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Q9JJY9

- IL22_MOUSE

UniProt

Q9JJY9 - IL22_MOUSE

Protein

Interleukin-22

Gene

Il22

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Cytokine that contributes to the inflammatory response in vivo.

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. negative regulation of inflammatory response Source: MGI
    2. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    3. reactive oxygen species metabolic process Source: MGI
    4. regulation of tyrosine phosphorylation of Stat3 protein Source: MGI

    Keywords - Molecular functioni

    Cytokine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-22
    Short name:
    IL-22
    Alternative name(s):
    IL-10-related T-cell-derived-inducible factor
    Short name:
    IL-TIF
    IL-TIF alpha
    Interleukin-22a
    Short name:
    IL-22a
    Gene namesi
    Name:Il22
    Synonyms:Il22a, Iltif, Iltifa
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1355307. Il22.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3333Sequence AnalysisAdd
    BLAST
    Chaini34 – 179146Interleukin-22PRO_0000015384Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi40 ↔ 132By similarity
    Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi68 – 681N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi89 ↔ 178By similarity
    Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ9JJY9.

    Expressioni

    Gene expression databases

    BgeeiQ9JJY9.
    CleanExiMM_IL22.
    GenevestigatoriQ9JJY9.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-8385663.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JJY9.
    SMRiQ9JJY9. Positions 40-179.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-10 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    GeneTreeiENSGT00510000048550.
    HOVERGENiHBG018572.
    InParanoidiQ14BB3.
    KOiK05445.
    OMAiYIRNRTY.
    OrthoDBiEOG7J9VR1.
    TreeFamiTF333253.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR020423. IL-10_CS.
    IPR020453. IL-22.
    [Graphical view]
    PfamiPF14565. IL22. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037726. Interleukin-22. 1 hit.
    PRINTSiPR01936. INTRLEUKIN22.
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9JJY9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVLQKSMSF SLMGTLAASC LLLIALWAQE ANALPVNTRC KLEVSNFQQP    50
    YIVNRTFMLA KEASLADNNT DVRLIGEKLF RGVSAKDQCY LMKQVLNFTL 100
    EDVLLPQSDR FQPYMQEVVP FLTKLSNQLS SCHISGDDQN IQKNVRRLKE 150
    TVKKLGESGE IKAIGELDLL FMSLRNACV 179
    Length:179
    Mass (Da):20,106
    Last modified:October 1, 2000 - v1
    Checksum:iACB0F5574AA79274
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ249491 mRNA. Translation: CAB75546.1.
    AJ294727 Genomic DNA. Translation: CAC19435.1.
    BC116235 mRNA. Translation: AAI16236.1.
    CCDSiCCDS36070.1.
    RefSeqiNP_058667.1. NM_016971.2.
    XP_006513928.1. XM_006513865.1.
    UniGeneiMm.103585.

    Genome annotation databases

    EnsembliENSMUST00000096691; ENSMUSP00000094449; ENSMUSG00000074695.
    GeneIDi50929.
    KEGGimmu:50929.
    UCSCiuc007hdv.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ249491 mRNA. Translation: CAB75546.1 .
    AJ294727 Genomic DNA. Translation: CAC19435.1 .
    BC116235 mRNA. Translation: AAI16236.1 .
    CCDSi CCDS36070.1.
    RefSeqi NP_058667.1. NM_016971.2.
    XP_006513928.1. XM_006513865.1.
    UniGenei Mm.103585.

    3D structure databases

    ProteinModelPortali Q9JJY9.
    SMRi Q9JJY9. Positions 40-179.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-8385663.

    Proteomic databases

    PRIDEi Q9JJY9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000096691 ; ENSMUSP00000094449 ; ENSMUSG00000074695 .
    GeneIDi 50929.
    KEGGi mmu:50929.
    UCSCi uc007hdv.2. mouse.

    Organism-specific databases

    CTDi 50616.
    MGIi MGI:1355307. Il22.

    Phylogenomic databases

    GeneTreei ENSGT00510000048550.
    HOVERGENi HBG018572.
    InParanoidi Q14BB3.
    KOi K05445.
    OMAi YIRNRTY.
    OrthoDBi EOG7J9VR1.
    TreeFami TF333253.

    Miscellaneous databases

    NextBioi 307947.
    PROi Q9JJY9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9JJY9.
    CleanExi MM_IL22.
    Genevestigatori Q9JJY9.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR020423. IL-10_CS.
    IPR020453. IL-22.
    [Graphical view ]
    Pfami PF14565. IL22. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037726. Interleukin-22. 1 hit.
    PRINTSi PR01936. INTRLEUKIN22.
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00520. INTERLEUKIN_10. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9."
      Dumoutier L., Louahed J., Renauld J.-C.
      J. Immunol. 164:1814-1819(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: AKR.
    2. "IL-TIF/IL-22: genomic organization and mapping of the human and mouse genes."
      Dumoutier L., Van Roost E., Colau D., Ameye G., Michaux L., Renauld J.-C.
      Genes Immun. 1:488-494(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 129.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiIL22_MOUSE
    AccessioniPrimary (citable) accession number: Q9JJY9
    Secondary accession number(s): Q14BB3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 16, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3