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Protein

Serine/threonine-protein kinase 32B

Gene

Stk32b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei52 – 521ATPPROSITE-ProRule annotationBy similarity
Active sitei146 – 1461Proton acceptorPROSITE-ProRule annotationBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi29 – 379ATPPROSITE-ProRule annotationBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 32B (EC:2.7.11.1)
Gene namesi
Name:Stk32bImported
Synonyms:Stk32Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1927552. Stk32b.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 414414Serine/threonine-protein kinase 32BPRO_0000232414Add
BLAST

Proteomic databases

PaxDbiQ9JJX8.
PRIDEiQ9JJX8.

PTM databases

PhosphoSiteiQ9JJX8.

Expressioni

Gene expression databases

BgeeiQ9JJX8.
CleanExiMM_STK32B.
GenevisibleiQ9JJX8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092432.

Structurei

3D structure databases

ProteinModelPortaliQ9JJX8.
SMRiQ9JJX8. Positions 14-372.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 283261Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0598. Eukaryota.
ENOG410XNPH. LUCA.
GeneTreeiENSGT00800000124105.
HOGENOMiHOG000021314.
HOVERGENiHBG106458.
InParanoidiQ9JJX8.
KOiK08793.
OMAiRCHIIHR.
OrthoDBiEOG7RZ5Q0.
PhylomeDBiQ9JJX8.
TreeFamiTF313395.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JJX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGNHSHKPP VFDENEEVNF DHFQILRAIG KGSFGKVCIV QKRDTKKMYA
60 70 80 90 100
MKYMNKQKCV ERDEVRNVFR ELQIMQGLEH PFLVNLWYSF QDEEDMFMVV
110 120 130 140 150
DLLLGGDLRY HLQQNVHFTE GTVKLYICEL ALALEYLQRY HIIHRDIKPD
160 170 180 190 200
NILLDEHGHV HITDFNIATV LKGSEKASSM AGTKPYMAPE VFQVYVDGGP
210 220 230 240 250
GYSYPVDWWS LGVTAYELLR GWRPYEIHSA TPIDEILNMF KVERVHYSST
260 270 280 290 300
WCEGMVSLLK KLLTKDPESR LSSLRDIQSM TYLADMNWDA VFEKALMPGF
310 320 330 340 350
VPNKGRLNCD PTFELEEMIL ESKPLHKKKK RLAKHRSRDS TKDSCPLNGH
360 370 380 390 400
LQQCLETVRK EFIIFNREKL RRQQGHNGQL SDLDGRIGSQ TSSKLQDGRN
410
NNILTHTCPR GCSS
Length:414
Mass (Da):47,916
Last modified:April 18, 2006 - v2
Checksum:i3C394415790594F3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti180 – 1801M → V in BAC38500 (PubMed:16141072).Curated
Sequence conflicti377 – 3771N → D in CAB76566 (PubMed:10700184).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250840 mRNA. Translation: CAB76566.1.
AK082468 mRNA. Translation: BAC38500.1.
BC052404 mRNA. Translation: AAH52404.1.
BC056396 mRNA. Translation: AAH56396.1.
BC058412 mRNA. Translation: AAH58412.1.
CCDSiCCDS39076.1.
RefSeqiNP_071861.1. NM_022416.2.
UniGeneiMm.103714.

Genome annotation databases

EnsembliENSMUST00000094836; ENSMUSP00000092432; ENSMUSG00000029123.
GeneIDi64293.
KEGGimmu:64293.
UCSCiuc008xft.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250840 mRNA. Translation: CAB76566.1.
AK082468 mRNA. Translation: BAC38500.1.
BC052404 mRNA. Translation: AAH52404.1.
BC056396 mRNA. Translation: AAH56396.1.
BC058412 mRNA. Translation: AAH58412.1.
CCDSiCCDS39076.1.
RefSeqiNP_071861.1. NM_022416.2.
UniGeneiMm.103714.

3D structure databases

ProteinModelPortaliQ9JJX8.
SMRiQ9JJX8. Positions 14-372.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092432.

PTM databases

PhosphoSiteiQ9JJX8.

Proteomic databases

PaxDbiQ9JJX8.
PRIDEiQ9JJX8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094836; ENSMUSP00000092432; ENSMUSG00000029123.
GeneIDi64293.
KEGGimmu:64293.
UCSCiuc008xft.2. mouse.

Organism-specific databases

CTDi55351.
MGIiMGI:1927552. Stk32b.

Phylogenomic databases

eggNOGiKOG0598. Eukaryota.
ENOG410XNPH. LUCA.
GeneTreeiENSGT00800000124105.
HOGENOMiHOG000021314.
HOVERGENiHBG106458.
InParanoidiQ9JJX8.
KOiK08793.
OMAiRCHIIHR.
OrthoDBiEOG7RZ5Q0.
PhylomeDBiQ9JJX8.
TreeFamiTF313395.

Miscellaneous databases

PROiQ9JJX8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JJX8.
CleanExiMM_STK32B.
GenevisibleiQ9JJX8. MM.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: BrainImported.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6JImported.
    Tissue: CerebellumImported.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6JImported.
    Tissue: BrainImported and Fetal brainImported.

Entry informationi

Entry nameiST32B_MOUSE
AccessioniPrimary (citable) accession number: Q9JJX8
Secondary accession number(s): Q7TMD3, Q8C4E0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: April 18, 2006
Last modified: June 8, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.