Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9JJZ9

- CNGB3_MOUSE

UniProt

Q9JJZ9 - CNGB3_MOUSE

Protein

Cyclic nucleotide-gated cation channel beta-3

Gene

Cngb3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones By similarity. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGA3.By similarity1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei584 – 5841cGMPBy similarity
    Binding sitei596 – 5961cGMPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi524 – 668145cGMPBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. cGMP binding Source: RefGenome
    2. intracellular cAMP activated cation channel activity Source: RefGenome
    3. intracellular cGMP activated cation channel activity Source: MGI
    4. protein binding Source: MGI
    5. voltage-gated potassium channel activity Source: RefGenome

    GO - Biological processi

    1. cyclic nucleotide metabolic process Source: MGI
    2. phototransduction, visible light Source: RefGenome
    3. potassium ion transmembrane transport Source: RefGenome
    4. regulation of membrane potential Source: RefGenome
    5. visual perception Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ion channel, Ligand-gated ion channel

    Keywords - Biological processi

    Ion transport, Sensory transduction, Transport, Vision

    Keywords - Ligandi

    cGMP, cGMP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclic nucleotide-gated cation channel beta-3
    Alternative name(s):
    Cone photoreceptor cGMP-gated channel subunit beta
    Cyclic nucleotide-gated cation channel modulatory subunit
    Cyclic nucleotide-gated channel beta-3
    Short name:
    CNG channel beta-3
    Cyclic nucleotide-gated channel subunit CNG6
    Gene namesi
    Name:Cngb3
    Synonyms:Cng6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1353562. Cngb3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: RefGenome
    2. photoreceptor outer segment Source: MGI
    3. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 694694Cyclic nucleotide-gated cation channel beta-3PRO_0000219321Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi507 – 5071N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9JJZ9.
    PRIDEiQ9JJZ9.

    PTM databases

    PhosphoSiteiQ9JJZ9.

    Expressioni

    Tissue specificityi

    Small subset of retinal photorecptor cells and testis.1 Publication

    Gene expression databases

    BgeeiQ9JJZ9.
    CleanExiMM_CNGB3.
    GenevestigatoriQ9JJZ9.

    Interactioni

    Subunit structurei

    Tetramer formed of three CNGA3 and one CNGB3 modulatory subunits.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JJZ9.
    SMRiQ9JJZ9. Positions 442-628.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 209209CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini231 – 24212ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini264 – 29431CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini316 – 35136ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini373 – 40937CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini431 – 568138ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini590 – 694105CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei210 – 23021Helical; Name=H1Sequence AnalysisAdd
    BLAST
    Transmembranei243 – 26321Helical; Name=H2Sequence AnalysisAdd
    BLAST
    Transmembranei295 – 31521Helical; Name=H3Sequence AnalysisAdd
    BLAST
    Transmembranei352 – 37221Helical; Name=H4Sequence AnalysisAdd
    BLAST
    Transmembranei410 – 43021Helical; Name=H5Sequence AnalysisAdd
    BLAST
    Transmembranei569 – 58921Helical; Name=H6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG289446.
    GeneTreeiENSGT00550000074376.
    HOGENOMiHOG000231425.
    HOVERGENiHBG051038.
    InParanoidiQ9JJZ9.
    KOiK04953.
    OMAiKMPLTEY.
    OrthoDBiEOG744T8M.
    PhylomeDBiQ9JJZ9.
    TreeFamiTF318250.

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    InterProiIPR018490. cNMP-bd-like.
    IPR018488. cNMP-bd_CS.
    IPR000595. cNMP-bd_dom.
    IPR005821. Ion_trans_dom.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 1 hit.
    PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
    PS00889. CNMP_BINDING_2. 1 hit.
    PS50042. CNMP_BINDING_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JJZ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKSLTVKFN KVNPMEGRME KKLCPNLSSL SQPTIAQGDN QSEKEPLRSR    50
    TPITFEKSHS KEDNSTGENS LRDFTPNPDP ECRAELTRTM AEMEKTRTGK 100
    ERPVSFKTKV LETSIINEYT DAHLHNLVER MRERTALYKK TLTEEENFPE 150
    VEASSQTAMS TNISPKQENN SKLKEHQDTF SFKPQRVPVK EHLRRMILPR 200
    SIDSYTDRVY LLWLLLVTIA YNWNCWLLPV RLVFPCQTPD NKNYWIITDI 250
    VCDIIYLCDI LLIQPRLQFV RGGEIIVDSN ELKRNYRSST KFRMDVASLL 300
    PFEVLYIFFG VNPIFRANRI LKYTSFFEFN HHLESIMDKA YVYRVIRTTG 350
    YLLFLLHINA CVYYWASDYE GIGSTKWVYN GEGNKYLRCF YWAVRTLITI 400
    GGLPEPQTSF EIVFQFLNFF SGVFVFSSLI GQMRDVIGAA TANQNYFQAC 450
    MDHIIAYMNK YSIPQSVQYR VRTWLEYTWN SQRILDESNL LENLPTAMQL 500
    SIALDINFSI IDKVELFKGC DTQMIYDLLL RLKSTIYLPG DFVCKKGEIG 550
    KEMYIIKHGE VQVLGGPDGA QVLVTLKAGS VFGEISLLAK GGGNRRTADV 600
    VAHGFANLLT LDKKTLQEIL LHYPTSKKLL MKKAKILLSQ KGKTTQAIPA 650
    RPGPAFLFPP KEETPRMLKV LLGNTGKVDL GRLLKGKRKT TTQK 694
    Length:694
    Mass (Da):79,722
    Last modified:October 1, 2000 - v1
    Checksum:i0B9F9CF3B180DA82
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ243572 mRNA. Translation: CAB71152.1.
    CCDSiCCDS17990.1.
    RefSeqiNP_038955.1. NM_013927.2.
    UniGeneiMm.445778.

    Genome annotation databases

    EnsembliENSMUST00000102999; ENSMUSP00000100064; ENSMUSG00000056494.
    GeneIDi30952.
    KEGGimmu:30952.
    UCSCiuc008sbx.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ243572 mRNA. Translation: CAB71152.1 .
    CCDSi CCDS17990.1.
    RefSeqi NP_038955.1. NM_013927.2.
    UniGenei Mm.445778.

    3D structure databases

    ProteinModelPortali Q9JJZ9.
    SMRi Q9JJZ9. Positions 442-628.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9JJZ9.

    Proteomic databases

    PaxDbi Q9JJZ9.
    PRIDEi Q9JJZ9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000102999 ; ENSMUSP00000100064 ; ENSMUSG00000056494 .
    GeneIDi 30952.
    KEGGi mmu:30952.
    UCSCi uc008sbx.1. mouse.

    Organism-specific databases

    CTDi 54714.
    MGIi MGI:1353562. Cngb3.

    Phylogenomic databases

    eggNOGi NOG289446.
    GeneTreei ENSGT00550000074376.
    HOGENOMi HOG000231425.
    HOVERGENi HBG051038.
    InParanoidi Q9JJZ9.
    KOi K04953.
    OMAi KMPLTEY.
    OrthoDBi EOG744T8M.
    PhylomeDBi Q9JJZ9.
    TreeFami TF318250.

    Miscellaneous databases

    NextBioi 307424.
    PROi Q9JJZ9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9JJZ9.
    CleanExi MM_CNGB3.
    Genevestigatori Q9JJZ9.

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    InterProi IPR018490. cNMP-bd-like.
    IPR018488. cNMP-bd_CS.
    IPR000595. cNMP-bd_dom.
    IPR005821. Ion_trans_dom.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 1 hit.
    PROSITEi PS00888. CNMP_BINDING_1. 1 hit.
    PS00889. CNMP_BINDING_2. 1 hit.
    PS50042. CNMP_BINDING_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and functional characterization of a new modulatory cyclic nucleotide-gated channel subunit from mouse retina."
      Gerstner A., Zong X., Hofmann F., Biel M.
      J. Neurosci. 20:1324-1332(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, TISSUE SPECIFICITY.
      Strain: C57BL/6.
      Tissue: Retina.

    Entry informationi

    Entry nameiCNGB3_MOUSE
    AccessioniPrimary (citable) accession number: Q9JJZ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2004
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3