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Q9JJZ6

- KLF13_MOUSE

UniProt

Q9JJZ6 - KLF13_MOUSE

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Protein

Krueppel-like factor 13

Gene

Klf13

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Transcription factor that activates expression from GC-rich minimal promoter regions, including genes in the cells of the erythroid lineage.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri168 – 19225C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri198 – 22225C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri228 – 25023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. negative regulation of cell proliferation Source: BHF-UCL
  2. negative regulation of erythrocyte differentiation Source: BHF-UCL
  3. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  4. regulation of transcription from RNA polymerase II promoter Source: MGI
  5. transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 13
Alternative name(s):
Basic transcription element-binding protein 3
Short name:
BTE-binding protein 3
Erythroid transcription factor FKLF-2
RANTES factor of late activated T-lymphocytes 1
Short name:
RFLAT-1
Transcription factor BTEB3
Gene namesi
Name:Klf13
Synonyms:Bteb3, Fklf2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1354948. Klf13.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Krueppel-like factor 13PRO_0000047185Add
BLAST

Proteomic databases

MaxQBiQ9JJZ6.
PaxDbiQ9JJZ6.
PRIDEiQ9JJZ6.

PTM databases

PhosphoSiteiQ9JJZ6.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiQ9JJZ6.
CleanExiMM_KLF13.
ExpressionAtlasiQ9JJZ6. baseline and differential.
GenevestigatoriQ9JJZ6.

Interactioni

Protein-protein interaction databases

BioGridi206125. 2 interactions.
IntActiQ9JJZ6. 1 interaction.
MINTiMINT-4099898.

Structurei

3D structure databases

ProteinModelPortaliQ9JJZ6.
SMRiQ9JJZ6. Positions 143-282.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2 – 146145Ala/Pro-richAdd
BLAST
Compositional biasi149 – 16921Arg/Lys-rich (basic)Add
BLAST
Compositional biasi265 – 28824Ser-richAdd
BLAST

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri168 – 19225C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri198 – 22225C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri228 – 25023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118984.
HOGENOMiHOG000233575.
HOVERGENiHBG050746.
InParanoidiQ9JJZ6.
KOiK09208.
OMAiECSWQEC.
OrthoDBiEOG7FJH0Q.
PhylomeDBiQ9JJZ6.
TreeFamiTF351003.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JJZ6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAAAYVDHF AAECLVSMSS RAVVHEPREG PEPRPEGAAA AAPTLPRVDE
60 70 80 90 100
RRDGKDSASL FVVARILADL NQQAPAPAPA ERREGAAARK ARTPCRLPPA
110 120 130 140 150
PPAPPPGPEP ASPGQAGAPA APPSPAWSEP EAALEQEPGP AGSGEPGLRQ
160 170 180 190 200
RGRRGRSRAD LESPQRKHKC HYAGCEKVYG KSSHLKAHLR THTGERPFAC
210 220 230 240 250
SWQECNKKFA RSDELARHYR THTGEKKFSC PICEKRFMRS DHLTKHARRH
260 270 280
ANFHPGMLQR RGGGSRTGSL SDYSRSDASS PTISPASSP
Length:289
Mass (Da):31,136
Last modified:November 2, 2001 - v2
Checksum:iE248EF12890DA090
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 3018ECLVS…EPREG → SASCPCQPRSRARAAGR in CAC06697. (PubMed:11087666)CuratedAdd
BLAST
Sequence conflicti32 – 321E → R in CAB75887. (PubMed:10642511)Curated
Sequence conflicti43 – 431P → L in CAB75887. (PubMed:10642511)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245644 mRNA. Translation: CAB75887.1.
AF251796 mRNA. Translation: AAF73964.1.
AJ275987 mRNA. Translation: CAC06697.1.
AF252285 mRNA. Translation: AAF65826.1.
CCDSiCCDS21331.1.
RefSeqiNP_067341.2. NM_021366.3.
UniGeneiMm.240473.

Genome annotation databases

EnsembliENSMUST00000063694; ENSMUSP00000067680; ENSMUSG00000052040.
GeneIDi50794.
KEGGimmu:50794.
UCSCiuc009hfn.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245644 mRNA. Translation: CAB75887.1 .
AF251796 mRNA. Translation: AAF73964.1 .
AJ275987 mRNA. Translation: CAC06697.1 .
AF252285 mRNA. Translation: AAF65826.1 .
CCDSi CCDS21331.1.
RefSeqi NP_067341.2. NM_021366.3.
UniGenei Mm.240473.

3D structure databases

ProteinModelPortali Q9JJZ6.
SMRi Q9JJZ6. Positions 143-282.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 206125. 2 interactions.
IntActi Q9JJZ6. 1 interaction.
MINTi MINT-4099898.

PTM databases

PhosphoSitei Q9JJZ6.

Proteomic databases

MaxQBi Q9JJZ6.
PaxDbi Q9JJZ6.
PRIDEi Q9JJZ6.

Protocols and materials databases

DNASUi 50794.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000063694 ; ENSMUSP00000067680 ; ENSMUSG00000052040 .
GeneIDi 50794.
KEGGi mmu:50794.
UCSCi uc009hfn.2. mouse.

Organism-specific databases

CTDi 51621.
MGIi MGI:1354948. Klf13.

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000118984.
HOGENOMi HOG000233575.
HOVERGENi HBG050746.
InParanoidi Q9JJZ6.
KOi K09208.
OMAi ECSWQEC.
OrthoDBi EOG7FJH0Q.
PhylomeDBi Q9JJZ6.
TreeFami TF351003.

Miscellaneous databases

ChiTaRSi Klf13. mouse.
NextBioi 307793.
PROi Q9JJZ6.
SOURCEi Search...

Gene expression databases

Bgeei Q9JJZ6.
CleanExi MM_KLF13.
ExpressionAtlasi Q9JJZ6. baseline and differential.
Genevestigatori Q9JJZ6.

Family and domain databases

Gene3Di 3.30.160.60. 3 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 3 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mouse BTEB3, a new member of the basic transcription element binding protein (BTEB) family, activates expression from GC-rich minimal promoter regions."
    Martin K.M., Cooper W.N., Metcalfe J.C., Kemp P.R.
    Biochem. J. 345:529-533(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. "FKLF-2: a novel Kruppel-like transcriptional factor that activates globin and other erythroid lineage genes."
    Asano H., Li X.S., Stamatoyannopoulos G.
    Blood 95:3578-3584(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: B6D2F2.
    Tissue: Yolk.
  3. "Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family."
    Scohy S., Gabant P., Van Reeth T., Hertveldt V., Dreze P.-L., Van Vooren P., Riviere M., Szpirer J., Szpirer C.
    Genomics 70:93-101(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal liver.
  4. "Identification of Mus musculus cDNA for RANTES factor of late activated T lymphocytes-1."
    Song A., Thamatrakoln K., Krensky A.M.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.

Entry informationi

Entry nameiKLF13_MOUSE
AccessioniPrimary (citable) accession number: Q9JJZ6
Secondary accession number(s): Q9ESX3, Q9JHF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: November 2, 2001
Last modified: November 26, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3