Il22

Protein namesⁱ	Recommended name: Interleukin-22 Short name: IL-22 Alternative name(s): IL-10-related T-cell-derived-inducible factor Short name: IL-TIF IL-TIF alpha Interleukin-22a Short name: IL-22a
Gene namesⁱ	Name:Il22 Synonyms:Il22a, Iltif, Iltifa
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 10

Organism-specific databases

MGIⁱ	MGI:1355307 Il22

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 33	Sequence analysisAdd BLAST		33
ChainⁱPRO_0000015384	34 – 179	Interleukin-22Add BLAST		146

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	40 ↔ 132	By similarity
Glycosylationⁱ	54	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	68	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	89 ↔ 178	By similarity
Glycosylationⁱ	97	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q9JJY9
PRIDEⁱ	Q9JJY9

PTM databases

PhosphoSitePlusⁱ	Q9JJY9

PhosphoSitePlusⁱ

Q9JJY9

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000074695
CleanExⁱ	MM_IL22
Genevisibleⁱ	Q9JJY9 MM

Interactionⁱ

GO - Molecular functionⁱ

cytokine activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

Molecular INTeraction database More...MINTⁱ	Q9JJY9
STRINGⁱ	10090.ENSMUSP00000094449

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9JJY9
SMRⁱ	Q9JJY9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the IL-10 family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IV9D Eukaryota ENOG4112217 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000048550
HOVERGENⁱ	HBG018572
InParanoidⁱ	Q9JJY9
KEGG Orthology (KO) More...KOⁱ	K05445
OMAⁱ	YIRNRTY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MJW
TreeFamⁱ	TF333253

Family and domain databases

InterProⁱ	View protein in InterPro IPR009079 4_helix_cytokine-like_core IPR020423 IL-10_CS IPR020453 IL-22
PANTHERⁱ	PTHR44864 PTHR44864, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF14565 IL22, 1 hit
PIRSFⁱ	PIRSF037726 Interleukin-22, 1 hit
PRINTSⁱ	PR01936 INTRLEUKIN22
SUPFAMⁱ	SSF47266 SSF47266, 1 hit
PROSITEⁱ	View protein in PROSITE PS00520 INTERLEUKIN_10, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9JJY9-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MAVLQKSMSF SLMGTLAASC LLLIALWAQE ANALPVNTRC KLEVSNFQQP 
        60         70         80         90        100
YIVNRTFMLA KEASLADNNT DVRLIGEKLF RGVSAKDQCY LMKQVLNFTL 
       110        120        130        140        150
EDVLLPQSDR FQPYMQEVVP FLTKLSNQLS SCHISGDDQN IQKNVRRLKE 
       160        170 
TVKKLGESGE IKAIGELDLL FMSLRNACV

Length:179

Mass (Da):20,106

Last modified:October 1, 2000 - v1

Checksum:ⁱACB0F5574AA79274

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ249491 mRNA Translation: CAB75546.1 AJ294727 Genomic DNA Translation: CAC19435.1 BC116235 mRNA Translation: AAI16236.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS36070.1
NCBI Reference Sequences More...RefSeqⁱ	NP_058667.1, NM_016971.2 XP_006513928.1, XM_006513865.3
UniGeneⁱ	Mm.103585

Genome annotation databases

Ensemblⁱ	ENSMUST00000096691; ENSMUSP00000094449; ENSMUSG00000074695
GeneIDⁱ	50929
KEGGⁱ	mmu:50929
UCSC genome browser More...UCSCⁱ	uc007hdv.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q9JJY9	Q9JJY8 Q3SXE1 UPI000A305657 UPI000A3156DE Q198B4	Mus musculus (Mouse) Mus pahari (Gairdner's shrew-mouse) (Coelomys pahari) Mus caroli (Ryukyu mouse) (Ricefield mouse) Rattus norvegicus (Rat)	179	UniRef90_Q9JJY9	Cluster: Interleukin-22	6

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q9JJY9	Q9GZX6 G3R0Q5 UPI000055D2DB UPI00001B13F9 UPI0005F535A2 A0A2K6PCP6 F6YBU5 G7PHZ7 A0A2K6BGF3 G1QTK0 +117	Homo sapiens (Human) Gorilla gorilla gorilla (Western lowland gorilla) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Macaca mulatta (Rhesus macaque) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Macaca nemestrina (Pig-tailed macaque) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) And more	179	UniRef50_Q9GZX6	Cluster: Interleukin-22	128

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ249491 mRNA Translation: CAB75546.1 AJ294727 Genomic DNA Translation: CAC19435.1 BC116235 mRNA Translation: AAI16236.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS36070.1
NCBI Reference Sequences More...RefSeqⁱ	NP_058667.1, NM_016971.2 XP_006513928.1, XM_006513865.3
UniGeneⁱ	Mm.103585

3D structure databases

ProteinModelPortalⁱ	Q9JJY9
SMRⁱ	Q9JJY9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

Molecular INTeraction database More...MINTⁱ	Q9JJY9
STRINGⁱ	10090.ENSMUSP00000094449

PTM databases

PhosphoSitePlusⁱ	Q9JJY9

PhosphoSitePlusⁱ

Q9JJY9

Proteomic databases

PaxDbⁱ	Q9JJY9
PRIDEⁱ	Q9JJY9

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000096691; ENSMUSP00000094449; ENSMUSG00000074695
GeneIDⁱ	50929
KEGGⁱ	mmu:50929
UCSC genome browser More...UCSCⁱ	uc007hdv.2 mouse

Organism-specific databases

CTDⁱ	50616
MGIⁱ	MGI:1355307 Il22

Phylogenomic databases

eggNOGⁱ	ENOG410IV9D Eukaryota ENOG4112217 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000048550
HOVERGENⁱ	HBG018572
InParanoidⁱ	Q9JJY9
KEGG Orthology (KO) More...KOⁱ	K05445
OMAⁱ	YIRNRTY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MJW
TreeFamⁱ	TF333253

Enzyme and pathway databases

Reactomeⁱ	R-MMU-8854691 Interleukin-20 family signaling

Reactomeⁱ

R-MMU-8854691 Interleukin-20 family signaling

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9JJY9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000074695
CleanExⁱ	MM_IL22
Genevisibleⁱ	Q9JJY9 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR009079 4_helix_cytokine-like_core IPR020423 IL-10_CS IPR020453 IL-22
PANTHERⁱ	PTHR44864 PTHR44864, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF14565 IL22, 1 hit
PIRSFⁱ	PIRSF037726 Interleukin-22, 1 hit
PRINTSⁱ	PR01936 INTRLEUKIN22
SUPFAMⁱ	SSF47266 SSF47266, 1 hit
PROSITEⁱ	View protein in PROSITE PS00520 INTERLEUKIN_10, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IL22_MOUSE
Accessionⁱ	Q9JJY9Primary (citable) accession number: Q9JJY9 Secondary accession number(s): Q14BB3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
	Last sequence update:	October 1, 2000
	Last modified:	March 28, 2018
	This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9JJY9 (IL22_MOUSE)

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Interleukin-22

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ