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Protein

Myozenin-2

Gene

Myoz2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.1 Publication

GO - Molecular functioni

  • actin binding Source: MGI
  • telethonin binding Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Myozenin-2
Alternative name(s):
Calsarcin-1
FATZ-related protein 2
Gene namesi
Name:Myoz2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1913063. Myoz2.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: MGI
  • Z disc Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264Myozenin-2PRO_0000111100Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei101 – 1011PhosphoserineCombined sources
Modified residuei107 – 1071PhosphothreonineCombined sources
Modified residuei111 – 1111PhosphothreonineCombined sources
Modified residuei116 – 1161PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9JJW5.
PaxDbiQ9JJW5.
PRIDEiQ9JJW5.

PTM databases

iPTMnetiQ9JJW5.
PhosphoSiteiQ9JJW5.

Expressioni

Tissue specificityi

Expressed specifically in heart and skeletal muscle. In skeletal muscle, localized to the soleus and plantaris muscles, which are predominantly composed of slow-twitch fibers.1 Publication

Developmental stagei

At E9.5, expressed weakly in heart. Higher levels of expression detected at E12.5 and E15.5 in both cardiac and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ9JJW5.
CleanExiMM_MYOZ2.
ExpressionAtlasiQ9JJW5. baseline and differential.
GenevisibleiQ9JJW5. MM.

Interactioni

Subunit structurei

Interacts via its C-terminus with spectrin repeats 3 and 4 of ACTN2. Interacts with ACTN1, LDB3, MYOT and PPP3CA (By similarity).By similarity

GO - Molecular functioni

  • actin binding Source: MGI
  • telethonin binding Source: MGI

Protein-protein interaction databases

IntActiQ9JJW5. 2 interactions.
MINTiMINT-4130052.
STRINGi10090.ENSMUSP00000029761.

Structurei

3D structure databases

ProteinModelPortaliQ9JJW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the myozenin family.Curated

Phylogenomic databases

eggNOGiENOG410IKXK. Eukaryota.
ENOG410ZK6W. LUCA.
GeneTreeiENSGT00530000063184.
HOGENOMiHOG000030910.
HOVERGENiHBG071289.
InParanoidiQ9JJW5.
OMAiDPRFMAF.
OrthoDBiEOG7NGQCH.
PhylomeDBiQ9JJW5.
TreeFamiTF331748.

Family and domain databases

InterProiIPR008438. MYOZ.
[Graphical view]
PANTHERiPTHR15941. PTHR15941. 1 hit.
PfamiPF05556. Calsarcin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JJW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSHSAMVKQ RKQQASAITK EIHGHDVDGM DLGKKVSIPR DIMIEELSHF
60 70 80 90 100
SNRGARLFKM RQRRSDKYTF ENFQYESRAQ INHNIAMQNG RVDGSNLEGG
110 120 130 140 150
SQQGPSTPPN TPDPRSPPNP ENIAPGYSGP LKEIPPERFN TTAVPKYYRS
160 170 180 190 200
PWEQAIGSDP ELLEALYPKL FKPEGKAELR DYRSFNRVAT PFGGFEKASK
210 220 230 240 250
MVKFKVPDFE LLLLTDPRFL AFANPLSGRR CFNRAPKGWV SENIPVVITT
260
EPTEDATVPE SDDL
Length:264
Mass (Da):29,762
Last modified:October 1, 2000 - v1
Checksum:i2DCDC6A30B0704FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY013296 mRNA. Translation: AAG38939.1.
AJ252148 mRNA. Translation: CAB92972.1.
BC024360 mRNA. Translation: AAH24360.1.
CCDSiCCDS17816.1.
RefSeqiNP_067478.1. NM_021503.2.
UniGeneiMm.141157.

Genome annotation databases

EnsembliENSMUST00000029761; ENSMUSP00000029761; ENSMUSG00000028116.
GeneIDi59006.
KEGGimmu:59006.
UCSCiuc008rfe.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY013296 mRNA. Translation: AAG38939.1.
AJ252148 mRNA. Translation: CAB92972.1.
BC024360 mRNA. Translation: AAH24360.1.
CCDSiCCDS17816.1.
RefSeqiNP_067478.1. NM_021503.2.
UniGeneiMm.141157.

3D structure databases

ProteinModelPortaliQ9JJW5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JJW5. 2 interactions.
MINTiMINT-4130052.
STRINGi10090.ENSMUSP00000029761.

PTM databases

iPTMnetiQ9JJW5.
PhosphoSiteiQ9JJW5.

Proteomic databases

MaxQBiQ9JJW5.
PaxDbiQ9JJW5.
PRIDEiQ9JJW5.

Protocols and materials databases

DNASUi59006.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029761; ENSMUSP00000029761; ENSMUSG00000028116.
GeneIDi59006.
KEGGimmu:59006.
UCSCiuc008rfe.2. mouse.

Organism-specific databases

CTDi51778.
MGIiMGI:1913063. Myoz2.

Phylogenomic databases

eggNOGiENOG410IKXK. Eukaryota.
ENOG410ZK6W. LUCA.
GeneTreeiENSGT00530000063184.
HOGENOMiHOG000030910.
HOVERGENiHBG071289.
InParanoidiQ9JJW5.
OMAiDPRFMAF.
OrthoDBiEOG7NGQCH.
PhylomeDBiQ9JJW5.
TreeFamiTF331748.

Miscellaneous databases

PROiQ9JJW5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JJW5.
CleanExiMM_MYOZ2.
ExpressionAtlasiQ9JJW5. baseline and differential.
GenevisibleiQ9JJW5. MM.

Family and domain databases

InterProiIPR008438. MYOZ.
[Graphical view]
PANTHERiPTHR15941. PTHR15941. 1 hit.
PfamiPF05556. Calsarcin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Calsarcins, a novel family of sarcomeric calcineurin-binding proteins."
    Frey N., Richardson J.A., Olson E.N.
    Proc. Natl. Acad. Sci. U.S.A. 97:14632-14637(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  2. "Full length sequencing of some human and murine muscular transcripts (Telethon Italy project B41)."
    Ievolella C., Zara I., Millino C., Faulkner G., Lanfranchi G.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skeletal muscleCurated.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech IIImported.
    Tissue: Mammary glandImported.
  4. "Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress."
    Frey N., Barrientos T., Shelton J.M., Frank D., Rutten H., Gehring D., Kuhn C., Lutz M., Rothermel B., Bassel-Duby R., Richardson J.A., Katus H.A., Hill J.A., Olson E.N.
    Nat. Med. 10:1336-1343(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-111, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-101; THR-107; THR-111 AND SER-116, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Heart and Lung.

Entry informationi

Entry nameiMYOZ2_MOUSE
AccessioniPrimary (citable) accession number: Q9JJW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.