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Protein

Sodium channel subunit beta-3

Gene

Scn3b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Sodium channel, Voltage-gated channel
Biological processIon transport, Sodium transport, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-RNO-445095. Interaction between L1 and Ankyrins.

Protein family/group databases

TCDBi8.A.17.1.2. the na(+) channel auxiliary subunit Beta1-Beta4 (sca-Beta) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel subunit beta-3
Gene namesi
Name:Scn3b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi621657. Scn3b.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 159ExtracellularSequence analysisAdd BLAST135
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 215CytoplasmicSequence analysisAdd BLAST35

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001493625 – 215Sodium channel subunit beta-3Add BLAST191

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 48PROSITE-ProRule annotation
Disulfide bondi45 ↔ 120PROSITE-ProRule annotation
Glycosylationi95N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi109N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi113N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi121N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9JK00.
PRIDEiQ9JK00.

PTM databases

PhosphoSitePlusiQ9JK00.
UniCarbKBiQ9JK00.

Expressioni

Tissue specificityi

Expressed broadly in neurons in the central and peripheral nervous systems, but not in glia and most non-neuronal cells. Weak detection in lung and adrenal gland.1 Publication

Gene expression databases

BgeeiENSRNOG00000057221.
GenevisibleiQ9JK00. RN.

Interactioni

Subunit structurei

The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1, beta-2, beta-3 and/or beta-4 subunits. Beta-1 and beta-3 are non-covalently associated with alpha, while beta-2 and beta-4 are covalently linked by disulfide bonds. Beta-1 or beta-3 subunits associate with neurofascin. Associates with SCN10A.3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi251452. 1 interactor.
STRINGi10116.ENSRNOP00000009367.

Structurei

3D structure databases

ProteinModelPortaliQ9JK00.
SMRiQ9JK00.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 138Ig-like C2-typeAdd BLAST114

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHF3. Eukaryota.
ENOG4111IPM. LUCA.
GeneTreeiENSGT00390000018560.
HOGENOMiHOG000276881.
HOVERGENiHBG056582.
InParanoidiQ9JK00.
KOiK04847.
OMAiLLIEMVY.
OrthoDBiEOG091G0OF7.
PhylomeDBiQ9JK00.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR027098. Na_channel_b1/b3.
IPR027096. Na_channel_b3.
PANTHERiPTHR10546. PTHR10546. 1 hit.
PTHR10546:SF5. PTHR10546:SF5. 1 hit.
PfamiView protein in Pfam
PF07686. V-set. 1 hit.
SMARTiView protein in SMART
SM00409. IG. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JK00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAFNRLLPL ASLVLIYWVR VCFPVCVEVP SETEAVQGNP MKLRCISCMK
60 70 80 90 100
REEVEATTVV EWFYRPEGGK DFLIYEYRNG HQEVESPFQG RLQWNGSKDL
110 120 130 140 150
QDVSITVLNV TLNDSGLYTC NVSREFEFEA HRPFVKTTRL IPLRVTEEAG
160 170 180 190 200
EDFTSVVSEI MMYILLVFLT LWLFIEMIYC YRKVSKAEEA AQENASDYLA
210
IPSENKENSV VPVEE
Length:215
Mass (Da):24,799
Last modified:October 1, 2000 - v1
Checksum:i056B488EF5EAEF4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243395 mRNA. Translation: CAB76838.1.
AF378093 mRNA. Translation: AAK55415.1.
BC070899 mRNA. Translation: AAH70899.1.
RefSeqiNP_620797.1. NM_139097.3.
XP_006243164.1. XM_006243102.2.
XP_006243165.1. XM_006243103.2.
UniGeneiRn.3402.

Genome annotation databases

EnsembliENSRNOT00000087022; ENSRNOP00000071448; ENSRNOG00000057221.
GeneIDi245956.
KEGGirno:245956.
UCSCiRGD:621657. rat.

Similar proteinsi

Entry informationi

Entry nameiSCN3B_RAT
AccessioniPrimary (citable) accession number: Q9JK00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: October 1, 2000
Last modified: August 30, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families