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Q9JJZ6

- KLF13_MOUSE

UniProt

Q9JJZ6 - KLF13_MOUSE

Protein

Krueppel-like factor 13

Gene

Klf13

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (02 Nov 2001)
      Previous versions | rss
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    Functioni

    Transcription factor that activates expression from GC-rich minimal promoter regions, including genes in the cells of the erythroid lineage.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri168 – 19225C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri198 – 22225C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri228 – 25023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. negative regulation of cell proliferation Source: BHF-UCL
    2. negative regulation of erythrocyte differentiation Source: BHF-UCL
    3. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    4. regulation of transcription from RNA polymerase II promoter Source: MGI
    5. transcription from RNA polymerase II promoter Source: MGI

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Krueppel-like factor 13
    Alternative name(s):
    Basic transcription element-binding protein 3
    Short name:
    BTE-binding protein 3
    Erythroid transcription factor FKLF-2
    RANTES factor of late activated T-lymphocytes 1
    Short name:
    RFLAT-1
    Transcription factor BTEB3
    Gene namesi
    Name:Klf13
    Synonyms:Bteb3, Fklf2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1354948. Klf13.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 289289Krueppel-like factor 13PRO_0000047185Add
    BLAST

    Proteomic databases

    PaxDbiQ9JJZ6.
    PRIDEiQ9JJZ6.

    PTM databases

    PhosphoSiteiQ9JJZ6.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiQ9JJZ6.
    BgeeiQ9JJZ6.
    CleanExiMM_KLF13.
    GenevestigatoriQ9JJZ6.

    Interactioni

    Protein-protein interaction databases

    BioGridi206125. 2 interactions.
    IntActiQ9JJZ6. 1 interaction.
    MINTiMINT-4099898.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JJZ6.
    SMRiQ9JJZ6. Positions 143-282.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi2 – 146145Ala/Pro-richAdd
    BLAST
    Compositional biasi149 – 16921Arg/Lys-rich (basic)Add
    BLAST
    Compositional biasi265 – 28824Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri168 – 19225C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri198 – 22225C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri228 – 25023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    GeneTreeiENSGT00750000117414.
    HOGENOMiHOG000233575.
    HOVERGENiHBG050746.
    InParanoidiQ9JJZ6.
    KOiK09208.
    OMAiECSWQEC.
    OrthoDBiEOG7FJH0Q.
    PhylomeDBiQ9JJZ6.
    TreeFamiTF351003.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 3 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JJZ6-1 [UniParc]FASTAAdd to Basket

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    MAAAAYVDHF AAECLVSMSS RAVVHEPREG PEPRPEGAAA AAPTLPRVDE    50
    RRDGKDSASL FVVARILADL NQQAPAPAPA ERREGAAARK ARTPCRLPPA 100
    PPAPPPGPEP ASPGQAGAPA APPSPAWSEP EAALEQEPGP AGSGEPGLRQ 150
    RGRRGRSRAD LESPQRKHKC HYAGCEKVYG KSSHLKAHLR THTGERPFAC 200
    SWQECNKKFA RSDELARHYR THTGEKKFSC PICEKRFMRS DHLTKHARRH 250
    ANFHPGMLQR RGGGSRTGSL SDYSRSDASS PTISPASSP 289
    Length:289
    Mass (Da):31,136
    Last modified:November 2, 2001 - v2
    Checksum:iE248EF12890DA090
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti13 – 3018ECLVS…EPREG → SASCPCQPRSRARAAGR in CAC06697. (PubMed:11087666)CuratedAdd
    BLAST
    Sequence conflicti32 – 321E → R in CAB75887. (PubMed:10642511)Curated
    Sequence conflicti43 – 431P → L in CAB75887. (PubMed:10642511)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ245644 mRNA. Translation: CAB75887.1.
    AF251796 mRNA. Translation: AAF73964.1.
    AJ275987 mRNA. Translation: CAC06697.1.
    AF252285 mRNA. Translation: AAF65826.1.
    CCDSiCCDS21331.1.
    RefSeqiNP_067341.2. NM_021366.3.
    UniGeneiMm.240473.

    Genome annotation databases

    EnsembliENSMUST00000063694; ENSMUSP00000067680; ENSMUSG00000052040.
    GeneIDi50794.
    KEGGimmu:50794.
    UCSCiuc009hfn.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ245644 mRNA. Translation: CAB75887.1 .
    AF251796 mRNA. Translation: AAF73964.1 .
    AJ275987 mRNA. Translation: CAC06697.1 .
    AF252285 mRNA. Translation: AAF65826.1 .
    CCDSi CCDS21331.1.
    RefSeqi NP_067341.2. NM_021366.3.
    UniGenei Mm.240473.

    3D structure databases

    ProteinModelPortali Q9JJZ6.
    SMRi Q9JJZ6. Positions 143-282.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 206125. 2 interactions.
    IntActi Q9JJZ6. 1 interaction.
    MINTi MINT-4099898.

    PTM databases

    PhosphoSitei Q9JJZ6.

    Proteomic databases

    PaxDbi Q9JJZ6.
    PRIDEi Q9JJZ6.

    Protocols and materials databases

    DNASUi 50794.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000063694 ; ENSMUSP00000067680 ; ENSMUSG00000052040 .
    GeneIDi 50794.
    KEGGi mmu:50794.
    UCSCi uc009hfn.2. mouse.

    Organism-specific databases

    CTDi 51621.
    MGIi MGI:1354948. Klf13.

    Phylogenomic databases

    eggNOGi COG5048.
    GeneTreei ENSGT00750000117414.
    HOGENOMi HOG000233575.
    HOVERGENi HBG050746.
    InParanoidi Q9JJZ6.
    KOi K09208.
    OMAi ECSWQEC.
    OrthoDBi EOG7FJH0Q.
    PhylomeDBi Q9JJZ6.
    TreeFami TF351003.

    Miscellaneous databases

    ChiTaRSi KLF13. mouse.
    NextBioi 307793.
    PROi Q9JJZ6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9JJZ6.
    Bgeei Q9JJZ6.
    CleanExi MM_KLF13.
    Genevestigatori Q9JJZ6.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 3 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse BTEB3, a new member of the basic transcription element binding protein (BTEB) family, activates expression from GC-rich minimal promoter regions."
      Martin K.M., Cooper W.N., Metcalfe J.C., Kemp P.R.
      Biochem. J. 345:529-533(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Heart.
    2. "FKLF-2: a novel Kruppel-like transcriptional factor that activates globin and other erythroid lineage genes."
      Asano H., Li X.S., Stamatoyannopoulos G.
      Blood 95:3578-3584(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: B6D2F2.
      Tissue: Yolk.
    3. "Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family."
      Scohy S., Gabant P., Van Reeth T., Hertveldt V., Dreze P.-L., Van Vooren P., Riviere M., Szpirer J., Szpirer C.
      Genomics 70:93-101(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fetal liver.
    4. "Identification of Mus musculus cDNA for RANTES factor of late activated T lymphocytes-1."
      Song A., Thamatrakoln K., Krensky A.M.
      Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.

    Entry informationi

    Entry nameiKLF13_MOUSE
    AccessioniPrimary (citable) accession number: Q9JJZ6
    Secondary accession number(s): Q9ESX3, Q9JHF8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 2, 2001
    Last sequence update: November 2, 2001
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3