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Protein

Tetraspanin-2

Gene

Tspan2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath.

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-2
Short name:
Tspan-2
Gene namesi
Name:Tspan2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi620982 Tspan2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Topological domaini35 – 54ExtracellularSequence analysisAdd BLAST20
Transmembranei55 – 75HelicalSequence analysisAdd BLAST21
Topological domaini76 – 90CytoplasmicSequence analysisAdd BLAST15
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Topological domaini112 – 188ExtracellularSequence analysisAdd BLAST77
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Topological domaini210 – 221CytoplasmicSequence analysisAdd BLAST12

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192381 – 221Tetraspanin-2Add BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi139N-linked (GlcNAc...) asparagineCombined sources1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9JJW1
PRIDEiQ9JJW1

PTM databases

UniCarbKBiQ9JJW1

Expressioni

Tissue specificityi

Expression is restricted to the nervous system.

Gene expression databases

BgeeiENSRNOG00000023338
GenevisibleiQ9JJW1 RN

Structurei

3D structure databases

ProteinModelPortaliQ9JJW1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137858
HOGENOMiHOG000230651
HOVERGENiHBG002324
InParanoidiQ9JJW1
KOiK17354
OMAiHSAFQCC
OrthoDBiEOG091G0K9H
PhylomeDBiQ9JJW1
TreeFamiTF352895

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JJW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRFRGGLRC IKYLLLGFNL LFWLAGSAVI AFGLWFRFGG TIKDLSSEEK
60 70 80 90 100
SPEYFYVGLY VLVGAGALMM AVGFFGCCGA MRESQCVLGS FFTCLLVIFA
110 120 130 140 150
AEVTTGVFAF IGKDVAIRHV QSMYEEAYSD YVRDRGRGNG TLITFHSAFQ
160 170 180 190 200
CCGKESSEQV QPTCPKELPG HKNCIDKIET IISVKLQLIG IVGIGIAGLT
210 220
IFGMIFSMVL CCAIRNSRDV I
Length:221
Mass (Da):24,190
Last modified:October 1, 2000 - v1
Checksum:iE369888361AF4824
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ271442 mRNA Translation: CAB69827.1
BC085733 mRNA Translation: AAH85733.1
RefSeqiNP_072111.1, NM_022589.1
UniGeneiRn.5872

Genome annotation databases

EnsembliENSRNOT00000035605; ENSRNOP00000033076; ENSRNOG00000023338
GeneIDi64521
KEGGirno:64521
UCSCiRGD:620982 rat

Similar proteinsi

Entry informationi

Entry nameiTSN2_RAT
AccessioniPrimary (citable) accession number: Q9JJW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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