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Protein

Krueppel-like factor 13

Gene

Klf13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that activates expression from GC-rich minimal promoter regions, including genes in the cells of the erythroid lineage.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri168 – 192C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri198 – 222C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri228 – 250C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
  • transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

  • negative regulation of cell proliferation Source: BHF-UCL
  • negative regulation of erythrocyte differentiation Source: BHF-UCL
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • regulation of transcription by RNA polymerase II Source: MGI
  • transcription by RNA polymerase II Source: MGI

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 13
Alternative name(s):
Basic transcription element-binding protein 3
Short name:
BTE-binding protein 3
Erythroid transcription factor FKLF-2
RANTES factor of late activated T-lymphocytes 1
Short name:
RFLAT-1
Transcription factor BTEB3
Gene namesi
Name:Klf13
Synonyms:Bteb3, Fklf2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1354948 Klf13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471851 – 289Krueppel-like factor 13Add BLAST289

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei269PhosphoserineBy similarity1
Modified residuei271PhosphoserineBy similarity1
Modified residuei280PhosphoserineCombined sources1
Modified residuei284PhosphoserineCombined sources1
Modified residuei288PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9JJZ6
MaxQBiQ9JJZ6
PaxDbiQ9JJZ6
PeptideAtlasiQ9JJZ6
PRIDEiQ9JJZ6

PTM databases

iPTMnetiQ9JJZ6
PhosphoSitePlusiQ9JJZ6

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSMUSG00000052040
CleanExiMM_KLF13
ExpressionAtlasiQ9JJZ6 baseline and differential
GenevisibleiQ9JJZ6 MM

Interactioni

Protein-protein interaction databases

BioGridi206125, 2 interactors
IntActiQ9JJZ6, 1 interactor
MINTiQ9JJZ6
STRINGi10090.ENSMUSP00000067680

Structurei

3D structure databases

ProteinModelPortaliQ9JJZ6
SMRiQ9JJZ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 146Ala/Pro-richAdd BLAST145
Compositional biasi149 – 169Arg/Lys-rich (basic)Add BLAST21
Compositional biasi265 – 288Ser-richAdd BLAST24

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri168 – 192C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri198 – 222C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri228 – 250C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
HOGENOMiHOG000233575
HOVERGENiHBG050746
InParanoidiQ9JJZ6
KOiK09208
OMAiQRKHKCH
OrthoDBiEOG091G1BN0
PhylomeDBiQ9JJZ6
TreeFamiTF351003

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q9JJZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAYVDHF AAECLVSMSS RAVVHEPREG PEPRPEGAAA AAPTLPRVDE
60 70 80 90 100
RRDGKDSASL FVVARILADL NQQAPAPAPA ERREGAAARK ARTPCRLPPA
110 120 130 140 150
PPAPPPGPEP ASPGQAGAPA APPSPAWSEP EAALEQEPGP AGSGEPGLRQ
160 170 180 190 200
RGRRGRSRAD LESPQRKHKC HYAGCEKVYG KSSHLKAHLR THTGERPFAC
210 220 230 240 250
SWQECNKKFA RSDELARHYR THTGEKKFSC PICEKRFMRS DHLTKHARRH
260 270 280
ANFHPGMLQR RGGGSRTGSL SDYSRSDASS PTISPASSP
Length:289
Mass (Da):31,136
Last modified:November 2, 2001 - v2
Checksum:iE248EF12890DA090
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13 – 30ECLVS…EPREG → SASCPCQPRSRARAAGR in CAC06697 (PubMed:11087666).CuratedAdd BLAST18
Sequence conflicti32E → R in CAB75887 (PubMed:10642511).Curated1
Sequence conflicti43P → L in CAB75887 (PubMed:10642511).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245644 mRNA Translation: CAB75887.1
AF251796 mRNA Translation: AAF73964.1
AJ275987 mRNA Translation: CAC06697.1
AF252285 mRNA Translation: AAF65826.1
CCDSiCCDS21331.1
RefSeqiNP_067341.2, NM_021366.3
UniGeneiMm.240473

Genome annotation databases

EnsembliENSMUST00000063694; ENSMUSP00000067680; ENSMUSG00000052040
GeneIDi50794
KEGGimmu:50794
UCSCiuc009hfn.2 mouse

Similar proteinsi

Entry informationi

Entry nameiKLF13_MOUSE
AccessioniPrimary (citable) accession number: Q9JJZ6
Secondary accession number(s): Q9ESX3, Q9JHF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: November 2, 2001
Last modified: March 28, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health