Q9JJV9 (SCN5A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sodium channel protein type 5 subunit alpha

Alternative name(s):
Sodium channel protein cardiac muscle subunit alpha
Sodium channel protein type V subunit alpha
Voltage-gated sodium channel subunit alpha Nav1.5
mH1

Gene names

Name:

Scn5a

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	2019 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na+ channel isoform. Channel inactivation is regulated by intracellular calcium levels By similarity.
Subunit structure	Interacts with the PDZ domain of the syntrophin SNTA1, SNTB1 and SNTB2 By similarity. Interacts with NEDD4, NEDD4L, WWP2 and GPD1L. Interacts with CALM By similarity. Interacts with FGF13; the interaction is direct and may regulate SNC5A density at membranes and function. Ref.5
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in the myocardium. Ref.1
Domain	The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
Post-translational modification	Regulated through phosphorylation by CaMK2D. Ubiquitinated by NEDD4L; which promotes its endocytosis By similarity.
Sequence similarities	Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.5/SCN5A subfamily. [View classification] Contains 1 IQ domain.

Ontologies

Keywords
Biological process	Ion transport Sodium transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat Transmembrane Transmembrane helix
Ligand	Calmodulin-binding Sodium
Molecular function	Ion channel Sodium channel Voltage-gated channel
PTM	Glycoprotein Methylation Phosphoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cardiac ventricle development Inferred from mutant phenotype PubMed 11972032. Source: MGI cellular response to calcium ion Inferred from sequence or structural similarity. Source: UniProtKB regulation of cardiac muscle cell contraction Inferred from mutant phenotype PubMed 16172272. Source: MGI regulation of heart rate by cardiac conduction Inferred from mutant phenotype PubMed 11972032PubMed 15809371PubMed 15932895PubMed 16172272. Source: MGI response to organic cyclic compound Inferred from mutant phenotype PubMed 19745168. Source: MGI
Cellular_component	T-tubule Inferred from direct assay PubMed 15746173PubMed 18178574. Source: MGI cell surface Inferred from direct assay PubMed 17884088. Source: BHF-UCL intercalated disc Inferred from direct assay PubMed 17884088PubMed 18184654. Source: BHF-UCL voltage-gated sodium channel complex Inferred by curator Ref.1. Source: MGI
Molecular_function	voltage-gated sodium channel activity involved in regulation of SA node cell action potential Inferred from mutant phenotype PubMed 15932895. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q9JJV9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9JJV9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     206-211: TTEFVD → VSENIK

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2019	2019	Sodium channel protein type 5 subunit alpha		PRO_0000376895
Regions
	Transmembrane	127 – 150	24	Helical; Name=S1 of repeat I; Potential
	Transmembrane	159 – 178	20	Helical; Name=S2 of repeat I; Potential
	Transmembrane	192 – 210	19	Helical; Name=S3 of repeat I; Potential
	Transmembrane	217 – 236	20	Helical; Voltage-sensor; Name=S4 of repeat I; Potential
	Transmembrane	253 – 276	24	Helical; Name=S5 of repeat I; Potential
	Transmembrane	390 – 415	26	Helical; Name=S6 of repeat I; Potential
	Transmembrane	712 – 736	25	Helical; Name=S1 of repeat II; Potential
	Transmembrane	748 – 771	24	Helical; Name=S2 of repeat II; Potential
	Transmembrane	780 – 799	20	Helical; Name=S3 of repeat II; Potential
	Transmembrane	806 – 825	20	Helical; Voltage-sensor; Name=S4 of repeat II; Potential
	Transmembrane	842 – 862	21	Helical; Name=S5 of repeat II; Potential
	Transmembrane	916 – 941	26	Helical; Name=S6 of repeat II; Potential
	Transmembrane	1203 – 1226	24	Helical; Name=S1 of repeat III; Potential
	Transmembrane	1240 – 1265	26	Helical; Name=S2 of repeat III; Potential
	Transmembrane	1272 – 1293	22	Helical; Name=S3 of repeat III; Potential
	Transmembrane	1298 – 1319	22	Helical; Voltage-sensor; Name=S4 of repeat III; Potential
	Transmembrane	1339 – 1361	23	Helical; Name=S5 of repeat III; Potential
	Transmembrane	1446 – 1472	27	Helical; Name=S6 of repeat III; Potential
	Transmembrane	1526 – 1549	24	Helical; Name=S1 of repeat IV; Potential
	Transmembrane	1561 – 1584	24	Helical; Name=S2 of repeat IV; Potential
	Transmembrane	1591 – 1614	24	Helical; Name=S3 of repeat IV; Potential
	Transmembrane	1625 – 1646	22	Helical; Voltage-sensor; Name=S4 of repeat IV; Potential
	Transmembrane	1662 – 1684	23	Helical; Name=S5 of repeat IV; Potential
	Transmembrane	1750 – 1774	25	Helical; Name=S6 of repeat IV; Potential
	Domain	1903 – 1932	30	IQ
	Region	1977 – 1980	4	Interaction with NEDD4, NEDD4L and WWP2 By similarity
Amino acid modifications
	Modified residue	526	1	Dimethylated arginine; alternate By similarity
	Modified residue	526	1	Omega-N-methylarginine; alternate By similarity
	Glycosylation	214	1	N-linked (GlcNAc...) Potential
	Glycosylation	283	1	N-linked (GlcNAc...) Potential
	Glycosylation	288	1	N-linked (GlcNAc...) Potential
	Glycosylation	291	1	N-linked (GlcNAc...) Potential
	Glycosylation	318	1	N-linked (GlcNAc...) Potential
	Glycosylation	328	1	N-linked (GlcNAc...) Potential
	Glycosylation	548	1	N-linked (GlcNAc...) Potential
	Glycosylation	592	1	N-linked (GlcNAc...) Potential
	Glycosylation	740	1	N-linked (GlcNAc...) Potential
	Glycosylation	803	1	N-linked (GlcNAc...) Potential
	Glycosylation	841	1	N-linked (GlcNAc...) Potential
	Glycosylation	864	1	N-linked (GlcNAc...) Potential
	Glycosylation	948	1	N-linked (GlcNAc...) Potential
	Glycosylation	1367	1	N-linked (GlcNAc...) Potential
	Glycosylation	1376	1	N-linked (GlcNAc...) Potential
	Glycosylation	1382	1	N-linked (GlcNAc...) Potential
	Glycosylation	1390	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	206 – 211	6	TTEFVD → VSENIK in isoform 2.		VSP_037444
Experimental info
	Sequence conflict	215	1	V → L in BAE27966. Ref.2
	Sequence conflict	215	1	V → L in BAE27800. Ref.2
	Sequence conflict	234	1	S → P in BAE27966. Ref.2
	Sequence conflict	234	1	S → P in BAE27800. Ref.2
	Sequence conflict	1008 – 1009	2	AA → TT in CAB70096. Ref.1
	Sequence conflict	1078	1	K → KQ in BAE27966. Ref.2
	Sequence conflict	1078	1	K → KQ in BAE27800. Ref.2
	Sequence conflict	1133	1	T → S in CAB70096. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 27, 2011. Version 2. Checksum: 5A3BC3C191859E79	FASTA	2,019	227,576
	10 20 30 40 50 60 MANFLLPRGT SSFRRFTRES LAAIEKRMAE KQARGSATSQ ESREGLPEEE APRPQLDLQA 70 80 90 100 110 120 SKKLPDLYGN PPRELIGEPL EDLDPFYSTQ KTFIVLNKGK TIFRFSATNA LYVLSPFHPV 130 140 150 160 170 180 RRAAVKILVH SLFSMLIMCT ILTNCVFMAQ HDPPPWTKYV EYTFTAIYTF ESLVKILARG 190 200 210 220 230 240 FCLHAFTFLR DPWNWLDFSV IVMAYTTEFV DLGNVSALRT FRVLRALKTI SVISGLKTIV 250 260 270 280 290 300 GALIQSVKKL ADVMVLTVFC LSVFALIGLQ LFMGNLRHKC VRNFTELNGT NGSVEADGIV 310 320 330 340 350 360 WNSLDVYLND PANYLLKNGT TDVLLCGNSS DAGTCPEGYR CLKAGENPDH GYTSFDSFAW 370 380 390 400 410 420 AFLALFRLMT QDCWERLYQQ TLRSAGKIYM IFFMLVIFLG SFYLVNLILA VVAMAYEEQN 430 440 450 460 470 480 QATIAETEEK EKRFQEAMEM LKKEHEALTI RGVDTVSRSS LEMSPLAPVT NHERRSKRRK 490 500 510 520 530 540 RLSSGTEDGG DDRLPKSDSE DGPRALNQLS LTHGLSRTSM RPRSSRGSIF TFRRRDQGSE 550 560 570 580 590 600 ADFADDENST AGESESHRTS LLVPWPLRRP STQGQPGFGT SAPGHVLNGK RNSTVDCNGV 610 620 630 640 650 660 VSLLGAGDAE ATSPGSHLLR PIVLDRPPDT TTPSEEPGGP QMLTPQAPCA DGFEEPGARQ 670 680 690 700 710 720 RALSAVSVLT SALEELEESH RKCPPCWNRF AQHYLIWECC PLWMSIKQKV KFVVMDPFAD 730 740 750 760 770 780 LTITMCIVLN TLFMALEHYN MTAEFEEMLQ VGNLVFTGIF TAEMTFKIIA LDPYYYFQQG 790 800 810 820 830 840 WNIFDSIIVI LSLMELGLSR MGNLSVLRSF RLLRVFKLAK SWPTLNTLIK IIGNSVGALG 850 860 870 880 890 900 NLTLVLAIIV FIFAVVGMQL FGKNYSELRH RISDSGLLPR WHMMDFFHAF LIIFRILCGE 910 920 930 940 950 960 WIETMWDCME VSGQSLCLLV FLLVMVIGNL VVLNLFLALL LSSFSADNLT APDEDGEMNN 970 980 990 1000 1010 1020 LQLALARIQR GLRFVKRTTW DFCCGLLRRR PKKPAALATH SQLPSCIAAP RSPPPPEVEK 1030 1040 1050 1060 1070 1080 APPARKETRF EEDKRPGQGT PGDTEPVCVP IAVAESDTDD QEEDEENSLG TEEEESSKQE 1090 1100 1110 1120 1130 1140 SQVVSGGHEP PQEPRAWSQV SETTSSEAEA STSQADWQQE REAEPRAPGC GETPEDSYSE 1150 1160 1170 1180 1190 1200 GSTADMTNTA DLLEQIPDLG EDVKDPEDCF TEGCVRRCPC CMVDTTQAPG KVWWRLRKTC 1210 1220 1230 1240 1250 1260 YRIVEHSWFE TFIIFMILLS SGALAFEDIY LEERKTIKVL LEYADKMFTY VFVLEMLLKW 1270 1280 1290 1300 1310 1320 VAYGFKKYFT NAWCWLDFLI VDVSLVSLVA NTLGFAEMGP IKSLRTLRAL RPLRALSRFE 1330 1340 1350 1360 1370 1380 GMRVVVNALV GAIPSIMNVL LVCLIFWLIF SIMGVNLFAG KFGRCINQTE GDLPLNYTIV 1390 1400 1410 1420 1430 1440 NNKSECESFN VTGELYWTKV KVNFDNVGAG YLALLQVATF KGWMDIMYAA VDSRGYEEQP 1450 1460 1470 1480 1490 1500 QWEDNLYMYI YFVVFIIFGS FFTLNLFIGV IIDNFNQQKK KLGGQDIFMT EEQKKYYNAM 1510 1520 1530 1540 1550 1560 KKLGSKKPQK PIPRPLNKYQ GFIFDIVTKQ AFDVTIMFLI CLNMVTMMVE TDDQSPEKVN 1570 1580 1590 1600 1610 1620 ILAKINLLFV AIFTGECIVK MAALRHYYFT NSWNIFDFVV VILSIVGTVL SDIIQKYFFS 1630 1640 1650 1660 1670 1680 PTLFRVIRLA RIGRILRLIR GAKGIRTLLF ALMMSLPALF NIGLLLFLVM FIYSIFGMAN 1690 1700 1710 1720 1730 1740 FAYVKWEAGI DDMFNFQTFA NSMLCLFQIT TSAGWDGLLS PILNTGPPYC DPNLPNSNGS 1750 1760 1770 1780 1790 1800 RGNCGSPAVG ILFFTTYIII SFLIVVNMYI AIILENFSVA TEESTEPLSE DDFDMFYEIW 1810 1820 1830 1840 1850 1860 EKFDPEATQF IEYLALSDFA DALSEPLRIA KPNQISLINM DLPMVSGDRI HCMDILFAFT 1870 1880 1890 1900 1910 1920 KRVLGESGEM DALKIQMEEK FMAANPSKIS YEPITTTLRR KHEEVSATVI QRAFRRHLLQ 1930 1940 1950 1960 1970 1980 RSVKHASFLF RQQAGSSGLS DEDAPEREGL IAYMMNENFS RRSGPLSSSS ISSTSFPPSY 1990 2000 2010 DSVTRATSDN LPVRASDYSR SEDLADFPPS PDRDRESIV
	Isoform 2 [UniParc]. Checksum: E382EEFD025079F9	FASTA	2,019	227,554
	10 20 30 40 50 60 MANFLLPRGT SSFRRFTRES LAAIEKRMAE KQARGSATSQ ESREGLPEEE APRPQLDLQA 70 80 90 100 110 120 SKKLPDLYGN PPRELIGEPL EDLDPFYSTQ KTFIVLNKGK TIFRFSATNA LYVLSPFHPV 130 140 150 160 170 180 RRAAVKILVH SLFSMLIMCT ILTNCVFMAQ HDPPPWTKYV EYTFTAIYTF ESLVKILARG 190 200 210 220 230 240 FCLHAFTFLR DPWNWLDFSV IVMAYVSENI KLGNVSALRT FRVLRALKTI SVISGLKTIV 250 260 270 280 290 300 GALIQSVKKL ADVMVLTVFC LSVFALIGLQ LFMGNLRHKC VRNFTELNGT NGSVEADGIV 310 320 330 340 350 360 WNSLDVYLND PANYLLKNGT TDVLLCGNSS DAGTCPEGYR CLKAGENPDH GYTSFDSFAW 370 380 390 400 410 420 AFLALFRLMT QDCWERLYQQ TLRSAGKIYM IFFMLVIFLG SFYLVNLILA VVAMAYEEQN 430 440 450 460 470 480 QATIAETEEK EKRFQEAMEM LKKEHEALTI RGVDTVSRSS LEMSPLAPVT NHERRSKRRK 490 500 510 520 530 540 RLSSGTEDGG DDRLPKSDSE DGPRALNQLS LTHGLSRTSM RPRSSRGSIF TFRRRDQGSE 550 560 570 580 590 600 ADFADDENST AGESESHRTS LLVPWPLRRP STQGQPGFGT SAPGHVLNGK RNSTVDCNGV 610 620 630 640 650 660 VSLLGAGDAE ATSPGSHLLR PIVLDRPPDT TTPSEEPGGP QMLTPQAPCA DGFEEPGARQ 670 680 690 700 710 720 RALSAVSVLT SALEELEESH RKCPPCWNRF AQHYLIWECC PLWMSIKQKV KFVVMDPFAD 730 740 750 760 770 780 LTITMCIVLN TLFMALEHYN MTAEFEEMLQ VGNLVFTGIF TAEMTFKIIA LDPYYYFQQG 790 800 810 820 830 840 WNIFDSIIVI LSLMELGLSR MGNLSVLRSF RLLRVFKLAK SWPTLNTLIK IIGNSVGALG 850 860 870 880 890 900 NLTLVLAIIV FIFAVVGMQL FGKNYSELRH RISDSGLLPR WHMMDFFHAF LIIFRILCGE 910 920 930 940 950 960 WIETMWDCME VSGQSLCLLV FLLVMVIGNL VVLNLFLALL LSSFSADNLT APDEDGEMNN 970 980 990 1000 1010 1020 LQLALARIQR GLRFVKRTTW DFCCGLLRRR PKKPAALATH SQLPSCIAAP RSPPPPEVEK 1030 1040 1050 1060 1070 1080 APPARKETRF EEDKRPGQGT PGDTEPVCVP IAVAESDTDD QEEDEENSLG TEEEESSKQE 1090 1100 1110 1120 1130 1140 SQVVSGGHEP PQEPRAWSQV SETTSSEAEA STSQADWQQE REAEPRAPGC GETPEDSYSE 1150 1160 1170 1180 1190 1200 GSTADMTNTA DLLEQIPDLG EDVKDPEDCF TEGCVRRCPC CMVDTTQAPG KVWWRLRKTC 1210 1220 1230 1240 1250 1260 YRIVEHSWFE TFIIFMILLS SGALAFEDIY LEERKTIKVL LEYADKMFTY VFVLEMLLKW 1270 1280 1290 1300 1310 1320 VAYGFKKYFT NAWCWLDFLI VDVSLVSLVA NTLGFAEMGP IKSLRTLRAL RPLRALSRFE 1330 1340 1350 1360 1370 1380 GMRVVVNALV GAIPSIMNVL LVCLIFWLIF SIMGVNLFAG KFGRCINQTE GDLPLNYTIV 1390 1400 1410 1420 1430 1440 NNKSECESFN VTGELYWTKV KVNFDNVGAG YLALLQVATF KGWMDIMYAA VDSRGYEEQP 1450 1460 1470 1480 1490 1500 QWEDNLYMYI YFVVFIIFGS FFTLNLFIGV IIDNFNQQKK KLGGQDIFMT EEQKKYYNAM 1510 1520 1530 1540 1550 1560 KKLGSKKPQK PIPRPLNKYQ GFIFDIVTKQ AFDVTIMFLI CLNMVTMMVE TDDQSPEKVN 1570 1580 1590 1600 1610 1620 ILAKINLLFV AIFTGECIVK MAALRHYYFT NSWNIFDFVV VILSIVGTVL SDIIQKYFFS 1630 1640 1650 1660 1670 1680 PTLFRVIRLA RIGRILRLIR GAKGIRTLLF ALMMSLPALF NIGLLLFLVM FIYSIFGMAN 1690 1700 1710 1720 1730 1740 FAYVKWEAGI DDMFNFQTFA NSMLCLFQIT TSAGWDGLLS PILNTGPPYC DPNLPNSNGS 1750 1760 1770 1780 1790 1800 RGNCGSPAVG ILFFTTYIII SFLIVVNMYI AIILENFSVA TEESTEPLSE DDFDMFYEIW 1810 1820 1830 1840 1850 1860 EKFDPEATQF IEYLALSDFA DALSEPLRIA KPNQISLINM DLPMVSGDRI HCMDILFAFT 1870 1880 1890 1900 1910 1920 KRVLGESGEM DALKIQMEEK FMAANPSKIS YEPITTTLRR KHEEVSATVI QRAFRRHLLQ 1930 1940 1950 1960 1970 1980 RSVKHASFLF RQQAGSSGLS DEDAPEREGL IAYMMNENFS RRSGPLSSSS ISSTSFPPSY 1990 2000 2010 DSVTRATSDN LPVRASDYSR SEDLADFPPS PDRDRESIV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mouse heart Na+ channels: primary structure and function of two isoforms and alternatively spliced variants." Zimmer T., Bollensdorff C., Haufe V., Birch-Hirschfeld E., Benndorf K. Am. J. Physiol. 282:H1007-H1017(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, TISSUE SPECIFICITY. Strain: BALB/c. Tissue: Heart.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: C57BL/6J.
[3]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[4]	"Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels." Wagner S., Dybkova N., Rasenack E.C., Jacobshagen C., Fabritz L., Kirchhof P., Maier S.K., Zhang T., Hasenfuss G., Brown J.H., Bers D.M., Maier L.S. J. Clin. Invest. 116:3127-3138(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION BY CAMK2D.
[5]	"Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts." Wang C., Hennessey J.A., Kirkton R.D., Wang C., Graham V., Puranam R.S., Rosenberg P.B., Bursac N., Pitt G.S. Circ. Res. 109:775-782(2011) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FGF13.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ271477 mRNA. Translation: CAB70096.1. AK147254 mRNA. Translation: BAE27800.1. AK147517 mRNA. Translation: BAE27966.1. AC121922 Genomic DNA. No translation available. AC171201 Genomic DNA. No translation available.
IPI	IPI00624932. IPI00894690.
RefSeq	NP_001240789.1. NM_001253860.1. NP_067519.2. NM_021544.4.
UniGene	Mm.103584.
3D structure databases
HSSP	HSSP built from PDB template 1BYY based on UniProtKB P04775.
ProteinModelPortal	Q9JJV9.
SMR	Q9JJV9. Positions 1775-1930.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-46142N.
STRING	10090.ENSMUSP00000112838.
PTM databases
PhosphoSite	Q9JJV9.
Proteomic databases
PaxDb	Q9JJV9.
PRIDE	Q9JJV9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000117911; ENSMUSP00000112838; ENSMUSG00000032511. ENSMUST00000120420; ENSMUSP00000113272; ENSMUSG00000032511.
GeneID	20271.
KEGG	mmu:20271.
UCSC	uc009sbc.1. mouse.
Organism-specific databases
CTD	6331.
MGI	MGI:98251. Scn5a.
Phylogenomic databases
eggNOG	COG1226.
GeneTree	ENSGT00650000092939.
HOGENOM	HOG000231755.
InParanoid	Q3UH91.
KO	K04838.
Gene expression databases
ArrayExpress	Q9JJV9.
Bgee	Q9JJV9.
Genevestigator	Q9JJV9.
Family and domain databases
InterPro	IPR024583. DUF3451. IPR005821. Ion_trans_dom. IPR000048. IQ_motif_EF-hand-BS. IPR008053. Na_channel_a5su. IPR001696. Na_channel_asu. IPR010526. Na_trans_assoc. [Graphical view]
Pfam	PF11933. DUF3451. 1 hit. PF00520. Ion_trans. 4 hits. PF06512. Na_trans_assoc. 1 hit. [Graphical view]
PRINTS	PR00170. NACHANNEL. PR01666. NACHANNEL5.
SMART	SM00015. IQ. 1 hit. [Graphical view]
PROSITE	PS50096. IQ. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	297947.
SOURCE	Search...

Entry information

Entry name

SCN5A_MOUSE

Accession

Primary (citable) accession number: Q9JJV9
Secondary accession number(s): E9Q1D2, Q3UH91

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 16, 2009
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 82 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program