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Protein

Krueppel-like factor 13

Gene

Klf13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that activates expression from GC-rich minimal promoter regions, including genes in the cells of the erythroid lineage.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri168 – 192C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri198 – 222C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri228 – 250C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • negative regulation of cell proliferation Source: BHF-UCL
  • negative regulation of erythrocyte differentiation Source: BHF-UCL
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of transcription from RNA polymerase II promoter Source: MGI
  • transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 13
Alternative name(s):
Basic transcription element-binding protein 3
Short name:
BTE-binding protein 3
Erythroid transcription factor FKLF-2
RANTES factor of late activated T-lymphocytes 1
Short name:
RFLAT-1
Transcription factor BTEB3
Gene namesi
Name:Klf13
Synonyms:Bteb3, Fklf2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1354948. Klf13.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471851 – 289Krueppel-like factor 13Add BLAST289

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei269PhosphoserineBy similarity1
Modified residuei271PhosphoserineBy similarity1
Modified residuei280PhosphoserineCombined sources1
Modified residuei284PhosphoserineCombined sources1
Modified residuei288PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9JJZ6.
MaxQBiQ9JJZ6.
PaxDbiQ9JJZ6.
PeptideAtlasiQ9JJZ6.
PRIDEiQ9JJZ6.

PTM databases

iPTMnetiQ9JJZ6.
PhosphoSitePlusiQ9JJZ6.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSMUSG00000052040.
CleanExiMM_KLF13.
ExpressionAtlasiQ9JJZ6. baseline and differential.
GenevisibleiQ9JJZ6. MM.

Interactioni

Protein-protein interaction databases

BioGridi206125. 2 interactors.
IntActiQ9JJZ6. 1 interactor.
MINTiMINT-4099898.
STRINGi10090.ENSMUSP00000067680.

Structurei

3D structure databases

ProteinModelPortaliQ9JJZ6.
SMRiQ9JJZ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 146Ala/Pro-richAdd BLAST145
Compositional biasi149 – 169Arg/Lys-rich (basic)Add BLAST21
Compositional biasi265 – 288Ser-richAdd BLAST24

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri168 – 192C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri198 – 222C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri228 – 250C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118984.
HOGENOMiHOG000233575.
HOVERGENiHBG050746.
InParanoidiQ9JJZ6.
KOiK09208.
OMAiFNQQTPN.
OrthoDBiEOG091G1BN0.
PhylomeDBiQ9JJZ6.
TreeFamiTF351003.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR030450. Sp1_fam.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR23235. PTHR23235. 1 hit.
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JJZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAYVDHF AAECLVSMSS RAVVHEPREG PEPRPEGAAA AAPTLPRVDE
60 70 80 90 100
RRDGKDSASL FVVARILADL NQQAPAPAPA ERREGAAARK ARTPCRLPPA
110 120 130 140 150
PPAPPPGPEP ASPGQAGAPA APPSPAWSEP EAALEQEPGP AGSGEPGLRQ
160 170 180 190 200
RGRRGRSRAD LESPQRKHKC HYAGCEKVYG KSSHLKAHLR THTGERPFAC
210 220 230 240 250
SWQECNKKFA RSDELARHYR THTGEKKFSC PICEKRFMRS DHLTKHARRH
260 270 280
ANFHPGMLQR RGGGSRTGSL SDYSRSDASS PTISPASSP
Length:289
Mass (Da):31,136
Last modified:November 2, 2001 - v2
Checksum:iE248EF12890DA090
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13 – 30ECLVS…EPREG → SASCPCQPRSRARAAGR in CAC06697 (PubMed:11087666).CuratedAdd BLAST18
Sequence conflicti32E → R in CAB75887 (PubMed:10642511).Curated1
Sequence conflicti43P → L in CAB75887 (PubMed:10642511).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245644 mRNA. Translation: CAB75887.1.
AF251796 mRNA. Translation: AAF73964.1.
AJ275987 mRNA. Translation: CAC06697.1.
AF252285 mRNA. Translation: AAF65826.1.
CCDSiCCDS21331.1.
RefSeqiNP_067341.2. NM_021366.3.
UniGeneiMm.240473.

Genome annotation databases

EnsembliENSMUST00000063694; ENSMUSP00000067680; ENSMUSG00000052040.
GeneIDi50794.
KEGGimmu:50794.
UCSCiuc009hfn.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245644 mRNA. Translation: CAB75887.1.
AF251796 mRNA. Translation: AAF73964.1.
AJ275987 mRNA. Translation: CAC06697.1.
AF252285 mRNA. Translation: AAF65826.1.
CCDSiCCDS21331.1.
RefSeqiNP_067341.2. NM_021366.3.
UniGeneiMm.240473.

3D structure databases

ProteinModelPortaliQ9JJZ6.
SMRiQ9JJZ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206125. 2 interactors.
IntActiQ9JJZ6. 1 interactor.
MINTiMINT-4099898.
STRINGi10090.ENSMUSP00000067680.

PTM databases

iPTMnetiQ9JJZ6.
PhosphoSitePlusiQ9JJZ6.

Proteomic databases

EPDiQ9JJZ6.
MaxQBiQ9JJZ6.
PaxDbiQ9JJZ6.
PeptideAtlasiQ9JJZ6.
PRIDEiQ9JJZ6.

Protocols and materials databases

DNASUi50794.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063694; ENSMUSP00000067680; ENSMUSG00000052040.
GeneIDi50794.
KEGGimmu:50794.
UCSCiuc009hfn.2. mouse.

Organism-specific databases

CTDi51621.
MGIiMGI:1354948. Klf13.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118984.
HOGENOMiHOG000233575.
HOVERGENiHBG050746.
InParanoidiQ9JJZ6.
KOiK09208.
OMAiFNQQTPN.
OrthoDBiEOG091G1BN0.
PhylomeDBiQ9JJZ6.
TreeFamiTF351003.

Miscellaneous databases

ChiTaRSiKlf13. mouse.
PROiQ9JJZ6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000052040.
CleanExiMM_KLF13.
ExpressionAtlasiQ9JJZ6. baseline and differential.
GenevisibleiQ9JJZ6. MM.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR030450. Sp1_fam.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR23235. PTHR23235. 1 hit.
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLF13_MOUSE
AccessioniPrimary (citable) accession number: Q9JJZ6
Secondary accession number(s): Q9ESX3, Q9JHF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: November 2, 2001
Last modified: November 2, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.