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Q9JJV9

- SCN5A_MOUSE

UniProt

Q9JJV9 - SCN5A_MOUSE

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Protein

Sodium channel protein type 5 subunit alpha

Gene
Scn5a
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na+ channel isoform. Channel inactivation is regulated by intracellular calcium levels By similarity.

GO - Molecular functioni

  1. protein binding Source: UniProtKB
  2. scaffold protein binding Source: BHF-UCL
  3. voltage-gated sodium channel activity Source: MGI
  4. voltage-gated sodium channel activity involved in cardiac muscle cell action potential Source: MGI
  5. voltage-gated sodium channel activity involved in SA node cell action potential Source: MGI

GO - Biological processi

  1. cardiac ventricle development Source: MGI
  2. cellular response to calcium ion Source: UniProtKB
  3. membrane depolarization during cardiac muscle cell action potential Source: GOC
  4. membrane depolarization during SA node cell action potential Source: GOC
  5. neuronal action potential Source: RefGenome
  6. regulation of cardiac muscle cell contraction Source: MGI
  7. regulation of heart rate by cardiac conduction Source: MGI
  8. response to organic cyclic compound Source: MGI
  9. sodium ion transmembrane transport Source: GOC
  10. sodium ion transport Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Calmodulin-binding, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel protein type 5 subunit alpha
Alternative name(s):
Sodium channel protein cardiac muscle subunit alpha
Sodium channel protein type V subunit alpha
Voltage-gated sodium channel subunit alpha Nav1.5
mH1
Gene namesi
Name:Scn5a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:98251. Scn5a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 126126Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei127 – 15024Helical; Name=S1 of repeat I; Reviewed predictionAdd
BLAST
Topological domaini151 – 1588Extracellular Reviewed prediction
Transmembranei159 – 17820Helical; Name=S2 of repeat I; Reviewed predictionAdd
BLAST
Topological domaini179 – 19113Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei192 – 21019Helical; Name=S3 of repeat I; Reviewed predictionAdd
BLAST
Topological domaini211 – 2166Extracellular Reviewed prediction
Transmembranei217 – 23620Helical; Voltage-sensor; Name=S4 of repeat I; Reviewed predictionAdd
BLAST
Topological domaini237 – 25216Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei253 – 27624Helical; Name=S5 of repeat I; Reviewed predictionAdd
BLAST
Topological domaini277 – 389113Extracellular Reviewed predictionAdd
BLAST
Transmembranei390 – 41526Helical; Name=S6 of repeat I; Reviewed predictionAdd
BLAST
Topological domaini416 – 711296Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei712 – 73625Helical; Name=S1 of repeat II; Reviewed predictionAdd
BLAST
Topological domaini737 – 74711Extracellular Reviewed predictionAdd
BLAST
Transmembranei748 – 77124Helical; Name=S2 of repeat II; Reviewed predictionAdd
BLAST
Topological domaini772 – 7798Cytoplasmic Reviewed prediction
Transmembranei780 – 79920Helical; Name=S3 of repeat II; Reviewed predictionAdd
BLAST
Topological domaini800 – 8056Extracellular Reviewed prediction
Transmembranei806 – 82520Helical; Voltage-sensor; Name=S4 of repeat II; Reviewed predictionAdd
BLAST
Topological domaini826 – 84116Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei842 – 86221Helical; Name=S5 of repeat II; Reviewed predictionAdd
BLAST
Topological domaini863 – 91553Extracellular Reviewed predictionAdd
BLAST
Transmembranei916 – 94126Helical; Name=S6 of repeat II; Reviewed predictionAdd
BLAST
Topological domaini942 – 1202261Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei1203 – 122624Helical; Name=S1 of repeat III; Reviewed predictionAdd
BLAST
Topological domaini1227 – 123913Extracellular Reviewed predictionAdd
BLAST
Transmembranei1240 – 126526Helical; Name=S2 of repeat III; Reviewed predictionAdd
BLAST
Topological domaini1266 – 12716Cytoplasmic Reviewed prediction
Transmembranei1272 – 129322Helical; Name=S3 of repeat III; Reviewed predictionAdd
BLAST
Topological domaini1294 – 12974Extracellular Reviewed prediction
Transmembranei1298 – 131922Helical; Voltage-sensor; Name=S4 of repeat III; Reviewed predictionAdd
BLAST
Topological domaini1320 – 133819Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei1339 – 136123Helical; Name=S5 of repeat III; Reviewed predictionAdd
BLAST
Topological domaini1362 – 144584Extracellular Reviewed predictionAdd
BLAST
Transmembranei1446 – 147227Helical; Name=S6 of repeat III; Reviewed predictionAdd
BLAST
Topological domaini1473 – 152553Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei1526 – 154924Helical; Name=S1 of repeat IV; Reviewed predictionAdd
BLAST
Topological domaini1550 – 156011Extracellular Reviewed predictionAdd
BLAST
Transmembranei1561 – 158424Helical; Name=S2 of repeat IV; Reviewed predictionAdd
BLAST
Topological domaini1585 – 15906Cytoplasmic Reviewed prediction
Transmembranei1591 – 161424Helical; Name=S3 of repeat IV; Reviewed predictionAdd
BLAST
Topological domaini1615 – 162410Extracellular Reviewed prediction
Transmembranei1625 – 164622Helical; Voltage-sensor; Name=S4 of repeat IV; Reviewed predictionAdd
BLAST
Topological domaini1647 – 166115Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei1662 – 168423Helical; Name=S5 of repeat IV; Reviewed predictionAdd
BLAST
Topological domaini1685 – 174965Extracellular Reviewed predictionAdd
BLAST
Transmembranei1750 – 177425Helical; Name=S6 of repeat IV; Reviewed predictionAdd
BLAST
Topological domaini1775 – 2019245Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: BHF-UCL
  2. integral component of membrane Source: UniProtKB
  3. intercalated disc Source: BHF-UCL
  4. plasma membrane Source: MGI
  5. sodium channel complex Source: MGI
  6. T-tubule Source: MGI
  7. voltage-gated sodium channel complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20192019Sodium channel protein type 5 subunit alphaPRO_0000376895Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei36 – 361Phosphoserine By similarity
Modified residuei38 – 381Phosphothreonine By similarity
Glycosylationi214 – 2141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi283 – 2831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi288 – 2881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi291 – 2911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi318 – 3181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi328 – 3281N-linked (GlcNAc...) Reviewed prediction
Modified residuei457 – 4571Phosphoserine By similarity
Modified residuei460 – 4601Phosphoserine By similarity
Modified residuei483 – 4831Phosphoserine By similarity
Modified residuei484 – 4841Phosphoserine By similarity
Modified residuei497 – 4971Phosphoserine By similarity
Modified residuei510 – 5101Phosphoserine By similarity
Modified residuei526 – 5261Dimethylated arginine; alternate By similarity
Modified residuei526 – 5261Omega-N-methylarginine; alternate By similarity
Modified residuei571 – 5711Phosphoserine By similarity
Modified residuei664 – 6641Phosphoserine By similarity
Modified residuei667 – 6671Phosphoserine By similarity
Glycosylationi740 – 7401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi803 – 8031N-linked (GlcNAc...) Reviewed prediction
Glycosylationi864 – 8641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1367 – 13671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1376 – 13761N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1382 – 13821N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1390 – 13901N-linked (GlcNAc...) Reviewed prediction
Modified residuei1505 – 15051Phosphoserine; by PKC By similarity

Post-translational modificationi

Regulated through phosphorylation by CaMK2D.
Ubiquitinated by NEDD4L; which promotes its endocytosis By similarity.
Phosphorylation at Ser-1505 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents By similarity.

Keywords - PTMi

Glycoprotein, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9JJV9.
PRIDEiQ9JJV9.

PTM databases

PhosphoSiteiQ9JJV9.

Expressioni

Tissue specificityi

Expressed in the myocardium.1 Publication

Gene expression databases

BgeeiQ9JJV9.
GenevestigatoriQ9JJV9.

Interactioni

Subunit structurei

Interacts with the PDZ domain of the syntrophin SNTA1, SNTB1 and SNTB2 By similarity. Interacts with NEDD4, NEDD4L, WWP2 and GPD1L. Interacts with CALM By similarity. Interacts with FGF13; the interaction is direct and may regulate SNC5A density at membranes and function.1 Publication

Protein-protein interaction databases

BioGridi203101. 2 interactions.
DIPiDIP-46142N.
IntActiQ9JJV9. 1 interaction.
MINTiMINT-4130032.
STRINGi10090.ENSMUSP00000112838.

Structurei

3D structure databases

ProteinModelPortaliQ9JJV9.
SMRiQ9JJV9. Positions 1775-1930.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1903 – 193230IQAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1841 – 190363Interaction with FGF13 By similarityAdd
BLAST
Regioni1977 – 19804Interaction with NEDD4, NEDD4L and WWP2 By similarity

Domaini

The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
The IQ domain mediates association with calmodulin By similarity.

Sequence similaritiesi

Contains 1 IQ domain.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00750000117555.
HOGENOMiHOG000231755.
InParanoidiQ3UH91.
KOiK04838.
OrthoDBiEOG7DJSK9.
TreeFamiTF323985.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR024583. DUF3451.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR008053. Na_channel_a5su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view]
PfamiPF11933. DUF3451. 1 hit.
PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.
PR01666. NACHANNEL5.
SMARTiSM00015. IQ. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q9JJV9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MANFLLPRGT SSFRRFTRES LAAIEKRMAE KQARGSATSQ ESREGLPEEE     50
APRPQLDLQA SKKLPDLYGN PPRELIGEPL EDLDPFYSTQ KTFIVLNKGK 100
TIFRFSATNA LYVLSPFHPV RRAAVKILVH SLFSMLIMCT ILTNCVFMAQ 150
HDPPPWTKYV EYTFTAIYTF ESLVKILARG FCLHAFTFLR DPWNWLDFSV 200
IVMAYTTEFV DLGNVSALRT FRVLRALKTI SVISGLKTIV GALIQSVKKL 250
ADVMVLTVFC LSVFALIGLQ LFMGNLRHKC VRNFTELNGT NGSVEADGIV 300
WNSLDVYLND PANYLLKNGT TDVLLCGNSS DAGTCPEGYR CLKAGENPDH 350
GYTSFDSFAW AFLALFRLMT QDCWERLYQQ TLRSAGKIYM IFFMLVIFLG 400
SFYLVNLILA VVAMAYEEQN QATIAETEEK EKRFQEAMEM LKKEHEALTI 450
RGVDTVSRSS LEMSPLAPVT NHERRSKRRK RLSSGTEDGG DDRLPKSDSE 500
DGPRALNQLS LTHGLSRTSM RPRSSRGSIF TFRRRDQGSE ADFADDENST 550
AGESESHRTS LLVPWPLRRP STQGQPGFGT SAPGHVLNGK RNSTVDCNGV 600
VSLLGAGDAE ATSPGSHLLR PIVLDRPPDT TTPSEEPGGP QMLTPQAPCA 650
DGFEEPGARQ RALSAVSVLT SALEELEESH RKCPPCWNRF AQHYLIWECC 700
PLWMSIKQKV KFVVMDPFAD LTITMCIVLN TLFMALEHYN MTAEFEEMLQ 750
VGNLVFTGIF TAEMTFKIIA LDPYYYFQQG WNIFDSIIVI LSLMELGLSR 800
MGNLSVLRSF RLLRVFKLAK SWPTLNTLIK IIGNSVGALG NLTLVLAIIV 850
FIFAVVGMQL FGKNYSELRH RISDSGLLPR WHMMDFFHAF LIIFRILCGE 900
WIETMWDCME VSGQSLCLLV FLLVMVIGNL VVLNLFLALL LSSFSADNLT 950
APDEDGEMNN LQLALARIQR GLRFVKRTTW DFCCGLLRRR PKKPAALATH 1000
SQLPSCIAAP RSPPPPEVEK APPARKETRF EEDKRPGQGT PGDTEPVCVP 1050
IAVAESDTDD QEEDEENSLG TEEEESSKQE SQVVSGGHEP PQEPRAWSQV 1100
SETTSSEAEA STSQADWQQE REAEPRAPGC GETPEDSYSE GSTADMTNTA 1150
DLLEQIPDLG EDVKDPEDCF TEGCVRRCPC CMVDTTQAPG KVWWRLRKTC 1200
YRIVEHSWFE TFIIFMILLS SGALAFEDIY LEERKTIKVL LEYADKMFTY 1250
VFVLEMLLKW VAYGFKKYFT NAWCWLDFLI VDVSLVSLVA NTLGFAEMGP 1300
IKSLRTLRAL RPLRALSRFE GMRVVVNALV GAIPSIMNVL LVCLIFWLIF 1350
SIMGVNLFAG KFGRCINQTE GDLPLNYTIV NNKSECESFN VTGELYWTKV 1400
KVNFDNVGAG YLALLQVATF KGWMDIMYAA VDSRGYEEQP QWEDNLYMYI 1450
YFVVFIIFGS FFTLNLFIGV IIDNFNQQKK KLGGQDIFMT EEQKKYYNAM 1500
KKLGSKKPQK PIPRPLNKYQ GFIFDIVTKQ AFDVTIMFLI CLNMVTMMVE 1550
TDDQSPEKVN ILAKINLLFV AIFTGECIVK MAALRHYYFT NSWNIFDFVV 1600
VILSIVGTVL SDIIQKYFFS PTLFRVIRLA RIGRILRLIR GAKGIRTLLF 1650
ALMMSLPALF NIGLLLFLVM FIYSIFGMAN FAYVKWEAGI DDMFNFQTFA 1700
NSMLCLFQIT TSAGWDGLLS PILNTGPPYC DPNLPNSNGS RGNCGSPAVG 1750
ILFFTTYIII SFLIVVNMYI AIILENFSVA TEESTEPLSE DDFDMFYEIW 1800
EKFDPEATQF IEYLALSDFA DALSEPLRIA KPNQISLINM DLPMVSGDRI 1850
HCMDILFAFT KRVLGESGEM DALKIQMEEK FMAANPSKIS YEPITTTLRR 1900
KHEEVSATVI QRAFRRHLLQ RSVKHASFLF RQQAGSSGLS DEDAPEREGL 1950
IAYMMNENFS RRSGPLSSSS ISSTSFPPSY DSVTRATSDN LPVRASDYSR 2000
SEDLADFPPS PDRDRESIV 2019
Length:2,019
Mass (Da):227,576
Last modified:July 27, 2011 - v2
Checksum:i5A3BC3C191859E79
GO
Isoform 2 (identifier: Q9JJV9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     206-211: TTEFVD → VSENIK

Show »
Length:2,019
Mass (Da):227,554
Checksum:iE382EEFD025079F9
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei206 – 2116TTEFVD → VSENIK in isoform 2. VSP_037444

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti215 – 2151V → L in BAE27966. 1 Publication
Sequence conflicti215 – 2151V → L in BAE27800. 1 Publication
Sequence conflicti234 – 2341S → P in BAE27966. 1 Publication
Sequence conflicti234 – 2341S → P in BAE27800. 1 Publication
Sequence conflicti1008 – 10092AA → TT in CAB70096. 1 Publication
Sequence conflicti1078 – 10781K → KQ in BAE27966. 1 Publication
Sequence conflicti1078 – 10781K → KQ in BAE27800. 1 Publication
Sequence conflicti1133 – 11331T → S in CAB70096. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ271477 mRNA. Translation: CAB70096.1.
AK147254 mRNA. Translation: BAE27800.1.
AK147517 mRNA. Translation: BAE27966.1.
AC121922 Genomic DNA. No translation available.
AC171201 Genomic DNA. No translation available.
RefSeqiNP_001240789.1. NM_001253860.1.
NP_067519.2. NM_021544.4.
UniGeneiMm.103584.

Genome annotation databases

EnsembliENSMUST00000117911; ENSMUSP00000112838; ENSMUSG00000032511.
ENSMUST00000120420; ENSMUSP00000113272; ENSMUSG00000032511. [Q9JJV9-1]
GeneIDi20271.
KEGGimmu:20271.
UCSCiuc009sbc.2. mouse. [Q9JJV9-2]
uc009sbe.2. mouse. [Q9JJV9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ271477 mRNA. Translation: CAB70096.1 .
AK147254 mRNA. Translation: BAE27800.1 .
AK147517 mRNA. Translation: BAE27966.1 .
AC121922 Genomic DNA. No translation available.
AC171201 Genomic DNA. No translation available.
RefSeqi NP_001240789.1. NM_001253860.1.
NP_067519.2. NM_021544.4.
UniGenei Mm.103584.

3D structure databases

ProteinModelPortali Q9JJV9.
SMRi Q9JJV9. Positions 1775-1930.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203101. 2 interactions.
DIPi DIP-46142N.
IntActi Q9JJV9. 1 interaction.
MINTi MINT-4130032.
STRINGi 10090.ENSMUSP00000112838.

PTM databases

PhosphoSitei Q9JJV9.

Proteomic databases

PaxDbi Q9JJV9.
PRIDEi Q9JJV9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000117911 ; ENSMUSP00000112838 ; ENSMUSG00000032511 .
ENSMUST00000120420 ; ENSMUSP00000113272 ; ENSMUSG00000032511 . [Q9JJV9-1 ]
GeneIDi 20271.
KEGGi mmu:20271.
UCSCi uc009sbc.2. mouse. [Q9JJV9-2 ]
uc009sbe.2. mouse. [Q9JJV9-1 ]

Organism-specific databases

CTDi 6331.
MGIi MGI:98251. Scn5a.

Phylogenomic databases

eggNOGi COG1226.
GeneTreei ENSGT00750000117555.
HOGENOMi HOG000231755.
InParanoidi Q3UH91.
KOi K04838.
OrthoDBi EOG7DJSK9.
TreeFami TF323985.

Miscellaneous databases

NextBioi 297947.
PROi Q9JJV9.
SOURCEi Search...

Gene expression databases

Bgeei Q9JJV9.
Genevestigatori Q9JJV9.

Family and domain databases

Gene3Di 1.20.120.350. 4 hits.
InterProi IPR027359. Channel_four-helix_dom.
IPR024583. DUF3451.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR008053. Na_channel_a5su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view ]
Pfami PF11933. DUF3451. 1 hit.
PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view ]
PRINTSi PR00170. NACHANNEL.
PR01666. NACHANNEL5.
SMARTi SM00015. IQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse heart Na+ channels: primary structure and function of two isoforms and alternatively spliced variants."
    Zimmer T., Bollensdorff C., Haufe V., Birch-Hirschfeld E., Benndorf K.
    Am. J. Physiol. 282:H1007-H1017(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
    Strain: BALB/c.
    Tissue: Heart.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Cited for: PHOSPHORYLATION BY CAMK2D.
  5. "Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts."
    Wang C., Hennessey J.A., Kirkton R.D., Wang C., Graham V., Puranam R.S., Rosenberg P.B., Bursac N., Pitt G.S.
    Circ. Res. 109:775-782(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FGF13.

Entry informationi

Entry nameiSCN5A_MOUSE
AccessioniPrimary (citable) accession number: Q9JJV9
Secondary accession number(s): E9Q1D2, Q3UH91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: July 27, 2011
Last modified: June 11, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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