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Q9JJY9 (IL22_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-22

Short name=IL-22
Alternative name(s):
IL-10-related T-cell-derived-inducible factor
Short name=IL-TIF
IL-TIF alpha
Interleukin-22a
Short name=IL-22a
Gene names
Name:Il22
Synonyms:Il22a, Iltif, Iltifa
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length179 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytokine that contributes to the inflammatory response in vivo.

Subcellular location

Secreted.

Sequence similarities

Belongs to the IL-10 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3333 Potential
Chain34 – 179146Interleukin-22
PRO_0000015384

Amino acid modifications

Glycosylation541N-linked (GlcNAc...) Potential
Glycosylation681N-linked (GlcNAc...) Potential
Glycosylation971N-linked (GlcNAc...) Potential
Disulfide bond40 ↔ 132 By similarity
Disulfide bond89 ↔ 178 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9JJY9 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: ACB0F5574AA79274

FASTA17920,106
        10         20         30         40         50         60 
MAVLQKSMSF SLMGTLAASC LLLIALWAQE ANALPVNTRC KLEVSNFQQP YIVNRTFMLA 

        70         80         90        100        110        120 
KEASLADNNT DVRLIGEKLF RGVSAKDQCY LMKQVLNFTL EDVLLPQSDR FQPYMQEVVP 

       130        140        150        160        170 
FLTKLSNQLS SCHISGDDQN IQKNVRRLKE TVKKLGESGE IKAIGELDLL FMSLRNACV 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9."
Dumoutier L., Louahed J., Renauld J.-C.
J. Immunol. 164:1814-1819(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: AKR.
[2]"IL-TIF/IL-22: genomic organization and mapping of the human and mouse genes."
Dumoutier L., Van Roost E., Colau D., Ameye G., Michaux L., Renauld J.-C.
Genes Immun. 1:488-494(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 129.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ249491 mRNA. Translation: CAB75546.1.
AJ294727 Genomic DNA. Translation: CAC19435.1.
BC116235 mRNA. Translation: AAI16236.1.
RefSeqNP_058667.1. NM_016971.2.
XP_006513928.1. XM_006513865.1.
UniGeneMm.103585.

3D structure databases

ProteinModelPortalQ9JJY9.
SMRQ9JJY9. Positions 40-179.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-8385663.

Proteomic databases

PRIDEQ9JJY9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000096691; ENSMUSP00000094449; ENSMUSG00000074695.
GeneID50929.
KEGGmmu:50929.
UCSCuc007hdv.2. mouse.

Organism-specific databases

CTD50616.
MGIMGI:1355307. Il22.

Phylogenomic databases

GeneTreeENSGT00510000048550.
HOVERGENHBG018572.
InParanoidQ14BB3.
KOK05445.
OMAIEGDDQH.
OrthoDBEOG7J9VR1.
TreeFamTF333253.

Gene expression databases

BgeeQ9JJY9.
CleanExMM_IL22.
GenevestigatorQ9JJY9.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020423. IL-10_CS.
IPR020453. IL-22.
[Graphical view]
PIRSFPIRSF037726. Interleukin-22. 1 hit.
PRINTSPR01936. INTRLEUKIN22.
SUPFAMSSF47266. SSF47266. 1 hit.
PROSITEPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio307947.
PROQ9JJY9.
SOURCESearch...

Entry information

Entry nameIL22_MOUSE
AccessionPrimary (citable) accession number: Q9JJY9
Secondary accession number(s): Q14BB3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 1, 2000
Last modified: March 19, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot