Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9JJZ8

- CNGA3_MOUSE

UniProt

Q9JJZ8 - CNGA3_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cyclic nucleotide-gated cation channel alpha-3

Gene

Cnga3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones (By similarity). Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3.By similarity1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei490 – 4901cGMPSequence Analysis
Binding sitei505 – 5051cGMPSequence Analysis

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi423 – 546124cGMPAdd
BLAST

GO - Molecular functioni

  1. cGMP binding Source: RefGenome
  2. intracellular cAMP activated cation channel activity Source: RefGenome
  3. intracellular cGMP activated cation channel activity Source: RefGenome
  4. intracellular cyclic nucleotide activated cation channel activity Source: MGI
  5. voltage-gated potassium channel activity Source: RefGenome

GO - Biological processi

  1. phototransduction, visible light Source: RefGenome
  2. potassium ion transmembrane transport Source: RefGenome
  3. regulation of membrane potential Source: RefGenome
  4. response to cAMP Source: Ensembl
  5. response to corticosteroid Source: Ensembl
  6. response to magnesium ion Source: Ensembl
  7. retinal cone cell development Source: MGI
  8. visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel

Keywords - Biological processi

Ion transport, Sensory transduction, Transport, Vision

Keywords - Ligandi

cGMP, cGMP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic nucleotide-gated cation channel alpha-3
Alternative name(s):
Cone photoreceptor cGMP-gated channel subunit alpha
Cyclic nucleotide-gated channel alpha-3
Short name:
CNG channel alpha-3
Short name:
CNG-3
Short name:
CNG3
Gene namesi
Name:Cnga3
Synonyms:Cng3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1341818. Cnga3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. dendrite Source: Ensembl
  3. integral component of plasma membrane Source: RefGenome
  4. perikaryon Source: Ensembl
  5. photoreceptor outer segment Source: MGI
  6. photoreceptor outer segment membrane Source: Ensembl
  7. plasma membrane Source: MGI
  8. transmembrane transporter complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 631631Cyclic nucleotide-gated cation channel alpha-3PRO_0000219318Add
BLAST

Proteomic databases

PRIDEiQ9JJZ8.

PTM databases

PhosphoSiteiQ9JJZ8.

Expressioni

Tissue specificityi

Prominently expressed in retina.

Gene expression databases

BgeeiQ9JJZ8.
CleanExiMM_CNGA3.
GenevestigatoriQ9JJZ8.

Interactioni

Subunit structurei

Tetramer formed of three CNGA3 and one CNGB3 modulatory subunits.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027288.

Structurei

3D structure databases

ProteinModelPortaliQ9JJZ8.
SMRiQ9JJZ8. Positions 292-540, 567-610.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei112 – 13322HelicalSequence AnalysisAdd
BLAST
Transmembranei244 – 26421HelicalSequence AnalysisAdd
BLAST
Transmembranei320 – 34021HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili567 – 61044By similarityAdd
BLAST

Domaini

The C-terminal coiled-coil domain mediates homotrimerization of CNGA subunits.By similarity

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG300025.
GeneTreeiENSGT00760000118772.
HOGENOMiHOG000007898.
HOVERGENiHBG000281.
InParanoidiQ9JJZ8.
KOiK04950.
OMAiMAKINTQ.
OrthoDBiEOG771268.
TreeFamiTF319048.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
PS00889. CNMP_BINDING_2. 1 hit.
PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JJZ8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKVNTQCSQ PSPTQLSIKN ADRDLDHVEN GLGRVSRLII SIRAWASRHL
60 70 80 90 100
HDEDQTPDSF LDRFHGSELK EVSTRESNAQ PNPGEQKPPD GGEGRKEEPI
110 120 130 140 150
VVDPSSNIYY RWLTAIALPV FYNWCLLVCR ACFDELQSEH LTLWLVLDYS
160 170 180 190 200
ADVLYVLDML VRARTGFLEQ GLMVRDTKRL WKHYTKTLHF KLDILSLIPT
210 220 230 240 250
DLAYLKLGVN YPELRFNRLL KFSRLFEFFD RTETRTNYPN VFRIGNLVLY
260 270 280 290 300
TLIIIHWNAC IYFAISKFIG FGTDSWVYPN TSKPEYARLS RKYIYSLYWS
310 320 330 340 350
TLTLTTIGET PPPVKDEEYL FVVIDFLVGI LIFATIVGNV GSMISNMNAP
360 370 380 390 400
RVEFQAKIDS VKQYMQFRKV TKDLETRVIR WFDYLWANRK TVDEKEVLKN
410 420 430 440 450
LPDKLKAEIA INVHLDTLKK VRIFQDCEAG LLVELVLKLR PTVFSPGDYI
460 470 480 490 500
CKKGDIGREM YIIKEGKLAV VADDGVTQFV VLSDGSYFGE ISILNIKGSK
510 520 530 540 550
SGNRRTANIR SIGYSDLFCL SKDDLMEALT EYPDAKRALE EKGRQILMKD
560 570 580 590 600
NLIDEDLVAA RVDTRDVEEK VEYLESSLDI LQTRFARLLA EYSASQMKLK
610 620 630
QRLTRLESQM NRRCCGFSPD RENSEDASKT D
Length:631
Mass (Da):72,702
Last modified:July 27, 2011 - v2
Checksum:i4FAD66E3A8A3FE6C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti110 – 1101Y → C in CAB89685. (PubMed:10813773)Curated
Sequence conflicti157 – 1571L → V in CAB42891. (PubMed:10377453)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ243933 mRNA. Translation: CAB89685.1.
BC035272 mRNA. Translation: AAH35272.1.
BC049145 mRNA. Translation: AAH49145.1.
AJ238239, AJ238240, AJ238241 Genomic DNA. Translation: CAB42891.1.
CCDSiCCDS14890.1.
RefSeqiNP_001268939.1. NM_001282010.1.
NP_034048.1. NM_009918.2.
XP_006495702.1. XM_006495639.1.
XP_006495703.1. XM_006495640.1.
UniGeneiMm.214224.

Genome annotation databases

EnsembliENSMUST00000027288; ENSMUSP00000027288; ENSMUSG00000026114.
GeneIDi12790.
KEGGimmu:12790.
UCSCiuc007ari.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ243933 mRNA. Translation: CAB89685.1 .
BC035272 mRNA. Translation: AAH35272.1 .
BC049145 mRNA. Translation: AAH49145.1 .
AJ238239 , AJ238240 , AJ238241 Genomic DNA. Translation: CAB42891.1 .
CCDSi CCDS14890.1.
RefSeqi NP_001268939.1. NM_001282010.1.
NP_034048.1. NM_009918.2.
XP_006495702.1. XM_006495639.1.
XP_006495703.1. XM_006495640.1.
UniGenei Mm.214224.

3D structure databases

ProteinModelPortali Q9JJZ8.
SMRi Q9JJZ8. Positions 292-540, 567-610.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000027288.

PTM databases

PhosphoSitei Q9JJZ8.

Proteomic databases

PRIDEi Q9JJZ8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027288 ; ENSMUSP00000027288 ; ENSMUSG00000026114 .
GeneIDi 12790.
KEGGi mmu:12790.
UCSCi uc007ari.1. mouse.

Organism-specific databases

CTDi 1261.
MGIi MGI:1341818. Cnga3.

Phylogenomic databases

eggNOGi NOG300025.
GeneTreei ENSGT00760000118772.
HOGENOMi HOG000007898.
HOVERGENi HBG000281.
InParanoidi Q9JJZ8.
KOi K04950.
OMAi MAKINTQ.
OrthoDBi EOG771268.
TreeFami TF319048.

Miscellaneous databases

NextBioi 282194.
PROi Q9JJZ8.
SOURCEi Search...

Gene expression databases

Bgeei Q9JJZ8.
CleanExi MM_CNGA3.
Genevestigatori Q9JJZ8.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
InterProi IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 1 hit.
PROSITEi PS00888. CNMP_BINDING_1. 1 hit.
PS00889. CNMP_BINDING_2. 1 hit.
PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and immunocytochemical localization of a cyclic nucleotide-gated channel alpha-subunit to all cone photoreceptors in the mouse retina."
    Hirano A.A., Hack I., Waessle H., Duvoisin R.M.
    J. Comp. Neurol. 421:80-94(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Retina.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  3. "Selective loss of cone function in mice lacking the cyclic nucleotide-gated channel CNG3."
    Biel M., Seeliger M., Pfeifer A., Kohler K., Gerstner A., Ludwig A., Jaissle G., Fauser S., Zrenner E., Hofmann F.
    Proc. Natl. Acad. Sci. U.S.A. 96:7553-7557(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 95-631.
    Strain: 129/Sv.
  4. "Molecular cloning and functional characterization of a new modulatory cyclic nucleotide-gated channel subunit from mouse retina."
    Gerstner A., Zong X., Hofmann F., Biel M.
    J. Neurosci. 20:1324-1332(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT.

Entry informationi

Entry nameiCNGA3_MOUSE
AccessioniPrimary (citable) accession number: Q9JJZ8
Secondary accession number(s): Q8CFV6, Q9WV01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3