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Protein

Interleukin-22

Gene

Il22

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine that contributes to the inflammatory response in vivo.

GO - Biological processi

  1. negative regulation of inflammatory response Source: MGI
  2. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  3. reactive oxygen species metabolic process Source: MGI
  4. regulation of tyrosine phosphorylation of Stat3 protein Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-22
Short name:
IL-22
Alternative name(s):
IL-10-related T-cell-derived-inducible factor
Short name:
IL-TIF
IL-TIF alpha
Interleukin-22a
Short name:
IL-22a
Gene namesi
Name:Il22
Synonyms:Il22a, Iltif, Iltifa
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1355307. Il22.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence AnalysisAdd
BLAST
Chaini34 – 179146Interleukin-22PRO_0000015384Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi40 ↔ 132By similarity
Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi68 – 681N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi89 ↔ 178By similarity
Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9JJY9.

Expressioni

Gene expression databases

BgeeiQ9JJY9.
CleanExiMM_IL22.
GenevestigatoriQ9JJY9.

Interactioni

Protein-protein interaction databases

MINTiMINT-8385663.

Structurei

3D structure databases

ProteinModelPortaliQ9JJY9.
SMRiQ9JJY9. Positions 40-179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00510000048550.
HOVERGENiHBG018572.
InParanoidiQ9JJY9.
KOiK05445.
OMAiHIQKNVQ.
OrthoDBiEOG7J9VR1.
TreeFamiTF333253.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020423. IL-10_CS.
IPR020453. IL-22.
[Graphical view]
PfamiPF14565. IL22. 1 hit.
[Graphical view]
PIRSFiPIRSF037726. Interleukin-22. 1 hit.
PRINTSiPR01936. INTRLEUKIN22.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JJY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVLQKSMSF SLMGTLAASC LLLIALWAQE ANALPVNTRC KLEVSNFQQP
60 70 80 90 100
YIVNRTFMLA KEASLADNNT DVRLIGEKLF RGVSAKDQCY LMKQVLNFTL
110 120 130 140 150
EDVLLPQSDR FQPYMQEVVP FLTKLSNQLS SCHISGDDQN IQKNVRRLKE
160 170
TVKKLGESGE IKAIGELDLL FMSLRNACV
Length:179
Mass (Da):20,106
Last modified:October 1, 2000 - v1
Checksum:iACB0F5574AA79274
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249491 mRNA. Translation: CAB75546.1.
AJ294727 Genomic DNA. Translation: CAC19435.1.
BC116235 mRNA. Translation: AAI16236.1.
CCDSiCCDS36070.1.
RefSeqiNP_058667.1. NM_016971.2.
XP_006513928.1. XM_006513865.1.
UniGeneiMm.103585.

Genome annotation databases

EnsembliENSMUST00000096691; ENSMUSP00000094449; ENSMUSG00000074695.
GeneIDi50929.
KEGGimmu:50929.
UCSCiuc007hdv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249491 mRNA. Translation: CAB75546.1.
AJ294727 Genomic DNA. Translation: CAC19435.1.
BC116235 mRNA. Translation: AAI16236.1.
CCDSiCCDS36070.1.
RefSeqiNP_058667.1. NM_016971.2.
XP_006513928.1. XM_006513865.1.
UniGeneiMm.103585.

3D structure databases

ProteinModelPortaliQ9JJY9.
SMRiQ9JJY9. Positions 40-179.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-8385663.

Proteomic databases

PRIDEiQ9JJY9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000096691; ENSMUSP00000094449; ENSMUSG00000074695.
GeneIDi50929.
KEGGimmu:50929.
UCSCiuc007hdv.2. mouse.

Organism-specific databases

CTDi50616.
MGIiMGI:1355307. Il22.

Phylogenomic databases

GeneTreeiENSGT00510000048550.
HOVERGENiHBG018572.
InParanoidiQ9JJY9.
KOiK05445.
OMAiHIQKNVQ.
OrthoDBiEOG7J9VR1.
TreeFamiTF333253.

Miscellaneous databases

NextBioi307947.
PROiQ9JJY9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JJY9.
CleanExiMM_IL22.
GenevestigatoriQ9JJY9.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020423. IL-10_CS.
IPR020453. IL-22.
[Graphical view]
PfamiPF14565. IL22. 1 hit.
[Graphical view]
PIRSFiPIRSF037726. Interleukin-22. 1 hit.
PRINTSiPR01936. INTRLEUKIN22.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9."
    Dumoutier L., Louahed J., Renauld J.-C.
    J. Immunol. 164:1814-1819(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: AKR.
  2. "IL-TIF/IL-22: genomic organization and mapping of the human and mouse genes."
    Dumoutier L., Van Roost E., Colau D., Ameye G., Michaux L., Renauld J.-C.
    Genes Immun. 1:488-494(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiIL22_MOUSE
AccessioniPrimary (citable) accession number: Q9JJY9
Secondary accession number(s): Q14BB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 1, 2000
Last modified: January 7, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.