Q9JJV9E9Q1D2Q3UH91SCN5A_MOUSESodium channel protein type 5 subunit alphaSodium channel protein cardiac muscle subunit alphaSodium channel protein type V subunit alphaVoltage-gated sodium channel subunit alpha Nav1.5mH1Scn5aMus musculusMouseEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMusMouse heart Na+ channels: primary structure and function of two isoforms and alternatively spliced variants.NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)FUNCTIONSUBCELLULAR LOCATIONALTERNATIVE SPLICINGTISSUE SPECIFICITYThe transcriptional landscape of the mammalian genome.NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)Lineage-specific biology revealed by a finished genome assembly of the mouse.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteins.INTERACTION WITH SNTA1; SNTB1 AND SNTB2Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels.PHOSPHORYLATION BY CAMK2DA tissue-specific atlas of mouse protein phosphorylation and expression.PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-457; SER-484 AND SER-539IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts.INTERACTION WITH FGF13MOG1 rescues defective trafficking of Na(v)1.5 mutations in Brugada syndrome and sick sinus syndrome.FUNCTIONSUBCELLULAR LOCATIONImmunoaffinity enrichment and mass spectrometry analysis of protein methylation.METHYLATION [LARGE SCALE ANALYSIS] AT ARG-526IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:11834499, PubMed:23420830). It is a tetrodotoxin-resistant Na(+) channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels (By similarity).Interacts with the PDZ domain of the syntrophin SNTA1, SNTB1 and SNTB2 (PubMed:9412493). Interacts with NEDD4, NEDD4L, WWP2 and GPD1L (By similarity). Interacts with CALM (By similarity). Interacts with FGF13; the interaction is direct and may regulate SNC5A density at membranes and function (PubMed:21817159). Interacts with FGF12 and FGF14 (By similarity). Interacts with ANK3 (By similarity). Interacts with PKP2 (via N-terminus) (By similarity). Interacts with TMEM233 (By similarity).Q9JJV9Q4U4S6false2Cell membraneMulti-pass membrane proteinCytoplasmPerinuclear regionCell membraneSarcolemmaT-tubuleCell junctionRANGRF promotes trafficking to the cell membrane. Colocalizes with PKP2 at intercalated disks in the heart (By similarity).Q9JJV9-11Q9JJV9-22Additional isoforms seem to exist.Expressed in the myocardium.The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.The IQ domain mediates association with calmodulin.Phosphorylation at Ser-1505 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents (By similarity). Regulated through phosphorylation by CaMK2D (PubMed:17124532).Ubiquitinated by NEDD4L; which promotes its endocytosis. Does not seem to be ubiquitinated by NEDD4 or WWP2.Lacks the cysteine which covalently binds the conotoxin GVIIJ. This cysteine (position 868) is speculated in other sodium channel subunits alpha to be implied in covalent binding with the sodium channel subunit beta-2 or beta-4.Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.5/SCN5A subfamily.Alternative splicingCalmodulin-bindingCell junctionCell membraneCytoplasmDisulfide bondGlycoproteinIon channelIon transportMembraneMethylationPhosphoproteinReference proteomeRepeatSodiumSodium channelSodium transportTransmembraneTransmembrane helixTransportUbl conjugationVoltage-gated channelTTEFVDVSENIKVLSPAATTKKQTSMANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSATSQESREGLPEEEAPRPQLDLQASKKLPDLYGNPPRELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPVRRAAVKILVHSLFSMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIVMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTELNGTNGSVEADGIVWNSLDVYLNDPANYLLKNGTTDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVTNHERRSKRRKRLSSGTEDGGDDRLPKSDSEDGPRALNQLSLTHGLSRTSMRPRSSRGSIFTFRRRDQGSEADFADDENSTAGESESHRTSLLVPWPLRRPSTQGQPGFGTSAPGHVLNGKRNSTVDCNGVVSLLGAGDAEATSPGSHLLRPIVLDRPPDTTTPSEEPGGPQMLTPQAPCADGFEEPGARQRALSAVSVLTSALEELEESHRKCPPCWNRFAQHYLIWECCPLWMSIKQKVKFVVMDPFADLTITMCIVLNTLFMALEHYNMTAEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMGNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRHRISDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDGEMNNLQLALARIQRGLRFVKRTTWDFCCGLLRRRPKKPAALATHSQLPSCIAAPRSPPPPEVEKAPPARKETRFEEDKRPGQGTPGDTEPVCVPIAVAESDTDDQEEDEENSLGTEEEESSKQESQVVSGGHEPPQEPRAWSQVSETTSSEAEASTSQADWQQEREAEPRAPGCGETPEDSYSEGSTADMTNTADLLEQIPDLGEDVKDPEDCFTEGCVRRCPCCMVDTTQAPGKVWWRLRKTCYRIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSECESFNVTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEDNLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKVNILAKINLLFVAIFTGECIVKMAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGSRGNCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYLALSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSATVIQRAFRRHLLQRSVKHASFLFRQQAGSSGLSDEDAPEREGLIAYMMNENFSRRSGPLSSSSISSTSFPPSYDSVTRATSDNLPVRASDYSRSEDLADFPPSPDRDRESIV
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