Q9JJY9 (IL22_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-22
Short name=IL-22

Alternative name(s):
IL-10-related T-cell-derived-inducible factor
Short name=IL-TIF
IL-TIF alpha
Interleukin-22a
Short name=IL-22a

Gene names

Name:	Il22
Synonyms:	Il22a, Iltif, Iltifa

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	179 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cytokine that contributes to the inflammatory response in vivo.
Subcellular location	Secreted.
Sequence similarities	Belongs to the IL-10 family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of inflammatory response Inferred from mutant phenotype PubMed 23075849. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 16982811. Source: MGI reactive oxygen species metabolic process Inferred from direct assay PubMed 12700595. Source: MGI regulation of tyrosine phosphorylation of Stat3 protein Inferred from direct assay PubMed 12700595. Source: MGI
Cellular_component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	protein binding Inferred from physical interaction PubMed 12700595. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 33	33	Potential
	Chain	34 – 179	146	Interleukin-22		PRO_0000015384
Amino acid modifications
	Glycosylation	54	1	N-linked (GlcNAc...) Potential
	Glycosylation	68	1	N-linked (GlcNAc...) Potential
	Glycosylation	97	1	N-linked (GlcNAc...) Potential
	Disulfide bond	40 ↔ 132		By similarity
	Disulfide bond	89 ↔ 178		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9JJY9 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: ACB0F5574AA79274	FASTA	179	20,106
	10 20 30 40 50 60 MAVLQKSMSF SLMGTLAASC LLLIALWAQE ANALPVNTRC KLEVSNFQQP YIVNRTFMLA 70 80 90 100 110 120 KEASLADNNT DVRLIGEKLF RGVSAKDQCY LMKQVLNFTL EDVLLPQSDR FQPYMQEVVP 130 140 150 160 170 FLTKLSNQLS SCHISGDDQN IQKNVRRLKE TVKKLGESGE IKAIGELDLL FMSLRNACV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9." Dumoutier L., Louahed J., Renauld J.-C. J. Immunol. 164:1814-1819(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: AKR.
[2]	"IL-TIF/IL-22: genomic organization and mapping of the human and mouse genes." Dumoutier L., Van Roost E., Colau D., Ameye G., Michaux L., Renauld J.-C. Genes Immun. 1:488-494(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: 129.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ249491 mRNA. Translation: CAB75546.1. AJ294727 Genomic DNA. Translation: CAC19435.1. BC116235 mRNA. Translation: AAI16236.1.
CCDS	CCDS36070.1.
RefSeq	NP_058667.1. NM_016971.2. XP_006513928.1. XM_006513865.1.
UniGene	Mm.103585.
3D structure databases
ProteinModelPortal	Q9JJY9.
SMR	Q9JJY9. Positions 40-179.
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
MINT	MINT-8385663.
Proteomic databases
PRIDE	Q9JJY9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000096691; ENSMUSP00000094449; ENSMUSG00000074695.
GeneID	50929.
KEGG	mmu:50929.
UCSC	uc007hdv.2. mouse.
Organism-specific databases
CTD	50616.
MGI	MGI:1355307. Il22.
Phylogenomic databases
GeneTree	ENSGT00510000048550.
HOVERGEN	HBG018572.
InParanoid	Q14BB3.
KO	K05445.
OMA	YIRNRTY.
OrthoDB	EOG7J9VR1.
TreeFam	TF333253.
Gene expression databases
Bgee	Q9JJY9.
CleanEx	MM_IL22.
Genevestigator	Q9JJY9.
Family and domain databases
Gene3D	1.20.1250.10. 1 hit.
InterPro	IPR009079. 4_helix_cytokine-like_core. IPR012351. 4_helix_cytokine_core. IPR020423. IL-10_CS. IPR020453. IL-22. [Graphical view]
Pfam	PF14565. IL22. 1 hit. [Graphical view]
PIRSF	PIRSF037726. Interleukin-22. 1 hit.
PRINTS	PR01936. INTRLEUKIN22.
SUPFAM	SSF47266. SSF47266. 1 hit.
PROSITE	PS00520. INTERLEUKIN_10. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	307947.
PRO	Q9JJY9.
SOURCE	Search...

Entry information

Entry name

IL22_MOUSE

Accession

Primary (citable) accession number: Q9JJY9
Secondary accession number(s): Q14BB3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
Last sequence update:	October 1, 2000
Last modified:	July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program