UniProtKB - Q9JJY9 (IL22_MOUSE)
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Protein
Interleukin-22
Gene
Il22
Organism
Mus musculus (Mouse)
Status
Functioni
Cytokine that contributes to the inflammatory response in vivo.
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
GO - Biological processi
- negative regulation of inflammatory response Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- reactive oxygen species metabolic process Source: MGI
- regulation of tyrosine phosphorylation of STAT protein Source: MGI
Keywordsi
Molecular function | Cytokine |
Enzyme and pathway databases
Reactomei | R-MMU-8854691 Interleukin-20 family signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-22Short name: IL-22 Alternative name(s): IL-10-related T-cell-derived-inducible factor Short name: IL-TIF IL-TIF alpha Interleukin-22a Short name: IL-22a |
Gene namesi | Name:Il22 Synonyms:Il22a, Iltif, Iltifa |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1355307 Il22 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 33 | Sequence analysisAdd BLAST | 33 | |
ChainiPRO_0000015384 | 34 – 179 | Interleukin-22Add BLAST | 146 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 40 ↔ 132 | By similarity | ||
Glycosylationi | 54 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 68 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 89 ↔ 178 | By similarity | ||
Glycosylationi | 97 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q9JJY9 |
PRIDEi | Q9JJY9 |
PTM databases
PhosphoSitePlusi | Q9JJY9 |
Interactioni
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
Protein-protein interaction databases
MINTi | Q9JJY9 |
STRINGi | 10090.ENSMUSP00000094449 |
Structurei
3D structure databases
ProteinModelPortali | Q9JJY9 |
SMRi | Q9JJY9 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the IL-10 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG410IV9D Eukaryota ENOG4112217 LUCA |
GeneTreei | ENSGT00510000048550 |
HOVERGENi | HBG018572 |
InParanoidi | Q9JJY9 |
KOi | K05445 |
OMAi | YIRNRTY |
OrthoDBi | EOG091G0MJW |
TreeFami | TF333253 |
Family and domain databases
InterProi | View protein in InterPro IPR009079 4_helix_cytokine-like_core IPR020423 IL-10_CS IPR020453 IL-22 |
PANTHERi | PTHR44864 PTHR44864, 1 hit |
Pfami | View protein in Pfam PF14565 IL22, 1 hit |
PIRSFi | PIRSF037726 Interleukin-22, 1 hit |
PRINTSi | PR01936 INTRLEUKIN22 |
SUPFAMi | SSF47266 SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00520 INTERLEUKIN_10, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9JJY9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAVLQKSMSF SLMGTLAASC LLLIALWAQE ANALPVNTRC KLEVSNFQQP
60 70 80 90 100
YIVNRTFMLA KEASLADNNT DVRLIGEKLF RGVSAKDQCY LMKQVLNFTL
110 120 130 140 150
EDVLLPQSDR FQPYMQEVVP FLTKLSNQLS SCHISGDDQN IQKNVRRLKE
160 170
TVKKLGESGE IKAIGELDLL FMSLRNACV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ249491 mRNA Translation: CAB75546.1 AJ294727 Genomic DNA Translation: CAC19435.1 BC116235 mRNA Translation: AAI16236.1 |
CCDSi | CCDS36070.1 |
RefSeqi | NP_058667.1, NM_016971.2 XP_006513928.1, XM_006513865.3 |
UniGenei | Mm.103585 |
Genome annotation databases
Ensembli | ENSMUST00000096691; ENSMUSP00000094449; ENSMUSG00000074695 |
GeneIDi | 50929 |
KEGGi | mmu:50929 |
UCSCi | uc007hdv.2 mouse |
Similar proteinsi
Entry informationi
Entry namei | IL22_MOUSE | |
Accessioni | Q9JJY9Primary (citable) accession number: Q9JJY9 Secondary accession number(s): Q14BB3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 16, 2001 |
Last sequence update: | October 1, 2000 | |
Last modified: | March 28, 2018 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |