Q9JJZ3 (Q9JJZ3_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
SH3 and multiple ankyrin repeat domains protein 3 Ensembl ENSMUSP00000064477

Submitted name:
Shank3b protein EMBL CAB89816.1

Gene names

Name:	Shank3 MGI 1930016 Ensembl ENSMUSP00000064477
Synonyms:	shank3 EMBL CAB89816.1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	709 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 PDZ (DHR) domain. RuleBase RU003354 Contains 1 SH3 domain. SAAS SAAS011511

Ontologies

Keywords
Domain	ANK repeat RuleBase RU003321 Repeat RuleBase RU003536
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	MAPK cascade Inferred from genetic interaction PubMed 15569713. Source: MGI embryonic epithelial tube formation Inferred from genetic interaction PubMed 15569713. Source: MGI negative regulation of actin filament bundle assembly Inferred from direct assay PubMed 19208628. Source: MGI
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9JJZ3 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 5CF7C46C7DC4B486	FASTA	709	77,277
	10 20 30 40 50 60 MGLCGSLLPT FSLSEQFRYK RRVYAQNLID DKQFAKLHTK ANLKKFMDYV QLHSTDKVAR 70 80 90 100 110 120 LLDKGLDPNF HDPDSGECPL SLAAQLDNAT DLLKVLRNGG AHLDFRTRDG LTAVHCATRQ 130 140 150 160 170 180 RNAGALTTLL DLGASPDYKD SRGLTPLYHS ALGGGDALCC ELLLHDHAQL GTTDENGWQE 190 200 210 220 230 240 IHQACRFGHV QHLEHLLFYG ANMGAQNASG NTALHICALY NQESCARVLL FRGANKDVRN 250 260 270 280 290 300 YNSQTAFQVA IIAGNFELAE VIKTHKDSDV VPFRETPSYA KRRRLAGPSG LASPRPLQRS 310 320 330 340 350 360 ASDINLKGDQ PAASPGPTLR SLPHQLLLQR LQEEKDRDRD GELENDISGP SAGRGGHNKI 370 380 390 400 410 420 SPSGPGGSGP APGPGPASPA PPAPPPRGPK RKLYSAVPGR KFIAVKAHSP QGEGEIPLHR 430 440 450 460 470 480 GEAVKVLSIG EGGFWEGTVK GRTGWFPADC VEEVQMRQYD TRHETREDRT KRLFRHYTVG 490 500 510 520 530 540 SYDSLTSHSD YVIDDKVAIL QKRDHEGFGF VLRGAKAETP IEEFTPTPAF PALQYLESVD 550 560 570 580 590 600 VEGVAWRAGL RTGDFLIEVN GVNVVKVGHK QVVGLIRQGG NRLVMKVVSV TRKPEEDGAR 610 620 630 640 650 660 RRAPPPPKRA PSTTLTLRSK SMTAELEELE KLDEILAVAA EPTLRPDIAD ADSRAATVKQ 670 680 690 700 RPTSRRITPA EISSLFERQG LPGPEKLPGS LRKGIPRTKS VGSSAASVS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Interaction of the Na+/Phosphate Cotransporter Type II with rSHANK." Dehmelt L., Nalbant P., Werner A. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57B1/6J EMBL CAB89816.1. Tissue: Kidney EMBL CAB89816.1.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000064477.
[3]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000064477.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC122401 Genomic DNA. No translation available. AC137513 Genomic DNA. No translation available. AJ245904 mRNA. Translation: CAB89816.1.
IPI	IPI00407453.
UniGene	Mm.146855.
3D structure databases
HSSP	HSSP built from PDB template 1Q3O based on UniProtKB Q9WV48.
SMR	Q9JJZ3. Positions 44-342, 413-455, 489-594.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000066545; ENSMUSP00000064477; ENSMUSG00000022623.
UCSC	uc007xhb.2. mouse.
Organism-specific databases
MGI	MGI:1930016. Shank3.
Phylogenomic databases
GeneTree	ENSGT00510000046474.
HOGENOM	HOG000198621.
HOVERGEN	HBG078069.
Gene expression databases
Genevestigator	Q9JJZ3.
Family and domain databases
Gene3D	1.25.40.20. 1 hit.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR001478. PDZ. IPR011511. SH3_2. IPR001452. SH3_domain. [Graphical view]
Pfam	PF12796. Ank_2. 2 hits. PF00595. PDZ. 1 hit. PF07653. SH3_2. 1 hit. [Graphical view]
SMART	SM00248. ANK. 5 hits. SM00228. PDZ. 1 hit. SM00326. SH3. 1 hit. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit. SSF50156. PDZ. 1 hit. SSF50044. SH3. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 4 hits. PS50106. PDZ. 1 hit. PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SHANK3. mouse.
SOURCE	Search...

Entry information

Entry name

Q9JJZ3_MOUSE

Accession

Primary (citable) accession number: Q9JJZ3

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2000
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)