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Protein

Sodium channel subunit beta-3

Gene

Scn3b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-RNO-445095. Interaction between L1 and Ankyrins.

Protein family/group databases

TCDBi8.A.17.1.2. the na(+) channel auxiliary subunit 1-4 (sca-) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel subunit beta-3
Gene namesi
Name:Scn3b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi621657. Scn3b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 159135ExtracellularSequence analysisAdd
BLAST
Transmembranei160 – 18021HelicalSequence analysisAdd
BLAST
Topological domaini181 – 21535CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 215191Sodium channel subunit beta-3PRO_0000014936Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 48PROSITE-ProRule annotation
Disulfide bondi45 ↔ 120PROSITE-ProRule annotation
Glycosylationi95 – 951N-linked (GlcNAc...)Sequence analysis
Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence analysis
Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence analysis
Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9JK00.
PRIDEiQ9JK00.

PTM databases

PhosphoSiteiQ9JK00.
UniCarbKBiQ9JK00.

Expressioni

Tissue specificityi

Expressed broadly in neurons in the central and peripheral nervous systems, but not in glia and most non-neuronal cells. Weak detection in lung and adrenal gland.1 Publication

Gene expression databases

GenevisibleiQ9JK00. RN.

Interactioni

Subunit structurei

The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1, beta-2, beta-3 and/or beta-4 subunits. Beta-1 and beta-3 are non-covalently associated with alpha, while beta-2 and beta-4 are covalently linked by disulfide bonds. Beta-1 or beta-3 subunits associate with neurofascin. Associates with SCN10A.3 Publications

Protein-protein interaction databases

BioGridi251452. 1 interaction.
STRINGi10116.ENSRNOP00000009367.

Structurei

3D structure databases

ProteinModelPortaliQ9JK00.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 138114Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHF3. Eukaryota.
ENOG4111IPM. LUCA.
GeneTreeiENSGT00390000018560.
HOGENOMiHOG000276881.
HOVERGENiHBG056582.
InParanoidiQ9JK00.
KOiK04847.
OMAiLLIEMVY.
OrthoDBiEOG7M3J19.
PhylomeDBiQ9JK00.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR027098. Na_channel_b1/b3.
IPR027096. Na_channel_b3.
[Graphical view]
PANTHERiPTHR10546. PTHR10546. 1 hit.
PTHR10546:SF1. PTHR10546:SF1. 1 hit.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JK00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAFNRLLPL ASLVLIYWVR VCFPVCVEVP SETEAVQGNP MKLRCISCMK
60 70 80 90 100
REEVEATTVV EWFYRPEGGK DFLIYEYRNG HQEVESPFQG RLQWNGSKDL
110 120 130 140 150
QDVSITVLNV TLNDSGLYTC NVSREFEFEA HRPFVKTTRL IPLRVTEEAG
160 170 180 190 200
EDFTSVVSEI MMYILLVFLT LWLFIEMIYC YRKVSKAEEA AQENASDYLA
210
IPSENKENSV VPVEE
Length:215
Mass (Da):24,799
Last modified:October 1, 2000 - v1
Checksum:i056B488EF5EAEF4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243395 mRNA. Translation: CAB76838.1.
AF378093 mRNA. Translation: AAK55415.1.
BC070899 mRNA. Translation: AAH70899.1.
RefSeqiNP_620797.1. NM_139097.3.
XP_006243164.1. XM_006243102.1.
XP_006243165.1. XM_006243103.1.
UniGeneiRn.3402.

Genome annotation databases

EnsembliENSRNOT00000087022; ENSRNOP00000071448; ENSRNOG00000057221.
GeneIDi245956.
KEGGirno:245956.
UCSCiRGD:621657. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243395 mRNA. Translation: CAB76838.1.
AF378093 mRNA. Translation: AAK55415.1.
BC070899 mRNA. Translation: AAH70899.1.
RefSeqiNP_620797.1. NM_139097.3.
XP_006243164.1. XM_006243102.1.
XP_006243165.1. XM_006243103.1.
UniGeneiRn.3402.

3D structure databases

ProteinModelPortaliQ9JK00.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi251452. 1 interaction.
STRINGi10116.ENSRNOP00000009367.

Protein family/group databases

TCDBi8.A.17.1.2. the na(+) channel auxiliary subunit 1-4 (sca-) family.

PTM databases

PhosphoSiteiQ9JK00.
UniCarbKBiQ9JK00.

Proteomic databases

PaxDbiQ9JK00.
PRIDEiQ9JK00.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000087022; ENSRNOP00000071448; ENSRNOG00000057221.
GeneIDi245956.
KEGGirno:245956.
UCSCiRGD:621657. rat.

Organism-specific databases

CTDi55800.
RGDi621657. Scn3b.

Phylogenomic databases

eggNOGiENOG410IHF3. Eukaryota.
ENOG4111IPM. LUCA.
GeneTreeiENSGT00390000018560.
HOGENOMiHOG000276881.
HOVERGENiHBG056582.
InParanoidiQ9JK00.
KOiK04847.
OMAiLLIEMVY.
OrthoDBiEOG7M3J19.
PhylomeDBiQ9JK00.

Enzyme and pathway databases

ReactomeiR-RNO-445095. Interaction between L1 and Ankyrins.

Miscellaneous databases

PROiQ9JK00.

Gene expression databases

GenevisibleiQ9JK00. RN.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR027098. Na_channel_b1/b3.
IPR027096. Na_channel_b3.
[Graphical view]
PANTHERiPTHR10546. PTHR10546. 1 hit.
PTHR10546:SF1. PTHR10546:SF1. 1 hit.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Beta3: an additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics."
    Morgan K., Stevens E.B., Shaw B., Cox P., Dixon A.K., Lee K., Pinnock R.D., Highes J., Richardson P.J., Mizuguchi K., Jackson A.P.
    Proc. Natl. Acad. Sci. U.S.A. 97:2308-2313(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, PROBABLE DISULFIDE BONDS.
    Tissue: Brain.
  2. "Differential modulation of sodium channel gating and persistent sodium currents by the beta1, beta2, and beta3 subunits."
    Qu Y., Curtis R., Lawson D., Gilbride K., Ge P., DiStefano P.S., Silos-Santiago I., Catterall W.A., Scheuer T.
    Mol. Cell. Neurosci. 18:570-580(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, TISSUE SPECIFICITY, SUBUNIT.
    Strain: Sprague-Dawley.
    Tissue: Spinal ganglion.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  4. "Sodium channel beta1 and beta3 subunits associate with neurofascin through their extracellular immunoglobulin-like domain."
    Ratcliffe C.F., Westenbroek R.E., Curtis R., Catterall W.A.
    J. Cell Biol. 154:427-434(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, INTERACTION WITH NEUROFASCIN.
  5. "Role of auxiliary beta1-, beta2-, and beta3-subunits and their interaction with Na(v)1.8 voltage-gated sodium channel."
    Vijayaragavan K., Powell A.J., Kinghorn I.J., Chahine M.
    Biochem. Biophys. Res. Commun. 319:531-540(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, INTERACTION WITH SCN10A.

Entry informationi

Entry nameiSCN3B_RAT
AccessioniPrimary (citable) accession number: Q9JK00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.