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Protein

Cyclic nucleotide-gated cation channel beta-3

Gene

Cngb3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones (By similarity). Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGA3.By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei584cGMPBy similarity1
Binding sitei596cGMPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi524 – 668cGMPBy similarityAdd BLAST145

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel
Biological processIon transport, Sensory transduction, Transport, Vision
LigandcGMP, cGMP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic nucleotide-gated cation channel beta-3
Alternative name(s):
Cone photoreceptor cGMP-gated channel subunit beta
Cyclic nucleotide-gated cation channel modulatory subunit
Cyclic nucleotide-gated channel beta-3
Short name:
CNG channel beta-3
Cyclic nucleotide-gated channel subunit CNG6
Gene namesi
Name:Cngb3
Synonyms:Cng6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1353562 Cngb3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 209CytoplasmicSequence analysisAdd BLAST209
Transmembranei210 – 230Helical; Name=H1Sequence analysisAdd BLAST21
Topological domaini231 – 242ExtracellularSequence analysisAdd BLAST12
Transmembranei243 – 263Helical; Name=H2Sequence analysisAdd BLAST21
Topological domaini264 – 294CytoplasmicSequence analysisAdd BLAST31
Transmembranei295 – 315Helical; Name=H3Sequence analysisAdd BLAST21
Topological domaini316 – 351ExtracellularSequence analysisAdd BLAST36
Transmembranei352 – 372Helical; Name=H4Sequence analysisAdd BLAST21
Topological domaini373 – 409CytoplasmicSequence analysisAdd BLAST37
Transmembranei410 – 430Helical; Name=H5Sequence analysisAdd BLAST21
Topological domaini431 – 568ExtracellularSequence analysisAdd BLAST138
Transmembranei569 – 589Helical; Name=H6Sequence analysisAdd BLAST21
Topological domaini590 – 694CytoplasmicSequence analysisAdd BLAST105

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi399

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002193211 – 694Cyclic nucleotide-gated cation channel beta-3Add BLAST694

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi507N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9JJZ9
PeptideAtlasiQ9JJZ9
PRIDEiQ9JJZ9

PTM databases

iPTMnetiQ9JJZ9
PhosphoSitePlusiQ9JJZ9

Expressioni

Tissue specificityi

Small subset of retinal photorecptor cells and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000056494
CleanExiMM_CNGB3
GenevisibleiQ9JJZ9 MM

Interactioni

Subunit structurei

Tetramer formed of three CNGA3 and one CNGB3 modulatory subunits.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100064

Structurei

3D structure databases

ProteinModelPortaliQ9JJZ9
SMRiQ9JJZ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0499 Eukaryota
ENOG410ZJ5U LUCA
GeneTreeiENSGT00900000140801
HOGENOMiHOG000231425
HOVERGENiHBG051038
InParanoidiQ9JJZ9
KOiK04953
OMAiNCWFIPL
OrthoDBiEOG091G03EW
PhylomeDBiQ9JJZ9
TreeFamiTF318250

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
Gene3Di2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR032943 CNG6
IPR018490 cNMP-bd-like
IPR018488 cNMP-bd_CS
IPR000595 cNMP-bd_dom
IPR014710 RmlC-like_jellyroll
PANTHERiPTHR10217:SF385 PTHR10217:SF385, 1 hit
PfamiView protein in Pfam
PF00027 cNMP_binding, 1 hit
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SUPFAMiSSF51206 SSF51206, 1 hit
PROSITEiView protein in PROSITE
PS00888 CNMP_BINDING_1, 1 hit
PS00889 CNMP_BINDING_2, 1 hit
PS50042 CNMP_BINDING_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JJZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKSLTVKFN KVNPMEGRME KKLCPNLSSL SQPTIAQGDN QSEKEPLRSR
60 70 80 90 100
TPITFEKSHS KEDNSTGENS LRDFTPNPDP ECRAELTRTM AEMEKTRTGK
110 120 130 140 150
ERPVSFKTKV LETSIINEYT DAHLHNLVER MRERTALYKK TLTEEENFPE
160 170 180 190 200
VEASSQTAMS TNISPKQENN SKLKEHQDTF SFKPQRVPVK EHLRRMILPR
210 220 230 240 250
SIDSYTDRVY LLWLLLVTIA YNWNCWLLPV RLVFPCQTPD NKNYWIITDI
260 270 280 290 300
VCDIIYLCDI LLIQPRLQFV RGGEIIVDSN ELKRNYRSST KFRMDVASLL
310 320 330 340 350
PFEVLYIFFG VNPIFRANRI LKYTSFFEFN HHLESIMDKA YVYRVIRTTG
360 370 380 390 400
YLLFLLHINA CVYYWASDYE GIGSTKWVYN GEGNKYLRCF YWAVRTLITI
410 420 430 440 450
GGLPEPQTSF EIVFQFLNFF SGVFVFSSLI GQMRDVIGAA TANQNYFQAC
460 470 480 490 500
MDHIIAYMNK YSIPQSVQYR VRTWLEYTWN SQRILDESNL LENLPTAMQL
510 520 530 540 550
SIALDINFSI IDKVELFKGC DTQMIYDLLL RLKSTIYLPG DFVCKKGEIG
560 570 580 590 600
KEMYIIKHGE VQVLGGPDGA QVLVTLKAGS VFGEISLLAK GGGNRRTADV
610 620 630 640 650
VAHGFANLLT LDKKTLQEIL LHYPTSKKLL MKKAKILLSQ KGKTTQAIPA
660 670 680 690
RPGPAFLFPP KEETPRMLKV LLGNTGKVDL GRLLKGKRKT TTQK
Length:694
Mass (Da):79,722
Last modified:October 1, 2000 - v1
Checksum:i0B9F9CF3B180DA82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243572 mRNA Translation: CAB71152.1
CCDSiCCDS17990.1
RefSeqiNP_038955.1, NM_013927.2
UniGeneiMm.445778

Genome annotation databases

EnsembliENSMUST00000102999; ENSMUSP00000100064; ENSMUSG00000056494
GeneIDi30952
KEGGimmu:30952
UCSCiuc008sbx.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCNGB3_MOUSE
AccessioniPrimary (citable) accession number: Q9JJZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health