hit
cd01251 PH2_ADAP, 1 hit
Gene3Di2.30.29.30, 2 hits
3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
IPR011993 PH-like_dom_sf
IPR037849 PH1_ADAP
IPR037851 PH2_ADAP
IPR001849 PH_domain
PfamiView protein in Pfam
PF01412 ArfGap, 1 hit
PF00169 PH, 2 hits
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00105 ArfGap, 1 hit
SM00233 PH, 2 hits
SUPFAMiSSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50115 ARFGAP, 1 hit
PS50003 PH_DOMAIN, 2 hits

Sequencei

Sequence statusi: Complete.

Q9JK15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDRERNKKR LLELLQAAGT GNGHCADCGA ADPDWASYKL GVFICLHCSG
60 70 80 90 100
VHRNFPDISK VKSVRLDFWD DSMVEFMTHN GNLSVKAKFE ARVPTFYYVP
110 120 130 140 150
QASDCLVLKE QWIRAKYERQ EFMAEKAVSP PGDREGFLWK RGRDNSQFLR
160 170 180 190 200
RRFVLLSREG LLKYYTKEEG KTPKAIINIK DLNATFQTEK IGHPHGLQIT
210 220 230 240 250
YRKEGQTRNL FVYHDSGKEI VDWFNALRAA RLQYLKLAFP DLPESELVPL
260 270 280 290 300
ITRNYLKQGF MEKTGPKHRE PFKKRWFALD PQERRLLYYK NPLDAFEQGQ
310 320 330 340 350
VFLGSNEQGY EVWEGLPQGI RGNRWKVGLT VITPERKFVF TCPTEKEQRE
360 370
WLESLRGVLS SPLSPLHLLT TSAKSG
Length:376
Mass (Da):43,524
Last modified:October 1, 2000 - v1
Checksum:iE357392F38F07166
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238993 mRNA Translation: CAB88403.1
RefSeqiNP_064486.1, NM_020101.1
UniGeneiRn.203877

Genome annotation databases

GeneIDi56826
KEGGirno:56826

Similar proteinsi

Entry informationi

Entry nameiADAP2_RAT
AccessioniPrimary (citable) accession number: Q9JK15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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