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Protein

P2X purinoceptor 4

Gene

P2rx4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
P2X purinoceptor 4
Short name:
P2X4
Alternative name(s):
ATP receptor
Purinergic receptor
Gene namesi
Name:P2rx4
Synonyms:P2x4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1338859 P2rx4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33CytoplasmicSequence analysisAdd BLAST33
Transmembranei34 – 54Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini55 – 338ExtracellularSequence analysisAdd BLAST284
Transmembranei339 – 359Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini360 – 388CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2176849
GuidetoPHARMACOLOGYi481

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002691941 – 388P2X purinoceptor 4Add BLAST388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi116 ↔ 165By similarity
Disulfide bondi126 ↔ 149By similarity
Glycosylationi131N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi132 ↔ 159By similarity
Glycosylationi153N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi184N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi199N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi208N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi217 ↔ 227By similarity
Disulfide bondi261 ↔ 270By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9JJX6
PeptideAtlasiQ9JJX6
PRIDEiQ9JJX6

PTM databases

iPTMnetiQ9JJX6
PhosphoSitePlusiQ9JJX6
SwissPalmiQ9JJX6

Interactioni

Subunit structurei

Functional P2XRs are organized as homomeric and heteromeric trimers.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031429

Chemistry databases

BindingDBiQ9JJX6

Structurei

3D structure databases

ProteinModelPortaliQ9JJX6
SMRiQ9JJX6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the P2X receptor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFJF Eukaryota
ENOG410XR0C LUCA
HOGENOMiHOG000232042
HOVERGENiHBG053086
InParanoidiQ9JJX6
PhylomeDBiQ9JJX6

Family and domain databases

Gene3Di2.60.490.10, 1 hit
InterProiView protein in InterPro
IPR003047 P2X4_purnocptor
IPR027309 P2X_extracellular_dom_sf
IPR001429 P2X_purnocptor
PANTHERiPTHR10125 PTHR10125, 1 hit
PfamiView protein in Pfam
PF00864 P2X_receptor, 1 hit
PIRSFiPIRSF005713 P2X_purinoceptor, 1 hit
PRINTSiPR01311 P2X4RECEPTOR
PR01307 P2XRECEPTOR
TIGRFAMsiTIGR00863 P2X, 1 hit
PROSITEiView protein in PROSITE
PS01212 P2X_RECEPTOR, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: Q9JJX6-1) [UniParc]FASTAAdd to basket
Also known as: P2X4a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGCCSVLGS FLFEYDTPRI VLIRSRKVGL MNRVVQLLIL AYVIGWVFVW
60 70 80 90 100
EKGYQETDSV VSSVTTKAKG VAVTNTSQLG FRIWDVADYV VPAQEENSLF
110 120 130 140 150
IMTNMIVTVN QTQGTCPEIP DKTSICDSDA NCTLGSSDTH SSGIGTGRCV
160 170 180 190 200
PFNASVKTCE VAAWCPVEND AGVPTPAFLK AAENFTLLVK NNIWYPKFNF
210 220 230 240 250
SKRNILPNIT TSYLKSCIYN ARTDPFCPIF RLGQIVADAG HSFQEMAVEG
260 270 280 290 300
GIMGIQIKWD CNLDRAASHC LPRYSFRRLD TRDLEHNVSP GYNFRFAKYY
310 320 330 340 350
RDLAGNEQRT LTKAYGIRFD IIVFGKAGKF DIIPTMINVG SGLALLGVAT
360 370 380
VLCDVIVLYC MKKRYYYRDK KYKYVEDYEQ GLSGEMNQ
Length:388
Mass (Da):43,438
Last modified:October 1, 2000 - v1
Checksum:i4F388F006DB6DF45
GO
Isoform b (identifier: Q9JJX6-2) [UniParc]FASTAAdd to basket
Also known as: P2X4b

The sequence of this isoform differs from the canonical sequence as follows:
     176-202: Missing.

Show »
Length:361
Mass (Da):40,254
Checksum:iA8930EAACBDB0F8C
GO
Isoform c (identifier: Q9JJX6-3) [UniParc]FASTAAdd to basket
Also known as: P2X4c

The sequence of this isoform differs from the canonical sequence as follows:
     328-349: Missing.

Show »
Length:366
Mass (Da):41,269
Checksum:i0762FA5FB21670B1
GO
Isoform d (identifier: Q9JJX6-4) [UniParc]FASTAAdd to basket
Also known as: P2X4d

The sequence of this isoform differs from the canonical sequence as follows:
     176-202: Missing.
     328-349: Missing.

Show »
Length:339
Mass (Da):38,086
Checksum:iF780AA6A300A1E77
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_022023176 – 202Missing in isoform b and isoform d. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_022024328 – 349Missing in isoform c and isoform d. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251459 mRNA Translation: CAB90749.1
AJ251460 mRNA Translation: CAB90750.1
AJ251461 mRNA Translation: CAB90751.1
AJ251462 mRNA Translation: CAB90752.1
CCDSiCCDS19654.2 [Q9JJX6-1]
CCDS80392.1 [Q9JJX6-3]
CCDS80393.1 [Q9JJX6-2]
UniGeneiMm.290884
Mm.463383

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiP2RX4_MOUSE
AccessioniPrimary (citable) accession number: Q9JJX6
Secondary accession number(s): Q9JJX3, Q9JJX4, Q9JJX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 1, 2000
Last modified: February 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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