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Protein

Solute carrier family 2, facilitated glucose transporter member 8

Gene

Slc2a8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Insulin-regulated facilitative glucose transporter. Binds cytochalasin B in a glucose-inhibitable manner. Seems to be a dual-specific sugar transporter as it is inhibitable by fructose.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei395MonosaccharideBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-428790. Facilitative Na+-independent glucose transporters.
R-RNO-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-RNO-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 8
Alternative name(s):
Glucose transporter type 8
Short name:
GLUT-8
Glucose transporter type X1
Gene namesi
Name:Slc2a8
Synonyms:Glut8, Glutx1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi620611. Slc2a8.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25CytoplasmicSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 70ExtracellularSequence analysisAdd BLAST24
Transmembranei71 – 91Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini92 – 96CytoplasmicSequence analysis5
Transmembranei97 – 117Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini118 – 127ExtracellularSequence analysis10
Transmembranei128 – 148Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini149 – 156CytoplasmicSequence analysis8
Transmembranei157 – 177Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini178 – 182ExtracellularSequence analysis5
Transmembranei183 – 203Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini204 – 257CytoplasmicSequence analysisAdd BLAST54
Transmembranei258 – 278Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini279 – 293ExtracellularSequence analysisAdd BLAST15
Transmembranei294 – 314Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini315 – 320CytoplasmicSequence analysis6
Transmembranei321 – 341Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini342 – 368ExtracellularSequence analysisAdd BLAST27
Transmembranei369 – 389Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini390 – 405CytoplasmicSequence analysisAdd BLAST16
Transmembranei406 – 426Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini427 – 439ExtracellularSequence analysisAdd BLAST13
Transmembranei440 – 460Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini461 – 478CytoplasmicSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi12 – 13LL → AA: Changes subcellular location mainly to the plasma membrane, threreby increasing transport activity. 1 Publication2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503771 – 478Solute carrier family 2, facilitated glucose transporter member 8Add BLAST478

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi350N-linked (GlcNAc...)Curated1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9JJZ1.
PRIDEiQ9JJZ1.

Expressioni

Tissue specificityi

Highly expressed in adult and pubertal testis, but not prepubertal testis. Moderate expression in hypothalamus, cerebellum, brainstem, hippocampus, and adrenal gland. Lower amounts present in most other tissues.1 Publication

Gene expression databases

BgeeiENSRNOG00000022274.
GenevisibleiQ9JJZ1. RN.

Interactioni

Subunit structurei

Interacts with AP2B1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022326.

Structurei

3D structure databases

ProteinModelPortaliQ9JJZ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni268 – 274Monosaccharide bindingBy similarity7

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi12 – 13Dileucine internalization motif2

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0254. Eukaryota.
ENOG410XNQK. LUCA.
GeneTreeiENSGT00850000132274.
HOGENOMiHOG000202868.
HOVERGENiHBG104335.
InParanoidiQ9JJZ1.
KOiK08145.
OMAiAIMFYAN.
OrthoDBiEOG091G1600.
PhylomeDBiQ9JJZ1.
TreeFamiTF325324.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 2 hits.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JJZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPEDPQETQ PLLRSPGARA PGGRRVFLAT FAAALGPLSF GFALGYSSPA
60 70 80 90 100
IPSLRRTAPP ALRLGDTAAS WFGAVVTLGA AAGGVLGGWL LDRAGRKLSL
110 120 130 140 150
LLCTVPFVTG FAVITAARDV WMLLGGRLLT GLACGVASLV APVYISEIAY
160 170 180 190 200
PAVRGLLGSC VQLMVVTGIL LAYVAGWVLE WRWLAVLGCV PPTLMLLLMC
210 220 230 240 250
YMPETPRFLL TQHQYQEAMA ALRFLWGSEE GWEEPPVGAE HQGFQLAMLR
260 270 280 290 300
RPGVHKPLII GICLMVFQQL SGVNAIMFYA NTIFEEAKFK DSSLASVTVG
310 320 330 340 350
IIQVLFTAVA ALIMDRAGRK LLLALSGVIM VFSMSAFGTY FKLTQSGPSN
360 370 380 390 400
SSHVGLLVPI SAEPADVHLG LAWLAVGSMC LFIAGFAVGW GPIPWLLMSE
410 420 430 440 450
IFPLHIKGVA TGVCVLTNWF MAFLVTKEFN SIMEILRPYG AFWLTAAFCI
460 470
LSVLFTLTFV PETKGRTLEQ ITAHFEGR
Length:478
Mass (Da):51,459
Last modified:October 1, 2000 - v1
Checksum:i95841FC1F18C9EE9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti83 – 84GG → QGA in BAA94383 (Ref. 2) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245935 mRNA. Translation: CAB75729.1.
AB033418 mRNA. Translation: BAA94383.1.
RefSeqiNP_445946.2. NM_053494.2.
UniGeneiRn.12923.

Genome annotation databases

EnsembliENSRNOT00000022327; ENSRNOP00000022326; ENSRNOG00000022274.
GeneIDi85256.
KEGGirno:85256.
UCSCiRGD:620611. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245935 mRNA. Translation: CAB75729.1.
AB033418 mRNA. Translation: BAA94383.1.
RefSeqiNP_445946.2. NM_053494.2.
UniGeneiRn.12923.

3D structure databases

ProteinModelPortaliQ9JJZ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022326.

Proteomic databases

PaxDbiQ9JJZ1.
PRIDEiQ9JJZ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022327; ENSRNOP00000022326; ENSRNOG00000022274.
GeneIDi85256.
KEGGirno:85256.
UCSCiRGD:620611. rat.

Organism-specific databases

CTDi29988.
RGDi620611. Slc2a8.

Phylogenomic databases

eggNOGiKOG0254. Eukaryota.
ENOG410XNQK. LUCA.
GeneTreeiENSGT00850000132274.
HOGENOMiHOG000202868.
HOVERGENiHBG104335.
InParanoidiQ9JJZ1.
KOiK08145.
OMAiAIMFYAN.
OrthoDBiEOG091G1600.
PhylomeDBiQ9JJZ1.
TreeFamiTF325324.

Enzyme and pathway databases

ReactomeiR-RNO-428790. Facilitative Na+-independent glucose transporters.
R-RNO-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-RNO-8856828. Clathrin-mediated endocytosis.

Miscellaneous databases

PROiQ9JJZ1.

Gene expression databases

BgeeiENSRNOG00000022274.
GenevisibleiQ9JJZ1. RN.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 2 hits.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGTR8_RAT
AccessioniPrimary (citable) accession number: Q9JJZ1
Secondary accession number(s): Q9JMA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.