Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

P2X purinoceptor 4

Gene

P2rx4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin (By similarity).By similarity

GO - Molecular functioni

  • ATP binding Source: InterPro
  • cadherin binding Source: MGI
  • extracellular ATP-gated cation channel activity Source: MGI
  • purinergic nucleotide receptor activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
P2X purinoceptor 4
Short name:
P2X4
Alternative name(s):
ATP receptor
Purinergic receptor
Gene namesi
Name:P2rx4
Synonyms:P2x4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1338859. P2rx4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33CytoplasmicSequence analysisAdd BLAST33
Transmembranei34 – 54Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini55 – 338ExtracellularSequence analysisAdd BLAST284
Transmembranei339 – 359Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini360 – 388CytoplasmicSequence analysisAdd BLAST29

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2176849.
GuidetoPHARMACOLOGYi481.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002691941 – 388P2X purinoceptor 4Add BLAST388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi75N-linked (GlcNAc...)Sequence analysis1
Glycosylationi110N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi116 ↔ 165By similarity
Disulfide bondi126 ↔ 149By similarity
Glycosylationi131N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi132 ↔ 159By similarity
Glycosylationi153N-linked (GlcNAc...)Sequence analysis1
Glycosylationi184N-linked (GlcNAc...)Sequence analysis1
Glycosylationi199N-linked (GlcNAc...)Sequence analysis1
Glycosylationi208N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi217 ↔ 227By similarity
Disulfide bondi261 ↔ 270By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9JJX6.
PeptideAtlasiQ9JJX6.
PRIDEiQ9JJX6.

PTM databases

iPTMnetiQ9JJX6.
PhosphoSitePlusiQ9JJX6.
SwissPalmiQ9JJX6.

Interactioni

Subunit structurei

Functional P2XRs are organized as homomeric and heteromeric trimers.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031429.

Chemistry databases

BindingDBiQ9JJX6.

Structurei

3D structure databases

ProteinModelPortaliQ9JJX6.
SMRiQ9JJX6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the P2X receptor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFJF. Eukaryota.
ENOG410XR0C. LUCA.
HOGENOMiHOG000232042.
HOVERGENiHBG053086.
InParanoidiQ9JJX6.
PhylomeDBiQ9JJX6.

Family and domain databases

Gene3Di2.60.490.10. 1 hit.
InterProiIPR003047. P2X4_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view]
PANTHERiPTHR10125. PTHR10125. 1 hit.
PTHR10125:SF18. PTHR10125:SF18. 1 hit.
PfamiPF00864. P2X_receptor. 1 hit.
[Graphical view]
PIRSFiPIRSF005713. P2X_purinoceptor. 1 hit.
PRINTSiPR01311. P2X4RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsiTIGR00863. P2X. 1 hit.
PROSITEiPS01212. P2X_RECEPTOR. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: Q9JJX6-1) [UniParc]FASTAAdd to basket
Also known as: P2X4a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGCCSVLGS FLFEYDTPRI VLIRSRKVGL MNRVVQLLIL AYVIGWVFVW
60 70 80 90 100
EKGYQETDSV VSSVTTKAKG VAVTNTSQLG FRIWDVADYV VPAQEENSLF
110 120 130 140 150
IMTNMIVTVN QTQGTCPEIP DKTSICDSDA NCTLGSSDTH SSGIGTGRCV
160 170 180 190 200
PFNASVKTCE VAAWCPVEND AGVPTPAFLK AAENFTLLVK NNIWYPKFNF
210 220 230 240 250
SKRNILPNIT TSYLKSCIYN ARTDPFCPIF RLGQIVADAG HSFQEMAVEG
260 270 280 290 300
GIMGIQIKWD CNLDRAASHC LPRYSFRRLD TRDLEHNVSP GYNFRFAKYY
310 320 330 340 350
RDLAGNEQRT LTKAYGIRFD IIVFGKAGKF DIIPTMINVG SGLALLGVAT
360 370 380
VLCDVIVLYC MKKRYYYRDK KYKYVEDYEQ GLSGEMNQ
Length:388
Mass (Da):43,438
Last modified:October 1, 2000 - v1
Checksum:i4F388F006DB6DF45
GO
Isoform b (identifier: Q9JJX6-2) [UniParc]FASTAAdd to basket
Also known as: P2X4b

The sequence of this isoform differs from the canonical sequence as follows:
     176-202: Missing.

Show »
Length:361
Mass (Da):40,254
Checksum:iA8930EAACBDB0F8C
GO
Isoform c (identifier: Q9JJX6-3) [UniParc]FASTAAdd to basket
Also known as: P2X4c

The sequence of this isoform differs from the canonical sequence as follows:
     328-349: Missing.

Show »
Length:366
Mass (Da):41,269
Checksum:i0762FA5FB21670B1
GO
Isoform d (identifier: Q9JJX6-4) [UniParc]FASTAAdd to basket
Also known as: P2X4d

The sequence of this isoform differs from the canonical sequence as follows:
     176-202: Missing.
     328-349: Missing.

Show »
Length:339
Mass (Da):38,086
Checksum:iF780AA6A300A1E77
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_022023176 – 202Missing in isoform b and isoform d. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_022024328 – 349Missing in isoform c and isoform d. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251459 mRNA. Translation: CAB90749.1.
AJ251460 mRNA. Translation: CAB90750.1.
AJ251461 mRNA. Translation: CAB90751.1.
AJ251462 mRNA. Translation: CAB90752.1.
CCDSiCCDS19654.2. [Q9JJX6-1]
CCDS80392.1. [Q9JJX6-3]
CCDS80393.1. [Q9JJX6-2]
UniGeneiMm.290884.
Mm.463383.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251459 mRNA. Translation: CAB90749.1.
AJ251460 mRNA. Translation: CAB90750.1.
AJ251461 mRNA. Translation: CAB90751.1.
AJ251462 mRNA. Translation: CAB90752.1.
CCDSiCCDS19654.2. [Q9JJX6-1]
CCDS80392.1. [Q9JJX6-3]
CCDS80393.1. [Q9JJX6-2]
UniGeneiMm.290884.
Mm.463383.

3D structure databases

ProteinModelPortaliQ9JJX6.
SMRiQ9JJX6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031429.

Chemistry databases

BindingDBiQ9JJX6.
ChEMBLiCHEMBL2176849.
GuidetoPHARMACOLOGYi481.

PTM databases

iPTMnetiQ9JJX6.
PhosphoSitePlusiQ9JJX6.
SwissPalmiQ9JJX6.

Proteomic databases

PaxDbiQ9JJX6.
PeptideAtlasiQ9JJX6.
PRIDEiQ9JJX6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1338859. P2rx4.

Phylogenomic databases

eggNOGiENOG410IFJF. Eukaryota.
ENOG410XR0C. LUCA.
HOGENOMiHOG000232042.
HOVERGENiHBG053086.
InParanoidiQ9JJX6.
PhylomeDBiQ9JJX6.

Miscellaneous databases

PROiQ9JJX6.
SOURCEiSearch...

Family and domain databases

Gene3Di2.60.490.10. 1 hit.
InterProiIPR003047. P2X4_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view]
PANTHERiPTHR10125. PTHR10125. 1 hit.
PTHR10125:SF18. PTHR10125:SF18. 1 hit.
PfamiPF00864. P2X_receptor. 1 hit.
[Graphical view]
PIRSFiPIRSF005713. P2X_purinoceptor. 1 hit.
PRINTSiPR01311. P2X4RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsiTIGR00863. P2X. 1 hit.
PROSITEiPS01212. P2X_RECEPTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP2RX4_MOUSE
AccessioniPrimary (citable) accession number: Q9JJX6
Secondary accession number(s): Q9JJX3, Q9JJX4, Q9JJX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.