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Protein

Epidermal growth factor-like protein 6

Gene

Egfl6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly.2 Publications

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • cell differentiation Source: UniProtKB-KW
  • extracellular matrix organization Source: MGI
  • multicellular organism development Source: UniProtKB-KW
  • positive regulation of cell-substrate adhesion Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell adhesion, Differentiation

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Epidermal growth factor-like protein 6
Short name:
EGF-like protein 6
Alternative name(s):
MAM and EGF domains-containing gene protein
Protein W80
Gene namesi
Name:Egfl6
Synonyms:Maeg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1858599. Egfl6.

Subcellular locationi

GO - Cellular componenti

  • basement membrane Source: MGI
  • membrane Source: InterPro
  • proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi362D → E: Loss of adhesive activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000029581219 – 550Epidermal growth factor-like protein 6Add BLAST532

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi59 ↔ 72PROSITE-ProRule annotation
Disulfide bondi63 ↔ 78PROSITE-ProRule annotation
Disulfide bondi80 ↔ 89PROSITE-ProRule annotation
Disulfide bondi96 ↔ 107PROSITE-ProRule annotation
Disulfide bondi103 ↔ 116PROSITE-ProRule annotation
Disulfide bondi118 ↔ 130PROSITE-ProRule annotation
Disulfide bondi176 ↔ 189PROSITE-ProRule annotation
Disulfide bondi183 ↔ 198PROSITE-ProRule annotation
Disulfide bondi221 ↔ 234PROSITE-ProRule annotation
Disulfide bondi228 ↔ 243PROSITE-ProRule annotation
Disulfide bondi245 ↔ 256PROSITE-ProRule annotation
Glycosylationi394N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9JJZ5.
PRIDEiQ9JJZ5.

PTM databases

iPTMnetiQ9JJZ5.
PhosphoSitePlusiQ9JJZ5.

Expressioni

Tissue specificityi

Expressed at basement membrane of pelage follicles (at protein level).1 Publication

Developmental stagei

Detected in early lateral dermatome and in all dermatome derivatives. Expressed at the basement membrane of embryonic skin and developing hair follicles. At E16.5, present in lung epithelium, and developing oral and tooth germ epithelia (at protein level).3 Publications

Gene expression databases

BgeeiENSMUSG00000000402.
CleanExiMM_EGFL6.
GenevisibleiQ9JJZ5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000412.

Structurei

3D structure databases

ProteinModelPortaliQ9JJZ5.
SMRiQ9JJZ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 90EGF-like 1PROSITE-ProRule annotationAdd BLAST36
Domaini92 – 131EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini135 – 171EGF-like 3PROSITE-ProRule annotationAdd BLAST37
Domaini172 – 210EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini217 – 257EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini397 – 543MAMPROSITE-ProRule annotationAdd BLAST147

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili327 – 357Sequence analysisAdd BLAST31

Sequence similaritiesi

Belongs to the nephronectin family.Curated
Contains 5 EGF-like domains.PROSITE-ProRule annotation
Contains 1 MAM domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410KD9I. Eukaryota.
ENOG410XR84. LUCA.
GeneTreeiENSGT00860000133741.
HOGENOMiHOG000059638.
HOVERGENiHBG108200.
InParanoidiQ9JJZ5.
OMAiPQSNFCL.
OrthoDBiEOG091G0ABU.
TreeFamiTF330819.

Family and domain databases

CDDicd06263. MAM. 1 hit.
Gene3Di2.40.155.10. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR032930. Egfl6.
IPR023413. GFP-like.
IPR009030. Growth_fac_rcpt_.
IPR000998. MAM_dom.
[Graphical view]
PANTHERiPTHR24050:SF18. PTHR24050:SF18. 1 hit.
PfamiPF07645. EGF_CA. 3 hits.
PF00629. MAM. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 5 hits.
SM00179. EGF_CA. 3 hits.
SM00137. MAM. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 3 hits.
PS50060. MAM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JJZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPPWGLALP LLLPWVTGGV GTSPWDYGLS ALAHQPGVCQ YGTKMACCYG
60 70 80 90 100
WKRNNKGVCE AMCEPRCKFG ECVGPNKCRC FPGYTGKTCT QDVNECGVKP
110 120 130 140 150
RPCQHRCVNT HGSYKCFCLS GHMLLPDATC SNSRTCARLN CQYGCEDTEE
160 170 180 190 200
GPRCVCPSSG LRLGPNGRVC LDIDECASSK AVCPSNRRCV NTFGSYYCKC
210 220 230 240 250
HIGFELKYIG RRYDCVDINE CALNTHPCSP HANCLNTRGS FKCKCKQGYR
260 270 280 290 300
GNGLQCSVIP EHSVKEILTA PGTIKDRIKK LLAHKRTMKK KVKLKMVTPR
310 320 330 340 350
PASTRVPKVN LPYSSEEGVS RGRNYDGEQK KKEEGKRERL EEEKGEKTLR
360 370 380 390 400
NEVEQERTLR GDVFSPKVNE AEDLDLVYVQ RKELNSKLKH KDLNISVDCS
410 420 430 440 450
FDLGVCDWKQ DREDDFDWHP ADRDNDVGYY MAVPALAGHK KNIGRLKLLL
460 470 480 490 500
PNLTPQSNFC LLFDYRLAGD KVGKLRVFVK NSNNALAWEE TKNEDGRWRT
510 520 530 540 550
GKIQLYQGID TTKSVIFEAE RGKGKTGEIA VDGVLLVSGL CPDDFLSVEG
Length:550
Mass (Da):61,520
Last modified:October 1, 2000 - v1
Checksum:iDEF936325C9F31B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245672 mRNA. Translation: CAB92138.1.
AL672174 Genomic DNA. Translation: CAM23572.1.
BC117702 mRNA. Translation: AAI17703.1.
AK053738 mRNA. Translation: BAC35499.1.
CCDSiCCDS30528.1.
RefSeqiNP_062270.1. NM_019397.3.
UniGeneiMm.37707.

Genome annotation databases

EnsembliENSMUST00000000412; ENSMUSP00000000412; ENSMUSG00000000402.
GeneIDi54156.
KEGGimmu:54156.
UCSCiuc009uww.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245672 mRNA. Translation: CAB92138.1.
AL672174 Genomic DNA. Translation: CAM23572.1.
BC117702 mRNA. Translation: AAI17703.1.
AK053738 mRNA. Translation: BAC35499.1.
CCDSiCCDS30528.1.
RefSeqiNP_062270.1. NM_019397.3.
UniGeneiMm.37707.

3D structure databases

ProteinModelPortaliQ9JJZ5.
SMRiQ9JJZ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000412.

PTM databases

iPTMnetiQ9JJZ5.
PhosphoSitePlusiQ9JJZ5.

Proteomic databases

PaxDbiQ9JJZ5.
PRIDEiQ9JJZ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000412; ENSMUSP00000000412; ENSMUSG00000000402.
GeneIDi54156.
KEGGimmu:54156.
UCSCiuc009uww.1. mouse.

Organism-specific databases

CTDi25975.
MGIiMGI:1858599. Egfl6.

Phylogenomic databases

eggNOGiENOG410KD9I. Eukaryota.
ENOG410XR84. LUCA.
GeneTreeiENSGT00860000133741.
HOGENOMiHOG000059638.
HOVERGENiHBG108200.
InParanoidiQ9JJZ5.
OMAiPQSNFCL.
OrthoDBiEOG091G0ABU.
TreeFamiTF330819.

Miscellaneous databases

PROiQ9JJZ5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000402.
CleanExiMM_EGFL6.
GenevisibleiQ9JJZ5. MM.

Family and domain databases

CDDicd06263. MAM. 1 hit.
Gene3Di2.40.155.10. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR032930. Egfl6.
IPR023413. GFP-like.
IPR009030. Growth_fac_rcpt_.
IPR000998. MAM_dom.
[Graphical view]
PANTHERiPTHR24050:SF18. PTHR24050:SF18. 1 hit.
PfamiPF07645. EGF_CA. 3 hits.
PF00629. MAM. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 5 hits.
SM00179. EGF_CA. 3 hits.
SM00137. MAM. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 3 hits.
PS50060. MAM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEGFL6_MOUSE
AccessioniPrimary (citable) accession number: Q9JJZ5
Secondary accession number(s): Q8BPM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.