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Protein

Interleukin-22

Gene

Il22

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine that contributes to the inflammatory response in vivo.

GO - Molecular functioni

GO - Biological processi

  • immune response Source: GO_Central
  • negative regulation of inflammatory response Source: MGI
  • positive regulation of JAK-STAT cascade Source: GO_Central
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • reactive oxygen species metabolic process Source: MGI
  • regulation of tyrosine phosphorylation of Stat3 protein Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

ReactomeiR-MMU-8854691. Interleukin-19, 20, 22, 24.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-22
Short name:
IL-22
Alternative name(s):
IL-10-related T-cell-derived-inducible factor
Short name:
IL-TIF
IL-TIF alpha
Interleukin-22a
Short name:
IL-22a
Gene namesi
Name:Il22
Synonyms:Il22a, Iltif, Iltifa
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1355307. Il22.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence analysisAdd
BLAST
Chaini34 – 179146Interleukin-22PRO_0000015384Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi40 ↔ 132By similarity
Glycosylationi54 – 541N-linked (GlcNAc...)Sequence analysis
Glycosylationi68 – 681N-linked (GlcNAc...)Sequence analysis
Disulfide bondi89 ↔ 178By similarity
Glycosylationi97 – 971N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9JJY9.
PRIDEiQ9JJY9.

PTM databases

PhosphoSiteiQ9JJY9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000074695.
CleanExiMM_IL22.
GenevisibleiQ9JJY9. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

MINTiMINT-8385663.
STRINGi10090.ENSMUSP00000094449.

Structurei

3D structure databases

ProteinModelPortaliQ9JJY9.
SMRiQ9JJY9. Positions 40-179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IV9D. Eukaryota.
ENOG4112217. LUCA.
GeneTreeiENSGT00510000048550.
HOVERGENiHBG018572.
InParanoidiQ9JJY9.
KOiK05445.
OMAiHIQKNVQ.
OrthoDBiEOG091G0MJW.
TreeFamiTF333253.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020443. IL-10/19/20/22/24/26_fam.
IPR020423. IL-10_CS.
IPR020453. IL-22.
[Graphical view]
PANTHERiPTHR11585. PTHR11585. 1 hit.
PfamiPF14565. IL22. 1 hit.
[Graphical view]
PIRSFiPIRSF037726. Interleukin-22. 1 hit.
PRINTSiPR01936. INTRLEUKIN22.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JJY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVLQKSMSF SLMGTLAASC LLLIALWAQE ANALPVNTRC KLEVSNFQQP
60 70 80 90 100
YIVNRTFMLA KEASLADNNT DVRLIGEKLF RGVSAKDQCY LMKQVLNFTL
110 120 130 140 150
EDVLLPQSDR FQPYMQEVVP FLTKLSNQLS SCHISGDDQN IQKNVRRLKE
160 170
TVKKLGESGE IKAIGELDLL FMSLRNACV
Length:179
Mass (Da):20,106
Last modified:October 1, 2000 - v1
Checksum:iACB0F5574AA79274
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249491 mRNA. Translation: CAB75546.1.
AJ294727 Genomic DNA. Translation: CAC19435.1.
BC116235 mRNA. Translation: AAI16236.1.
CCDSiCCDS36070.1.
RefSeqiNP_058667.1. NM_016971.2.
XP_006513928.1. XM_006513865.2.
UniGeneiMm.103585.

Genome annotation databases

EnsembliENSMUST00000096691; ENSMUSP00000094449; ENSMUSG00000074695.
GeneIDi50929.
KEGGimmu:50929.
UCSCiuc007hdv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249491 mRNA. Translation: CAB75546.1.
AJ294727 Genomic DNA. Translation: CAC19435.1.
BC116235 mRNA. Translation: AAI16236.1.
CCDSiCCDS36070.1.
RefSeqiNP_058667.1. NM_016971.2.
XP_006513928.1. XM_006513865.2.
UniGeneiMm.103585.

3D structure databases

ProteinModelPortaliQ9JJY9.
SMRiQ9JJY9. Positions 40-179.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-8385663.
STRINGi10090.ENSMUSP00000094449.

PTM databases

PhosphoSiteiQ9JJY9.

Proteomic databases

PaxDbiQ9JJY9.
PRIDEiQ9JJY9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000096691; ENSMUSP00000094449; ENSMUSG00000074695.
GeneIDi50929.
KEGGimmu:50929.
UCSCiuc007hdv.2. mouse.

Organism-specific databases

CTDi50616.
MGIiMGI:1355307. Il22.

Phylogenomic databases

eggNOGiENOG410IV9D. Eukaryota.
ENOG4112217. LUCA.
GeneTreeiENSGT00510000048550.
HOVERGENiHBG018572.
InParanoidiQ9JJY9.
KOiK05445.
OMAiHIQKNVQ.
OrthoDBiEOG091G0MJW.
TreeFamiTF333253.

Enzyme and pathway databases

ReactomeiR-MMU-8854691. Interleukin-19, 20, 22, 24.

Miscellaneous databases

PROiQ9JJY9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000074695.
CleanExiMM_IL22.
GenevisibleiQ9JJY9. MM.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020443. IL-10/19/20/22/24/26_fam.
IPR020423. IL-10_CS.
IPR020453. IL-22.
[Graphical view]
PANTHERiPTHR11585. PTHR11585. 1 hit.
PfamiPF14565. IL22. 1 hit.
[Graphical view]
PIRSFiPIRSF037726. Interleukin-22. 1 hit.
PRINTSiPR01936. INTRLEUKIN22.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL22_MOUSE
AccessioniPrimary (citable) accession number: Q9JJY9
Secondary accession number(s): Q14BB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.