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Q9JJZ9

- CNGB3_MOUSE

UniProt

Q9JJZ9 - CNGB3_MOUSE

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Protein

Cyclic nucleotide-gated cation channel beta-3

Gene
Cngb3, Cng6
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones By similarity. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGA3.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei584 – 5841cGMP By similarity
Binding sitei596 – 5961cGMP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi524 – 668145cGMP By similarityAdd
BLAST

GO - Molecular functioni

  1. cGMP binding Source: RefGenome
  2. intracellular cAMP activated cation channel activity Source: RefGenome
  3. intracellular cGMP activated cation channel activity Source: MGI
  4. protein binding Source: MGI
  5. voltage-gated potassium channel activity Source: RefGenome

GO - Biological processi

  1. cyclic nucleotide metabolic process Source: MGI
  2. phototransduction, visible light Source: RefGenome
  3. potassium ion transmembrane transport Source: RefGenome
  4. regulation of membrane potential Source: RefGenome
  5. visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel

Keywords - Biological processi

Ion transport, Sensory transduction, Transport, Vision

Keywords - Ligandi

cGMP, cGMP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic nucleotide-gated cation channel beta-3
Alternative name(s):
Cone photoreceptor cGMP-gated channel subunit beta
Cyclic nucleotide-gated cation channel modulatory subunit
Cyclic nucleotide-gated channel beta-3
Short name:
CNG channel beta-3
Cyclic nucleotide-gated channel subunit CNG6
Gene namesi
Name:Cngb3
Synonyms:Cng6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1353562. Cngb3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 209209Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei210 – 23021Helical; Name=H1; Reviewed predictionAdd
BLAST
Topological domaini231 – 24212Extracellular Reviewed predictionAdd
BLAST
Transmembranei243 – 26321Helical; Name=H2; Reviewed predictionAdd
BLAST
Topological domaini264 – 29431Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei295 – 31521Helical; Name=H3; Reviewed predictionAdd
BLAST
Topological domaini316 – 35136Extracellular Reviewed predictionAdd
BLAST
Transmembranei352 – 37221Helical; Name=H4; Reviewed predictionAdd
BLAST
Topological domaini373 – 40937Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei410 – 43021Helical; Name=H5; Reviewed predictionAdd
BLAST
Topological domaini431 – 568138Extracellular Reviewed predictionAdd
BLAST
Transmembranei569 – 58921Helical; Name=H6; Reviewed predictionAdd
BLAST
Topological domaini590 – 694105Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: RefGenome
  2. photoreceptor outer segment Source: MGI
  3. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 694694Cyclic nucleotide-gated cation channel beta-3PRO_0000219321Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi507 – 5071N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9JJZ9.
PRIDEiQ9JJZ9.

PTM databases

PhosphoSiteiQ9JJZ9.

Expressioni

Tissue specificityi

Small subset of retinal photorecptor cells and testis.1 Publication

Gene expression databases

BgeeiQ9JJZ9.
CleanExiMM_CNGB3.
GenevestigatoriQ9JJZ9.

Interactioni

Subunit structurei

Tetramer formed of three CNGA3 and one CNGB3 modulatory subunits By similarity.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9JJZ9.
SMRiQ9JJZ9. Positions 442-628.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG289446.
GeneTreeiENSGT00550000074376.
HOGENOMiHOG000231425.
HOVERGENiHBG051038.
InParanoidiQ9JJZ9.
KOiK04953.
OMAiKMPLTEY.
OrthoDBiEOG744T8M.
PhylomeDBiQ9JJZ9.
TreeFamiTF318250.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
PS00889. CNMP_BINDING_2. 1 hit.
PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JJZ9-1 [UniParc]FASTAAdd to Basket

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MLKSLTVKFN KVNPMEGRME KKLCPNLSSL SQPTIAQGDN QSEKEPLRSR    50
TPITFEKSHS KEDNSTGENS LRDFTPNPDP ECRAELTRTM AEMEKTRTGK 100
ERPVSFKTKV LETSIINEYT DAHLHNLVER MRERTALYKK TLTEEENFPE 150
VEASSQTAMS TNISPKQENN SKLKEHQDTF SFKPQRVPVK EHLRRMILPR 200
SIDSYTDRVY LLWLLLVTIA YNWNCWLLPV RLVFPCQTPD NKNYWIITDI 250
VCDIIYLCDI LLIQPRLQFV RGGEIIVDSN ELKRNYRSST KFRMDVASLL 300
PFEVLYIFFG VNPIFRANRI LKYTSFFEFN HHLESIMDKA YVYRVIRTTG 350
YLLFLLHINA CVYYWASDYE GIGSTKWVYN GEGNKYLRCF YWAVRTLITI 400
GGLPEPQTSF EIVFQFLNFF SGVFVFSSLI GQMRDVIGAA TANQNYFQAC 450
MDHIIAYMNK YSIPQSVQYR VRTWLEYTWN SQRILDESNL LENLPTAMQL 500
SIALDINFSI IDKVELFKGC DTQMIYDLLL RLKSTIYLPG DFVCKKGEIG 550
KEMYIIKHGE VQVLGGPDGA QVLVTLKAGS VFGEISLLAK GGGNRRTADV 600
VAHGFANLLT LDKKTLQEIL LHYPTSKKLL MKKAKILLSQ KGKTTQAIPA 650
RPGPAFLFPP KEETPRMLKV LLGNTGKVDL GRLLKGKRKT TTQK 694
Length:694
Mass (Da):79,722
Last modified:October 1, 2000 - v1
Checksum:i0B9F9CF3B180DA82
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ243572 mRNA. Translation: CAB71152.1.
CCDSiCCDS17990.1.
RefSeqiNP_038955.1. NM_013927.2.
UniGeneiMm.445778.

Genome annotation databases

EnsembliENSMUST00000102999; ENSMUSP00000100064; ENSMUSG00000056494.
GeneIDi30952.
KEGGimmu:30952.
UCSCiuc008sbx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ243572 mRNA. Translation: CAB71152.1 .
CCDSi CCDS17990.1.
RefSeqi NP_038955.1. NM_013927.2.
UniGenei Mm.445778.

3D structure databases

ProteinModelPortali Q9JJZ9.
SMRi Q9JJZ9. Positions 442-628.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9JJZ9.

Proteomic databases

PaxDbi Q9JJZ9.
PRIDEi Q9JJZ9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000102999 ; ENSMUSP00000100064 ; ENSMUSG00000056494 .
GeneIDi 30952.
KEGGi mmu:30952.
UCSCi uc008sbx.1. mouse.

Organism-specific databases

CTDi 54714.
MGIi MGI:1353562. Cngb3.

Phylogenomic databases

eggNOGi NOG289446.
GeneTreei ENSGT00550000074376.
HOGENOMi HOG000231425.
HOVERGENi HBG051038.
InParanoidi Q9JJZ9.
KOi K04953.
OMAi KMPLTEY.
OrthoDBi EOG744T8M.
PhylomeDBi Q9JJZ9.
TreeFami TF318250.

Miscellaneous databases

NextBioi 307424.
PROi Q9JJZ9.
SOURCEi Search...

Gene expression databases

Bgeei Q9JJZ9.
CleanExi MM_CNGB3.
Genevestigatori Q9JJZ9.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
InterProi IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 1 hit.
PROSITEi PS00888. CNMP_BINDING_1. 1 hit.
PS00889. CNMP_BINDING_2. 1 hit.
PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and functional characterization of a new modulatory cyclic nucleotide-gated channel subunit from mouse retina."
    Gerstner A., Zong X., Hofmann F., Biel M.
    J. Neurosci. 20:1324-1332(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, TISSUE SPECIFICITY.
    Strain: C57BL/6.
    Tissue: Retina.

Entry informationi

Entry nameiCNGB3_MOUSE
AccessioniPrimary (citable) accession number: Q9JJZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi