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Q9JJX6

- P2RX4_MOUSE

UniProt

Q9JJX6 - P2RX4_MOUSE

Protein

P2X purinoceptor 4

Gene

P2rx4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin By similarity.By similarity

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. extracellular ATP-gated cation channel activity Source: MGI
    3. purinergic nucleotide receptor activity Source: RefGenome

    GO - Biological processi

    1. calcium ion transport Source: MGI
    2. cellular response to ATP Source: UniProtKB
    3. nitric oxide biosynthetic process Source: MGI
    4. purinergic nucleotide receptor signaling pathway Source: GOC
    5. regulation of excitatory postsynaptic membrane potential Source: MGI
    6. vasodilation Source: MGI

    Keywords - Molecular functioni

    Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    P2X purinoceptor 4
    Short name:
    P2X4
    Alternative name(s):
    ATP receptor
    Purinergic receptor
    Gene namesi
    Name:P2rx4
    Synonyms:P2x4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1338859. P2rx4.

    Subcellular locationi

    GO - Cellular componenti

    1. apical part of cell Source: MGI
    2. integral component of nuclear inner membrane Source: RefGenome
    3. integral component of plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 388388P2X purinoceptor 4PRO_0000269194Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi116 ↔ 165By similarity
    Disulfide bondi126 ↔ 149By similarity
    Glycosylationi131 – 1311N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi132 ↔ 159By similarity
    Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi208 – 2081N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi217 ↔ 227By similarity
    Disulfide bondi261 ↔ 270By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ9JJX6.
    PaxDbiQ9JJX6.
    PRIDEiQ9JJX6.

    PTM databases

    PhosphoSiteiQ9JJX6.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9JJX6.

    Interactioni

    Subunit structurei

    Functional P2XRs are organized as homomeric and heteromeric trimers.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JJX6.
    SMRiQ9JJX6. Positions 31-358.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3333CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini55 – 338284ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini360 – 38829CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei34 – 5421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei339 – 35921Helical; Name=2Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the P2X receptor family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG47843.
    HOGENOMiHOG000232042.
    HOVERGENiHBG053086.
    InParanoidiQ9JJX6.
    PhylomeDBiQ9JJX6.

    Family and domain databases

    Gene3Di2.60.490.10. 1 hit.
    InterProiIPR003047. P2X4_purnocptor.
    IPR027309. P2X_extracellular_dom.
    IPR001429. P2X_purnocptor.
    [Graphical view]
    PANTHERiPTHR10125. PTHR10125. 1 hit.
    PTHR10125:SF18. PTHR10125:SF18. 1 hit.
    PfamiPF00864. P2X_receptor. 1 hit.
    [Graphical view]
    PRINTSiPR01311. P2X4RECEPTOR.
    PR01307. P2XRECEPTOR.
    TIGRFAMsiTIGR00863. P2X. 1 hit.
    PROSITEiPS01212. P2X_RECEPTOR. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform a (identifier: Q9JJX6-1) [UniParc]FASTAAdd to Basket

    Also known as: P2X4a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGCCSVLGS FLFEYDTPRI VLIRSRKVGL MNRVVQLLIL AYVIGWVFVW    50
    EKGYQETDSV VSSVTTKAKG VAVTNTSQLG FRIWDVADYV VPAQEENSLF 100
    IMTNMIVTVN QTQGTCPEIP DKTSICDSDA NCTLGSSDTH SSGIGTGRCV 150
    PFNASVKTCE VAAWCPVEND AGVPTPAFLK AAENFTLLVK NNIWYPKFNF 200
    SKRNILPNIT TSYLKSCIYN ARTDPFCPIF RLGQIVADAG HSFQEMAVEG 250
    GIMGIQIKWD CNLDRAASHC LPRYSFRRLD TRDLEHNVSP GYNFRFAKYY 300
    RDLAGNEQRT LTKAYGIRFD IIVFGKAGKF DIIPTMINVG SGLALLGVAT 350
    VLCDVIVLYC MKKRYYYRDK KYKYVEDYEQ GLSGEMNQ 388
    Length:388
    Mass (Da):43,438
    Last modified:October 1, 2000 - v1
    Checksum:i4F388F006DB6DF45
    GO
    Isoform b (identifier: Q9JJX6-2) [UniParc]FASTAAdd to Basket

    Also known as: P2X4b

    The sequence of this isoform differs from the canonical sequence as follows:
         176-202: Missing.

    Show »
    Length:361
    Mass (Da):40,254
    Checksum:iA8930EAACBDB0F8C
    GO
    Isoform c (identifier: Q9JJX6-3) [UniParc]FASTAAdd to Basket

    Also known as: P2X4c

    The sequence of this isoform differs from the canonical sequence as follows:
         328-349: Missing.

    Show »
    Length:366
    Mass (Da):41,269
    Checksum:i0762FA5FB21670B1
    GO
    Isoform d (identifier: Q9JJX6-4) [UniParc]FASTAAdd to Basket

    Also known as: P2X4d

    The sequence of this isoform differs from the canonical sequence as follows:
         176-202: Missing.
         328-349: Missing.

    Show »
    Length:339
    Mass (Da):38,086
    Checksum:iF780AA6A300A1E77
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei176 – 20227Missing in isoform b and isoform d. 1 PublicationVSP_022023Add
    BLAST
    Alternative sequencei328 – 34922Missing in isoform c and isoform d. 1 PublicationVSP_022024Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ251459 mRNA. Translation: CAB90749.1.
    AJ251460 mRNA. Translation: CAB90750.1.
    AJ251461 mRNA. Translation: CAB90751.1.
    AJ251462 mRNA. Translation: CAB90752.1.
    CCDSiCCDS19654.2. [Q9JJX6-1]
    UniGeneiMm.290884.
    Mm.463383.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ251459 mRNA. Translation: CAB90749.1 .
    AJ251460 mRNA. Translation: CAB90750.1 .
    AJ251461 mRNA. Translation: CAB90751.1 .
    AJ251462 mRNA. Translation: CAB90752.1 .
    CCDSi CCDS19654.2. [Q9JJX6-1 ]
    UniGenei Mm.290884.
    Mm.463383.

    3D structure databases

    ProteinModelPortali Q9JJX6.
    SMRi Q9JJX6. Positions 31-358.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    ChEMBLi CHEMBL2176849.
    GuidetoPHARMACOLOGYi 481.

    PTM databases

    PhosphoSitei Q9JJX6.

    Proteomic databases

    MaxQBi Q9JJX6.
    PaxDbi Q9JJX6.
    PRIDEi Q9JJX6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:1338859. P2rx4.

    Phylogenomic databases

    eggNOGi NOG47843.
    HOGENOMi HOG000232042.
    HOVERGENi HBG053086.
    InParanoidi Q9JJX6.
    PhylomeDBi Q9JJX6.

    Miscellaneous databases

    ChiTaRSi P2RX4. mouse.
    PROi Q9JJX6.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q9JJX6.

    Family and domain databases

    Gene3Di 2.60.490.10. 1 hit.
    InterProi IPR003047. P2X4_purnocptor.
    IPR027309. P2X_extracellular_dom.
    IPR001429. P2X_purnocptor.
    [Graphical view ]
    PANTHERi PTHR10125. PTHR10125. 1 hit.
    PTHR10125:SF18. PTHR10125:SF18. 1 hit.
    Pfami PF00864. P2X_receptor. 1 hit.
    [Graphical view ]
    PRINTSi PR01311. P2X4RECEPTOR.
    PR01307. P2XRECEPTOR.
    TIGRFAMsi TIGR00863. P2X. 1 hit.
    PROSITEi PS01212. P2X_RECEPTOR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Alternatively spliced variants of the mouse P2X4 receptor: cloning and characterisation."
      Simon J., Michel A.D., Chessell I.P., Kidd E.J., Jones C.A., Barnard E.A., Humphrey P.P.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C AND D).

    Entry informationi

    Entry nameiP2RX4_MOUSE
    AccessioniPrimary (citable) accession number: Q9JJX6
    Secondary accession number(s): Q9JJX3, Q9JJX4, Q9JJX5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3